Day: July 12, 2021

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1737-93-5, name is 3,5-Dichloro-2,4,6-trifluoropyridine. A new synthetic method of this compound is introduced below., COA of Formula: C5Cl2F3N

General procedure: A mixture of commercially available 3,5-dichloro-2,4,6-(trifluoro)pyridine 1 (1 mmole), aryl boronic acids 2a-i (2.2 mmol), Pd(OAc)2 (2 mol %), x-phos (5 mol %), and K3PO4 (1.5 mmole) was added into a solution of H2O/DMF (1:1) (2 mL) in pressure tubes. The reaction mixture was stirred at 60-80C for 12 hrs. After completion of reaction (TLC controlled), the organic and aqueous layers were separated and the latter was extracted with CH2Cl2 (3×25 mL). The combined organic layers were dried (Na2SO4), filtered, and the filtrate was concentrated in vacuo. The product was purified by column chromatography (silica gel, EtOAc/heptane). All products were characterized by NMR, GC-MS, HRMS, and IR spectroscopic techniques.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1737-93-5, 3,5-Dichloro-2,4,6-trifluoropyridine.

Reference:
Article; Sharif, Muhammad; Shoaib, Khurram; Ahmed, Shahzad; Iqbal, Jamshed; Abilov, Zharylkasyn A.; Spannenberg, Anke; Langer, Peter; Tetrahedron Letters; vol. 57; 29; (2016); p. 3060 – 3062;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 50488-42-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 50488-42-1, name is 2-Bromo-5-(trifluoromethyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows.

III. methyl 5-trifluoromethyl-pyridine-2-carboxylate A mixture of 2-bromo-5-trifluoromethyl-pyridine (10 g, 44.25 mmol), TEA (17.9 g, 177 mmol) and Pd(dppf)Cl2 (3.24 g, 4.42 mmol) was stirred at 80C under an average pressure of 1.5 MPa with CO gas. The reaction mixture was filtered and the filtrate was concentrated. The residue was extracted between EA (100 mL) and H20 (100 mL). The EA layer was washed with saturated aqueous NaHC03 (2 X 100 mL), brine (1 X 100 mL), dried, concentrated and purified by column chromatography on silica gel to give the title compound as a white solid (6 g, 66% yield): 1H NMR (400 MHz, CDC13) delta ppm 8.97-8.98 (m, 1H), 8.23-8.25 (m, 1H), 8.07-8.09 (m, 1H), 4.03 (s, 3H); ES-LCMS m/z 206 ( +H)+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 50488-42-1, 2-Bromo-5-(trifluoromethyl)pyridine.

Reference:
Patent; GLAXOSMITHKLINE LLC; QIN, Donghui; CHRISTENSEN, IV, Siegfried Benjamin; WU, Chengde; ZHANG, Zhiliu; YU, Haiyu; YUAN, Jiangxing; LIN, Xiaojuan; XU, Shanli; LV, Maoyun; YAO, Chen; LI, Lei; HUANG, Xing; GAO, Min; WO2013/166621; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6283-81-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6283-81-4, name is Ethyl 3-oxo-3-(pyridin-3-yl)propanoate, molecular formula is C10H11NO3, molecular weight is 193.2, as common compound, the synthetic route is as follows.

1 g (5 mmol) of ethyl 3-pyridylacetoacetate was weighed,2,6-dihydroxytoluene 0.64 g (5 mmol) in 100 mL eggplant vials,Then add 5mL of anhydrous ethanol,Ice bath drop concentrated H2SO4 2.5mL,N2 gas protection room temperature stirring reaction 4h,(Chloroform / methanol = 40/1) to give 0.8 g of a white solid, which was purified by column chromatography on a white solid, filtered, dried and purified by column chromatography.Yield 61.03%,

Statistics shows that 6283-81-4 is playing an increasingly important role. we look forward to future research findings about Ethyl 3-oxo-3-(pyridin-3-yl)propanoate.

Reference:
Patent; Xi’an Jiaotong University; Li Yiping; Zhao Yang; Gao Yanjuan; Ma Ying; Jin Zhengyu; Hu Yanzhen; Wang Yawen; (23 pag.)CN106674176; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 128071-98-7 ,Some common heterocyclic compound, 128071-98-7, molecular formula is C5H3BrFN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of 4-bromo-2-fluoropyridine (0.635 g), Pd2(dba)3 (catalytic quantity), Xantphos (catalytic quantity) and Cs2CO3 (1.5 g) in 1,4-dioxane (5ml) was degassed by applying alternating N2 atmosphere and vacuum. Intermediate (132) in 1,4-dioxane (15ml) was added under N2-atmosphere. The reaction mixture was stirred at 1000C for 2 hours. The reaction mixture was filtrated. After extraction (DCM/water), the collected organic layers were dried (MgSO4), filtered and the filtrate was evaporated. The residue was purified by HPLC (HPLC method A). Two product fraction groups were collected and their solvents were evaporated, yielding intermediate (133) (trans; relative; mixture) and intermediate (134) (cis; relative; mixture).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 128071-98-7, 4-Bromo-2-fluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; JANSSEN PHARMACEUTICA NV; WO2008/3665; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 116632-24-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116632-24-7, name is 2-Amino-4,6-dichloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dichloro-6-hydroxypyridine; Sodium nitrite (64 mg, 0.93 mmol) dissolved in water (0.6 mL), was added dropwise to a stirred solution of 2-amino-4,6-dichloropyridine (prepared according to the method described in Recl. Trav. Chim. Pays-Bas, 1950, 69, 673) (126 mg, 0.77 mmol) in 5% sulphuric acid (aq) (5 mL) at 0 C., over 5 min. The mixture was stirred at 0 C. for 1 h and then diluted with water (20 mL) and extracted with DCM (3×20 mL). The combined extracts were washed with brine (20 mL), dried over MgSO4 and concentrated in vacuo to afford the 2,4-dichloro-6-hydroxypyridine (116 mg, 0.71 mmol, 92%) M.S. (ESI) (m/z) 164,166 [M+H]+.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 116632-24-7, 2-Amino-4,6-dichloropyridine.

Reference:
Patent; N.V. Organon; US2007/185156; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 17228-69-2 ,Some common heterocyclic compound, 17228-69-2, molecular formula is C6H6ClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Under an N2 atmosphere, KOtBu (1.3 mmol), complex 1 (1 mol %), dioxane (2 ml), amines (1.3 mmol) and aryl chlorides (1.0 mmol) were successively added into a Schlenk tube. The mixture was stirred vigorously at 90 C for 4 h. Then the solvent was removed under reduced pressure and the residue was purified by column chromatography on silica gel (eluent: PE/EA = 15:1) to give the pure products. The reported yields are the average of two runs.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 17228-69-2, 2-Chloro-4-methoxypyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Nirmala, Muthukumaran; Saranya, Gandhi; Viswanathamurthi, Periasamy; Bertani, Roberta; Sgarbossa, Paolo; Malecki, Jan Grzegorz; Journal of Organometallic Chemistry; vol. 831; (2017); p. 1 – 10;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 89570-82-1, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 89570-82-1, name is 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below.

Formula () 3- chloro-2-hydrazino-5-trifluoromethyl-pyridine (211mg, 1mmol) shown in ethanol (10ml), acetic acid (0.1mmol), 2- fluorobenzaldehyde (1 mmol of) mixing, Join CEM pressure tank, and then in the microwave synthesizer (150W, 85 , 200psi, 15minutes) under the conditions of work, after the completion of the microwave instrument through which compressed air is cooled to room temperature, filtration, and recrystallized from ethanol to obtain the objective compound of formula (-1) shown chloro-2- (2- (2-fluorophenyl) hydrazine-yl) -5-trifluoromethyl-pyridine, yield 71%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,89570-82-1, its application will become more common.

Reference:
Patent; Zhejiang University Of Technology; Zhao, Wen; Di, Zhiwen; Yang, Mingyan; Sun, Zhaohui; Liu, Xinghai; Min, Lijing; Shi, Yanxian; Weng, Jianquan; Tan, Chengxia; Li, Baoju; (12 pag.)CN105541706; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 126954-66-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 126954-66-3, name is 2,5-Dichloronicotinonitrile. A new synthetic method of this compound is introduced below.

To a solution of 2,5-dichloronicotinonitrile (160 mg, 0.92 mmol) in n-butanol (15.0 mL) was added hydrazine hydrate (0.4 mL, 15 mmol). The mixture was stirred at 120 C for 7 h. The reaction mixture was concentrated in vacuo to remove the solvent, and the residue was purified by silica gel column chromatography (PE/EtOAc (v/v) = 4/1) to give the title compound as a white solid (86 mg, 55 %).MS (ESI, pos. ion) m/z: 169.0 [M+H]?H NIVIR (400 MHz, CDC13) (ppm): 8.33 (s, 1H), 8.29 (s, 1H), 5.69 (s, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,126954-66-3, 2,5-Dichloronicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; REN, Qingyun; TANG, Changhua; YIN, Junjun; YI, Kai; LEI, Yibo; WANG, Yejun; ZHANG, Yingjun; (215 pag.)WO2018/127096; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1209459-88-0, name is 4-Bromo-N-methylpicolinamide, the common compound, a new synthetic route is introduced below. COA of Formula: C7H7BrN2O

Step 2. Methyl l-(4-(2-(methylcarbamoyl)pyridin-4-yl)phenyl)cyclobutane-l- carboxylate: Into a 20 mL microwave vial equipped with a magnetic stir bar and under N2 were added 4-bromo-N-methyl-pyridine-2-carboxamide (204mg, 948.77 muiotatauiotaomicron), methyl l-[4-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)phenyl]cyclobutanecarboxylate (300 mg, 948.77 mupiiotaomicron), tetrakis(triphenylphosphine)palladium(0) (109mg, 94.88 mupiiotaomicron), potassium carbonate (393 mg, 2.85 mmol), MeOH (3 mL) and DMF (6 mL). The vial was sealed and the suspension degassed with nitrogen for 10 minutes and the mixture was heated to 150 C for 10 minutes. The mixture was purified by column chromatography through silica gel eluting with 100:0 to 0: 100 hexanes:EtOAc as a gradient over 25 minutes. The desired fractions were combined, concentrated and further dried under high vacuum O/N to provide a yellow solid (250 mg). LCMS (ESI+) m/z = 325 (M+l).

The synthetic route of 1209459-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TEMPEST THERAPEUTICS, INC.; POWELL, David Andrew; ROPPE, Jeffrey Roger; SEIDERS, Thomas Jon; DING, Jinyue; SHENG, Tao; JACINTHO, Jason Duarte; (65 pag.)WO2019/79614; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 669066-91-5, Adding some certain compound to certain chemical reactions, such as: 669066-91-5, name is 5-Bromo-3-fluoropicolinic acid,molecular formula is C6H3BrFNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 669066-91-5.

N,N-Diisopropylethylamine (200 mu, 1 mmol) was added to a mixture of 2- methylbiphenyl-3-amine (70 mg, 0.4 mmol), 5-(methoxycarbonyl)pyridine-2-carboxylic acid (Oakwood Chemical, cat017196, 75 mg, 0.42 mmol), and N,N,N’,N’-tetramethyl-0-(7- azabenzotriazol-l -yl)uronium hexafluorophosphate (220 mg, 0.57 mmol) in N,N- dimethylformamide (2 mL, 20 mmol). The reaction mixture was allowed to stir at room temperature (rt) overnight. The reaction mixture was quenched with saturated aqueous NaHCC , and extracted with ethyl acetate (3 x 20 mL). The combined organic layers were washed with brine, dried over MgSCn, filtered and concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-35%) to afford the desired product. LC-MS calculated for C21H19N2O3 (M+H)+: m/z = 347.1 ; found 347.1. This compound was prepared using a similar procedure as described for Example 1, Step 2, with 5-bromo-3-fluoropyridine-2-carboxylic acid (Aldrich, cat753483) replacing 5- (methoxycarbonyl)pyridine-2-carboxylic acid and prolong the reaction time to 3 days. LC-MS calculated for C19H15BrFN2O (M+H)+: m/z = 385.0; found 385.0.

According to the analysis of related databases, 669066-91-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; YU, Zhiyong; ZHANG, Fenglei; YAO, Wenqing; (173 pag.)WO2017/106634; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem