Day: August 6, 2021

Synthetic Route of 76006-08-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 76006-08-1, name is 5-Chloro-1H-pyrazolo[3,4-c]pyridine, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 5-chloro-1H-pyrazolo[3,4-c]pyridine (15 g, 1 equiv) in DMF (150 mL) was added iodine (37.2 g, 1.5 equiv) and potassium hydroxide (13.7 g, 2.5 equiv) at 0 C. The reaction mixture was stirred at room temperature for 12 h and then diluted with 10% aqueous sodium thiosulfate (250 mL) and extracted with EtOAc. The combined organic extracts were washed with brine and then dried. The obtained solid (15 g) was slurried with MTBE, filtered and dried.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 76006-08-1, 5-Chloro-1H-pyrazolo[3,4-c]pyridine.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAK, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; (905 pag.)WO2017/35353; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 24517-64-4, Adding some certain compound to certain chemical reactions, such as: 24517-64-4, name is 2-Amino-3-cyanopyridine,molecular formula is C6H5N3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24517-64-4.

8.1 Compound 9: 2-Aminonicotinonitrile 8 (100 g, 0.839 mol) was dissolved in HOAc (800 mL) . To the solution was added Na2C03 (88.97 g, 0.839 mol). Then, Br2 (46.4 mL, 0.923 mol) was added dropwise. The reaction mixture was stirred at room temperature for 50 min. To the mixture was added water (600 mL) . The mixture was cooled to about 5C. The precipitate thus formed was collected by filtration and dried to give compound 9 (207 g, 96%) .

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 24517-64-4, 2-Amino-3-cyanopyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; OTSUKA PHARMACEUTICAL CO., LTD.; ABUDUSAIMI, Mamuti; YE, Fangguo; SUN, Jiangqin; MIYAMOTO, Hisashi; CHENG, Jay-Fei; OKA, Daisuke; WO2013/29548; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1121-60-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1121-60-4, name is Picolinaldehyde. A new synthetic method of this compound is introduced below.

General procedure: To a mixture of 1,2-phenylenediamines (1.0 mmol) andaldehydes (1.1 mmol) in ethanol, 25 mol % of Ag2CO3/Celite (3 mL) was added. The resulting mixture was stirredat 70 C for 3 h. After this time, the reaction mixture wasdiluted with ethanol (50 mL) and the catalyst was separatedby filtration. Water was then added to the organic layer, andthe products were filtered and washed with water. All of theproducts are known compounds and characterized easily bycomparison with melting point, IR, [1-6] H NMR spectraldata reported in literature.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1121-60-4, Picolinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Soleimani, Ebrahim; Khodaei, Mohammad Mehdi; Yazdani, Hossein; Saei, Parisa; Zavar Reza, Javad; Journal of the Iranian Chemical Society; vol. 12; 7; (2015); p. 1281 – 1285;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 72093-07-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.72093-07-3, name is 5-Chloro-2-methylpyridine, molecular formula is C6H6ClN, molecular weight is 127.57, as common compound, the synthetic route is as follows.

To a solution of 5-chloro-2-methylpyridine (Step A, 1.1 g, 8.7 mmol) in 15 mL anhydrous ether was added phenyl lithium (1.8 M in cyclohexane/ether, 7.2 mL, 13 mmol) at 0C, and the reaction was stirred at room temperature for 30 min. The resulting mixture was cooled back to 0C, and was added (LR, 2R)-1-phenylpropylene oxide (2.3 g, 17 mmol), and the reaction was allowed to warm to room temperature overnight. The reaction mixture was partitioned between EtOAc (100 mL) and water (100 mL). The organic layer was separated and the aqueous layer extracted with EtOAc (2 x 100 mL). The combined organic extracts were dried over anhydrous MGS04, filtered, and concentrated to dryness, and the residue was purified by flash column chromatography on silica gel eluted with 10 to 40% EtOAc in hexane to afford the title compound. 1H NMR (500 MHz, CD30D) : 8 8.28 (d, 1H), 7.59 (dd, 1H), 7.25-7. 12 (m, 5H), 7.05 (d, 1H), 4.03 (m, 1H), 3.29 (dd, 1H), 3.19 (dd, 1H), 3.12 (m, 1H), 1.12 (d, 3H).

Statistics shows that 72093-07-3 is playing an increasingly important role. we look forward to future research findings about 5-Chloro-2-methylpyridine.

Reference:
Patent; MERCK & CO., INC.; WO2004/48317; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 75308-46-2, name is tert-Butyl 2,6-dichloroisonicotinate. A new synthetic method of this compound is introduced below., Quality Control of tert-Butyl 2,6-dichloroisonicotinate

To a solution of 2,6-dichloro-isonicotinic acid tert.-butyl ester (780 mg, 3.14 mmol), and 2,4,6-trivinylcyclotriboroxane pyridine complex (640 mg, 2.66 mmol, prepared according to F. Kerins, D. F. O’Shea J. Org. Chem. 67 (2002) 4968-4971) in DME (12 mL), a solution of 2 M aq. K2CO3 (3 mL) followed by Pd(PPh3)4 (30 mg, 0.041 mmol) and PPh3 (50 mg, 0.187 mmol) is added. The mixture is stirred at 100 C. for 15 h before it is cooled to rt, diluted with ether and washed with 1 N aq. NaOH solution (3×30 mL). The aq. phase is extracted once more with ether and the combined org. extracts are dried over Na2SO4, filtered and evaporated. The crude product is purified by CC on silica gel eluting with heptane:EA 5:1 to give 2,6-divinyl-isonicotinic acid tert-butyl ester (703 mg) as a colourless oil; LC-MS: tR=1.03 min, [M+1]+=232.01.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 75308-46-2, tert-Butyl 2,6-dichloroisonicotinate.

Reference:
Patent; Actelion Pharmaceuticals Ltd.; US2010/63108; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 72990-37-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 72990-37-5, name is 3-Chloroisonicotinaldehyde. A new synthetic method of this compound is introduced below.

General procedure: A solution of commercially available quinoline derivatives (1equiv.), p-toluenesulfonamide (1equiv.) and aldehyde (1equiv.) in toluene (1 M) was refluxed at 120C for 12h in a reaction tube under N2. After the mixture was cooled to room temperature, the solvent was removed under reduced pressure. Then the residue was purified by silica gel column chromatography to afford the vinyl quinoline derivatives.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,72990-37-5, 3-Chloroisonicotinaldehyde, and friends who are interested can also refer to it.

Reference:
Article; Yue, Xuyi; Dhavale, Dhruva D.; Li, Junfeng; Luo, Zonghua; Liu, Jialu; Yang, Hao; Mach, Robert H.; Kotzbauer, Paul T.; Tu, Zhude; Bioorganic and Medicinal Chemistry Letters; vol. 28; 6; (2018); p. 1011 – 1019;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 14294-11-2, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14294-11-2, name is 1-(Pyridin-2-yl)thiourea, molecular formula is C6H7N3S, molecular weight is 153.21, as common compound, the synthetic route is as follows.

General procedure: Arylthiourea 2 (1 mmol) was added to a solution (in case of 1a) or suspension (for 1b,c) of 3-substituted 1,2,4-triazine 1 (1 mmol) in acetic anhydride. The reaction mixture was stirred at room temperature for 7-27 h. The precipitate obtained was filtered and washed with a small amount of acetic anhydride, diethyl ether and dried in air. For the analytical data, see Online Supplementary Materials.

The chemical industry reduces the impact on the environment during synthesis 14294-11-2, I believe this compound will play a more active role in future production and life.

Reference:
Article; Mochulskaya, Nataliya N.; Slepukhin, Pavel A.; Charushin, Valery N.; Kodess, Mikhail I.; Mendeleev Communications; vol. 26; 5; (2016); p. 375 – 377;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 669066-91-5 ,Some common heterocyclic compound, 669066-91-5, molecular formula is C6H3BrFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 5-bromo-3-fluoropyridine-2-carboxylic acid (2.7 g, 12.27 mmol, 1 equiv.) and H2S04 (5 mL) in MeOH (10 mL) was stirred at 85 C for 1 hour. The mixture was basified to pH 7 with saturated NaHCO3. The resulting mixture was extracted with EA (3x) and evaporated to afford the title compound (2.3 g) as off white solid. ESI-MS m/z= 233.90[M+Hjt

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 669066-91-5, 5-Bromo-3-fluoropicolinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ENANTA PHARMACEUTICALS, INC.; OR, Yat, Sun; BLAISDELL, Thomas, P.; SHOOK, Brian, C.; KIM, In, Jong; (98 pag.)WO2018/226801; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 106877-33-2, name is 5-Amino-2-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Computed Properties of C6H5F3N2

EXAMPLE 824-(Aminomethyl)-l-(7H-pyrrolor2,3-dlpyrimidin-4-yl)-N-(6-(trifluoromethyl)pyridin-3- yl)piperidine-4-carboxamide82A. ferf-Butyl 4-cvano-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)piperidine- 1 – carboxylate; 6-(Trifluoromethyl)pyridin-3 -amine (319 mg, 1.97 mmol) was added in one portion to 1- (t°t-butoxycarbonyl)-4-cyanopiperidine-4-carboxylic acid (500mg, 1.97 mmol), HATU (822 mg, 2.16 mmol) and DIPEA (1030 mul, 5.90 mmol) in DMA (9832 mul) at 2O0C under nitrogen. The resulting solution was stirred at 20 0C for 24 hours. The reaction mixture was diluted with EtOAc (10ml), and washed sequentially with water (2 x 10ml) and saturated brine (10ml). The organic layer was dried over MgSO4, filtered and evaporated to afford crude product. The crude product was purified by flash silica chromatography, elution gradient 10 to 50% EtOAc in isohexane. Pure fractions were evaporated to dryness to afford tert-butyl 4-cyano-4-(6-(trifluoromethyl)pyridin-3-ylcarbamoyl)piperidine- 1 – carboxylate (330 mg, 42.1 %) as a white solid .IH NMR (400.132 MHz, DMSO) delta 1.42 (9H, s), 1.97 – 2.05 (2H, m), 2.22 (2H, d), 3.00 (2H, s), 4.07 (2H, d), 7.93 (IH, d), 8.34 – 8.36 (IH, m), 8.97 (IH, d), 10.72 (IH, s)MS m/e MH+ 397

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 106877-33-2, 5-Amino-2-(trifluoromethyl)pyridine.

Reference:
Patent; ASTEX THERAPEUTICS LIMITED; THE INSTITUTE OF CANCER RESEARCH:ROYAL CANCER HOSPITAL; CANCER RESEARCH TECHNOLOGY LIMITED; ASTRAZENECA AB; WO2008/75110; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 68470-59-7 ,Some common heterocyclic compound, 68470-59-7, molecular formula is C7H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Sodium azide (48 mg, 073 mmo) was added to a soution of 2(bromomethy 6methypyridne (91 mg, 049 mmo) n dry DMFm). (t8 The reaction mixture was irradiated with microwaves 90 00 for 30 mn. After cooing, water was added and the reaction mixture was extracted with Et20. The organic phase was dried over Na2SO4 and the sovent removed to yied the desred product (33 mg, 46%). 1HNMR (300MHz, CDC3), 6 ppm: 758 (t, J = 8 Hz, IH), 7.13(d, J 8 Hz, 1H), 7.08 (d, J = 8Hz, 1H), 4,43 (s, 2H), 2.54 (s, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 68470-59-7, 2-(Bromomethyl)-6-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUEVAS CORDOBES, Felix; ALMANSA-ROSALES, Carmen; GARCIA LOPEZ, Monica; WO2015/91939; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem