Day: June 17, 2021

Related Products of 6320-39-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6320-39-4, name is 3-Amino-4-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

Example 113-(1-[1,3]oxazolo[4,5-c]pyridin-2-ylpyrrolidin-3-yl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (One Enantiomer Isolated) A solution of 3-aminopyridin-4-ol (0.250 g, 2.27 mmol, Bosche Scientific) and potassium O-ethyl dithiocarbonate (0.400 g, 2.50 mmol) in ethanol (1 mL) was heated to reflux. When the reaction was determined complete, it was cooled to ambient temperature and partitioned between 1N HCl and ethyl acetate. The organic layer was washed with water, dried over sodium sulfate, decanted and concentrated. This crude product was dissolved in toluene (6 mL) and thionyl chloride (0.365 mL, 5.01 mmol) followed by DMF (3 microL) was added. The mixture was heated to reflux for 1 h, cooled and the solvent removed in vacuo. A portion of this crude product (14 mg) was dissolved in 1,4-dioxane (0.40 mL), along with 3-pyrrolidin-3-yl-3-[4-(7-{[2-(trimethylsilyl)ethoxy]methyl}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile (20.0 mg, 0.0457 mmol, enantiomer 2 from Example 9, Step 2b), and N,N-diisopropylethylamine (16 microL, 0.091 mmol) was added. The mixture was heated to 70 C. for 1.5 h. The solvent was removed in vacuo and the residue was sequentially stirred with 50% TFA/DCM for 1.5 h, concentrated, and stirred with 0.3 mL EDA in methanol for 30 min. Purification via preparative-HPLC/MS (C18 column eluting with a gradient of ACN/H2O containing 0.15% NH4OH) afforded product. 1H NMR (400 MHz, d6-DMSO): delta 8.89 (s, 1H), 8.68 (s, 1H), 8.44 (s, 1H), 8.11 (dd, 1H), 7.72 (dd, 1H), 7.60 (d, 1H), 6.99 (d, 1H), 6.96 (dd, 1H), 4.88 (dt, 1H), 3.90 (dd, 1H), 3.71-3.63 (m, 1H), 3.58-3.30 (m, 4H), 3.04-2.93 (m, 1H), 1.80-1.66 (m, 2H); LCMS (M+H)+: 426.1.

According to the analysis of related databases, 6320-39-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Rodgers, James D.; Shepard, Stacey; Arvanitis, Argyrios G.; Wang, Haisheng; Storace, Louis; Folmer, Beverly; Shao, Lixin; Zhu, Wenyu; Glenn, Joseph; US2010/298334; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1187190-69-7, 6-Chloro-4-methoxynicotinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1187190-69-7, blongs to pyridine-derivatives compound. HPLC of Formula: C7H5ClN2O

Step C: 6-Ethenyl-4-methoxypyridine-3-carbonitrile: A 20 mL microwave tube was charged with 6-chloro-4-methoxypyridine-3-carbonitrile (200.0 mg, 1.2 mmol), bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex with dichloromethane (97.0 mg, 0.12 mmol), potassium vinyl trifluoroborate (318.0 mg, 2.37 mmol), triethylamine (0.33 mL, 2.37 mmol), and EtOH (6 mL). The microwave tube was evacuated, filled with nitrogen (two times), and heated to 140 C. After 1 h, the reaction mixture was diluted with water and extracted with EtOAc. The combined organic layers were washed with brine and dried over a2S04. The extracts were concentrated and chromatographed over a column of S1O2 (0-30% EtOAc / hexanes as eluent). Evaporation of the solvent yielded the title compound.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1187190-69-7, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; DONG, Shuzhi; PASTERNAK, Alexander; GU, Xin; FU, Qinghong; JIANG, Jinlong; DING, Fa-Xiang; TANG, Haifeng; DEJESUS, Reynalda, K.; SUZUKI, Takao; WO2015/100147; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1121-60-4 ,Some common heterocyclic compound, 1121-60-4, molecular formula is C6H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: In a typical experiment,a mixture of aromatic aldehyde 2 (1mmol) and o-phenylenediamine (1) (1 mmol) was taken in a test tube.The reaction mixture was stirred on magnetic stirrer in concentrated solar radiation (CSR) for 20-30 minutes and monitored by TLC. On completion of the reaction, the reaction mixture was cooled to room temperature.The 2-aryl-1H-benzimidazoles 3 were isolated by using column chromatography over Silica gel using hexane-EtOAc as eluent as and when required.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1121-60-4, its application will become more common.

Reference:
Article; Harsh, Simran; Yusuf, Mohamad; Sharma, Rohit; Kumar, Yogesh; Kumar, Rupesh; Arkivoc; vol. 2018; 7; (2018); p. 119 – 130;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 38496-18-3, Adding some certain compound to certain chemical reactions, such as: 38496-18-3, name is 2,6-Dichloronicotinic acid,molecular formula is C6H3Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 38496-18-3.

To a stirred solution of 292 2,6-dichloronicotinic acid (20.0 g, 104.16 mmol, 1.0 eq) in 165 THF (80 mL) and 30 MeOH (40 mL) was added LiOH.H2O (13.11 g, 312.49 mmol, 3.0 eq) at rt. The resulting mixture was stirred at same temperature for 12 h. Progress of reaction was monitored by LCMS. After completion of reaction, mixture was concentrated and diluted with water (100 mL), followed by dropwise addition of 1N 31 HCl (50 mL), the formation of white precipitate was observed which was filtered and dried under vacuum to afford 293 6-chloro-2-methoxynicotinic acid as white solid (19.0 g, 97.23%). (0415) LCMS: 188 [M+1]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 38496-18-3, 2,6-Dichloronicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; giraFpharma LLC; Chakravarty, Sarvajit; PHAM, Son Minh; Kankanala, Jayakanth; AGARWAL, Anil Kumar; PUJALA, Brahmam; SONI, Sanjeev; ARYA, Satish K.; PALVE, Deepak; KUMAR, Varun; (360 pag.)US2019/106436; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 757251-62-0, name is 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide

Step 2: Preparation of 1-(4-chloropyridin-2-yl)ethanone. To a solution of 4-chloro-N-methoxy-N-methylpicolinamide (11.25 g, 56.08 mmol) in THF (50 mL) at 0°Cwas added MeMgBr(28.O4mL, 84.12 mmol). The mixture was then stirred at r.t. overnight and quenched withsaturated aqueous NH4C1. The resulting mixture was extracted with EtOAc. The organic layer was dried over anhydrous Na2SO4 and concentrated. The residue was purified by flash chromatography to give the desired product. ?H NMR (400 MHz, CDC13): 8.52(d, J = 5.2 Hz, 1H), 7.96 (s, 1H), 7.40 (d, J = 5.2 Hz, 1H), 2.64 (s, 3H).LC-MS: mz 156.0 (M+H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 757251-62-0, 4-Chloro-N-methoxy-N-methylpyridine-2-carboxamide.

Reference:
Patent; AGIOS PHARMACEUTICALS, INC.; KONTEATIS, Zenon D.; POPOVICI-MULLER, Janeta; TRAVINS, Jeremy M.; ZAHLER, Robert; CAI, Zhenwei; ZHOU, Ding; WO2015/3640; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 10386-27-3, name is 2-Bromoisonicotinonitrile. A new synthetic method of this compound is introduced below., Application In Synthesis of 2-Bromoisonicotinonitrile

To a solution of 2-(pyridin-2-yl)-4,5,6,7-tetrahydrooxazolo[4,5-c] pyridine (I- 23.4) (40 mg, 0.2 mmol) in DMF (2 mL) was added 2-bromoisonicotinonitrile (54 mg, 0.3 mmol), DIEA (52 mg, 0.4 mmol). The mixture was heated to 1000C and stirred for 16 h. The mixture was cooled to room temperature and poured into water. The mixture was extracted with EtOAc. The combined organic phase was dried over anhydrous Na2SO4 and concentrated. The residue was purified by preparative TLC to afford 2-(2- (pyridin-2-yl)-6,7-dihydrooxazolo[4,5-c]pyridin-5(4H)-yl)isonicotinonitrile (10 mg, 17percent) as a yellow solid. 1H NMR (400 MHz, CDCl3): delta 8.67 (d, IH), 8.25 (d, IH), 8.03 (d, IH), 7.75 (t, IH), 7.30 (t, IH), 6.81 (s, IH), 6.75 (d, IH), 4.52 (s, 2H), 4.07 (t, 2H), 2.91 (t, 2H); LC/MS: m/e = 304 (M+H)+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 10386-27-3, 2-Bromoisonicotinonitrile.

Reference:
Patent; SEPRACOR INC.; BURDI, Douglas; SPEAR, Kerry, L.; HARDY, Larry, Wendell; WO2010/114971; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 903522-29-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.903522-29-2, name is 3,5-Difluoroisonicotinic acid, molecular formula is C6H3F2NO2, molecular weight is 159.09, as common compound, the synthetic route is as follows.

3,5-Difluoropyridine-4-carboxylic acid (0.510 g, 3.14 mmol) was added to anoven dried 250 mL round bottom flask. The flask was sealed with a septum, purged with nitrogen, and anhydrous THF (50mL) was added. Next, triethylamine (0.542 mL, 3.77 mmol) was added via syringe. The solution was sonicated until itbecame homogeneous, then ethyl chloroformate (0.372 mL, 3.77 mmol) was added. The reaction was stirred for 30 min.before being filtered through a short pad of Celite into a separate oven dried 250 mL round bottom flask. NaBH4 (0.261 g,6.91 mmol) was added followed by MeOH (5 mL). The reaction was stirred for 45 min. at room temperature. A samplealiquot was taken from the reaction, dissolved in HPLC grade MeCN (1 mL), and analyzed with LC-MS to confirm thecompletion of the reaction. The reaction was quenched with sat. ammonium chloride and diluted with EtOAc (150 mL).The organic layer was washed with DI water (50 mL) and brine, then dried over sodium sulfate and condensed to give a yellow oil. The oil was dissolved in DCM and purified by flash chromatography (5 g SiO2 cartridge, 0-12% MeOH/DCMgradient) to give the title compound as a clear semisolid (0.285 g, 63%). This compound has been previously reported andcharacterized (CAS 924649-16-1). 1H NMR (300 MHz, CDCl3) d = 4.81 (s, 2H), 8.28 (s, 2H) 8.30 (s, 2 H).

Statistics shows that 903522-29-2 is playing an increasingly important role. we look forward to future research findings about 3,5-Difluoroisonicotinic acid.

Reference:
Article; Porter, Jacob D.; Vivas, Oscar; Weaver, C. David; Alsafran, Abdulmohsen; DiMilo, Elliot; Arnold, Leggy A.; Dickson, Eamonn J.; Dockendorff, Chris; Bioorganic and Medicinal Chemistry Letters; vol. 29; 23; (2019);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 694-85-9, name is 1-Methylpyridin-2(1H)-one, molecular formula is C6H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H7NO

0.8mmol), compound A-3 (0.4mmol, 1 eq.), Three times with nitrogen was added 3mLpermuted dimethylsulfoxide (DMSO), injection of 100muL (0.80mmol) Compound B-1, wasstirred for 24 hours under blue light , compound C-3. The yield was 60percent.

With the rapid development of chemical substances, we look forward to future research findings about 694-85-9.

Reference:
Patent; Zunyi Medical College; He, Chunyang; Li, Xiaofei; (12 pag.)CN105669546; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 754131-60-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 754131-60-7, name is 3-Bromo-2-(bromomethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a stirred solution of the above crude 3-bromo-2-bromomethylpyridine (70g, 0. 28MOL) in dioxane (SOOML) and water (250mL), was added NACN (28g, 0. 74MOL) at 0C and then stirred at RT for 16h. The reaction mixture was quenched with 3Lit of water and extracted with ethylacetate (4X500ML). The organic layer was washed with water (400L), brine (250mL), dried over NA2SO4 and concentrated to give crude product. The crude was purified by column chromatography over silica gel (pet. ether/ethylacetate, 8: 2) to give 3- BROMOPYRIDINE-2-YL-ACETONITRILE (22g, 40%). [TLC: Pet. ether/ethylacetate, 7: 3, RF= 0. 35] MS (EST) : 199.2 ; MS (ESR) : 197.2.

According to the analysis of related databases, 754131-60-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; APPLIED RESEARCH SYSTEMS ARS HOLDING N. V.; WO2004/98607; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 641569-94-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.641569-94-0, name is 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid, molecular formula is C17H14N4O2, molecular weight is 306.32, as common compound, the synthetic route is as follows.

Dissolve 4-Methyl-3-[[4- (3-pyridinyl) -2-pyrimidinyl] amino] benzoic acid (16.6 mg) and compound D (20 mg) in CH2Cl2 (0.5 mL),N, N-diisopropylamine (14 uL),N, N-Dimethyl-4-aminopyridine (3.3 mg),1- (3-Dimethylaminopropyl) -3-ethylcarbodiimide hydrochloride (15.5 mg) was added and allowed to stir at room temperature. The mixture was stirred overnight, washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over sodium sulfate and filtered. The obtained filtrate was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (chloroform: methanol = 95: 5 ? 9: 1) to obtain IMT-5 precursor (tin compound) (34.6 mg, white solid).

Statistics shows that 641569-94-0 is playing an increasingly important role. we look forward to future research findings about 4-Methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)benzoic acid.

Reference:
Patent; Kyoto University; Arkray Corporation; Saji, Hideo; Kimura, Hiroyuki; Matsuda, Hirokazu; Soma, Tasukukei; Nakanishi, Shuichi; (26 pag.)JP2019/64987; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem