Day: July 20, 2021

Electric Literature of 114077-82-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 114077-82-6, name is 4-Chloronicotinaldehyde, molecular formula is C6H4ClNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 5 4-chloro-3-hydroxymethylpyridine To a solution of 4-chloro-3-pyridyl carboxyaldehyde (140 mg, 1.0 mmol) in THF (1 mL) at 0 C. was added methanol (1 mL) followed by portionwise addition of sodium borohydride (75 mg, 2.0 mmol). After 1 hr, acetic acid (0.15 ml) was added and the reaction mixture was evaporated to dryness with rotary evaporator at room temperature. The solid residue was chromatographed on silica gel column (1% MeOH/dichloromethane) to afford 60 mg (42%) of the title compound. 1H NMR (CDCl3) delta 4.30 (br s, 1H), 4.80 (s, 2H), 7.30 (d, 1H, J=5), 8.34 (d, 1H, J=5), 8.62 (s, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 114077-82-6, 4-Chloronicotinaldehyde.

Reference:
Patent; Microcide Pharmaceuticals, Inc.; US6066630; (2000); A;; ; Patent; Microcide Pharmaceuticals, Inc.; US6087355; (2000); A;; ; Patent; Microcide Pharmaceuticals, Inc.; US5859256; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 16013-85-7, Adding some certain compound to certain chemical reactions, such as: 16013-85-7, name is 2,6-Dichloro-3-nitropyridine,molecular formula is C5H2Cl2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 16013-85-7.

Method for svnthesising A.4m; 2,6-dichloro-3-nitro-pyridine (2.5 g, 12.9 mmol) is taken up in a solvent mixture of THF and NMP (5:1, 13 mL), combined with two spatula tips of silicon carbide and CuCN (2.3 g, 26.0 mmol) and heated to 1800C in the microwave reactor for 45 min. Then the solid obtained is suspended in H2O, extracted with ethyl acetate, washed with NaCl-sln., the organic phase is dried on MgSO4, the solvent is eliminated in vacuo and 6-chloro-3- nitro-pyridine-2-carbonitrile (HPLC-MS: tRet. = 1.01 min, MS(M+H)+ = 182, method LCMSBASl) is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 16013-85-7, 2,6-Dichloro-3-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; ENGELHARDT, Harald; BOEHMELT, Guido; KOFINK, Christiane; KUHN, Daniel; MCCONNELL, Darryl; STADTMUELLER, Heinz; WO2010/7116; (2010); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 106447-97-6, 2-Amino-4-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

Weighing N-bromo succinimide (1.12g, 6 . 3mmol) is added to thf (7.25 ml) in, cooling to 0 C, the 4 – (trifluoromethyl) pyridin-2-amine (0.97g, 6mmol) dissolved in tetrahydrofuran (5.75 ml) in, dropping slowly added to the above-mentioned solution, keeping the temperature at 0 C, after dripping, slowly to room temperature, stirring 0.5 hours, adding sodium thiosulfate (0.25g) aqueous solution (4.75 ml) quenching, concentrated, crude product by silica gel column chromatography (petroleum ether: ethyl acetate = 3:1) purification, to obtain the title compound (1.2g, yield 83.3%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,106447-97-6, 2-Amino-4-(trifluoromethyl)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; Shandong Xuanzhu Oharma Co., Ltd.; Wu, Yongjian; (47 pag.)CN105541792; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 945717-09-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 945717-09-9 as follows.

To a solution of 22700mg, 0.306mmol) and 7(63.7mg, 0.6ilmmol) in 2OmL of Et3N was added Pd(PPh3)2C12 (10.73 rng, 0.Ol5mmoI) and CuT (5.82mg, 0.O3lmmol). The mixture was protected with N2 atmosphere, then was heated at 70C for 24 hours. TLC analysis showedcomplete conversion of starting material to a major product. The reaction mixture was then concentrated in vacua The crude product was purified by Prep-HPLC to give the target product Compound 100(19mg, yield: 18.46%).LCMS: m/z 337 (M+H)?1H NMR (400 MFIz, CDCI3): oe 8.40-8.39 (in, 1 El), 7.66 (s, IH), 7.59-7.56 (m, 11-1), 7.47 (s, 1 El),7.44-7.41 (m, 1H), 7.34-7.33 (in, 1H), 6.50 (s, 1H), 2.47 (s, 3H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,945717-09-9, its application will become more common.

Reference:
Patent; HUA MEDICINE (SHANGHAI) LTD.; CHEN, Li; JIN, Xiaowei; (176 pag.)WO2017/117708; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1052714-46-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1052714-46-1, name is 6-Bromo-5-fluoropicolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

Synthesis of methyl 6-bromo-5-fluoropicolinate To a solution of 6-bromo-5-fluoropicolinic acid (1.0 equiv.) in methanol (0.2 M) was added H2SO4 (4.2 equiv.) and the reaction was stirred at room temperature for two hours. Upon completion of the reaction as monitored by LC/MS, the reaction was diluted with ethyl acetate and quenched slowly with saturated aqueous NaHC03. The reaction was poured into a separatory funnel and extracted with ethyl acetate. The organic phase was dried with magnesium sulfate, filtered, and concentrated in vacuo to provide methyl 6-bromo-5-fiuoropicolinate as a white solid (>99%). LC/MS = 233.9/235.9 (M+H), Rt = 0.69 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1052714-46-1, 6-Bromo-5-fluoropicolinic acid.

Reference:
Patent; NOVARTIS AG; BURGER, Matthew; DRUMM III, Joseph; NISHIGUCHI, Gisele; RICO, Alice; SIMMONS, Robert Lowell; TAFT, Benjamin; TANNER, Huw; WO2013/175388; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 73583-37-6 ,Some common heterocyclic compound, 73583-37-6, molecular formula is C5H3BrClN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Cyclopropylmethanol (0.247 mL, 3.12 mmol) was dissolved in dry THF (10 mL) and sodium hydride (60% w/w) (125 mg, 3.12 mmol) was added portion-wise, under nitrogen, at rt. After -30 min, 4- bromo-2-chloropyridine (0.173 mL, 1.559 mmol) was added slowly and the reaction was stirred at rt for 5 days. The reaction was diluted with Et20 (30 mL) and washed with water (20 mL). The organic layer was washed with brine, dried using a hydrophobic frit and evaporated to give a yellow oil (0.432g). The residue was loaded in DCM and purified on the Biotage SP4 silica (Si) SNAP 25g column using a 0-20% EtOAc/cyclohexane gradient. Appropriate fractions were combined and evaporated to give a colourless oil (295 mg) This was loaded in cyclohexane and purified by Biotage SP4 SNAP 25g silica using a gradient of 0-10% EtOAc/cyclohexane gradient. Fractions containing product were combined and evaporated under vacuum to give a colourless oil which was dissolved in 1 :1 MeOH:DMSO 1 mL (x3) and purified by MDAP. The solvent was evaporated under vacuum to give a the title compound as a colourless oil (97 mg). LCMS (2 min, Formic Acid): Rt = 1.21 min, MH+ = 228/230.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 73583-37-6, 4-Bromo-2-chloropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE LLC; AMANS, Dominique; BAMBOROUGH, Paul; BIT, Rino, Antonio; BROWN, John, Alexander; CAMPBELL, Matthew; LINDON, Matthew, John; SHIPLEY, Tracy, Jane; THEODOULOU, Natalie, Hope; WELLAWAY, Christopher, Roland; WESTAWAY, Susan, Marie; WO2014/78257; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 26156-51-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 26156-51-4, name is Methyl 2-methoxyisonicotinate, molecular formula is C8H9NO3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

B) (2-methoxypyridin-4-yl)methanol To a suspension of lithium aluminum hydride (2.92 g) in diethyl ether (200 mL) and THF (50 mL) was added dropwise a solution of methyl 2-methoxyisonicotinate (8.57 g) in diethyl ether (50 mL) at 0C, and the reaction mixture was stirred at 0C for 20 min. Water (3.0 mL), 4N aqueous sodium hydroxide solution (3.0 mL) and water (9.0 mL) were successively added to the reaction mixture at 0C, and the mixture was stirred at room temperature for 15 min. The resulting white precipitate was filtered off, and the solvent in the filtrate was evaporated under reduced pressure to give a crude product of the title compound (6.74 g) as a pale-yellow oil.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 26156-51-4, Methyl 2-methoxyisonicotinate.

Reference:
Patent; Takeda Pharmaceutical Company Limited; MIWATASHI, Seiji; SUZUKI, Hideo; OKAWA, Tomohiro; MIYAMOTO, Yasufumi; YAMASAKI, Takeshi; HITOMI, Yuko; HIRATA, Yasuhiro; EP2816032; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 571188-59-5

5)Synthesis of Compound 18: 490mg 4-(6-amino-pyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester was added to 15ml of anhydroustoluene. The system was cooled to 0 C. 1.05eq LiHMDS was added dropwise. Aftercompletion of the dropwise addition, reaction was continued for 30min at roomtemperature. After the completion of the reaction, the system was cooled to 0 C. A solution of 5ml toluene containing 300mg ofCompound 17 was added dropwise. After the completion of the dropwise addition,the reaction was warmed to room temperature and reacted for 40min. After thecompletion of the reaction, the system was cooled to 0 C, and saturated NH4Clsolution was added to quench the reaction. After liquid separation, the organicphase was concentrated. Ethyl acetate was added and the system was filtered togive 470mg yellow solid as Compound 18.

With the rapid development of chemical substances, we look forward to future research findings about 571188-59-5.

Reference:
Patent; Tetranov Biopharm, LLC; Wu, Yusheng; Niu, Chengshan; Zou, Dapeng; Zhang, Sen; Guo, Ruiyun; Li, Jingya; (24 pag.)CN104447739; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 504-24-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 504-24-5, name is 4-Aminopyridine, molecular formula is C5H6N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

4-OAP was prepared using the Chichibabin reactionof 4-aminopyridine (4-AP) and sodium amide indry dioxane, followed by alkylation with octyl iodide[25]. 4-OAP was isolated from the reaction mixture viaextraction with hexane and recrystallized first fromhexane and then from acetone (99.9%, m.p. 64 ±0.2C). The molecular and structural formulas wereconfirmed via elemental analysis plus IR and 1HNMR spectroscopy. OAP chloride was prepared byshaking a 0.1 M solution of 4-OAP (100 mL) with 1 MHCl (100 mL). The organic phase was separated andfiltered through a paper filter. All chloroform wasevaporated under an air stream. The residue was driedat 60C. The yield was 95%. According to the datafrom potentiometric titration, the content of the mainsubstance was 99.8%.

According to the analysis of related databases, 504-24-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Borshch; Ageeva; Frolova, A. Yu.; Russian Journal of Physical Chemistry; vol. 93; 5; (2019); p. 828 – 834; Zh. Fiz. Khim.; vol. 93; 5; (2019); p. 661 – 667,7;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5470-17-7, name is 3-Bromo-2-chloro-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. name: 3-Bromo-2-chloro-5-nitropyridine

(1) 3-Bromo-2-chloro-5-nitropyridine (2.38g) in N, N- dimethylformamide (10) 4- piperidinol (2.23g) was added and the solution at 60 0.5 hour to it stirred. Water was added to the reaction solution, the precipitated solid was filtered and collected to give a yellow solid (2.83g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5470-17-7, 3-Bromo-2-chloro-5-nitropyridine.

Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; Watanabe, Masayuki; Furukawa, Hiroyuki; Hamada, Maiko; Fuji, Naoto; Ushio, Hiroyuki; Takashima, Toru; (81 pag.)KR2015/2661; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem