Day: July 23, 2021

Related Products of 114-33-0 , The common heterocyclic compound, 114-33-0, name is N-Methylnicotinamide, molecular formula is C7H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: Complex 11 was prepared by the reaction of an acetonitrile solution of copper(II) acetate monohydrate (1mmol, 0.20g) with N-methylnicotinamide (2mmol, 0.27g) followed by addition of 2,5-dichlorobenzoic acid (2mmol, 0.38g). The reaction mixture was stirred until a blue product was precipitated (1day). The fine blue microcrystals were filtered off, washed with a small portion of water and dried at ambient temperature. The mother liquors obtained from filtration were left to crystallize. The blue crystals suitable for X-ray structure determination were separated after several days. Yield: 0.67g (85%).

The synthetic route of 114-33-0 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hala?ka, Jozef; Lokaj, Jan; Jomova, Klaudia; R??i?kova, Zde?ka; Mazur, Milan; Moncol, Jan; Polyhedron; vol. 175; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 153034-86-7, 2-Chloro-4-iodopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 153034-86-7, blongs to pyridine-derivatives compound. name: 2-Chloro-4-iodopyridine

General procedure: An oven dried Schlenk tube was purged with nitrogen and charged with 3-iodopyridine (0.875 mmol, 179.3 mg), BiPh3 (0.25 mmol, 110 mg), K3PO4 (1.5 mmol, 318 mg), Pd(OAc)2 (0.025 mmol, 5.6 mg), PPh3 (0.1 mmol, 26.2 mg) followed by dry DMF (3 mL) under nitrogen atmosphere. The reaction mixture was stirred in an oil bath at 90C for 1h. It was brought to rt, treated with water (10mL), and extracted with ethyl acetate (2×20 mL). The organic extract was treated with brine, dried over anhydrous MgSO4, and concentrated using rotary evaporator under the reduced pressure. The crude was subjected to silica gel column chromatography (5% EtOAc/Hexane) to obtain 3-phenylpyridine (1.1) as colorless oil (115 mg, 98%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,153034-86-7, its application will become more common.

Reference:
Article; Rao, Maddali L.N.; Dhanorkar, Ritesh J.; Tetrahedron; vol. 71; 2; (2015); p. 338 – 349;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 127356-26-7, 6-Methoxypyridine-3,4-diamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 6-Methoxypyridine-3,4-diamine, blongs to pyridine-derivatives compound. Application In Synthesis of 6-Methoxypyridine-3,4-diamine

To a solution of 6-methoxypyridine-3,4-diamine (0.45 g, 3.23 mmol) in ethanol was added ethyl trifluoropyruvate (0.393 mL, 3.23 mmol). The reaction mixture was heated to reflux at 90 C. for 16 h. The volatiles were removed under reduced pressure. To the residue was added Pet-ether. The resultant solid was isolated via filtration and dried to afford 7-methoxy-3-(trifluoromethyl)pyrido[3,4-b]pyrazin-2-ol and 7-methoxy-2-(trifluoromethyl)pyrido[3,4-b]pyrazin-3-ol as mixture of regioisomer (0.37 g 46% yield). MS: MS m/z 246.2 (M++1).; A solution of 7-methoxy-3-(trifluoromethyl)pyrido[3,4-b]pyrazin-2-ol and 7-methoxy-2-(trifluoromethyl)pyrido[3,4-b]pyrazin-3-ol (0.37 g, 1.509 mmol) in POCl3 (5 mL) was heated to 100 C. for 2 h. The solvent was removed under reduced pressure and the residue was diluted with ice cold water. The aqueous solution was basified to pH ?9.0 by using sodium bicarbonate, then was extracted with ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under reduced pressure to get crude compound. The crude compound was purified by silica gel chromatography using 10% ethyl acetate in Pet-ether to get 2-chloro-7-methoxy-3-(trifluoromethyl)pyrido[3,4-b]pyrazine (0.135 g, 0.435 mmol, 28.8% yield) and 3-chloro-7-methoxy-2-(trifluoromethyl)pyrido[3,4-b]pyrazine (0.035 g, 0.435 mmol, 4.8% yield) as yellow solids.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,127356-26-7, 6-Methoxypyridine-3,4-diamine, and friends who are interested can also refer to it.

Reference:
Patent; Bristol-Myers Squibb Company; Sun, Li-Qiang; Zhao, Qian; Renduchintala, Kishore V.; Sarkunam, Kandhasamy; Nagalakshmi, Pulicharla; Gillis, Eric P.; Scola, Paul Michael; (81 pag.)US9643999; (2017); B2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145901-11-7, name is 1H-Pyrrolo[2,3-b]pyridin-6-amine. A new synthetic method of this compound is introduced below., SDS of cas: 145901-11-7

General procedure: A mixture of substituted 2,4-dichloropyrimidine (1.0 equiv.), and substituted aniline (1.0-1.05 equiv.), and DIPEA (1.2 equiv.) in isopropanol (0.1 M) was stirred and heated at reflux. The reaction time, work-up, and product isolation procedure are described below.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145901-11-7, 1H-Pyrrolo[2,3-b]pyridin-6-amine.

Reference:
Patent; H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC.; SCHOeNBRUNN, Ernst; LAWRENCE, Nicholas J.; LAWRENCE, Harshani R.; (173 pag.)WO2020/51572; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 107504-08-5, 5-Fluoro-2-picolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H4FNO2, blongs to pyridine-derivatives compound. COA of Formula: C6H4FNO2

To a solution of 5-fluoropicolinic acid (500 mg, 3.54 mmol) in DCM (14 mL)/DMF (3.5 mL) was added l-hydroxy-7 azabenzotriazole (HOAt) (487 mg, 3.58 mmol), and EDC (713 mg, 3.72 mmol). The resulting mixture was stirred at 23 0 for 10 min followed by the addition of ammonium hydroxide (641 mu, 4.61 mmol). The reaction mixture was stirred at 23 C for 16 hours. Saturated aqueous NaHC03 solution was added to the reaction and the resulting mixture was extracted with DCM (3 x 40 mL). Combined organic phases were washed with water, brine, dried (MgSC^), filtered, and concentrated to give 275 mg of the crude desired product as pale yellow oil, which was used without further purification: MS(ES,m/z): 141.1 (M + 1).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,107504-08-5, 5-Fluoro-2-picolinic acid, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn; FU, Jianmin; XU, Shimin; PAONE, Daniel; LI, Jing; GINNETTI, Anthony; Lim, John; WO2015/51479; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.942947-94-6, name is 5-Bromo-4-chloropyridin-2-amine, molecular formula is C5H4BrClN2, molecular weight is 207.4557, as common compound, the synthetic route is as follows.Product Details of 942947-94-6

To a 1 L 3 necked round-bottomed flask equipped with a magnetic stirrer, heating mantle, and N2 inlet was added 5-bromo-4-chloropyridin-2 -amine (25 g, 121 mmol) and sodium hydrogen sulfide hydrate (26.5 g, 362 mmol). The flask was evacuated and purged with N2 three times. To the solids, N2 sparged l-methyl-2-pyrrolidinone (250 mL) was added. The green suspension was heated to 70 C for 17 hours. The suspension was cooled to room temperature. A cooled bleach scrubber containing 750 mL of bleach was installed and to the suspension concentrated HCl (24.90 mL, 301 mmol) was added. Gas evolution was noted. The resulting dark brown/red suspension was sparged with N2 for 30 minutes. The solids were removed under N2 filtration and were washed with N2 sparged ethanol (100 mL) to give a solution of 2-amino-5-bromopyridine-4-thiol (350 mL) which was used directly in the next step.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,942947-94-6, 5-Bromo-4-chloropyridin-2-amine, and friends who are interested can also refer to it.

Reference:
Patent; ABBVIE INC.; KALLEMEYN, Jeff M.; KU, Yi-Yin; MULHERN, Mathew M.; WO2015/157360; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1008-91-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1008-91-9, name is 1-(Pyridin-4-yl)piperazine, molecular formula is C9H13N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: (2-(7-Aza-1H-benzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate), (HATU) (1.2 equivalents) was added to a solution of acid (1 equivalent), the appropriate amine (1.5 equivalents) and DIEA (2 equivalents) in dry acetonitrile (10 mL) at room temperature under argon atmosphere. The reaction mixture was stirred at room temperature for 1-2 h. Solvent was evaporated under reduced pressure and the crude product was purified using a Teledyne Isco Combiflash Rf purification machine to provide the desired amide in excellent yield.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1008-91-9, 1-(Pyridin-4-yl)piperazine.

Reference:
Article; Mathew, Bini; Hobrath, Judith V.; Connelly, Michele C.; Kiplin Guy; Reynolds, Robert C.; Bioorganic and Medicinal Chemistry Letters; vol. 27; 20; (2017); p. 4614 – 4621;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 134031-24-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 134031-24-6, name is 2,4-Dichloronicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

INTERMEDIATE 11 fert-Butyl (36 -4-(2-chloro-3-formylpyridin-4-yl)-3-ethylpiperazine-l-carboxylate tert-Butyl (3i?)-3-ethylpiperazine-l-carboxylate (1.1 g, 5.1 mmol) was suspended in 1-butanol (8.1 g, 110 mmol) and DIPEA (1.3 g, 10 mmol) and 2,4-dichloropyridine-3- carbaldehyde (0.90 g, 5.1 mmol) was added. The suspension was heated at 70C for 5 h. The reaction mixture was concentrated in vacuo and the residue was purified by column chromatography, using an EtOAc/hexane gradient, to give the title compound (0.45 g, 25%) as a yellow oil. LCMS (ES+) 354 [M+H]+, RT 1.47 minutes (method 1).

According to the analysis of related databases, 134031-24-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; FORD Daniel James; REUBERSON James Thomas; US2015/376167; A1; (2015);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 131747-43-8 ,Some common heterocyclic compound, 131747-43-8, molecular formula is C7H4F3NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 64. a) To a stirred solution of 2-trifiuoromethyl nicotinic acid (0.38 g, 2 mmol) in dimethylformamide (10 mL) at room temperature was added 1,1-carbonyldiimidazole (0.34 g, 2.10 mmol) in one portion. The resulting yellow mixture was allowed to stir for ninety minutes whereupon 3,4-bis(benzyloxy)-N’-hydroxy-5-nitrobenzamidine (0.79 g, 2 mmol) was added in one portion. The resulting mixture was stirred at room temperature for two hours and then poured onto water (100 mL). The resulting precipitate was filtered off, washed with water and dried. After recrystallisation from dichloromethane/isopropanol 3 ,4-bis(benzyloxy)-5-nitro-N’-(2- (trifluoromethyl)nicotinoyloxy)benzimidamide was obtained, as a light yellow solid, 0.88 g (78%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 131747-43-8, 2-Trifluoromethylnicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PORTELA & CA. S.A.; WO2007/13830; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6221-01-8, Pyridine-2,5-dicarbaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of Pyridine-2,5-dicarbaldehyde, blongs to pyridine-derivatives compound. Quality Control of Pyridine-2,5-dicarbaldehyde

General procedure: To a solution of 2,5-dicarbaldehyde pyridine (50 mg), in 1,2-dichloroethane (3.6 mL), was added the aniline derivative (6 eq) and acetic acid (2 eq) were added. After stirring for 5 min at room temperature, the solution was treated with sodium triacetoxyborohydride (3 eq). It was then stirred at room temperature overnight and purified via preparative thin layer chromatography.

The synthetic route of 6221-01-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Virani, Saniya; Liang, Zhongxing; Yoon, Younghyoun; Shim, Hyunsuk; Mooring, Suazette R.; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 220 – 224;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem