Day: June 8, 2021

Related Products of 944401-65-4, Adding some certain compound to certain chemical reactions, such as: 944401-65-4, name is 5-Bromo-6-fluoropyridin-2-amine,molecular formula is C5H4BrFN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 944401-65-4.

A solution of sodium nitrite (21.67g, 314.13mmol) in water (150mL) was added dropwise to a stirred mixture of 5-bromo-6-fluoropyridin-2-amine (50g, 261.78mmol) and sulphuric acid (1.2mL, 22.51mmol) in water (750mL) at 0-5C. The resulting suspension was stirred for 48 h at ambient temperature then the precipitate collected by filtration, washed with water (200mL) and dried under vacuum to afford the desired material (40. Og, 80%) as a pale yellow solid, which was used without further purification. NMR Spectrum: 1H NMR (300MHz, DMSO-d6) delta 6.55 (1H, d), 8.00 (1H, t), 11.71 (1H, bs). Mass Spectrum: m/z (ES+)[M+H]+ = 192.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 944401-65-4, 5-Bromo-6-fluoropyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; BARLAAM, Bernard Christophe; PIKE, Kurt Gordon; WO2015/170081; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H5ClN2O3

Under nitrogen, Example 23B (70 mg, 0.42 mmol), 2-chloro-4-methoxy-5-nitropyridine (94 mg, 0.5 mmol), Pd2 (dba)3 (38 mg , 0.04 mmol), Xantphos (24 mg, 0.04 mmol) and cesium carbonate (271 mg, 0.83 mmol) in dioxane (5mL) were stirred at 90 deg.C for 12 hours. LCMS showed the reaction was complete. After the reaction mixture was diluted with water (40mL) (50mL × 2) and extracted with dichloromethane. The organic layer was washed with brine (30mL × 2), dried over anhydrous sodium sulfate, filtered and concentrated. The resulting residue was purified by silica gel column (petroleum ether: ethyl acetate = 4: 1, 3: 1) to give the title compound (50mg, yield 37.5%) as a yellow oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 607373-83-1, 2-Chloro-4-methoxy-5-nitropyridine.

Reference:
Patent; Nanjing Mingde New Drug Research and Development Co. Ltd.; Qilu Pharmaceutical Co., Ltd.; Ding, Zhaozhong; Zhang, Minghui; Chen, Shuhui; Liu, Xile; Zhu, Yidong; Fan, Chuanwen; Zhao, Baoping; Zhang, Long; Chen, Dong; Yang, Yingying; Zheng, Qingmei; Zheng, Shansong; Wan, Haiwen; Hu, Jinqing; (93 pag.)CN105330698; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 153034-78-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153034-78-7, name is 2-Fluoro-3-iodo-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

In a 20-ml flask, 2-fluoro-3-iodo-5-methylpyridine (1.0 g, 4.2 mmol), potassium acetate (828 mg, 8.4 mmol), acetic acid (1 ml) and aniline (393 mg, 4.2 mmol) were mixed, and the solution was heated to reflux for 10 hours. After allowing the solution to stand overnight at room temperature, aniline (393 mg, 4.2 mmol) was added, and the mixture was further heated to reflux for 10 hours. After allowing the mixture again to stand overnight at room temperature, aniline (393 mg, 4.2 mmol) was added, and the mixture was further heated to reflux for 8 hours. This reaction solution was cooled to room temperature, ethyl acetate (20 ml) was added thereto. The organic layer was separated and washed with water (5 ml) two times. The organic layer was washed twice with a saturated aqueous sodium bicarbonate solution (10 ml) and further washed with saturated brine (10 ml) . The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure, diisopropyl ether (about 50 ml) was added to the residue, and a precipitate was filtered off. The filtrate was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (hexane : ethyl acetate = 4:1). The obtained extract was concentrated under reduced pressure, and dried under reduced pressure at 50C, to yield the title compound (539 mg, 1.7 mmol) as a yellow oily material (yield 41.2%) . 1H-NMR (CDCl3, TMS, 300 MHz) delta (ppm) : 2.17 (s, 3H), 6.77 (brs, IH), 6.98-7.03 (m, IH), 7.28-7.34 (m, 2H), 7.53-7.57 (m, 2H), 7.77-7.79 (s, 2H), 7.96-7.97 (m, IH).13C-NMR (CDCl3, TMS, 300 MHz) delta (ppm) : 17 . 04 , 81 . 16, 119.57 , 122 .48 , 125.72 , 128. 99, 140. 60, 147 .20, 147 .93, 151 . 92 High resolution mass spectrometry (Ci2HiIlN2 )Theoretical value : 308 .9889 [M-H] + Measured value : 309. 9892 [M-H] +

According to the analysis of related databases, 153034-78-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2008/16184; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 132865-44-2, name is 5-Chloro-6-methoxynicotinaldehyde, the common compound, a new synthetic route is introduced below. Computed Properties of C7H6ClNO2

A mixture of 5-chloro-6-methoxynicotinaldehyde (59.56 mg, 0.347 1 mmol), 4-(2-(3,6- diazabicyclo[3. 1.1 ]heptan-3 -yl)pyrimidin-5 -yl)-6-(2-morpholinoethoxy)pyrazolo[ 1,5 -a]pyridine3-carbonitrile (Intermediate P117; 31 mg, 0.069 mmol) and NaBH(AcO)3 (147.1 mg, 0.6943 mmol) in DCM (694.3 tL) was stirred overnight at ambient temperature. The reaction mixture was purified directly by silica chromatography (using 0-10% MeOH in EtOAc with 0.1% NH4OH as the gradient eluent) to cleanly afford the title compound (15.19 mg, 35% yield). MS (apci) m/z = 602.3 (M+H).

The synthetic route of 132865-44-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ANDREWS, Steven W.; ARONOW, Sean; BLAKE, James F.; BRANDHUBER, Barbara J.; COOK, Adam; HAAS, Julia; JIANG, Yutong; KOLAKOWSKI, Gabrielle R.; MCFADDIN, Elizabeth A.; MCKENNEY, Megan L.; MCNULTY, Oren T.; METCALF, Andrew T.; MORENO, David A.; TANG, Tony P.; REN, Li; (668 pag.)WO2018/71447; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 6313-54-8 ,Some common heterocyclic compound, 6313-54-8, molecular formula is C6H4ClNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Preparation 1; SYNTHESIS OF 2-[4-(5-FLUORO-2-TRIFLUOROMETHYLBENZOYL)PIPERAZIN-1-YL]ISONICOTINIC ACID METHYL ESTER; A. A mixture of 2-chloroisonicotinic acid (1.000 g, 6.340 mmol) and 5 drops of concentrated sulfuric acid in anhydrous methanol (50 mL) was refluxed for 3 hours. The reaction mixture was concentrated in vacuo, diluted with 20 mL of water and extracted with ethyl acetate. The organic phase was washed with water and brine, dried and concentrated. The compound obtained was used for next step reaction without further purification. Yield 0.816 g, 75%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6313-54-8, 2-Chloroisonicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; XENON PHARMACEUTICALS INC.; US2008/167321; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1374639-78-7, name is tert-Butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-1-carboxylate, molecular formula is C28H38N8O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C28H38N8O3

A solution of tert-butyl 4-(6-((7-cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3- d]pyrimidin-2-yl)amino)pyridin-3-yl)piperazine-l-carboxylate (Ila) (50 g) in toluene (300 mL) was cooled to 10 C. Hydrochloric acid (6N, 100 mL) was added to the above solution in drop wise at 15 C. The reaction mass was stirred for 1 hour at 25-30 C. Hydrochloric acid (IN, 200 mL) was added to the above reaction mass at 25-30 C and stirred for 10 minutes at the same temperature. The reaction mass was then filtered and washed with toluene (1 x 50 mL) followed by hydrochloric acid (IN, 50 mL). Organic layer was separated and aqueous layer was cooled to 15 C. pH of aqueous layer was adjusted to pH=12.0-12.5 using saturated solution of sodium hydroxide (50% w/w) and stirred for 1 hour at 15-20 C. The resulted precipitate was then filtered, washed with water (3 chi 80 mL) and dried at 50 C for 6 hours to provide the title compound. (0169) Yield: 35.1 g; Purity by HPLC: 99.31 %

With the rapid development of chemical substances, we look forward to future research findings about 1374639-78-7.

Reference:
Patent; DR. REDDY?S LABORATORIES LIMITED; PEDDIREDDY, Subba Reddy; KOTTUR, Mohan Kumar; ORUGANTI, Srinivas; KANDAGATLA, Bhaskar; DAS GUPTA, Shirshendu; (39 pag.)WO2018/51280; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89466-16-0 ,Some common heterocyclic compound, 89466-16-0, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of scheme 8-38 compound S1 (1 g, 3.89 mmol) and 6-bromo-3-methylpyridin-2-amine (870 mg, 4.67 mmol) in DCE (10 ml) was added DIPEA (2.56 mL, 15.56 mmol) and EEDQ (1.92 g, 7.78 mmol). The reaction was stirred at 90 C. overnight. The solvent was removed under vacuum. The residue was purified by column chromatography on silica gel (petroleum ether: ethyl acetate=2:1) to afford compound 2 (710 mg, 43.0% yield) as a white solid. LC/MS (ESI) m/z: 426 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 89466-16-0, 6-Bromo-3-methylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 951626-91-8, 5-Bromo-3-chloro-1H-pyrrolo[2,3-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 951626-91-8, blongs to pyridine-derivatives compound. Recommanded Product: 951626-91-8

Step 1: 3-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrrolo[2,3-b]pyridine To a solution of 5-bromo-3-chloro-lH-pyrrolo[2,3-b]pyridine (1.0 g, 4.32mmol) in 1,4-dioxane (20 mL) was added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (1.32 g, 5.18 mmol), potassium acetate (1.27 g, 12.96 mmol) and l,l’-bis(diphenylphosphino)ferrocene- palladium(II)dichloride (315 mg, 0.43 mmol). The reaction mixture was purged with nitrogen for 2 min and heated to 100 C for 2 h and subsequently concentrated to dryness in vacuo. The resulting viscous mass was diluted with water and extracted with ethyl acetate (2 x 50 mL). The combined organic layers were dried over sodium sulfate and concentrated to dryness in vacuo. The resulting residue was purified by column chromatography (silica gel, 100-200 mesh, 30% ethyl acetate in petroleum ether ) affording 3-chloro-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrrolo[2,3- bjpyridine (770 mg, 64%): lU NMR (400 MHz, Chloroform-d) delta 11.61 (s, 1H), 8.76 (s, 1H), 8.45 (s, 1H), 7.33 (s, 1H), 1.40 (s, 12H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,951626-91-8, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 19621-92-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 19621-92-2, name is 6-Oxo-1,6-dihydropyridine-2-carboxylic acid. A new synthetic method of this compound is introduced below.

Compound 1-193[00475] Compound 1-193 was synthesized as a yellow solid (33%) via the condensation of Compound 1-107 (1 equiv) with 6-hydroxypicolinic acid (3.0 equiv), HATU (2.5 equiv) and Hunig’s base (5 equiv) in acetonitrile at 45 C. Purification was carried out using Si02 chromatography employing a 0-40% (7:1 acetonitrile/MeOH)/DCM gradient following a DCM and sodium bicarbonate-based work-up.1H NMR (400 MHz, CD3OD) 8.85 (d, IH), 8.82-8.79 (m, 2H), 8.47 (s, IH), 8.02-7.98 (m, 2H), 7.62 (s, IH), 7.35-7.27 (m, IH), 7.14-7.06 (m, 2H), 7.05-6.95 (m, IH), 6.93 (d, IH), 6.04 (s, 2H) ppm. 1H NMR (400 MHz, CD3OD) 8.81 (d, IH), 8.45 (s, IH), 7.85-7.77 (m, IH), 7.77-7.40 (bs, IH), 7.55 (s, IH), 7.33-7.27 (m, IH), 7.13-7.05 (m, 2H), 6.98-6.93 (m, IH), 6.91 (d, IH), 6.91-6.86 (m, IH), 6.01 (s, 2H) ppm.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,19621-92-2, its application will become more common.

Reference:
Patent; IRONWOOD PHARMACEUTICALS, INC.; KIM, Charles; NAKAI, Takashi; WAI-HO LEE, Thomas; MOORE, Joel; PERL, Nicholas, Robert; ROHDE, Jason; IYENGAR, Rajesh, R.; MERMERIAN, Ara; WO2012/3405; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 59352-90-8, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 59352-90-8 as follows.

The mixture of 5-bromo-6-methylpyridine-2,3-diamine (500.0 mg, 2.47 mmol) and diethyloxalate (3.0 mL) was stirred at 100° C. for 12 hours and then cooled to room temperature. Et2O was added to the reaction mixture to form a solid. The formed solid was then filtered and dried under reduced pressure to obtain light brown solid compound of 7-bromo-6-methylpyrido[2,3-b]pyrazine-2,3-diol (611.0 mg, 97percent). [1093] LCMS ESI (+): 256 (M+1), 258 (M+3) [1094] 1H-NMR (400 MHz, DMSO-d6); delta: 12.40 (s, 1H), 11.94 (s, 1H), 7.53 (s, 1H), 2.48 (s, 3H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,59352-90-8, its application will become more common.

Reference:
Patent; C&C RESEARCH LABORATORIES; Ho, Pil Su; Yoon, Dong Oh; Han, Sun Young; Lee, Won Il; Kim, Jung Sook; Park, Woul Seong; Ahn, Sung Oh; Kim, Hye Jung; US2014/315888; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem