Day: August 5, 2021

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 52718-95-3, name is Methyl 2-bromonicotinate, molecular formula is C7H6BrNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: Methyl 2-bromonicotinate

1,3-Benzene-diboronic acid (0.66 g, 3.99 mmol), compound 6 (1.80 g, 8.37 mmol), K2CO3 (1.10 g, 7.97 mmol) and Pd(dppf)Cl2 (0.146 g, 0.2 mmol) were dissolved in a degassed mixture of THF/water (20 mL/4 mL). The mixture was heated to 70C and stirred overnight under N2. After cooling to room temperature, saturated solution of chloride ammonium (100 mL) was added, and aqueous layer was extracted with dichloromethane (3×50 mL). The combined organic extracts were dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by column chromatography on silica gel (petroleum ether:ethyl acetate=5:1; V/V) to give the compound 7 as a colorless oil (1.03 g, 74%).

With the rapid development of chemical substances, we look forward to future research findings about 52718-95-3.

Reference:
Article; Tan, Shuai; Wu, Xiugang; Zheng, Yanqiong; Wang, Yafei; Chinese Chemical Letters; vol. 30; 11; (2019); p. 1951 – 1954;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 27048-04-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 27048-04-0, name is 6-Chloro-3-nitropyridin-2-amine. A new synthetic method of this compound is introduced below.

EXAMPLE P3 Preparation of 2-bromo-6-chloro-3-nitro-pyridine tert-Butyl nitrite (990 mg, 9.60 mmol) was added portionwise at 65 C. under a nitrogen atmosphere to a stirred suspension of 2-amino-6-chloro-3-nitropyridine (1.00 g, 5.76 mmol) and copper(II) bromide (1.56 g, 6.91 mmol) in acetonitrile (25 mL), and stirring was continued for 30 min. After cooling, the reaction mixture was partitioned between ethyl acetate and 2 M aq. hydrochloric acid solution. The organic layer was dried (MgSO4), and evaporated. Chromatography of the residue (SiO2, heptane-dichloromethane gradient) afforded the title compound (1.11 g, 81%). Yellow solid, MS (EI) 235.9/237.9 (78/100, M+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,27048-04-0, its application will become more common.

Reference:
Patent; Kuehne, Holger; Luebbers, Thomas; Mattei, Patrizio; Maugeais, Cyrille; Pflieger, Philippe; Scalone, Michelangelo; US2007/185154; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 13362-28-2, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13362-28-2, name is 2-Amino-4-pyridinecarboxylic acid. A new synthetic method of this compound is introduced below.

[0258] To a solution of [4-(5-methyl-l,2,4-oxadiazol-3-yl)phenyl]methanamine (95 mg, 0.50 mmol, 1.00 equiv) in DMF (4 mL) were added 2-aminopyridine-4-carboxylic acid (69.5 mg, 0.50 mmol, 1.00 equiv) and DIPEA (100 mg, 0.77 mmol, 1.50 equiv) at r.t. The mixture was stirred at r.t. for 10 min, added HATU (230 mg, 0.60 mmol, 1.20 equiv), stirred for 15 ht., filtered, concentrated, and purified by Prep-HPLC with the following conditions: (2- AnalyseHPLC-SHIMADZU(HPLC-lO)): Column, Gemini-NX C18 AXAI Packed, (0797) 2l.2*l50mm 5um; mobile phase, water (0.05% NH3H2O) and ACN (33.0% ACN up to 41.0% in 5 min); Detector, uv 254nm. to afford 6.9 mg (4%) of 2-amino-/V-[[4-(5-methyl-l,2,4- oxadiazol-3-yl)phenyl]methyl]pyridine-4-carboxamide as a white solid. LRMS (ES) m/z 310 (M+H). 1H-NMR: (DMSO, 400 MHz , rrhi): d 9.14-9.11 (1H, t, / = 6.0), 7.99-7.93 (3H, m), 7.46-7.44 (2H, d, / = 8.0), 6.86-6.83 (2H, m), 7.54-7.47 (3H, m), 6.14 (2H, s), 4.50-4.48 (2H, d, / = 6.0), 2.80 (1H, s), 2.63 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13362-28-2, its application will become more common.

Reference:
Patent; CYTOKINETICS, INC.; MORGAN, Bradley P.; VANDERWAL, Mark; CHUANG, Chihyuan; (0 pag.)WO2020/5888; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 186593-43-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine, molecular formula is C6H7BrN2, molecular weight is 187.0372, as common compound, the synthetic route is as follows.

Step 2: To a 0.18 M solution of 5?-amino-1,2?-dimethyl-5-morpholino-[3,3?-bipyridin]-6(1H)-one (1.00 equiv.) in DME and 5-bromo-6-methylpyridin-3-amine (1.00 equiv.) was added PdCl2(dppf).CH2Cl2 adduct (0.10 equiv.) and 2M aqueous sodium carbonate (3.00 equiv.). The reaction mixture was irradiated at 125 C. for 20 min. LC-MS showed primarily conversion to P. The cooled reaction mixture was diluted with 2:1 DCM:MeOH and filtered. The filtrate was concentrated and purified by flash chromatography over silica gel (ethyl acetate with a 0-15% methanol gradient) to give 5?-amino-1,2?-dimethyl-5-morpholino-[3,3?-bipyridin]-6(1H)-one as a brown solid. LCMS (m/z) (M+H)=301.0, Rt=0.33 min.

The chemical industry reduces the impact on the environment during synthesis 186593-43-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVARTIS AG; Barsanti, Paul A.; Burger, Matthew; Lou, Yan; Nishiguchi, Gisele; Polyakov, Valery; Ramurthy, Savithri; Rico, Alice; Setti, Lina; Smith, Aaron; Taft, Benjamin; Tanner, Huw; DiPesa, Alan; Yusuff, Naeem; US2014/275003; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 63071-09-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 63071-09-0, name is 2-Hydroxymethyl-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Hydroxy-methylpyridine 3b, 7, or 13, 1.9 mmol, was dissolved in 25 mL of 1,2-dichloroethane, 1.65 g (19 mmol) of activated manganese dioxide was added, and the mix-ture was stirred for 6 h at 50C. The precipitate was filtered off, the filtrate was evaporated under reduced pressure, and the residue was used in the next step without additional purification. 3-Methylpyridine-2-carbaldehyde (1c). Yield 185 mg (1.52 mmol, 80%), light oily material. 1 H NMR spectrum (CDCl 3 ), delta, ppm: 2.66 s (3H, Me), 7.39 d.d (1H, 5-H, J = 7.8, 4.6 Hz), 7.62 d (1H, 4-H, J = 7.8 Hz), 8.66 d (1H, 6-H, J = 4.6 Hz), 10.20 s (1H, CHO). Mass spectrum, m/z 122.06 (I rel 100%) [M + H] + . Calculated: M 122.06.

According to the analysis of related databases, 63071-09-0, the application of this compound in the production field has become more and more popular.

Reference:
Article; Krinochkin; Kopchuk; Chepchugov; Kovalev; Zyryanov; Rusinov; Chupakhin; Russian Journal of Organic Chemistry; vol. 53; 7; (2017); p. 963 – 970; Zh. Org. Khim.; vol. 53; 7; (2017); p. 951 – 958,8;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 38496-18-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38496-18-3, name is 2,6-Dichloronicotinic acid, molecular formula is C6H3Cl2NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Tris(2-(2-methoxyethoxy)ethyl)amine (3.0mL, 9.4mmol) was added to a mixture of 2,6-dichloronicotinic acid (40g (90percentpurity), 0.19 mol), acetamide (80g, 1.4mol), potassium carbonate (78g, 0.56mol), copper(I) chloride (0.93g, 9.4mmol) and xylene (80mL), which was stirred overnight at 145°C. After cooling, copper(I) chloride (0.46g, 4.6mmol) was added to the reaction solution, which was stirred overnight at 145°C. After cooling the reaction solution to 105°C, water (100mL) was added, the solution was stirred for 1 hour at the same temperature, and cooled down to room temperature. 5N hydrochloric acid (150mL) was added, the solution was neutralized with a citric acid aqueous solution, then, ethyl acetate was added, and the solution was filtered through Celite pad. The organic layer was washed with brine, then, the solvent was evaporated in vacuo. The residue was purified by silica gel column chromatography (ethyl acetate), recrystallization by the ethyl acetate-hexane was carried out to obtain the title compound (1.4g, 8.3mmol, 4.5percent) as white crystal. 1H-NMR Spectrum (DMSO-d6) delta(ppm) : 6.61 (1H, d, J=8.1 Hz), 7.53 (2H, brs), 8.01 (1H, d, J=8.1 Hz).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 38496-18-3, 2,6-Dichloronicotinic acid.

Reference:
Patent; Eisai Co., Ltd.; EP1669348; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 955369-56-9, name is 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one. This compound has unique chemical properties. The synthetic route is as follows. Application In Synthesis of 2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-3(2H)-one

Pd(OH)2/C (100.00 mg, 131.66 mumol, 20% purity) was added into the compound 24-A (100.00 mg, 279.78 mumol) in ethanol (8.00 mL) solution. The reaction mixture was stirred under hydrogen (15 Psi) at 25C for 12 hours. The reaction mixture was filtered, the filtrate was concentrated under reduced pressure to remove the solvent so as to give the compound 24-B. MS m/z: 360.2 [M+H]+

With the rapid development of chemical substances, we look forward to future research findings about 955369-56-9.

Reference:
Patent; Shijiazhuang Sagacity New Drug Development Co., Ltd.; QIAN, Wenyuan; YANG, Chundao; LI, Zhengwei; LI, Jie; LI, Jian; CHEN, Shuhui; (137 pag.)EP3572413; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 147149-98-2, 4-Amino-2-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 147149-98-2, blongs to pyridine-derivatives compound. Product Details of 147149-98-2

2-Trifluoromethyl-4-aminopyridine (1.123 kg, 6.92 mol) was added to a 30 L reactor.2-methyltetrahydrofuran (31.82kg),2,4-Dichloro-6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine (1.857 kg, 6.30 mol),Turn on the agitation,Nitrogen protection,Slowly added N,N-diisopropylethylamine (1.220 kg, 9.44 mol);After heating and refluxing for 30 minutes, the heating was turned off and naturally cooled for 2 hours.After the reaction was completely monitored by HPLC, the mixture was cooled to room temperature, diluted with ethyl acetate (18.00 kg), and poured into a 0.5 mol/L hydrochloric acid solution (15.00 kg) to maintain the internal temperature below 25 C and stirred.Liquid separation,The organic phase was washed twice with 0.25-0.35 mol/L hydrochloric acid solution (10.00 kg).Wash with saturated brine, dry over anhydrous sodium sulfate, and filter.Organic phase concentrationThe title compound was 2.070kg,The yield was 78.2%.

The synthetic route of 147149-98-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nanjing Shenghe Pharmaceutical Co., Ltd.; Zhao Liwen; Zhang Jin; Chen Cheng; Xu Chenglong; Wang Cheng; (19 pag.)CN110054616; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 58530-53-3, 2,4-Dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 58530-53-3, blongs to pyridine-derivatives compound. SDS of cas: 58530-53-3

Preparation 742-Bromo-4-pyrrolidin-1-ylpyridine2,4-Dibromopyridine (300mg, 0.94mmol) and pyrrolidine (335mg, 4.7mmol) were combined in ethanol and heated at 700C overnight. The reaction mixture was concentrated in vacuo and the residue purified by column chromatography using an ISCO silica cartridge eluting with 0- 70% ethyl acetate: pentane. (208mg, 0.91 mmol, 97%).1H-NMR (CDCI3, 400MHz): delta 2.0 (m, 4H), 3.3 (m, 4H), 6.3 (m, 1 H), 6.6 (s, 1 H)1 7.9 (d, 1 H). LRMS m/z (APCI) 227 [MH]+.

The synthetic route of 58530-53-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PFIZER LIMITED; WO2007/57775; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 89570-82-1, Adding some certain compound to certain chemical reactions, such as: 89570-82-1, name is 3-Chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine,molecular formula is C6H5ClF3N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89570-82-1.

General procedure: The synthetic route of title compounds was outlined in Scheme (1). 2,3-Dichloro-5-(trifluoromethyl)pyridine (7.50mmol) was dissolved in ethanol (300 mL), then hydrazine hydrate (30 mmol) was dropwised under refluxing condition for 72 h to give 3-chloro-2-hydrazinyl-5-(trifluoromethyl)pyridine 1. A CEM designed 10 mL pressure-rated vial was charged with 3-chloro-2-hydrazinyl-5-(trifluoromethyl) pyridine 1 (211 mg, 1 mmol) and aldehyde (1mmol), HOAc (0.1 mmol) in the solution of ethanol at the condition of microwave (15 min, 85C). All the other compounds are synthesized according the procedure.

According to the analysis of related databases, 89570-82-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Min, Li-Jing; Shi, Yan-Xia; Yang, Ming-Yan; Zhai, Zhi-Wen; Weng, Jian-Quan; Tan, Cheng-Xia; Liu, Xing-Hai; Li, Bao-Ju; Zhang, Yong-Gang; Letters in drug design and discovery; vol. 13; 4; (2016); p. 324 – 328;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem