Adding a certain compound to certain chemical reactions, such as: 30529-70-5, 2-Chloro-6-methylnicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C7H6ClNO2, blongs to pyridine-derivatives compound. COA of Formula: C7H6ClNO2
Description 47: methyl l-chloro–methyl-S-pyridinecarboxylate (D47); To a solution of 2-chloro-6-methyl-3-pyridinecarboxylic acid (8 g, 46.6 mmol) (available from Sigma-Aldrich No.357847) in DCM (100 ml) and MeOH (50.0 ml) stirred under nitrogen at room temperature was added TMS-diazomethane 2 M in hexane (46.6 ml, 93 mmol). The reaction mixture was stirred at room temperature for 20 minutes. The solvents were removed to give the title compound D47 (7 g).MS: (ES/+) m/z: 186 (M+l) C8H8ClNO2 requires 185.1H NMR (400 MHz, CDCl3) ppm 8.10 (d, 1 H), 7.18 (d, 1 H), 3.96 (s, 3 H), 2.61 (s, 3 H).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,30529-70-5, 2-Chloro-6-methylnicotinic acid, and friends who are interested can also refer to it.
Reference:
Patent; GLAXO GROUP LIMITED; AMANTINI, David; DI FABIO, Romano; WO2010/122151; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem