Day: June 24, 2021

Synthetic Route of 84249-14-9, Adding some certain compound to certain chemical reactions, such as: 84249-14-9, name is 2-Amino-4-bromopyridine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 84249-14-9.

Compound 2 (400 mg, 2.31 mmol), trimethylsilylacetylene (0.38 ml, 2.77 mmol), cesium carbonate (39.1 mg, 0.12 mmol), 4,5- bis (diphenylphosphino) -9,9-dimethylxanthene (69.4 mg , 0.12 mmol) and was dissolved bis (benzonitrile) palladium (II) dichloride (46.0 mg, a 0.12 mmol) in DMF (5 ml). Further added triethylamine (2 ml) to this was stirred for 2 hours at 50 in an oil bath. After completion of the reaction, THF and (3 ml) and tetrabutylammonium fluoride (2.77 ml) was added and the solvent was concentrated under reduced pressure, and allowed to react for 30 minutes at room temperature. The solvent was evaporated, adsorbed resulting residue was applied to a silica gel column,Methanol – was eluted with a mixed solvent of chloroform (1:50) to give Compound 5a (90.1 mg, 33%).

According to the analysis of related databases, 84249-14-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NIHON UNIVERSITY; SUZUKI, AZUSA; YOKOYAMA, SHOTA; SAITO, YOSHIO; (22 pag.)JP2015/221769; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 775288-71-6 ,Some common heterocyclic compound, 775288-71-6, molecular formula is C9H12N4O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 54 (305 mg , 0.96 mmol), 69 (200 mg, 0.96 mmol) and benzotriazole-l -yl- oxy-tris-(dimethylamino)- phosphonium hexafluorophosphate reagent (637 mg, 1.44 mmol) in anhydrous DMSO (10 mL) was added DIPEA (0.67 mL, 3.84 mmol). The reaction mixture was stirred at room temperature for 12 h. The progress of the reaction mass was monitored by LCMS. The reaction mixture diluted with water (100 rriL) and the resulting mixture was extracted with ethyl acetate (2 x 100 mL). The organic layer was washed with brine (100ml), dried (Na2S04), filtered, and evaporated under vacuum. The crude product was purified by column chromatography to give 40 mg of the desired product. LC-MS: m/z calcd for C23H21N7O5S, 507.52, found: 508.0 (M+H)+. *H NMR (500 MHz, DMSO-d6): deltaEta 3.55 (2H, s, NCH2CH2N), 3.7 (2H, s, NCH2CH2N), 3.75 (2H, s, NCH2CH2N), 3.8 (5H, s, NCH2CH2N & ArOCH3), 6.74 (1H, s, SCHCH), 6.98 (2H, d, J = 10 Hz, ArCH), 7.4 (2H, d, J = 10 Hz, ArCH), 7.5 (1H, d, J = 10 Hz, ArCH), 7.56 (2H, s, NH2), 8.18 (1H, d, J = 10 Hz, ArCH) and 8.26 (1H, d, J = 5 Hz, ArCH).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,775288-71-6, its application will become more common.

Reference:
Patent; GE HEALTHCARE LIMITED; MEDI-PHYSICS, INC.; JONES, Clare; GLASER, Matthias Eberhard; WYNN, Duncan; NAIRNE, James; MOKKAPATI, Umamaheshwar P.; NEWINGTON, Ian, Martin; RANGASWAMY, Chitralekha; JOSE, Jinto; JOHANSSON, Saga; WO2013/90497; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 100-48-1, name is Isonicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 100-48-1

Example 4: Accumulating reaction of the 2-hydroxy-4-substituted pyridine using a resting bacterial cell of each bacteria As in Example 1, the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) was cultured, and then each bacteria in 10 mL of the culture was collected by centrifugation to obtain the resting bacterial cells. Then each resting bacterial cells were added to 2 mL of a 0.1 M boric acid-sodium hydrate buffer (adjusted to pH7.0) containing 4-substituted pyridine described in Table 3 (0.5 w/v%) respectively, and were suspended. Then each suspension was charged to a reaction vessel (15 mL volume) and a reaction was carried out at 27C, pH7.0, while shaking. After the reaction for 44 hours, each 2-hydroxy-4-substituted pyridine was measured. The results are shown in Table 3.

With the rapid development of chemical substances, we look forward to future research findings about 100-48-1.

Reference:
Patent; YUKI GOSEI KOGYO CO., LTD.; EP1801102; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1452-63-7, Adding some certain compound to certain chemical reactions, such as: 1452-63-7, name is Picolinohydrazide,molecular formula is C6H7N3O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1452-63-7.

2) Add carbon disulfide (11.42 g) and potassium hydroxide (8.42 g) to 100 mL of an ethanol solution of the 2-pyridine carbohydrazide obtained in the step 1) to obtain a compound 2 (23.71 g), Add hydrazine hydrate (8.01 g) to the aqueous solution of Compound 2. The reaction gives 4-amino-3-(2-pyridyl)-5-mercapto-1,2,4 triazole (16.13 g);

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1452-63-7, Picolinohydrazide, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shandong Normal University; Ma Jianping; Zhu Guiying; Jin Guoxia; Wu Xiangwen; (14 pag.)CN109293636; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69045-84-7, name is 2,3-Dichloro-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H2Cl2F3N

General procedure: To a stirred solution of 4a (74.5 g, 410 mmol) in DMF (450 mL) was added NaH (60% dispersion in oil, 19.7 g, 491 mmol) at 0 C and the mixture was stirred at the temperature for 30 min. Then 2,3-dichloro-5-(trifluoromethyl)pyridine (60.0 mL, 433 mmol) was added to the mixture, which was allowed to warm to room temperature, and stirred at room temperature for 1 h and at 50 C for 1 h. The reaction was quenched with sat. NH4Cl on ice-bath and extracted with EtOAc and the combined organic layer was washed with water and brine, dried over MgSO4, filtered and concentrated under reduced pressure. The residual solid was purified by silica gel chromatography (hexane-EtOAc, 9:1 to 2:1) to give a pale-yellow solid, which was recrystallized from EtOAc/hexane to give 5a (79.0 g, 53%) as white crystals.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 69045-84-7, 2,3-Dichloro-5-(trifluoromethyl)pyridine.

Reference:
Article; Rikimaru, Kentaro; Wakabayashi, Takeshi; Abe, Hidenori; Tawaraishi, Taisuke; Imoto, Hiroshi; Yonemori, Jinichi; Hirose, Hideki; Murase, Katsuhito; Matsuo, Takanori; Matsumoto, Mitsuharu; Nomura, Chisako; Tsuge, Hiroko; Arimura, Naoto; Kawakami, Kazutoshi; Sakamoto, Junichi; Funami, Miyuki; Mol, Clifford D.; Snell, Gyorgy P.; Bragstad, Kenneth A.; Sang, Bi-Ching; Dougan, Douglas R.; Tanaka, Toshimasa; Katayama, Nozomi; Horiguchi, Yoshiaki; Momose, Yu; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3332 – 3358;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 59576-26-0, name is 1-(4-Methylpyridin-2-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 1-(4-Methylpyridin-2-yl)ethanone

Preparation 20 A suspension of 2-acetyl-4-methylpyridine (0.65 g) in N,N-dimethylformamide dimethyl acetal (4 ml) was refluxed for 10 hours and evaporated under reduced pressure. The residue was triturated with diisopropyl ether, filtered and dried under reduced pressure to give 3-dimethylamino-1-(4-methylpyridin-2-yl)prop-2-en-1-one (777 mg). 1H-NMR (DMSO-d6): delta2.37(3H,s), 2.91(3H,s), 3.16(3H,s), 6.36(1H,d,J=12.7 Hz), 7.32(1H,d,J=4.9 Hz), 7.7-7.9(2H,m), 8.47(1H,d,J=4.9 Hz)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 59576-26-0, 1-(4-Methylpyridin-2-yl)ethanone.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6521643; (2003); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1480-65-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1480-65-5, name is 5-Chloro-2-fluoropyridine. A new synthetic method of this compound is introduced below.

Example 116 EPO (5R)-7-(5-ChIoropyridin-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-2,7-diazaspiro[4.5]decan-l-one A mixture of (5R)-2-(tetrahydro-2H-pyran-4-yl)-2,7-diazaspiro[4.5]decan-l-one hydrochloride (29.4 mg, 0.000107 mol, this compound was prepared by using procedures analogous to those described for the synthesis of example 1, steps 1-5), 5-chloro-2-fluoropyridine (17 mg, 0.00013 mol) and potassium carbonate (0.029 mL, 0.00032 mol) in N,N-dimethylformamide (0.6 mL, 0.008 mol) was heated at 120 0C for 5 h. The crude product was purified by prep-HPLC to afford the desired product. LC-MS: 350.2 (M+H)+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1480-65-5, 5-Chloro-2-fluoropyridine, and friends who are interested can also refer to it.

Reference:
Patent; INCYTE CORPORATION; WO2006/53024; (2006); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1628-89-3, name is 2-Methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1628-89-3

Compound 11: Under oxygen atmosphere, to a 25 ml reaction flask are sequentially added silver nitrate (0.1mmol), 2-methoxy pyridine (0.5mmol), sodium acetate (1.0mmol), potassium persulfate (1.5mmol), formamide (2.0 ml) and water (0.4 ml). The mixture at 80 C reacts for 4h. Cooling to room temperature, reducing pressure and evaporating the solvent column chromatography separation to obtain the product, yield 83%.

With the rapid development of chemical substances, we look forward to future research findings about 1628-89-3.

Reference:
Patent; Nanjing Normal University; Han, Wei; Yao, Lifang; (11 pag.)CN105669542; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 849067-96-5, name is Methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate, the common compound, a new synthetic route is introduced below. Quality Control of Methyl 1H-pyrrolo[2,3-b]pyridine-5-carboxylate

Preparation of methyl 1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-5-carboxylate (G-1 -2)G-1 -1a G-1 -2 To a solution of G-1-1a (58 g, 0.33 mol) in dry THF (800 mL) was added NaH (20 g, 0.495 mol) at 0-100C in small portions. The resulting mixture was stirred at 1O0C for 1 h. BsCI (70.1 g, 0.397 mol) was added drop-wise. The resulting mixture was allowed to warm to room temperature and stirred overnight. TLC (Petroleum ether: EtOAc = 2:1 ) indicated the reaction was complete. The reaction mixture was cooled and quenched with water. The mixture was extracted with EtOAc (400 mLchi3). The combined organic layers were washed with saturated aqueous NaCI, dried with Na2SO4, filtered and concentrated to give crude product, which was purified by re-crystallization with petroleum ether: EtOAc =3:1 to give compound G-1-2 (60 g , 57.6%) as a grey yellow solid.

The synthetic route of 849067-96-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER INC.; WO2009/16460; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1721-26-2, name is Ethyl 2-methylnicotinate, molecular formula is C9H11NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Computed Properties of C9H11NO2

Preparation of 3-carboethoxy-2-pyridinecarboxaldehyde: To a stirred solution of ethyl 2-methylnicotinate (1.657 g, 10.0 mmol) in 1,4-dioxane (10 mL) and water (1 mL) was added selenium dioxide (1.568 g, 14.1 mmol) and the resultant mixture was heated to reflux overnight. The reaction mixture was cooled to room temperature and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (3:1 hexanes/ethyl acetate) and provided the title compound (0.90 g, 50percent) as a yellow oil. 1H NMR (CDCl3) delta 1.41 (t, 3H, J=7.5 Hz), 4.45 (q, 2H; J=7.5 Hz), 7.56 (dd, 1H, J=6.0, 6.0 Hz), 8.11 (dd, 1H, J=6.0, 1.0 Hz), 8.87 (dd, 1H, J=6.0, 1.0 Hz), 10.34 (s, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 1721-26-2.

Reference:
Patent; Bridger, Gary; Skerlj, Renato; Kaller, Al; Harwig, Curtis; Bogucki, David; Wilson, Trevor R.; Crawford, Jason; McEachern, Ernest J.; Atsma, Bem; Nan, Siqiao; Zhou, Yuanxi; Schols, Dominique; Smith, Christopher Dennis; Di Fluri, Maria Rosaria; US2002/147192; (2002); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem