The origin of a common compound about 4-(Pyridin-3-yl)pyrimidin-2-amine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66521-66-2, its application will become more common.

Application of 66521-66-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 66521-66-2 as follows.

General procedure: Reactions were carried out with 4-(pyridin-3-yl)pyrimidin-2-amine 1 (0.50 mmol), aldehyde 2 (0.50 mmol) and malonate 3 (5 mmol) in the presence of catalyst III or IV (10 molpercent) at 50 °C and stirred for 48h. After completion of the reaction (as observed by TLC), the crude product was purified by preparative TLC (GF254 silica gel: hexane/EtOAc = 7/1), giving the target chiral product

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,66521-66-2, its application will become more common.

Reference:
Article; Bai, Song; Liu, Shan; Zhu, Yunying; Lu, Jiali; Ai, Lina; Xue, Jing; Wu, Qin; Journal of Chemical Research; vol. 42; 8; (2018); p. 428 – 433;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The important role of 4-Bromopyridine hydrochloride

With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 19524-06-2, name is 4-Bromopyridine hydrochloride, molecular formula is C5H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 19524-06-2

General procedure: In a 10-mL glass tube were placed halide (1.0mmol); 2-formylphenyl or 2-pyridyl MIDA boronate (1.5mmol) or allyl MIDA boronate; K2CO3 (3.0 mmol); Pd EnCat30(6mol%); and ethanol/H2O (4:1v/v) or water, and a magnetic stir bar. The vessel was sealed with a septum and placed into the microwave cavity. The temperature was ramped from rt to 120C or 135C. Once the reaction temperature was reached, the reaction mixture was held at this temperature for 10-18 min. After the mixture was allowed to cool to room temperature, the reaction vessel was opened and the contents were poured into a separating funnel. Water and ethylacetate (3×10mL) were added. The combined organics were dried over Na2SO4, filtered, and concentrated in vacuo. The organic residue was adsorbed onto silicagel, and then purified by column flash chromatography (hexane = ethyl acetate as eluent) to afford the desired product 1a-x. The biaryls, bipyridines, or allylphenols prepared are known compounds. [23-45] The products were confirmed by comparing the 1H NMR and mass spectral data with authentic samples reported in the literature.

With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.

Reference:
Article; Da Silva, Joaquim F. M.; Yepes Perez, Andres F.; De Almeida, Natalia P.; Synthetic Communications; vol. 45; 17; (2015); p. 1995 – 2004;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New downstream synthetic route of 19798-77-7

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 19798-77-7, 4-Amino-3-chloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 4-Amino-3-chloropyridine, blongs to pyridine-derivatives compound. name: 4-Amino-3-chloropyridine

In a second step, the first step of the product 2- [1- (2-methylbutyl) -1H-indol-3-yl] acetic acid was added to dichloromethane(20 mL) and stirred at room temperature. EDCI (1.27 g) (10g) wasstirred for 10 min, and the organic phase was added to saturated brine(10 mL), and the mixture was stirred at room temperature for 3 h.The organic phase was separated by column chromatography and eluted with ethyl acetate-petroleum ether (1: 3) to giveN- (3-chloropyridin-4-yl) -2- [1- (Methylbutyl) -1H-indol-3-yl] acetamide (1.4 g).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,19798-77-7, 4-Amino-3-chloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Shi Jiangong; Guo Ying; Xu Chengbo; Ba Mingyu; Chen Minghua; Chen Qing; Zhu Chenggen; Tang Ke; Jiang Jiandong; Guo Jiamei; Guo Qinglan; Lin Sheng; Yang Yongchun; (44 pag.)CN107174581; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Extended knowledge of 573675-27-1

The synthetic route of 573675-27-1 has been constantly updated, and we look forward to future research findings.

Reference of 573675-27-1 , The common heterocyclic compound, 573675-27-1, name is 3-Amino-5-bromopicolinonitrile, molecular formula is C6H4BrN3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 2A mixture of compound K2 (1 g, 5.05 mmol) and sodium acetate (829 mg, 10.1 mmol) in formic acid (50 mL) was stirred at reflux overnight, and then concentrated. Sodium hydroxide (3M) was added to the residue; the mixture was stirred for 10 min and filtered. The solid was washed with water and resuspended in hydrochloride (3M), stirred for another 10 min. The solid was collected and dried to give compound K3 (0.8 g). MS for K3: m/e = 226 and 228 (M+l).

The synthetic route of 573675-27-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, Wen-Lian; HE, Shuwen; WALSH, Shawn, P.; CUMMING, Jared, N.; (70 pag.)WO2016/118404; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Analyzing the synthesis route of 4-Chloro-2-(trifluoromethyl)nicotinic acid

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1018678-39-1, 4-Chloro-2-(trifluoromethyl)nicotinic acid, other downstream synthetic routes, hurry up and to see.

Application of 1018678-39-1, Adding some certain compound to certain chemical reactions, such as: 1018678-39-1, name is 4-Chloro-2-(trifluoromethyl)nicotinic acid,molecular formula is C7H3ClF3NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1018678-39-1.

A mixture of 4-chloro-2-(trifluoromethyl)nicotinic acid (1 .5 g, 6.65 mmol) in thionyl chloride (10.0 ml.) was stirred at 100C for 5 h. The reaction mixture was concentrated invacuo to afford the title compound (1 .60 g, Crude) Rf = 0.9 (5 % methanol in Dichloromethane).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1018678-39-1, 4-Chloro-2-(trifluoromethyl)nicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; JIRICEK, Jan; NG, Shuyi Pearly; RAO, Srinivasa P S; (126 pag.)WO2019/244049; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 102368-13-8

Statistics shows that 102368-13-8 is playing an increasingly important role. we look forward to future research findings about 1,1′-Thiocarbonylbis(pyridin-2(1H)-one).

Synthetic Route of 102368-13-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.102368-13-8, name is 1,1′-Thiocarbonylbis(pyridin-2(1H)-one), molecular formula is C11H8N2O2S, molecular weight is 232.2584, as common compound, the synthetic route is as follows.

General procedure: Diisothiocyanate with various linker lengths (A6) were prepared according to publishedliterature.2 Commercially available diamine linkers (A5) were converted intodiisothiocyanate using TCDP (1,1?-thiocarbonyldi-2(1H)-pyridone) in single step processquantitative yield. To a solution of A6 (0.32 mmol) in dry pyridine (3 ml), A4 (15 mg,0.063 mmol) was added, followed by DMAP (catalyst amount) in CH2Cl2 (0.2 ml). Themixture was then stirred for 12 h. Volatiles were removed by reduced pressure. Themixture left was purified by column chromatography [0 to 2% methanol in CH2Cl2 (v/v)]to afford desired compound (84 – 92%).

Statistics shows that 102368-13-8 is playing an increasingly important role. we look forward to future research findings about 1,1′-Thiocarbonylbis(pyridin-2(1H)-one).

Reference:
Article; Watkins, Derrick; Gong, Changjun; Kellish, Patrick; Arya, Dev P.; Bioorganic and Medicinal Chemistry; vol. 25; 4; (2017); p. 1309 – 1319;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Introduction of a new synthetic route about Methyl 2,6-dichloro-5-fluoronicotinate

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 189281-66-1, Methyl 2,6-dichloro-5-fluoronicotinate, other downstream synthetic routes, hurry up and to see.

Reference of 189281-66-1, Adding some certain compound to certain chemical reactions, such as: 189281-66-1, name is Methyl 2,6-dichloro-5-fluoronicotinate,molecular formula is C7H4Cl2FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 189281-66-1.

Description 111Methyl 2-chloro-5-fluoro-6-methylnicotinate (Dl 11)FXQN CIA mixture of methyl 2,6-dichloro-5-fluoronicotinate (DuO, 6 g), 2,4,6-trimethyl-1,3,5,2,4,6- trioxatriborinane (3.36 g), K2C03 (9.99 g) and Pd(Ph3P)4 (1.548 g) in 1,4-dioxane (50 mL) was heated to 110C for 20 hours. The mixture was filtered, and the filtrate was concentrated. The residue was purified by column chromatography (silica gel, petroleum ether/EtOAc = 10:1) toafford the title compound (3.5 g) as yellow oil. MS (ES1): C8H7C1FNO2 requires 203; found 204[M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 189281-66-1, Methyl 2,6-dichloro-5-fluoronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R&D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; LIN, Xichen; WO2015/180612; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 56622-54-9

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56622-54-9, its application will become more common.

Reference of 56622-54-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56622-54-9, name is (6-Methylpyridin-3-yl)methanamine. A new synthetic method of this compound is introduced below.

Into a round-bottom flask were charged 3-(5-methylpyridin-2-yl)-5-(pyrrolidine-l – carbonyl)benzoic acid (80 mg, 0.26 mmol), (6-methylpyridin-3-yl)methanamine (60 mg, 0.49 mmol), N- (3-dimethylaminopropyl)-N’-ethylcarbodiimide hydrochloride (90 mg, 0.47 mmol), 1- hydroxybenzotriazole hydrate (80 mg, 0.52 mmol), NN-diisopropylethylamine (80 mg, 0.62 mmol) and methylene chloride (5 mL). The mixture was stirred at room temperature overnight and then concentrated. The residue was purified via preparative HPLC to afford the desired product as a white solid.LC-MS: 415.5 [M+l]+; 1H NMR (400 MHz, CD3OD): 8.56 (t, J = 1.7 Hz, IH), 8.53-8.52 (m, IH), 8.46 (d, J = 2.1 Hz, IH), 8.29 (t, J = 1.6 Hz, IH), 8.04 (t, J = 1.6 Hz, IH), 7.89 (d, J = 8.1 Hz, IH), 7.81-7.77 (m, 2H), 7.32 (d, J = 8.0 Hz, IH), 4.63 (s, 2H), 3.66 (t, J = 7.0 Hz, 2H), 3.54 (t, J = 6.7 Hz, 2H), 2.54 (s, 3H),2.43 (s, 3H), 2.05-1.94 (m, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56622-54-9, its application will become more common.

Reference:
Patent; RENOVIS, INC.; WO2009/110985; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

New learning discoveries about 3-Bromo-2-chloro-5-nitropyridine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5470-17-7, its application will become more common.

Adding a certain compound to certain chemical reactions, such as: 5470-17-7, 3-Bromo-2-chloro-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5470-17-7, blongs to pyridine-derivatives compound. Recommanded Product: 3-Bromo-2-chloro-5-nitropyridine

Example 340: Preparation of 2-((3-bromo-5-nitropyridin-2-yl)(ethyl)amino)ethan-l-ol3- Bromo-2-chloro-5-nitropyridine (2 g, 8.42 mmol), triethylamine (1.174 ml, 8.42 mmol) and 2-(ethylamino)ethan-l -ol (0.751 g, 8.42 mmol) were mixed in Acetonitrile (30 ml). Heated to 80 C for 14 h and then concentrated. 1.76 g of product was recovered after automated chromatography on silica gel (DCM-EtOAc).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5470-17-7, its application will become more common.

Reference:
Patent; SALK INSTITUTE FOR BIOLOGICAL STUDIES; SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE; YALE UNIVERSITY; SHAW, Reuben J.; EGAN, Daniel F.; COSFORD, Nicholas; TURK, Benjamin; VAMOS, Mitchell; PANICKAR, Dhanya Raveendra; CHUN, Matthew; SHEFFLER, Doug; (315 pag.)WO2016/33100; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 65515-28-8

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 65515-28-8, Methyl 2,6-dichloronicotinate, other downstream synthetic routes, hurry up and to see.

Related Products of 65515-28-8, Adding some certain compound to certain chemical reactions, such as: 65515-28-8, name is Methyl 2,6-dichloronicotinate,molecular formula is C7H5Cl2NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 65515-28-8.

5-[2-(2-Chloro-4-hydroxy-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-3-methyl-3H-benzooxazol-2-one (157 mg, obtained in Example 172) was added to a solution of methyl-2,6-dichloropyridine-3-carboxylate (81 mg, [CAS Reg. No. 65515-28-8]) in DMF (3 mL) followed by the addition of triethylamine (0.071 mL). Stirring was continued for 10 minutes at r.t. Then 1,4-diazabicyclo[2.2.2]octane (7 mg) was added. The mixture was stirred over night at r.t. The reaction mixture was poured into water, extracted with ethyl acetate and the organic layer was washed with brine, dried over Na2SO4 and evaporated. The residue was purified by flash chromatography (silica gel, gradient of heptane in ethyl acetate) to give the desired compound as a colorless foam (195 mg, 87%). MS (neg. ion, m/e)=569.2 [(M-H)-].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 65515-28-8, Methyl 2,6-dichloronicotinate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Hunziker, Daniel; Lerner, Christian; Mueller, Werner; Sander, Ulrike Obst; Pflieger, Philippe; Waldmeier, Pius; US2010/249124; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem