Day: June 16, 2021

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 58530-53-3, name is 2,4-Dibromopyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C5H3Br2N

A mixture was prepared of 2,4-dibromopyridine (10 g, 42.21 mmol), phenylboronic acid (5.1 g, 42.21 mmol), and potassium carbonate (11.7 g, 84.42 mmol) in 100 mL dimethoxyethane and 40 mL of water. Nitrogen was bubbled directly into the mixture for 30 minutes. Next, tetrakis(triphenylphosphine)palladium(0) was added (244 mg, 2.11 mmol) and the mixture was heated to reflux under nitrogen overnight. The mixture was cooled and diluted with ethyl acetate and water. The layers were separated and the aqueous layer was extracted with ethyl acetate. The organic layers were washed with brine, dried over magnesium sulfate, filtered, and evaporated to a residue. The residue was purified by column chromatography eluting with 0, 2, and 5% ethyl acetate/hexanes. Obtained 4.28 g of a yellow liquid (43%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 58530-53-3, 2,4-Dibromopyridine.

Reference:
Patent; UNIVERSAL DISPLAY CORPORATION; XIA, Chuanjun; ALLEYNE, Bert; KWONG, Raymond C.; FIORDELISO, James; WEAVER, Michael S.; ANSARI, Nasrin; DEANGELIS, Alan; RAYABARAPU, Dinesh; ADAMOVICH, Vadim; US2015/307535; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 15862-34-7 ,Some common heterocyclic compound, 15862-34-7, molecular formula is C5H3BrN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 5-Bromo-3-nitro-pyridin-2-ol (10.0 g, 45.66 mmol) in 70 ml of toluene and 7 ml of DMF was added PBr3 (6.60 ml, 68.49 mmol) and the reaction mixture was heated at 12O0C for 20 min under nitrogen atmosphere. After the completion of the reaction mixture (TLC monitoring), water (100 mL) was added and extracted with ethyl acetate (3 x 200 mL). The combined organics was washed with water, brine, dried (Na2SO4), filtered and concentrated to get the desired product (10.30 g, 80.03%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15862-34-7, its application will become more common.

Reference:
Patent; PROLYSIS LTD; WO2007/107758; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 78790-79-1, name is 3-Amino-4-cyanopyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 3-Amino-4-cyanopyridine

4-Amino-3-(3H-imidazo[4,5-b]pyridin-2-yl)-1,7-naphthyridin-2(1H)-one LiHMDS (3.0 eq) was added to ethyl 3H-imidazo[4,5-b]pyridin-2-ylacetate (1.0 eq) in THF at -78 C. After 20 minutes, a solution of 3-aminopyridine-4-carbonitrile (1.1 eq) in THF was added. The resulting mixture was allowed to warm to room temperature, stirred 3 hours, and then refluxed overnight. The mixture was cooled to 0 C. and quenched with an aqueous saturated NH4Cl solution. A precipitate formed, was filtered off, and was washed repeatedly with ether to yield the desired compound as a brown solid. Purification by reverse phase chromatography afforded the desired product as a yellow solid. LC/MS m/z 279.0 (MH+), Rt 1.29 minutes.

The synthetic route of 78790-79-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Renhowe, Paul A.; Machajewski, Timothy; Shafer, Cynthia M.; Wernette-Hammond, Mary Ellen; Pecchi, Sabina; US2002/103230; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 18820-82-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 18820-82-1, name is Pyridine hydrobromide. A new synthetic method of this compound is introduced below.

A 5 mL water solution of NiCl2*6H2O (0.5950 g, 2.50 mM) was added into 10 mL methanol solution of Na2tdas (0.9710 g, 5.00 mM), and the solution was stirred for one hour. The solution above was then added into 10 mL water solution of N-hydrogenpyridinium bromide (0.8000 g, 5.00 mM), and the mixture was stirred for ten minutes, during which a brownish sediment appeared. Brownish microcrystals were obtained after recrystallization of the brownish sediment from diethyl ether.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,18820-82-1, Pyridine hydrobromide, and friends who are interested can also refer to it.

Reference:
Article; Wang, Chi-Feng; Qiao, Fang; Chi, Yan-Hui; Shi, Jing-Min; Cottrill, Ethan; Pan, Ning; Zhu-Ge, Wei-Wei; Fu, Yong-Xin; Xu, Jun; Qian, Xiao-Ping; Journal of Coordination Chemistry; vol. 68; 21; (2015); p. 3884 – 3893;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 77332-89-9, name is 3-Chloro-2-iodopyridine, the common compound, a new synthetic route is introduced below. Recommanded Product: 77332-89-9

3-Chloro-2-iodopyridine (1.552 g, 6.482 mmol), isobutylboronic acid (0.725 g, 7.112 mmol), potassium carbonate (2.7 g, 0.0195 mol) and silver oxide (3.8 g, 0.0164 mol) were suspended in THF (25 mL). The mixture was degassed three times and 1,1-Bis(diphenylphosphino)ferrocene-palladium(11)dichloride dichloromethane (1:1) (0.520 g, 0.637 mmol) was added. The reaction mixture was heated at 75 C. under nitrogen for seven hours. The mixture was diluted EtOAc (15 mL) and washed with an aqueous solution of hydrochloric acid (2.0 M, 2×15 mL). The organic layer was discarded and the aqueous layer basified with careful addition of a saturated aqueous solution of sodium hydrogen carbonate (50 mL). The product was extracted with EtOAc (2×15 mL). The organics were combined, dried over sodium sulfate, filtered, and concentrated in vacuo. The resulting crude was purified by silica gel chromatography eluting with 0 to 5% EtOAc in heptane to yield the title compound as a colourless oil (0.582 g, 53% yield).1H NMR (400 MHz, d6-DMSO): delta 0.87-0.89 (d, 6H), 2.09-2.17 (m, 1H), 2.72-2.74 (d, 2H), 7.24-7.27 (m, 1H), 7.83-7.86 (m, 1H), 8.44-8.45 (m, 1H).LCMS Rt=1.30 minutes MS m/z 170 [MH]+

The synthetic route of 77332-89-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; US2012/10183; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1480-65-5 , The common heterocyclic compound, 1480-65-5, name is 5-Chloro-2-fluoropyridine, molecular formula is C5H3ClFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of 5-chloro-2-fluoropyridine 4d (5.00g, 38.0mmol) and guanidine carbonate (20.5g, 114mmol) in NMP (50mL) was added K2CO3 (26.3g, 190mmol), and the mixture was heated to 130°C and stirred for 8h. To the mixture at room temperature were added EtOAc (100mL) and H2O (200mL), and the layers were separated. The aqueous layer was extracted with EtOAc (3×100mL), and the combined organic layer was washed with 10percent aqueous NaCl (3×50mL) and concentrated in vacuo. To the resulting residue was added EtOAc (500mL), and the solution was filtered through a pad of NH silica gel. The filtrate was evaporated, and the residue was suspended in EtOAc/ hexane (1:3, 40mL). The mixture was stirred at 40°C for 1h. The mixture was cooled to room temperature and stirred for 1h, and then filtered. The obtained solids were dissolved into H2O (15mL) at 50°C, and the solution was gradually cooled to room temperature. The slurry was stirred at room temperature for 1h, and then filtered to give 5d (3.03g, 47percent) as a white solid. Mp 162?163°C; 1H NMR (500MHz, DMSO-d6) delta 6.60 (dd, J=8.8, 0.6Hz, 1H), 6.75 (br s, 4H), 7.48 (dd, J=8.8, 2.8Hz, 1H), 8.04 (d, J=2.5Hz, 1H); 13C NMR (125MHz, DMSO-d6) delta 119.3, 120.0, 136.5, 143.7, 157.6, 162.1; IR (ATR) 3468, 3414, 2362, 1627, 1573, 1543, 1518, 1463, 1370, 1314, 1278, 1229, 1133, 1110, 1004, 914, 857, 834, 756, 730, 614, 572, 520, 459, 436, 405cm?1; HRMS-ESI (m/z): [M+H]+ calcd for C6H8ClN4 171.0437; found, 171.0432.

The synthetic route of 1480-65-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Ishimoto, Kazuhisa; Nagata, Toshiaki; Murabayashi, Mika; Ikemoto, Tomomi; Tetrahedron; vol. 71; 3; (2015); p. 407 – 418;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 15128-82-2, name is 2-Nitropyridin-3-ol. A new synthetic method of this compound is introduced below., HPLC of Formula: C5H4N2O3

To an ice-cold solution of 2-nitropyridin-3-ol (10.0 g, 71 mmol) and triethylamine (14.9 ml, 107 mmol) in methylene chloride (150 ml) was added, dropwise, triflic anhydride (14.5 ml, 86 mmol) and the mixture was stirred for 2h. Water was added and the mixture extracted with methylene chloride. The organic phase was dried with sodium sulfate and the solvent was evaporated in vacuo. The residue was purified by column chromatography on silica gel using n-heptane/ethyl acetate (v/v 2:8 to 3:7) as eluent. The title compound was obtained as a light brown liquid (18.4 g, 95%).MS ISP (m/e): 273.1 [(M+H)+].1H NMR (CDCI3, 400 MHz): delta (ppm) = 8.65 (dd, 1H), 8.00 (dd, 1H), 7.80 (dd, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15128-82-2, 2-Nitropyridin-3-ol.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BAUMANN, Karlheinz; GOETSCHI, Erwin; GREEN, Luke; JOLIDON, Synese; KNUST, Henner; LIMBERG, Anja; LUEBBERS, Thomas; THOMAS, Andrew; WO2011/92272; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 68470-59-7, name is 2-(Bromomethyl)-6-methylpyridine, molecular formula is C7H8BrN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-(Bromomethyl)-6-methylpyridine

Step A: Preparation of 4-methyl-3-[2-methyl-4-(6-methyl-pyridin-2-ylmethoxy)-6-oxo-6H-pyrimidin-1-yl]-benzoic acid methyl ester To a solution of Intermediate 2 (460 mg, 1.68 mmol) in N,N-dimethylformamide (2 mL) was added 2-(bromomethyl)-6-methylpyridine (312 mg, 1.68 mmol), potassium carbonate (350 mg, 2.53 mmol) and 18-crown-6 (40 mg). The slurry was stirred at ambient temperature for one hour. The reaction was partitioned between ethyl acetate and water. The organic layer was washed with water and brine and dried over magnesium sulfate. The slurry was filtered and concentrated in vacuo. The crude material was purified using normal phase chromatography (ethyl acetate/heptane) to provide the alkylated product as a white semi-solid (100 mg, 16% yield). MS (M+H): 380

With the rapid development of chemical substances, we look forward to future research findings about 68470-59-7.

Reference:
Patent; CONFLUENCE LIFE SCIENCES, INC.; SELNESS, Shaun R.; Devadas, Balekudru; Hockerman, Susan L.; Monahan, Joseph B.; US2013/143906; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 571189-16-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 571189-16-7, name is tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate, molecular formula is C14H20N4O4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-tert-Butoxycarbonyl-4-(6-nitro-3-pyridyl)pyridazine (9.8 g, 31.78 mmol), ferric chloride hexahydrate added in a 250 mL three-neck round bottom flask at room temperature (0.6 g, 2.22 mmol) activated carbon (1.77 g) and ethanol(150mL), heat up to 80 C for 0.5h, cool down to 65 C, slowly add hydrazine hydrate (4.5mL, 73.9mmol), continue to heat upThe reaction was stirred at 80 C for 14 h, filtered while hot, washed three times with ethanol, most of the ethanol was removed under reduced pressure, and a yellow solid was evaporated.Filtration, drying and recrystallization from ethanol gave yellow acicular solid 1-tert-butoxycarbonyl-4-(6-amino-3-pyridyl)pyridazine8.617 g, yield 97.4%, purity 98.8%.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 571189-16-7, tert-Butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate.

Reference:
Patent; Hubei University; Ren Jiaqiang; Zhang Jianxin; Chen Qi; Li Linglan; Chen Yong; (15 pag.)CN108822026; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1207758-80-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1207758-80-2, name is 3-(5-Bromo-2-pyridyl)-3-oxetanol, molecular formula is C8H8BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of sodium carbonate (0.54 g, 5.08 mmol) dissolved in water (2.5 mL, 140 mmol) and 1,4-dioxane (6.10 mL, 78.2 mmol) is sonicated for 5 minutes then degassed with bubbling N2 for 15 min. The product of step 1-Example 8 (0.300 g, 1.30 mmol) and step 4-Example 8 (0.647 g, 1.56 mmol) are added successively. After addition, [1,1?-bis(diphenylphosphino)ferrocene]dichloropalladium(II) (0.0668 g, 0.0913 mmol) is added and the reaction mixture heated at 60 C. for 2 hours before being cooled to room temperature and diluted with ethylacetate. The mixture is washed with water (20 mL), followed by brine (20 mL), dried over MgSO4 and the solvent removed under reduced pressure. The crude material is purified by chromatography eluting neat heptanes to 70% ethylacetate in hexanes to give the title compound (410 mg): m/z (CI) M+H 437.

According to the analysis of related databases, 1207758-80-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ZOETIS LLC; Billen, Denis; Curtis, Michael; Ewin, Richard Andrew; Goodwin, Richard M.; Johnson, Paul D.; Johnson, Timothy Allan; Kyne, Graham M.; Maddux, Todd M.; Sheehan, Susan Mary Kult; Vairagoundar, Rajendran; US2014/88046; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem