Day: June 18, 2021

Related Products of 62068-78-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62068-78-4, name is 2,6-Dichloronicotinamide, molecular formula is C6H4Cl2N2O, molecular weight is 191.02, as common compound, the synthetic route is as follows.

2-Benzylamino-6-chloro-nicotinamide (3) (1188) To a solution of 2,6-dichloro-nicotinamide (1) (2.3 g, 12.2 mmol) in acetonitrile (anhydrous, 100 mL) were added 2-benzylamine (2) (1.3 g, 12.2 mmol) and triethylamine (1.7 mL, 12.2 mmol). The reaction was heated at 60 C. for 4 hours. The solution was cooled to room temperature and filtered. The filtrate was evaporated in vacuo. Purification was achieved by Biotage silica gel chromatography with 5%-50% EtOAc/hexanes gradient to afford 1.71 g (54% yield) of the title compound. (1189) 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 8.82 (br. s., 1H), 7.52 (d, J=8.2 Hz, 1H), 7.40-7.23 (m, 6H), 6.50 (d, J=8.2 Hz, 1H), 5.66 (br. s., 2H), 4.70 (d, J=5.5 Hz, 2H).

Statistics shows that 62068-78-4 is playing an increasingly important role. we look forward to future research findings about 2,6-Dichloronicotinamide.

Reference:
Patent; ANACOR PHARMACEUTICALS, INC.; AKAMA, Tsutomu; US2015/291629; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 15855-06-8 , The common heterocyclic compound, 15855-06-8, name is 2-Chloro-6-methoxypyridine-4-carboxylic Acid, molecular formula is C7H6ClNO3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Intermediate 9; 1-[4′-(4,5-Difluoro-2,3-dihydro-indole-1-carbonyl)-6′-methoxy-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-yl]-1,3-dihydro-imidazo[4,5-b]pyridin-2-one; Step 1: (2-Chloro-6-methoxy-pyridin-4-yl)-(4,5-difluoro-2,3-dihydro-indol-1-yl)-methanone; 1.22 g (3.80 mmol) TBTU were added at RT to 0.685 g (3.65 mmol) 2-chloro-6-methoxyisonicotinic acid, 0.700 g (3.65 mmol) 4,5-fluoroindoline-dihydrochloride and 1.12 mL (8.00 mmol) triethylamine in 10.0 mL DMF. The mixture was stirred for 2 h at RT and then poured onto 200 mL of potassium carbonate solution (aqueous, 7%). The precipitate formed was suction filtered, washed with water and dried i. vac.Yield: 1.05 g (89% of th.)ESI-MS: m/z=325/327 (M+H)+ (CI)Rt (HPLC): 1.66 min (method C)

The synthetic route of 15855-06-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2010/324028; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.105752-11-2, name is 3-Amino-4-iodopyridine, molecular formula is C5H5IN2, molecular weight is 220.0111, as common compound, the synthetic route is as follows.Formula: C5H5IN2

To a mixture of 4-iodopyridin-3-amine (40 g, 182 mmol) and ethyl acrylate (27 g, 272 mmol) in DMF (300 mL), DIPEA (28 g, 218 mmol) was added. Then Pd(OAc)2 (4 g, 18 mmol) and P(o-tol)3 (11 g, 36 mmol) were added quickly under N2 atmosphere. The mixture was stirred at 85 C for 12 h under N2 atmosphere. After cooling down, the solvent was removed under reduced pressure. The residue was purified by silica gel column (DCM/ MeOH = 20/1) to give ethyl (E)-3-(3-aminopyridin-4-yl)acrylate (20 g, yield: 57%) as a yellow oil. ESI-MS (M+H): 193.1. ?H NMR (400 MHz, CDC13) (5: 8.15 (s, 1H), 8.02-7.98 (m, 1H), 7.72 (d, J= 16.4 Hz, 1H), 7.18 (d, J= 5.2 Hz, 1H), 6.48 (d, J= 16Hz, 1H), 4.27 (q, J= 7.2 Hz, 2H), 4.07 (s, 2H), 1.34 (t, J= 7.2Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,105752-11-2, 3-Amino-4-iodopyridine, and friends who are interested can also refer to it.

Reference:
Patent; BIOGEN MA INC.; CAPACCI, Andrew, George; DECHANTSREITER, Michael; ENYEDY, Istvan; JONES, John, H.; LIN, Edward, Yin-Shiang; LUCAS, Brian, Stuart; MA, Bin; (273 pag.)WO2018/140876; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 58584-94-4, name is 2,6-Dichloro-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

Step 2. To 3-(tributylstannyl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine (1.1 g, 2.31 mmol) was added the obtained product, dioxane (6 mL), QPhos (49 mg, 0.07 mmol) and Pd2dba3 (21 mg, 0.023 mmol). The mixture was heated at 110 C for one hour, then at 90 C for 15 hours. The product was concentrated and purified by chromatography on silica gel (gradient ethyl acetate :hexane 1:10 to 1:1) to provide a mixture of crude isomers: 3-(6- chloro-5-methylpyridin-2-yl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine as a pink solid (58 mg, 8 ) and 3-(6-chloro-3-methylpyridin-2-yl)-2-(trifluoromethyl)imidazo[l,2-a]pyridine (more polar) (130 mg).

With the rapid development of chemical substances, we look forward to future research findings about 58584-94-4.

Reference:
Patent; PTC THERAPEUTICS, INC.; BAIAZITOV, Ramil; CHOI, Soongyu; DU, Wu; HWANG, Seongwoo; LEE, Chang-Sun; LIU, Ronggang; MOON, Young-Choon; PAGET, Steven, D.; REN, Hongyu; SYDORENKO, Nadiya; WILDE, Richard, Gerald; WO2015/76800; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 20265-38-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 20265-38-7, name is 2-Methoxypyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: An oven-dried resealable Schlenk tube was charged with (S)-2-chloro-N-(1-(5-fluoropyridin-2-yl)ethyl)pyrimidin-4-amine (Preparation 1a, 43 mg, 0.17 mmol), 2-methoxypyridin-3-amine (23 mg, 0.19 mmol), cesium carbonate (111 mg, 0.34 mmol) and 1,4-dioxane (3 mL). The Schlenk tube was subjected to three cycles of evacuation-backfilling with argon then tris(dibenzylideneacetone)dipalladium(0) (16 mg, 0.02 mmol) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (10 mg, 0.02 mmol) were added. After three further cycles of evacuation-backfilling with argon, the Schlenk tube was capped and then stirred and heated to 100 ºC. After 24 hours the mixture was cooled and the solvent was evaporated under reduced pressure. Ethyl acetate was added and the organic solution was washed with water (x3) and brine, dried (MgSO4) and the solvent evaporated under reduced pressure. The residue was purified by reverse phase chromatography (C-18 silica from Waters©, water/acetonitrile/methanol as eluents [0.1percent v/v formic acid buffered] 0percent to 100percent) to yield the title compound (11 mg, 19percent) as a solid.LRMS (m/z): 341 (M+1)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 20265-38-7, 2-Methoxypyridin-3-amine.

Reference:
Patent; Almirall, S.A.; Eastwood, Paul Robert; Bach Tana, Jordi; Pages Santacana, Lluis Miquel; EP2554544; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 100-70-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: a. Ground phosphoruspentasulfide (115 g, 0.5 mol) was added to asolution of 4-cyanopyridine (52 g, 0.5 mol) in 250 mLof 20% ammonium in methanol under vigorous stirringmaintaining the reaction mixture temperature below35-40C. The reaction mixture was kept at roomtemperature for 12 h, After the reactionended, 150 mL of water was added and the mixturewas heated up to 70-75C by water bath till the gasevolution stopped. After cooling the precipitate wasfiltered off, washed with water, and dried. Yield 89%(61.8 g), Rf 0.45, mp 137 (136-137 [21]). Found,%: 52.09; H 4.31; N 20.30; S 23.30. C6H6N2S.Calculated, %: 52.15; H 4.38; N 20.27; S 23.20.

According to the analysis of related databases, 100-70-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Khromova, N. Yu.; Malekin; Kutkin; Kondrat’Ev; Russian Journal of General Chemistry; vol. 85; 10; (2015); p. 2295 – 2298; Zh. Obshch. Khim.; vol. 85; 10; (2015); p. 1663 – 1666,4;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 918504-27-5, name is N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide

General procedure: Aryl bromide (1 eq.), K2C03(2 eq.) and boronic acid / pinacol ester (1.2 eq.) were suspended in DME/H20 (0.15 m, 4:1 ) and degassed with argon for 10 min. Pd(PPh3)4(0.05 eq.) was added and the suspension, which was then irradiated at 130C for 30 min ^w). The resulting mixture was passed through a Celite pad and the solvent was removed under reduced pressure. The crude mixture was purified via flash chromatography (Si02, DCM/MeOH (content of MeOH increased in 0.5%-steps from 0 to 5% (v/v)) to yield the titled compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 918504-27-5, N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide.

Reference:
Patent; HEPAREGENIX GMBH; ALBRECHT, Wolfgang; LAUFER, Stefan; SELIG, Roland; KLOeVEKORN, Phillip; PRAeFKE, Bent; (121 pag.)WO2018/134254; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 926293-55-2, name is 6-Bromo-2-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C7H6BrNO

A mixture of 6-chloro-2-methyl-pyridine-3-carbaldehyde (715 mg, 4.60 mmol), methyl 4-hydroxyphenylacetate (694 mg, 4.18 mmol) and K2CO3 (404 mg, 2.92 mmol) in DMF (8.4 mL) was heated to 130 0C for 1 h then filtered and concentrated. The residue was dissolved in EtOAc (40 mL) and washed with brine (3 x 10 mL) then dried (MgSO4) and EPO concentrated. Purification by chromatography on silica gel (30% EtOAc/hexanes) gave [4-(5- formyl-6-methyl-pyridin-2-yloxy)-phenyl]-acetic acid methyl ester as a yellow oil (687 mg, 58%). 1H NMR (CDCl3) delta 2.75 (s, 3H)5 3.66 (s, 2H), 3.73 (s, 3H), 6.76 (d, IH, J= 8.7 Hz), 7.13 (d, 2H, J= 8.7 Hz), 7.34 (d, 2H, J= 8.7 Hz), 8.09 (d, IH, J= 8.4 Hz), 10.24 (s, IH).

With the rapid development of chemical substances, we look forward to future research findings about 926293-55-2.

Reference:
Patent; ANORMED INC.; WO2007/22371; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 36052-27-4, Adding some certain compound to certain chemical reactions, such as: 36052-27-4, name is Methyl 3-aminopicolinate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36052-27-4.

A solution of methyl 3-aminopyridine-2-carboxylate (1 g, 6.57 mmol, 1.00 equiv) and N-bromosuccinimide (1.29 g, 7.25 mmol, 1.10 equiv) in acetonitrile (25 mL) was stirred at room temperature. After being stirred for 2 h the mixture was concentrated under vacuum. The residue was applied onto a silica gel column with ethyl acetate/petroleum ether (2:1) to give the title compound (0.81 g, 54%) as a yellow solid. LC-MS (ES, m/z): 231, 233 [M+H]+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 36052-27-4, Methyl 3-aminopicolinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Genentech, Inc.; Blaquiere, Nicole; Castanedo, Georgette; Feng, Jianwen A.; Hu, Baihua; Staben, Steven; Yuen, Po-wai; Wu, Guosheng; Lin, Xingyu; Burch, Jason; US2015/57260; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 72830-09-2, Adding some certain compound to certain chemical reactions, such as: 72830-09-2, name is 2-Chloromethyl-3,4-dimethoxypyridinium chloride,molecular formula is C8H11Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 72830-09-2.

Example 1 : Preparation of Pantoprazole Sodium2-Mercapto-5-difluoromethoxy benzimidazole (50 g) was added to an aqueous solution of sodium hydroxide (21.3 g in 350 mL de-ionized water) at room temperature to obtain a clear solution. An aqueous solution of 2-chloromethyl-3, 4-dimethoxypyridine hydrochloride (50 g in 150 mL water) was added to the above solution over a period of about 2.0-2.5 hours. The reaction mixture was stirred vigorously for about 2-2.5 hours. Progress of the reaction was monitored by thin-layer chromatography. The reaction mixture was extracted with dichloromethane and washed with water. Organic layer was concentrated. Methanol (50 mL) was added to the organic layer. The reaction mixture was cooled to -5 to -200C. Aqueous solution of sodium hydroxide (11.8 g in 50 mL water) was added followed by addition of sodium hypochlorite solution (431 mL) in an aqueous solution of sodium hydroxide (20 g/ 100 mL) over a period of about 30 to about 45 minutes. The progress of the reaction was monitored by thin-layer chromatography. After completion of the reaction, the reaction mixture was quenched with 5% sodium hydrogen sulphite solution (500 mL). Water (500 mL) was added. pH of the reaction mixture was adjusted to 9.0-10.5. Layers were separated and the aqueous layer was extracted with dichloromethane. The combined dichloromethane layers were concentrated completely to obtain a red-brown colored residue.The residue was dissolved in acetone (375 mL). The reaction mixture was cooled to 20-250C. Aqueous solution of sodium hydroxide (9.2 g in 25 mL water) was added followed by addition of a seed crystal of pantoprazole sodium. The reaction mixture was stirred, cooled, stirred, filtered and washed with cold acetone to obtain crude pantoprazole sodium as a wet cake.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 72830-09-2, 2-Chloromethyl-3,4-dimethoxypyridinium chloride, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RANBAXY LABORATORIES LIMITED; WO2009/10937; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem