Day: August 4, 2021

Application of 1403257-80-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1403257-80-6, name is 5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide, molecular formula is C23H30BrN3O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1: Synthesis of N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-5-(6-formylpyridin-3-yl)-2-methylbenzamide To a stirred solution of 5-bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide (1 g, 2.15 mmol) and (6-formylpyridin-3-yl)boronic acid (0.539 g, 2.31 mmol) in dioxane/water mixture (15 mL+3 mL), Na2CO3 (0.82 g, 7.74 mmol) was added and solution purged with argon for 15 min. Then Pd (PPh3)4 (0.288 g, 0.25 mmol) was added and argon was purged again for 10 min. Reaction mass was heated at 80 C. for 2 h. On completion, reaction mixture was diluted with water and extracted with 10% MeOH/DCM. Combined organic layers were dried over Na2SO4 and solvent removed under reduced pressure to afford crude material which was purified by column chromatography over silica gel to afford the desired compound (0.60 g, 57%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1403257-80-6, 5-Bromo-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-(ethyl(tetrahydro-2H-pyran-4-yl)amino)-2-methylbenzamide.

Reference:
Patent; KUNTZ, KEVIN W.; CHESWORTH, RICHARD; DUNCAN, KENNETH W.; KEILHACK, HEIKE; WARHOLIC, NATALIE; KLAUS, CHRISTINE; ZHENG, WANJUN; SEKI, MASASHI; SHIROTORI, SYUJI; KAWANO, SATOSHI; US2012/264734; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1010120-55-4, name is 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine, the common compound, a new synthetic route is introduced below. Safety of 5-Bromo[1,2,4]triazolo[1,5-a]pyridin-2-amine

4-[ 4-( 4,4,5,5-Tetramethyl-[1 ,3,2]dioxaborolan-2-yl)-benzyl]-thiomorpholine-1, 1-dioxide(1.1eq.) was added to a solution of 5-bromo-[1,2,4]triazolo[1,5-a]pyrid in-2-ylamine (4:1). K2C03 (2eq.) and PdCbdppf (0.03 eq.) were added to the solution. The resulting mixture was then heated in anoil bath at 90C for 16h under N 2. Water was added and the solution was extracted with ethyl acetate.The organic layers were dried over anhydrous MgS04 and evaporated in vacuo. The final compoundwas obtained after purification by flash chromatography.[00162] 1H (400 MHz, CDCh) 8 7.94-7.92 (d, 2H), 7.52-7.48 (m, 3H), 7.37-7.34 (m, 1H), 7.02-7.00(m, 1H), 6.00 (d, 2H), 3.76 (d, 2H), 3.15-3.13 (m, 4H), 2.93-2.91 (m, 4H).[00163] m/z 358.2 (M+H+, 100%).

The synthetic route of 1010120-55-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GALAPAGOS NV; VAN ‘T KLOOSTER, Gerben Albert Eleutherius; BRYS, Reginald Christophe Xavier; VAN ROMPAEY, Luc Juliaan Corina; NAMOUR, Florence Sylvie; WO2013/189771; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 885588-12-5, name is 2-Bromo-5-fluoro-4-pyridinecarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. name: 2-Bromo-5-fluoro-4-pyridinecarboxylic acid

A mixture of 2-bromo-5-fluoroisonicotinic acid [885588-12-5] (1.00 g, 4.55 mmol), (li?)-l- methyl-l,2,3,4-tetrahydroisoquinoline [84010-66-2] (803 mg, 5.45 mmol), HATU (2.34 g, 6.14 mmol) and DIPEA (2.34 mL, 13.5 mmol) in DMF (50 mL) was stirred at rt for 20 h. The reaction mixture was diluted with EtOAc and brine. The layers were separated and the aqueous phase was extracted with EtOAc. The combined organic extracts were dried over MgS04, filtered and evaporated in vacuo. The crude mixture was purified by preparative LC (irregular SiOH, 15-40 mih, 80 g Grace, liquid injection (DCM), mobile phase gradient: heptane / EtOAc from 90: 10 to 0: 100) to afford intermediate 113 (1.62 g, quant.).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 885588-12-5, 2-Bromo-5-fluoro-4-pyridinecarboxylic acid.

Reference:
Patent; JANSSEN SCIENCES IRELAND UNLIMITED COMPANY; LANCOIS, David Francis Alain; GUILLEMONT, Jerome Emile Georges; RABOISSON, Pierre Jean-Marie Bernard; RIGAUX, Peter; MICHAUT, Antoine Benjamin; QUATREVAUX, Sabrina Dany France; SOVY, Chao; ROYMANS, Dirk Andre Emmy; (99 pag.)WO2019/206828; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 19524-06-2, name is 4-Bromopyridine hydrochloride. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H5BrClN

In a Schlenk flask under argon 4-bromo-5-methylthiophene-2-ylboronicacid (3.2 g, 14.14 mmol) was dissolved in THF (25 mL) and degassed.4-bromopyridine hydrochlorid (4.43 g, 22.68 mmol), Pd(dppf)Cl2(740 mg, 0.91 mmol) and aq Na2CO3 solution (20percent, 25 mL) wereadded and the mixture was stirred under reflux overnight at 80 °C.The reaction mixture was extracted three times with DCM, the combined organic phases werewashed with water and brine, dried over MgSO4, filtered and the solvents was removed underreduced pressure. Purification by flash column chromatography (pure cyclohexane + 1percentNEt3) afforded a brownish solid with a yield of 51percent.

With the rapid development of chemical substances, we look forward to future research findings about 19524-06-2.

Reference:
Article; Sarter, Christopher; Heimes, Michael; Jaeschke, Andres; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1103 – 1110;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 81565-18-6, Adding some certain compound to certain chemical reactions, such as: 81565-18-6, name is 2-Chloro-4-(trifluoromethyl)pyridine,molecular formula is C6H3ClF3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 81565-18-6.

Intermediate 7 [ 2-R4-(METHVLTHIO) PHENYLL-4-(TRIFLUOROMETHYL)-PYRIDINE] To a mixture of 2-chloro-4- (trifluoromethyl) pyridine (19.9g, [0.] [11MOL),] 4- [(METHYLTHIO) PHENYLBORONIC] acid (21.9g, 0. [13MOL), 1M] aqueous sodium carbonate [(180ML)] and 1,2-dimethoxyethane (270mL) under an atmosphere of nitrogen was added palladium tetrakistriphenylphosphine (3.78g, 3. [3MMOL)] and the reaction heated at [100C] for 14 hours. After cooling and concentration in vacuo, the residue was partitioned between ethyl acetate (350mL) and water (400mL) and separated. The aqueous layer was further extracted with ethyl acetate (2 x [150ML)] and the combined organic layers were dried over sodium sulfate and [CONCENTRATED IN VACUO.] Filtration through a pad of silica gel (200g) eluting with a gradient of ethyl acetate in cyclohexane gave the title compound (29.4g) LC retention time 3.62mins, MS m/z 269 [(MH+).]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 81565-18-6, 2-Chloro-4-(trifluoromethyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; BESWICK, Paul; MODI, Sandeep; PEGG, Neil; SKIDMORE, John; SWARBRICK, Martin; WO2004/24691; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 55279-30-6, Adding some certain compound to certain chemical reactions, such as: 55279-30-6, name is Methyl 3-aminoisonicotinate,molecular formula is C7H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55279-30-6.

4. Preparation of Methyl 3-Amino-2-chloroisonicotinate A mixture of 18 g (118 mmol) of methyl 3-aminoisonicotinate and 12 g (60 mmol) of 1,3-dichloro-5,5-dimethylhydantoin in 1500 mL of tetrachloroethylene was warmed slowly to 80 C. with stirring and held there for 3 hours. The solution was then cooled, filtered, washed with dilute aqueous sodium bicarbonate, dried over magnesium sulfate, filtered, and concentrated by evaporation under reduced pressure to obtain a dark oil. This oil was purified by careful column chromatography to give 6.7 g (30 percent of theory) of the title compound as a colorless solid melting at 91-92 C. Elemental Analysis C7 H7 ClN2 O2 Calc.: %C, 45.1; %H, 3.78; %N, 15.0 Found: %C, 45.2; %H, 3.94; %N, 15.1 1 H NMR CDCl3: 7.7 (d, 1H, J=5.1); 7.6 (d, 1H, J=5.1); 6.2 (br, 2H); 3.9 (s, 3H); 13 C NMR CDCl3: 166.7, 141.9, 139.0, 134.7, 122.8, 116.5, 52.3.

According to the analysis of related databases, 55279-30-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DowElanco; US5461161; (1995); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 56026-36-9, Methyl 6-(hydroxymethyl)nicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 56026-36-9, blongs to pyridine-derivatives compound. Recommanded Product: Methyl 6-(hydroxymethyl)nicotinate

A solution of compound 9 (2.5 g, 14.96 mmol) in 25 DMF (10 mL) was treated with 26 imidazole (1.527 g, 22.43 mmol) and 27 t-butyldimethylsilyl chloride (TBS-Cl, 2.480 g, 16.45 mmol). After 2 h, LCMS showed completion of reaction. The reaction was washed with sat. aq. NaHCO3 and brine, and the organic layer was dried over Na2SO4. The crude 28 methyl 6-(((tert-butyldimethylsilyl)oxy)methyl)nicotinate (93% yield) was taken to next step without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,56026-36-9, its application will become more common.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; POUDEL, Yam B.; He, Liqi; Gangwar, Sanjeev; Posy, Shoshana L.; Sivaprakasam, Prasanna; (38 pag.)US2019/55245; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 34160-40-2, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 34160-40-2, name is 6-Bromo-2-pyridinecarboxaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

192 mg (1 mmol) of 6-bromo-2-pyridinecarboxaldehyde and 152 mg (1.2 mmol) of phenylboronic acid were dissolved in 10 mL of tetrahydrofuran (THF). 1 ml (1 mmol) of Na2CO3 in aqueous solution (1M) and 8 mg (0.7%) of Pd(PPh3)4 were added. The reaction mixture was heated during 45mn, at a temperature of 130C in a micro-wave reactor. The solution was filtered on paper, 10 ml of AcOEt were added and the organic phase was successively washed with NaHCO3, with H2O and with an aqueous solution of NaCl. The organic phase was dried over MgSO4, filtered and evaporated to dryness. After a chromatography on silica gel (Pentane/Et2O, 1/1), 136 mg of aldehyde A were obtained as colourless oil with a yield of 74%. [Show Image] 1H NMR (300 MHz, CDCl3) delta (ppm): 10.17 (s, 1 H), 8.11 (d, J=6Hz, 2H), 7.89 (m, 3H), 7.49 (m, 3H) 13C{1H} NMR (75 MHz, CDCl3) delta (ppm): 114.5, 119.2, 121.8, 123.7, 124.4, 132.5, 132.8, 147.5, 188.7.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 34160-40-2, 6-Bromo-2-pyridinecarboxaldehyde.

Reference:
Patent; TOTAL PETROCHEMICALS RESEARCH FELUY; EP1849791; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 145100-50-1, name is 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide. A new synthetic method of this compound is introduced below., Computed Properties of C7H4F6N2O4S2

EXAMPLE 2This example illustrates a preparation of abiraterone acetate (I) on an industrial scale starting from prasterone acetate (Ill) according to the invention.51 kg of potassium tert-butylate in THF (760 kg) and prasterone acetate (100 kg) are stirred at a temperature below -70 C. Then N-(2-pyridyl)-bis(trifluoromethanesulfonimide) (1 33 kg) is added maintaining the stirring for 2 hours at a temperature between -70 and -80 C.The cold solution is poured onto a biphasic solution consisting of isopropyl acetate(360 kg) and a 10% ammonium chloride aqueous solution.The phases are separated and the organic phase is first washed with an aqueoussolution of ammonium chloride, then with 450 kg 10% sodium acetate aqueoussolution, and eventually with an aqueous solution of sodium chloride.A part of the solvent is distilled off at reduced pressure obtaining the precipitation of a solid which is eliminated by filtration. The residual solution is then distilled until obtaining an oil which is crystallized from the mixture methanol/triethylamine. The sample obtained after drying (112 kg) verified in HPLC (A = 220 nm) against anauthentic sample is intermediate (II) with 98.14% titer.112 kg of intermediate (II) is dissolved in THF (1079 kg), then bis(triphenylphosphinepalladium(l l)dichloride Pd(P Ph3)2C12 (3.2 kg), diethyl(pyridyl)borane (129.3 kg) and an aqueous solution of sodium carbonate are added under stirring at 20-25 00.Reflux is kept for 1 hour (TLC check), further 400 g of bis(triphenylphosphinepalladium(l l)dichloride Pd(PPh3)2C12 is added, obtaining complete transformation (TLC check) after further 30 minutes of reaction. Cooling down to 20-25 C is performed, the phases are separated by washing the organic phase with an aqueous solution of sodium chloride.The organic phase is then distilled until obtaining a dark oil which is then solubilized with methanol, recovering by fractional crystallization the excess diethyl(pyridyl)borane.Methanol is eliminated by distillation, the residue is dissolved in isopropyl acetate, then the solution is filtered after treatment with decolorising carbon and silica gel.The solution, adjusted at T = 20 ± 5 00 is then treated with oxalic acid dihydrate (60 kg).Stirring is performed at T = 20 ± 5 00 for 8 hours and then the solid is filtered and washed with isopropyl acetate.The abiraterone acetate oxalate obtained is stirred at a temperature between 0 and 500 with methylene chloride (880 kg) and an aqueous solution of sodium bicarbonate.The phases are separated and the organic phase is distilled.The solid obtained is dissolved in isopropyl acetate, then treated with Quadrasil(registered trademark of Johnson Matthey Finland Oy) for 6 hours, for the removal of the catalyst; the Quadrasil scavengers, sold by Sigma-Aldrich, consist of porous silica beads having defined pore size, wherein the silica surface is functionalised with metal binders, and allow a quick and effective removal of traces of metals fromaqueous or organic solutions.After filtration, a part of the solvent is distilled off, cooling down to 0 ± 5 00 is performed obtaining the crystallisation of the product.The abiraterone acetate obtained after drying (65 kg) meets the specifications reported in the corresponding chapter of the European Pharmacopoeia.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 145100-50-1, 1,1,1-Trifluoro-N-(pyridin-2-yl)-N-((trifluoromethyl)sulfonyl)methanesulfonamide.

Reference:
Patent; INDUSTRIALE CHIMICA S.R.L.; LENNA, Roberto; DI BRISCO, Riccardo; WO2015/14686; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 6274-82-4, name is 2,6-Dimethoxyisonicotinic acid, molecular formula is C8H9NO4, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Recommanded Product: 6274-82-4

General procedure: 4.1.2.1. General synthetic procedure for preparation of diarylketones(Procedure 1). 1 equivalent of nBuLi (1.6 M in hexane) was addedonto a solution of bromoderivative completely dissolved in dry THF at-40 C. After one hour stirring, 0.4 equivalents of carboxylic aciddissolved in dry THF was added and the mixture was warmed to roomtemperature. After 24 h, ethyl formate, ethyl acetate and water wereadded. The organic phase was partially evaporated, washed with brine,dried over Na2SO4, filtered and evaporated to dryness. The productsobtained were purified by flash chromatography.

With the rapid development of chemical substances, we look forward to future research findings about 6274-82-4.

Reference:
Article; Aramburu, Laura; Gajate, Consuelo; Medarde, Manuel; Mollinedo, Faustino; Alvarez, Raquel; Pelaez, Rafael; Vicente-Blazquez, Alba; Bioorganic Chemistry; vol. 98; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem