Day: July 5, 2021

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 65-22-5, name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H10ClNO3

General procedure: In a round bottom flask, pyridoxal hydrochloride (0.201g; 1.0mmol) was added to methanol (15mL) and the resulting suspension was subjected to magnetic stirring at room temperature until complete dissolution of the pyridoxal molecule. Then, the corresponding aniline (0.120g of 2-fluoroaniline; 0.130g of 2-chloroaniline, 0.170g of 2-bromoaniline or 0.220g of 2-iodoaniline; 1.0mmol for each) dissolved in methanol (5 mL) was added. The resulting mixture was kept under magnetic stirring at reflux temperature for 2.0h. After this period, the flask contents were cooled to room temperature and the solvent evaporated. The resulting solid was washed with small portions of ice water and diethyl ether and dried in a desiccator with CaCl2. For the synthesis of the ligand containing aniline, the same conditions were used, but without potassium hydroxide (0.093g of aniline was added to 15mL of methanol and 1mmol of pyridoxal hydrochloride; 0.201g). Properties – orange crystals, yield 85%. Melting point: 207C. Anal.Calc. for [C14H13BrN2O2] C, 47.02; H, 3.95; N, 7.83. Found: C, 46.93; H, 3.90; N, 7.79%. IR (KBr pellets, cm-1): 3209 [w, nu(O-H)]; 1627 [m, nu(C=N)]; 1387 [m, nu(C-N)], 1257 [s, nu(C-O)phenol], 1033 [s, nu(C-O)alcohols], 694 [m, nu(C-Br)alcohols] and 620 [s, nu(O-H)alcohols] (w=weak; m=medium; s=strong). 1H NMR (ppm, DMSO-d6): delta 2.46 (s, 3H, CH3); 4.80 (s, 2H, CH2); 7.32-7.81 (m, 4H, Ar); 8.03 (s, 1H, Py) and 9.21 (s, 1H, CHimine)

With the rapid development of chemical substances, we look forward to future research findings about 65-22-5.

Reference:
Article; Pereira, Mateus Brum; Fontana, Liniquer Andre; Siqueira, Josieli Demetrio; Auras, Bruna L.; da Silva, Marcos P.; Neves, Ademir; Gabriel, Philipe; Terenzi, Hernan; Iglesias, Bernardo Almeida; Back, Davi Fernando; Inorganica Chimica Acta; vol. 469; (2018); p. 561 – 575;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 851386-35-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 851386-35-1, name is 2,3-Difluoro-5-iodopyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: 1-(3-Fluoro-5-iodo-pyridin-2-ylamino)-2-methyl-propan-2-ol 2,3-Difluoro-5-iodopyridine (500 mg, 2.07 mmol) was dissolved in NMP (500 muL) and pyridine (201 mul, 2.49 mmol, 1.2 equiv.) and 1-amino-2-methylpropan-2-ol (555 mg, 6.22 mmol, 3 equiv.) were added at room temperature. The mixture was stirred for 16 hours at 100° C. The reaction mixture was cooled and extracted with saturated NaHCO3 solution and two times with a small volume of dichloromethane. The crude product was purified by flash chromatography by directly loading the dichloromethane layers onto a silica gel column and eluting with an ethyl acetate:heptane gradient 0:100 to 100:0. The desired 1-(3-fluoro-5-iodopyridin-2-ylamino)-2-methylpropan-2-ol (590 mg, 1.9 mmol, 91.7percent yield) was obtained as a colorless oil, MS: m/e=311.0 (M+H+).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 851386-35-1, 2,3-Difluoro-5-iodopyridine.

Reference:
Patent; Green, Luke; Guba, Wolfgang; Jaeschke, Georg; Jolidon, Synese; Lindemann, Lothar; Ricci, Antonio; Rueher, Daniel; Stadler, Heinz; Vieira, Eric; US2011/251169; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 15855-06-8, name is 2-Chloro-6-methoxypyridine-4-carboxylic Acid, the common compound, a new synthetic route is introduced below. HPLC of Formula: C7H6ClNO3

b) To a suspension of 2-chloro-6-methoxy-isonicotinic acid (244 g, 1.30 mol) in methanol (2.5 L), H2SO4 (20 mL) is added. The mixture is stirred at reflux for 24 h before it is cooled to 0 C. The solid material is collected, washed with methanol (200 mL) and water (500 mL) and dried under HV to give 2-chloro-6-methoxy-isonicotinic acid methyl ester (165 g) as a white solid; LC-MS: tR=0.94 min, [M+1]+=201.89.

The synthetic route of 15855-06-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Morrison, Keith; Mueller, Claus; Nayler, Oliver; Steiner, Beat; US2012/108638; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 71255-09-9 ,Some common heterocyclic compound, 71255-09-9, molecular formula is C7H7NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Et3N (1.0 equiv) was added to a suspension of 2-(4-bromo-2,5-dimethoxyphenyl)ethanamine hydrochloride (2C-B*HCl, 1.0 mmol) and the required aldehyde (1.1 equiv) in EtOH (10 mL) and the reaction was stirred until formation of the imine was complete according to TLC or GC (between 30 min and 3 h depending on the aldehyde). NaBH4 (2.0 mmol) was then added and the reactionwas stirred for another 30 min. The reaction mixture was concentratedunder reduced pressure and the residue was partitioned between CH2Cl2 and water (30 mL, 1:1). The organic layer was isolated and the aqueous layer was extracted with CH2Cl2 (2 x 15 mL). The combined organic extracts were dried over Na2SO4, filtered and evaporated under reduced pressure. The residue was purified by flash chromatography (CH2Cl2/MeOH/NH3 98:2:0.04). The purified free base was dissolved in EtOH (2 mL) and HCl (1 M in EtOH, 2 mL) was added and the resulting solution was diluted with Et2O until a precipitate was formed. The crystals were collected by filtration and dried under reduced pressure to provide the desired products.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,71255-09-9, its application will become more common.

Reference:
Article; Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Braeuner-Osborne, Hans; Kristensen, Jesper Langgaard; Bioorganic and Medicinal Chemistry; vol. 23; 14; (2015); p. 3933 – 3937;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 76093-33-9, name is (R)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C16H16N2O6

(7) Preparation of (4S)-3-[1-(3,3-diphenylpropyl)-3-methylpyrrolidin -3-yl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate To a solution of (R)-5-methoxycarbonyl-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (67.5g, 0.2mol) in dichloromethane was added 1.5mL DMF. To the mixture was slowly added oxalyl chloride (51g, 0.4mol) dropwisely in an ice bath. The reaction was conducted at 25C. After the completion of reaction, the resulting mixture was evaporated under reduced pressure to remove oxalyl chloride. To the reaction flask were slowly added dichloromethane (300mL), 1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-ol (29.5g, 0.1mol) and DIPEA (25.8g, 0.2mol) dropwisely under cooling in an ice bath respectively and successively. The reaction was conducted at 25C. After the completion of reaction monitored by HPLC, the reaction solution was washed with water thrice. The organic phase was dried over sodium sulfate, and filtered by suction. The filtrate was evaporated to dryness, and purified by column chromatography (silica gel column, eluted with petroleum ether: ethyl acetate = 80:1 (volumetric ratio)) to produce (4S)-3-[1-(3,3-diphenylpropyl)-3-methylpyrrolidin-3-yl] 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (34 g) in a yield of 56 %.

With the rapid development of chemical substances, we look forward to future research findings about 76093-33-9.

Reference:
Patent; Xuanzhu Pharma Co., Ltd.; ZHANG, Hui; FAN, Mingwei; SUN, Liang; EP2703398; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 84487-10-5, name is 2-Amino-4-bromo-3-nitropyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 84487-10-5

2-Amino-3-nitro-4-bromopyridine (1 g, 4.59 mmol)Dissolved in 20 ml of 95% ethanol, added stannous chloride(2.61 g, 13.76 mmol).The reaction solution was warmed to reflux and stirred at this temperature for 2-3 hours.Pour the reaction solution into 80 ml of 1N sodium hydroxide solution.Extracted with ethyl acetate (30 mL×3), and the extract was washed with brine.Dry over anhydrous sodium sulfate,Concentrated to a crude product.The crude product was subjected to silica gel column chromatography ( petroleum ether / ethyl acetate = 5:1)2,3-diamino-4-bromopyridine(322 mg, yield 37%)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 84487-10-5, 2-Amino-4-bromo-3-nitropyridine.

Reference:
Patent; Shanghai Jiao Tong University; Wang Yongxiang; Fu Lei; Xie Dongsheng; Lu Jun; (37 pag.)CN103435561; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 5350-93-6, Adding some certain compound to certain chemical reactions, such as: 5350-93-6, name is 6-Chloropyridin-3-amine,molecular formula is C5H5ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5350-93-6.

To 0.5 g (3.9 mmol) of 6-chloro-pyridin-3-ylamine in 6 mL of 12M HC1 at-20°C were added a solution of 0.36 g (5.2 mmol, 1. 3 eq) of sodium nitrite dissolved in 2 mL of H20. The reaction mixture was stirred for 15 min, and 4.4 g (19.5 mmol, 5 eq) of tin chloride dihydrate dissolved in 2 mL of 12M HC1 were added. The reaction mixture was allowed to reach 0°C within 40 min, and the white precipitate was recovered by filtration and washed with Et20 to yield 0.35 g (62percent) of (6-chloro-pyridin-3-yl) -hydrazine hydrochloride as a white solid, MS: 144 (MH+).

According to the analysis of related databases, 5350-93-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2005/92856; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 626-64-2 , The common heterocyclic compound, 626-64-2, name is Pyridin-4-ol, molecular formula is C5H5NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

4-pyridinol (M-40) (20.0 g, 210 mmol)Was suspended in carbon tetrachloride (400 mL)NBS (77.0 g, 431 mmol) was added and, under light shielding,And the mixture was stirred at room temperature for 24 hours.After distilling off the solvent under reduced pressure,The residue was suspended in acetone (400 mL) / methanol (120 mL) and stirred at room temperature for 30 minutes.The precipitated solid was collected by filtration,This was suspended in acetonitrile (1.0 L)And the mixture was stirred at room temperature for 1 hour. After collecting the solid by filtration,After drying under reduced pressure, the compound (M-41)(Yield 46.0 g, yield 86%)As a white solidIt was.

The synthetic route of 626-64-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kaken Pharmaceutical Co., Ltd.; Watanabe, Atsushi; Sato, Yuki; ogura, Keiji Tamada; Tatsumi, Yoshiyuki; (283 pag.)JP2018/145180; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 31301-51-6, name is 2-Chloro-5-fluoropyridine, the common compound, a new synthetic route is introduced below. Product Details of 31301-51-6

j00200J To a stirred solution of 2-chloro-5-fluoropyridine (10.0 g, 76.0 mmol, 1.0 eq.) in anhydrous THF (100 ml) was added LDA (58 mL, 116 mmol, 2M) dropwise at -78 C under N2. The mixture was kept at this temperature for 3 h, to which was added a solution of ?2 (23.2 g, 91.0 mmol) in THF (100 mL) dropwise at -78 C. The mixture was stirred for 1 h, and quenched with water (200 mL). The aqueous mixture was warmed to rt, ad extracted with EtOAc (100 mL x 2). The combined organic layers were washed with brine (50 mL x 2), dried over Na2 SO4, filtered and concentrated under vacuum. The crude product was purified by chromatography on silica gel (PE to EtOAc/PE = 1/20, v/v) to afford 2-chloro-5-fluoro-4-iodopyridine (11.8 g, 60%) as a white solid. ?H NMR (400 IVIHz, CDC13): 8.13 (s, 1H), 7.76 (d, 1H).

The synthetic route of 31301-51-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (109 pag.)WO2017/1936; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1061358-78-8, name is 2-Chloro-5-(trifluoromethyl)pyridin-4-amine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Quality Control of 2-Chloro-5-(trifluoromethyl)pyridin-4-amine

5-(2-chloro-5-(trifluoromethyl)pyridin-4-ylamino)-iV-methylthiazole-4- carboxamide; A mixture of 2-chloro-5-(trifluoromethyl)pyridin-4-amine (41 mg, 0.21 mmol) and 5- bromo-7V-methylthiazole-4-carboxamide (54 mg, 0.24 mmol; synthesized from the corresponding ethyl-ester), Pd2(dba)3 (19 mg, 0.021 mmol), xantphos (37 mg, 0.064 mmol) and cesium carbonate (138 mg, 0.42 mmol) in dioxane (3.5 ml) were heated in a Biotage Initiator microwave synthesizer at 140 C for 2 h. The solvent was removed and the residue was purified by silica gel chromatography (DCM/MeOH gradient) to give the title compound as a pale yellow solid in 27% isolated yield.

With the rapid development of chemical substances, we look forward to future research findings about 1061358-78-8.

Reference:
Patent; THE SCRIPPS RESEARCH INSTITUTE; WO2008/115369; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem