Month: June 2021

Adding a certain compound to certain chemical reactions, such as: 5349-17-7, 2-Bromo-1-(pyridin-4-yl)ethanone hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5349-17-7, blongs to pyridine-derivatives compound. Product Details of 5349-17-7

General procedure: Potassium carbonate (418 mg, 3 mmol, 1 eq.) was added to a solution of malonitrile (200 mg, 3 mmol, 1 eq.) in dry DMF (5 mL). The reaction was stirred at room temperature for 1 hour and isopropyl isothiocyanate (311 mL, 3 mmol, 1 eq.) was added. After 1 hour stirring at room temperature, 2-bromo-1-(4-methoxyphenyl)ethan-1-one was added (687 mg, 3 mmol, 1 eq.) followed by potassium carbonate (418 mg, 3 mmol, 1 eq.). The mixture was further stirred for 15 hours, and poured into stirring ice/water (50 mL). The resulting precipitate was filtered and washed with water. The title compound was purified by recristalization from hexane/EtOAc and dried under vaccum (823 mg, yield: 87%, purity: 95.7%, Rt = 1.65 min. by method C).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5349-17-7, its application will become more common.

Reference:
Article; Boutard, Nicolas; Sabiniarz, Aleksandra; Czerwi?ska, Klaudia; Jarosz, Ma?gorzata; Cierpich, Anna; Kolasi?ska, Ewa; Wiklik, Katarzyna; Gluza, Karolina; Commandeur, Claude; Buda, Anna; Stasiowska, Agata; Bobowska, Aneta; Galek, Mariusz; Fabritius, Charles-Henry; Bugaj, Marta; Palacz, Edyta; Mazan, Andrzej; Zar?bski, Adrian; Krawczy?ska, Karolina; ?urawska, Ma?gorzata; Zawadzki, Przemys?aw; Milik, Mariusz; W?grzyn, Paulina; Dobrza?ska, Monika; Brzozka, Krzysztof; Kowalczyk, Piotr; Bioorganic and Medicinal Chemistry Letters; vol. 29; 4; (2019); p. 607 – 613;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 87407-12-3 , The common heterocyclic compound, 87407-12-3, name is 3-(Trifluoromethyl)picolinic acid, molecular formula is C7H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 3-trifluoromethyl-2-pyridine carboxylic acid (0.33 g, 1.6 mmol), (dimethylamino)-N,N-dimethyl(3H-[l,2,3]triazolo[4,5-]pyridin-3-yloxy)methaniminium hexafluorophosphate (i.e. HATU, 0.059 g, 1.6 mmol), and N,N-diisopropylethylamine (0.33 g, 2.6 mmol) were stirred in 10 mL dichloromethane. After 15 min, 2-[5-[3- (trifluoromethyl)-lH-pyrazol-l-yl]-2-pyrazinyl]benzenamine (i.e. the compound obtained in Example 3, Step C above) (0.4 g, 1.3 mmol) was added and the reaction was stirred at ambient temperature for approximately 16 h. The reaction mixture was then diluted with water and extracted with ethyl acetate. The combined organic extracts were washed with water, dried over Na2S04, evaporated under reduced pressure and then purified using silica gel column chromatography (20% ethyl acetate in petroleum ether as eluent) to yield 0.36 g of the title compound, a compound of the present invention. in NMR (400 MHz, dmso-d6) delta 12.20 (s, 1H), 9.31 (s, 1H), 9.05 (m, 2H), 8.91 (bs, 1H), 8.36 (m, 2H), 7.97 (d, 1H), 7.85 (m, 1H), 7.61 (t, 1H), 7.41 (t, 1H), 7.18 (d, 1H).

The synthetic route of 87407-12-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; BEREZNAK, James, Francis; TAGGI, Andrew, Edmund; KAR, Moumita; REDDY, Ravisekhara, P.; CAMPBELL, Mathew, James; WO2014/172190; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 65-22-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. This compound has unique chemical properties. The synthetic route is as follows.

2.2.1 PLSC·2H2O Semicarbazide hydrogenchloride (1.07 g, 10 mmol) was dissolved in warm H2O (10 mL), to which a warm solution of pyridoxal hydrogenchloride (2.00 g, 10 mmol) in H2O (10 mL) was added. To this solution Na2CO3·10H2O (3.00 g, 15 mmol) dissolved in H2O (10 mL) was added in portions, and the mixture was mildly heated for a couple of minutes. The obtained solution was left at room temperature for about 20 h, after which the single crystals were filtered and washed with H2O. Yield: 2.30 g (88%). Anal. Calc. for C9H16N4O5: C, 41.54; H, 6.20; N, 21.53. Found: C, 41.43; H, 6.16; N, 21.50%. Selected IR bands [ /cm-1]: 3466, 3381, nu(OH), nu(NH2); 3202, nu(NH); 2850, nu(NH+); 1697, 1678, nu(C=O); 1583, nu(CN); 1280, nu(COphenolic). UV-Vis (DMF) [lambdamax/nm (log epsilon/M-1 cm-1)]: 289 (4.12), 298sh (4.08), 327bp (3.75) (sh-shoulder, bp-broad peak).

According to the analysis of related databases, 65-22-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Vojinovi?-Je?i?, Ljiljana S.; Jovanovi?, Ljiljana S.; Leovac, Vukadin M.; Radanovi?, Mirjana M.; Rodi?, Marko V.; Barta Hollo, Berta; Meszasaros Szecsenyi, Katalin; Ivkovi?, Sonja A.; Polyhedron; vol. 101; (2015); p. 196 – 205;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 67754-03-4, Methyl 2,5-dichloronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 67754-03-4, blongs to pyridine-derivatives compound. HPLC of Formula: C7H5Cl2NO2

Description 64: 1-(5-chloro-3-(methoxycarbonyl)pyridin-2-yl)azetidine-3- carboxylic acid (D64)To a mixture 3-Azetidinecarboxylic acid (41 1 mg, 4.06 mmol) and triethylamine (1 .17ml, 8.47 mmol) in methanol (3ml), methyl 2-chloropyridine-3-carboxylate (700 mg, 3.38 mmol) was added and the mixture was heated at 150C under microwave irradiation 10 min (2 cycles of 5 min each ). Solvents were evaporated in vacuo and the residue was taken in water (5ml) and 1 M HCI (5ml) and extracted with ethylacetate (3x5ml). Collected organics after solvent evaporation afforded the title compound (D64) (880 mg)MS: (ES/+) m/z: 270.8 [MH+] C1 1 H1 1 CIN204 requires 270.04 1 H NMR (400 MHz, CHLOROFORM-d) delta ppm 8.23 – 8.32 (m, 1 H) 7.90 – 8.06 (m, 1 H) 4.31 – 4.45 (m, 2 H) 4.17 – 4.30 (m, 2 H) 3.84 – 3.95 (m, 3 H) 3.58 (tt, J=8.93, 6.1 1 Hz, 1 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,67754-03-4, its application will become more common.

Reference:
Patent; ROTTAPHARM S.P.A.; BORRIELLO, Manuela; ROVATI, Lucio; STASI, Luigi Piero; BUZZI, Benedetta; COLACE, Fabrizio; WO2012/76063; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1202070-39-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1202070-39-0, name is (R)-1-(5-Fluoropyridin-2-yl)ethanamine hydrochloride, molecular formula is C7H10ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step D: N-rrii?Vl-r5-Fluoropyridin-2-vnethyll-3-(5-methylpyridin-2-vn-5-[(R/SV2.2,2- trifluoro- 1 -hvdroxyethvPbenzamide; To a solution of 3-(5-methylpyridin-2-yl)-5-(2,2,2-trifluoro-l- hydroxyethyl)benzoic acid (25 mg, 0.072 mmol) in N^-dimethylformamide (0.7 mL) were added (li?)-l-(5-fluoropyridin-2-yl)ethanamine hydrochloride salt (23 mg, 0.11 mmol), EDC (20.7 mg, 0.11 mmol), HOAT (0.5 M in DMF; 72 muL, 0.036 mmol) and triethylamine (60 muL, 0.43 mmol). The reaction mixture was heated to 60 C. After 3 h, the mixture was cooled to ambient temperature and the solid in the reaction was filtered off. Purification by reverse phase chromatography (C-18, 75% water/ acetonitrile ? 48% water/ acetonitrile with 0.1% trifluoroacetic acid) gave the trifiuoroacetate salt of the title compound. HRMS 434.1484(M+l). 1H NMR (500 MHz, DMSOd6): delta 9.09 (d, J= 7.6 Hz, 1 H); 8.57 (d, J= 8.0 Hz, 2 H); 8.52 (d, J= 3.0 Hz, 1 H); 8.38 (s, 1 H); 8.05 (s, 1 H); 7.98 (d, J= 8.1 Hz, 1 H); 7.78 (dd, J= 8.2, 2.2 Hz, 1 H); 7.70 (td, J= 8.8, 3.0 Hz, 1 H); 7.52 (dd, J= 8.8, 4.5 Hz, 1 H); 7.01 (d, J= 5.6 Hz, 1 H); 5.37-5.31 (m, 1 H); 5.29-5.23 (m, 1 H); 2.37 (s, 3 H); 1.55 (d, J= 7.1 Hz, 3 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1202070-39-0, (R)-1-(5-Fluoropyridin-2-yl)ethanamine hydrochloride.

Reference:
Patent; MERCK & CO., INC.; WO2009/58298; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 71701-92-3, Adding some certain compound to certain chemical reactions, such as: 71701-92-3, name is 3-Bromo-2-chloro-5-(trifluoromethyl)pyridine,molecular formula is C6H2BrClF3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 71701-92-3.

To a solution of 3-bromo-2-chloro-5-(trifluoromethyl)pyridine (20.00 g, 0.077 mol) in toluene (400 ml), DMF (dimethylformaldehyde) (7.72 ml, 0.10 mol) was dropwise added at – 65C, followed by the addition of n-BuLi (1.57M solution in hexane; 64 ml, 0.10 mol). After stirring for 30 min, the reaction was terminated with 1 N HCI, and then, the reaction mixture was extracted with ethyl acetate. The organic layer was washed with water, dried over anhydrous magnesium sulfate, filtered, and concentrated in a vacuum to obtain 2-chloro-5- (trifluoromethyl)pyridine-3-carbaldehyde. This produce was used in the subsequent reaction without further purification.

According to the analysis of related databases, 71701-92-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DONG-A ST CO.,LTD; PARK, Jang Hyun; SONG, Seung Hyun; CHUNG, Han Kook; KIM, Heung Jae; LEE, Ji Hye; JANG, Byeong Jun; KIM, Eun Jung; JUNG, Hae Hum; RYU, Chae Lim; HWANG, Jae-Sung; LEE, Hyung Ki; KANG, Kyung Koo; KIM, Soon Hoe; WO2014/157994; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine, the common compound, a new synthetic route is introduced below. SDS of cas: 89466-18-2

6-bromo-2-methoxy-3-amine (1.02g, WO2011068211 pamphlet) In acetonitrile (20mL) solution,At 0 , 37% aqueous solution of formaldehyde (1.22g)And the mixture was stirred for 10 minutes. The reaction mixture was cooled to room temperature, sodium triacetoxyborohydride (3.18g) was added,The reaction was stirred overnight at the same temperature.Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate,After filtered, and concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexaEmissions: ethyl acetate = 9: 1 ? 4: 1) was purified by,6-bromo-2-methoxy -N, N-dimethyl-3-amine and 6-bromo-2-methoxy -N- methyl-pyridin-3-amine 2 was obtained 1 mixture (475 mg).

The synthetic route of 89466-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAISHO PHARMACEUTICAL COMPANY LIMITED; NISSAN CHEMICAL INDUSTRIES LIMITED; KURODA, SHOICHI; USHIKI, YASUNOBU; KAWAGUCHI, TAKANORI; FUSEGI, KEIKO; BOHNO, MASAHIRO; IMAI, YUDAI; UNEUCHI, FUMITO; IWAKIRI, KANAKO; TANAKA, HIROAKI; BOHNO, AYAKO; CHONAN, TOMOMICHI; ITOH, SHIN; OTA, HIROFUMI; ISHIYAMA, SEISHI; OKADA, TAKUYA; SASAKO, SHIGETADA; MONMA, SOUICHI; NIWA, MARIE; OKADA, TAKUMI; (289 pag.)JP2015/231988; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1196154-43-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1196154-43-4 as follows.

1,4-Dioxaspiro[4.5]decan-8-ol (0.25 g, 1.58 mmol) and 2-[2-chloro-6-(trifluoromethyl)pyridin-4-yl]propan-2-ol (0.2 g, 0.835 mmol) were dissolved in tetrahydrofuran (2 mL) and cooled to 0 C. and a 60% mixture of sodium hydride (70.0 mg, 1.75 mmol) in mineral oil was added and the reaction was stirred for 30 minutes at 0 C. and at 25 C. for 60 hours at which time TLC analysis indicated the presence of some product. The reaction was quenched with water, and was extracted with ethyl acetate and the organic extracts were washed with water, saturated NaCl, dried (MgSO4), and evaporated in vacuo. The residue was purified by LC (pH 2) to give the product. MS(ES):362 (M+1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1196154-43-4, its application will become more common.

Reference:
Patent; Incyte Corporation; Vaddi, Krishna; US2015/246046; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.100-70-9, name is Picolinonitrile, molecular formula is C6H4N2, molecular weight is 104.11, as common compound, the synthetic route is as follows.Recommanded Product: 100-70-9

Compound 18 was synthesized according to the procedures reported in the literature (J. Org. Chem. 1998, 63, 1740-1741) as shown in Scheme 38.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,100-70-9, Picolinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; PURDUE PHARMA L.P.; NI, Chiyou; SHAO, Bin; TAFESSE, Laykea; YAO, Jiangchao; YU, Jianming; ZHOU, Xiaoming; WO2012/35421; (2012); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1211589-43-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211589-43-3, name is 3-Bromo-6-fluoropicolinic acid, molecular formula is C6H3BrFNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Para-toluenesulfonyl chloride (27.6 g) was added to a solution of Example 1.4.3 (14.5 g),pyridine (26.7 mL) and tert-butanol (80 mL) in dichloromethane (100 mL) at 0 C. The reaction wasstirred for 15 minutes, warmed to room temperature, and stirred overnight. The solution was concentrated and partitioned between ethyl acetate and Na2C03 solution. The layers were separated,and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, rinsedwith Na2C03 solution and brine, dried over sodium sulfate, filtered, and concentrated to provide thetitle compound.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211589-43-3, 3-Bromo-6-fluoropicolinic acid.

Reference:
Patent; ABBVIE INC.; BOGHAERT, Erwin, R.; JUDD, Andrew, S.; PHILLIPS, Andrew, C.; SOUERS, Andrew, J.; BRUNCKO, Milan; (503 pag.)WO2017/214301; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem