Month: July 2021

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13603-44-6, name is 2,6-Dimethylpyridin-4-ol, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.name: 2,6-Dimethylpyridin-4-ol

Alternative procedure: Bromine (72.8 mL, 1.4 mol) was added via addition funnel over60 mm to a mechanically stirred cold (ice-water bath) solution of 2,6-dimethylpyridin-4- ol (87 g, 706 mmol) and 4-methylmorpholine (156 mL, 1.4 mol) in dichloromethane (1 L) and methanol (100 mL) and then stirred for 2 h at rt. Additional bromine (15 mL) was added based on monitoring by LCMS. The product was filtered, washed with ether, anddried under vacuum to give 3,5-dibromo-2,6-dimethylpyridin-4-ol 176.8 g (88%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,13603-44-6, 2,6-Dimethylpyridin-4-ol, and friends who are interested can also refer to it.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; WANG, Tao; YIN, Zhiwei; (82 pag.)WO2017/6261; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 791644-48-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 791644-48-9, name is 2-Chloro-5-fluoronicotinonitrile, molecular formula is C6H2ClFN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 38.5 g (245.93 mmol) of 2-chloro-5-fluoronicotinonitrile was initially charged in 1,2-ethanediol (380 ml), and hydrazine hydrate (119.6 ml) was then added. With stirring, the mixture was heated at reflux for 4 h. The product precipitated on cooling. Water (380 ml) was added to the crystals, and the mixture was subjected to extractive stirring at RT for 10 min. The suspension was then filtered with suction over a frit, and the filter product was washed with water (200 ml) and with -10 C. cold THF (200 ml). Drying under high vacuum over phosphorus pentoxide. Yield: 22.8 g (61% of theory) 1H NMR (400 MHz, DMSO-d6): delta=5.54 (s, 2H), 7.96 (dd, 1H), 8.38 (m, 1H), 12.07 (m, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 791644-48-9, 2-Chloro-5-fluoronicotinonitrile.

Reference:
Patent; Follmann, Markus; Stasch, Johannes-Peter; Redlich, Gorden; Griebenow, Nils; Lang, Dieter; Wunder, Frank; Huebsch, Walter; Vakalopoulos, Alexandros; Tersteegen, Adrian; US2014/357637; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 588729-99-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 588729-99-1, name is 3-Amino-5-bromo-2-chloropyridine. This compound has unique chemical properties. The synthetic route is as follows.

Step 1: The 2-chloro-3-amino-5-bromo pyridine (500 mg, 2 . 46mmol) was dissolved in THF (10 ml), added LiHMDS (7.4 ml, 7 . 4mmol), stirring for ten minutes, then adding 4-fluorobenzenesulfonyl chloride (1.44g, 7 . 4mmol), stir at room temperature overnight. By adding dichloromethane (20 ml) dilution, washed with saturated sodium bicarbonate, with dichloromethane (4×30 ml) extraction, combined organic phase, dried, concentrated, the residue column chromatography (petroleum ether: ethyl acetate = 20:1) shall be N-(5-bromo-2-chloro-pyridine-3-yl) – 4-fluorobenzene sulfonaide (770 mg, 87%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 588729-99-1, 3-Amino-5-bromo-2-chloropyridine.

Reference:
Patent; Shanghai Huilun Life Sciences & Technology Co., Ltd.; Cheng, Jianjun; Qin, Jihong; (61 pag.)CN103936762; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 766-11-0, name is 5-Bromo-2-fluoropyridine, molecular formula is C5H3BrFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 5-Bromo-2-fluoropyridine

Phenol (8.02 g, 85.23 mmol) was dissolved in 50 ml of anhydrous tetrahydrofuran and stirred in an ice bath.Sodium hydride (2.5 g, 113.64 mmol) was gradually added and stirred for 30 min, and the reaction was continued at 80 C for 30 min.After cooling to room temperature, 2-fluoro-5-bromo-pyridine (10 g, 56.82 mmol) was added and refluxed at 80 C for 12 h.After the reaction was completed, it was cooled to room temperature, and the reaction was quenched with 100 ml of water, and extracted with ethyl acetate (100 ml×3).The organic phase was combined, washed with saturated brine, dried, filtered, and evaporated.Silica gel column chromatography gave 12.3 g of colorless oil, yield 86%.The elution system was petroleum ether: ethyl acetate = 100:1.

With the rapid development of chemical substances, we look forward to future research findings about 766-11-0.

Reference:
Patent; Shandong University; Zhao Guisen; Ran Fansheng; Liu Meixia; Liu Yang; Wang Luhua; (48 pag.)CN109369654; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 65189-15-3, name is 5,6-Dichloronicotinonitrile, molecular formula is C6H2Cl2N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C6H2Cl2N2

A mixture of 5,6-dichloro-nicotinonitrile (Bionet GC-0755, 500 mg, 2.89 mmol) and ethanolamine (0.87 ml_, 14.45 mmol) was prepared in anhydrous dioxane (5 ml.) and heated at 800C for 24 hours. The reaction mixture was diluted with MTBE (50 ml.) and washed with water (2×25 ml.) and brine (25 ml). The aqueous layers were extracted with MTBE (50 ml_).The organic layers were combined, dried (Na2SC>;4) and concentrated under reduced pressure to give the title compound as a white powder (510 mg, 89%). HPLC (Method A), Rt:1.9 min (purity: 99.9%). UPLC/MS, M-(ESI): 196.0.

With the rapid development of chemical substances, we look forward to future research findings about 65189-15-3.

Reference:
Patent; MERCK SERONO S.A.; QUATTROPANI, Anna; GERBER, Patrick; DORBAIS, Jerome; WO2010/100142; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 929617-35-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 929617-35-6, name is 5-Bromo-1H-pyrazolo[3,4-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A solution containing 5-bromo-lH-pyrazolo[3,4-c]pyridine (168.0 g, 848.4 mmol) and NIS (286.3 g, 1.27 mol) in DMF (1.2 L) was stirred on at room temperature. The reaction mixture was poured into water then filtered. The solid was washed with water and 5% Na2S205. The crude product was dried under high vacuum overnight to give 5-bromo-3-iodo-lH- pyrazolo[3,4-c]pyridine.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 929617-35-6, 5-Bromo-1H-pyrazolo[3,4-c]pyridine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; DO, Steven; HU, Huiyong; KOLESNIKOV, Aleksandr; LEE, Wendy; TSUI, Vickie Hsiao-Wei; WANG, Xiaojing; WEN, Zhaoyang; WO2013/24002; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1065100-83-5, name is (1H-Pyrrolo[2,3-b]pyridin-3-yl)methanol. A new synthetic method of this compound is introduced below., category: pyridine-derivatives

(2) Add 7-azaindole-3-methanol to dichloromethane, heat to 50°C, add KMnO4 and mix well.The reaction was stirred for 3 h, filtered, evaporated under reduced pressure, and recrystallized to give 7-azaindole-3-carboxylic acid.In step (1), 7-azaindole and water are used in a molar ratio of 1 mol/L; 7-azaindole and tetramethylguanidine are used in a molar ratio of 2:5;The mass ratio of 7-azaindole to MFI zeolite is 6:7;The molar ratio of 7-azaindole to formaldehyde is 1:1.2;The microwave radiation power is 300W.The molar ratio of 7-azaindole-3-methanol to KMnO4 used in step (2) is 12:15.The yield of 7-azaindole-3-carboxylic acid produced was 94.3percent and the purity was 99.3percent.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1065100-83-5, (1H-Pyrrolo[2,3-b]pyridin-3-yl)methanol.

Reference:
Patent; Dongguan Lianzhou Knowledge Property Right Scheduled Operations Management Co., Ltd.; Chen Dongjin; (6 pag.)CN107903261; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19798-77-7, name is 4-Amino-3-chloropyridine. This compound has unique chemical properties. The synthetic route is as follows. Safety of 4-Amino-3-chloropyridine

In the second step, the first step product 2- (1-butyl-1H-indol-3-yl) acetic acid was added to dichloromethane (20 mL)EDCI (1.27 g) was added at room temperature,Stirring dissolved;3-Chloro-4-aminopyridine (0.9 g) was added,DMAP (0.15 g),The reaction was stirred at room temperature for 3 h.Add water (10mL) for 10min,The organic phase was added to saturated brine (10 mL) for 10 min,The organic phase was separated by column chromatography,Eluting with ethyl acetate-petroleum ether (1: 3)To give a pale yellow solidN- (3-chloropyridin-4-yl) -2- (1-butyl-1H-indol-3-yl) acetamide (1.3 g).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 19798-77-7, 4-Amino-3-chloropyridine.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Chen Qing; Chen Minghua; Ba Mingyu; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107151223; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6345-27-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.6345-27-3, name is Isonicotinimidamide hydrochloride, molecular formula is C6H8ClN3, molecular weight is 157.6, as common compound, the synthetic route is as follows.

To a stirred solution of G-1 (2.5 g, 6.4 mmol) in ethanol (24 mL) was added, at room temperature isonicotinimidamide hydrochloride H-1 (1.5 g, 9.65 mmol) followed by potassium tert-butoxide (1.44 g, 12.9 mmol). [0112] The reaction mixture was then heated at 80° C. for 16 hours. After 100percent consumption of G-1 (monitoring by LCMS), the reaction mixture was allowed to cool to room temperature and concentrated in vacuum. The residue was, then, diluted with dichloromethane (150 mL) and treated with water (150 mL). The aqueous crude mixture was extracted with dichloromethane (2×150 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuum. The crude compound was then purified on silica gel using dichloromethane/ethyl acetate: 50/50 to afford the desired intermediate I-1 as a light white solid (2.58 g, 90percent yield).

Statistics shows that 6345-27-3 is playing an increasingly important role. we look forward to future research findings about Isonicotinimidamide hydrochloride.

Reference:
Patent; Bonfanti, Jean-Francois; Muller, Philippe; Doubler, Frederic Marc Maurice; Fortin, Jerome Michel Claude; Lounis, Nacer; US2015/87651; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-33-6, name is 3-Bromo-2-hydroxy-5-nitropyridine, molecular formula is C5H3BrN2O3, molecular weight is 218.99, as common compound, the synthetic route is as follows.SDS of cas: 15862-33-6

Under ice-cooling, to a solid mixture of 3-bromo-5-nitro-2-ol (21.4 mmol) and quinoline (10.7Mmol) was slowly added dropwise phosphorus oxychloride (27.8 mmol). The mixture was stirred at 120 C for 3.5 hours, cooled to to 100 C, was added 10 ml of water. The reaction was stirred vigorously in an ice water bath for 1 hour. The precipitate was collected by filtration, washed with water, and dried to give 4.15 g of the title compound. 1H-NMR (CD30D) S9.09 (lH, d, J = 2.4Hz), 8.40 (lH, d, J = 2.4Etazeta).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,15862-33-6, 3-Bromo-2-hydroxy-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; CHIA TAI TIANQING PHARMACEUTICALGROUP CO LTD; Beijing Centaurus Biopharma Technology Co., Ltd.; XIAO, DENGMING; LIANG, ZHI; HU, YUANDONG; HU, QUAN; ZHANG, QINGHUI; HAN, YONGXIN; WANG, HUAN; PENG, YONG; KONG, FANSHENG; LUO, HONG; (60 pag.)CN103130792; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem