Day: June 25, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 87109-10-2, name is 3-Phenylpyridin-2-amine. A new synthetic method of this compound is introduced below., name: 3-Phenylpyridin-2-amine

To a solution of 3-phenylpyridin-2-amine (10.0 g, 55.8 mmol) and di-tert-butyl dicarbonate (48.7 g, 223 mmol) in DCM (200 mL) was added DMAP (13.6 g, 112 mmol) in batches. The resulting mixture was stined at 26 C for 16 h, then washed with brine (100 mL x 3), dried over Na2SO4and concentrated. The residue was purified by flash silica gel chromatography (ISCO; 120 g SepaFlash Silica Flash Column, EtOAc in petroleum ether: 0- 40%, 50 mL/min, dry loaded) to give the title compound.?H NMR (400 MHz, CDC13) oe 8.52 (d, J = 3.1 Hz, 1H), 7.75 (dd, J = 1.6, 7.4 Hz, 1H), 7.34-7.45 (m, 6H), 1.30 (s, 18H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 87109-10-2, 3-Phenylpyridin-2-amine.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STUMP, Craig A.; CHEN, Yi Heng; LIU, Ping; MENG, Dongfang; WU, Jane; LI, Chun Sing; QI, Zhiqi; (163 pag.)WO2016/161572; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 114-33-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 114-33-0, name is N-Methylnicotinamide, molecular formula is C7H8N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Appropriate nitrogen donor ligand (1 mmol) was added to an aqueous solution of copper(II) acetate (0.5 mmol) under stirring. After a few minutes, x-methylsalicylic acid (1 mmol) and the necessary amount of solvent (ethanol or acetonitrile) were added to reach the final volume (30-40 mL). Eventually, the reaction mixture was stirred for few days at room temperature until the reaction finished. The precipitate was filtered off and the mother liquids were left to crystallize at room temperature and the crystals were dried at room temperature. The obtained crystals were suitable for X-ray structure determination.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 114-33-0, N-Methylnicotinamide.

Reference:
Article; Pucho?ova, Miroslava; ?vorec, Jozef; ?vorc, Lubomir; Valigura, Du?an; Chemical Papers; vol. 70; 1; (2016); p. 75 – 81;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 115170-40-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 115170-40-6 as follows.

To a solution of 5-bromo-2,3-dihydro-1 H-pyrrolo(2,3-b)pyridine (CAS Number 1 15170-40-6; 0.300 g, 1 .507 mmol) in 1 ,4-dioxane:water (1 : 1 , 8 ml) were added phenylboronic acid (0.294 g, 2.412 mmol) and K2CO3 (0.624 g, 4.52 mmol) at rt. The reaction mixture was degassed for 30min before addition of Pd(PPh3)4 (0.087 g, 0.075 mmol) thenheated at 80C for 1 h. The reaction was cooled to rt, poured into water (100 ml) and extracted with EtOAc (3 x 50 ml). The combined organic phase was dried over Na2SO4, filtered and concentrated under reduced pressure yielding 5-phenyl-2,3-dihydro-1 H-pyrrolo[2,3-b]pyridine (0.440 g, 2.24 mmol). MS: ES+ 197.1 .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,115170-40-6, its application will become more common.

Reference:
Patent; MISSION THERAPEUTICS LIMITED; STOCKLEY, Martin Lee; KEMP, Mark Ian; MADIN, Andrew; (167 pag.)WO2018/65768; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 153034-94-7 , The common heterocyclic compound, 153034-94-7, name is 2-Fluoro-4-iodo-5-picoline, molecular formula is C6H5FIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: ethyl 4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrole-3-carboxylate To a slurry of copper(I) iodide (0.14 g, 0.73 mmol) and potassium carbonate (3.03 g, 21.9 mmol) in 1,4-dioxane (15 mL) were added 2-fluoro-4-iodo-5-methylpyridine (5.03 g, 21.2 mmol), ethyl 4-(2-chlorophenyl)-1H-pyrrole-3-carboxylate (0.95 g, 3.8 mmol), and trans-N,N’-dimethylcyclohexane-1,2-diamine (0.23 mL, 1.46 mmol). The reaction mixture was allowed to stir in a sealed vial for 48 h at 105 C. and then allowed to cool to rt. The mixture was diluted with EtOAc and washed with brine. The organic solutions were combined, concentrated, and purified by column chromatography to give ethyl 4-(2-chlorophenyl)-1-(2-fluoro-5-methylpyridin-4-yl)-1H-pyrrole-3-carboxylate (1.2 g, 88%). LCMS (FA): m/z=359.3 (M+H).

The synthetic route of 153034-94-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MILLENNIUM PHARMACEUTICALS, INC.; Chau, Ryan W.; Cullis, Courtney A.; Duffey, Matthew O.; Gipson, Krista E.; Hu, Yongbo; Li, Gang; Sintchak, Michael D.; Vos, Tricia J.; US2013/165464; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 108-99-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 108-99-6, name is 3-Methylpyridine, molecular formula is C6H7N, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Catalyst (0.03 mmol), H2O (3 ml), substrate (4 mmol), and H2O2 (20 mmol, 30% aq.) were charged in the reaction flask, which was first bathed in cold water (about 283 K). The mixture was then stirred at room temperature for 16-24 h. The reaction was detected by thin-layer chromatography (TLC). After the reaction, the system was concentrated by evaporation, and the catalyst precipitated from the mixture after the addition of anhydrous ethyl alcohol. The recovered catalyst, obtained by filtration, was washed with anhydrous ethyl alcohol and diethyl ether and then used for the next oxidation after drying. The filtrate was extracted with dichloromethane. The combined organic layers were dried over anhydrous Na2SO4, and the pure products were obtained by evaporation or column chromatography. The products were analyzed by 1H NMR and 13C NMR.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 108-99-6, 3-Methylpyridine.

Reference:
Article; Zhao, Wei; Wang, Xing; Yang, Chunxia; Synthetic Communications; vol. 44; 1; (2014); p. 150 – 160;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 959616-64-9, name is Methyl 2-chloro-5-fluoro-6-methoxynicotinate, molecular formula is C8H7ClFNO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-chloro-5-fluoro-6-methoxynicotinate

A mixture of methyl 2-chloro-5-fluoro-6-methoxy-pyridine-3-carboxylate (200 mg, 0.911 mmol), 4-fluoro-2-methoxyphenol (114 pL, 1.00 mmol) and cesium carbonate (742 mg, 2.28 mmol) in MeCN (8 mL) was stirred at 80 C for 3 h, then allowed to cool to room temperature with stirring. Water (30 mL) and methanol (5 mL) were added and the resulting mixture was sonicated briefly then stirred for 4 h. The precipitate was collected by filtration, washed with water and dried under vacuum to give methyl 5-fluoro-2-(4-fluoro-2-methoxy-phenoxy)-6-methoxy- pyridine-3-carboxylate (237 mg, 0.727 mmol, 79.9% yield) as a beige solid. MS, ES+m/z 326.0 [M+H]+. -NMR (400 MHz, DMSO-rie) d 8.12 (d, J=l0.11 Hz, 1 H), 7.18 (dd, J=8.72, 5.94 Hz, 1 H), 7.09 (dd, J=l0.74, 2.91 Hz, 1 H), 6.81 (td, J=8.46, 2.78 Hz, 1 H), 3.83 (s, 3 H), 3.72 (s, 3 H), 3.57 (s, 3 H).

With the rapid development of chemical substances, we look forward to future research findings about 959616-64-9.

Reference:
Patent; LIEBER INSTITUTE, INC.; HUANG, Yifang; POSLUSNEY, Michael; ERNST, Glen; BARROW, James; (0 pag.)WO2020/14246; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 69008-70-4, N,N-Dipropylpyridin-4-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 69008-70-4, blongs to pyridine-derivatives compound. SDS of cas: 69008-70-4

To a solution of 4-dipropylaminopyridine (1.16 g, 6.50 mmol) in benzonitrile (2.0 mL) was added 1-iodoadamantane (2.04 g, 7.80 mmol).Was added and stirred at 145 C. for 60 hours. After cooling to room temperature,The reaction solution was purified by silica column chromatography (chloroform / methanol),Brown solid 1- (1-adamantyl) -4-dipropylaminopyridinium iodide(0.717 g, yield 25%) was obtained.

The synthetic route of 69008-70-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ???????????????; ???????; Araki Keisuke; Nakamura Maki Tsukasa; Yoshioka Masato; Naranoki Yuusuke; (35 pag.)JP2019/210213; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13534-89-9, name is 2,3-Dibromopyridine, the common compound, a new synthetic route is introduced below. Quality Control of 2,3-Dibromopyridine

General procedure: A mixture of MeCN and MeOH (2:1, 15 ml) wasadded to a mixture of 2,3-dibromopyridine (1) (474 mg,2.0 mmol), arylboronic acid (2.1 mmol), K2CO3 (560 mg,4.0 mmol), PPh3 (52 mg, 10 mol %) and Pd(OAc)2 (23 mg,5 mol %) in a screw-cap vial. Reaction mixture was flushedwith argon, sealed, and stirred at 50C for 24 h in an oilbath. Then the reaction mixture was cooled to room temperature and filtered through Celite. Filtrate was concentratedunder reduced pressure, the residue was dissolved in CH2Cl2(20 ml), washed with water (3×10 ml) and dried overNa2SO4. Solvent was evaporated under reduced pressure,and the residue was purified by column chromatography on silica (hexane-EtOAc, 30:1) to provide pure pyridines 2a-j. 3-Bromo-2-phenylpyridine (2a).53 Yield 387 mg(83%), colorless oil.

The synthetic route of 13534-89-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shestakov, Aleksandr N.; Pankova, Alena S.; Kuznetsov, Mikhail A.; Chemistry of Heterocyclic Compounds; vol. 53; 10; (2017); p. 1103 – 1113; Khim. Geterotsikl. Soedin.; vol. 53; 10; (2017); p. 1103 – 1113,11;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 55676-21-6, 1-(2-Chloropyridin-3-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 55676-21-6, blongs to pyridine-derivatives compound. Product Details of 55676-21-6

KOH (0.5 N MeOH, 6.0 mL, 3.0 mmol) was added to a solution of the compound 6 (467 mg, 3.0 mmol) prepared in Example 1 and 2-methoxybenzaldehyde (408 mg, 3.0 mmol) in THF The reaction was stopped by adding 0.5 N HCl (6 mL) to the mixed light yellow solution at 0 ° C and mixing at 0 ° C to room temperature for 3 hours. After evaporation of the solvent from this solution, the mixture was taken up in saturated NaHCO3 solution (30 mL) and extracted three times with dichloromethane (20 mL). The concentrated residue was purified by silica gel column chromatography using 30percent EtOAc / n-hexane as the extraction solvent to give compound 7l (673 mg, 82percent).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55676-21-6, its application will become more common.

Reference:
Patent; Duksung Women’s University Industry-Academic Cooperation Foundation; Jae, In Lee; (15 pag.)KR101766414; (2017); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16063-70-0, name is 2,3,5-Trichloropyridine, the common compound, a new synthetic route is introduced below. Formula: C5H2Cl3N

To a solution of tert- butyl N-(2-amino-5-fluoro-phenyl)-N-methyl-carbamate (80 g, 333 mmol, compound A 1.4) and 2,3,5 -trichloropyridine (66.8 g, 366 mmol, CAS: 16063-70-0) in dioxane (2 L) were added cesium carbonate (217 g, 666 mmol), palladium(II) acetate (3.74 g, 16.7 mmol), and BINAP ( 20.7 g, 33.3 mmol, CAS: 98327-87-8). The reaction mixture was stirred at 120 C for 16 h under nitrogen atmosphere. After the reaction mixture was cooled back to room temperature, it was diluted with EtOAc (800 mL). The precipitate was removed by filtration and the filtrate was concentrated in vacuo, and the crude product was purified by silica gel flash chromatography (0.2% to 5% EtOAc in petroleum ether) to give intermediate fe/7-butyl N-[2-[(3,5-dichloro-2-pyridyl)amino]-5-fluoro-phenyl]-N-methyl-carbamate (75 g, 58% yield) as a white solid. MS (ESI): 390.1 ([{37C1}M+H]+), 388.1 ([{37C1+35C1 }M+H]+), 386.1 (0192) ([{35C1}M+H]+).

The synthetic route of 16063-70-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; SHEN, Hong; TAN, Xuefei; ZHOU, Chengang; ZHOU, Mingwei; HU, Yimin; SHI, Houguang; DEY, Fabian; LIU, Yongqiang; DING, Xiao; (86 pag.)WO2020/104436; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem