Day: August 12, 2021

Electric Literature of 13603-44-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.13603-44-6, name is 2,6-Dimethylpyridin-4-ol, molecular formula is C7H9NO, molecular weight is 123.15, as common compound, the synthetic route is as follows.

To a solution of 4-fluor-benzaldehyde (1.00 g, 8.06 mmol, 1.00 eq.) in DMA (7 mL), 2,6- dimethyl-4-hydroxypyridine (1.09 g, 8.86 mmol, 1.10 eq.) and K2C03(1.11 g, 8.46 mmol, 1.05 eq.) were added. The reaction mixture was heated to reflux for 4 hours. The reaction mixture was diluted with ethyl acetate, washed with water and a sat. NaCI soln., dried over MgS04, and concentrated in vacuo. The residue was purified by flashmaster (column: 100 g, flow: 45 mL/min, 40 fractions of 45 mL, Hept/AcOEt 8:2 to 100% AcOEt) to yield the title compound as a white solid.LC-MS 3: tR= 0.78 min; [M+H]+= 228.1

Statistics shows that 13603-44-6 is playing an increasingly important role. we look forward to future research findings about 2,6-Dimethylpyridin-4-ol.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CIANA, Claire-Lise; KIMMERLIN, Thierry; SIEGRIST, Romain; WO2014/141175; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 69142-64-9, name is Ethyl 6-aminopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C8H10N2O2

To a solution of ethyl 6-aminopicolinate (91; 5.5 g, 33 mmol) in t-BuOH (120 mL) and acetone (40 mL) was added DMAP (0.08g, 0.66 mmol) and di-t-butyl dicarbonate (10.8 g, 49.5 mmol). The reaction mixture was stirred at room temperature for 18 h. The solvent was removed by concentration under reduced pressure and a mixture of hexane/dichloromethane (180 mL, 3:1) was added. The resulting mixture was cooled to – 20 0C for 2 h. The resulting solids were collected by filtration and dried to afford ethyl 6- (tert-butoxycarbonylamino)picolinate 92 (11.0 g, 91%).

With the rapid development of chemical substances, we look forward to future research findings about 69142-64-9.

Reference:
Patent; SIRTRIS PHARMACEUTICALS, INC.; VU, Chi, B.; DISCH, Jeremy, S.; NG, Pui, Yee; BLUM, Charles, A.; PERNI, Robert, B.; WO2010/3048; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 126325-50-6, name is 3-Amino-2-bromo-4-picoline. A new synthetic method of this compound is introduced below., COA of Formula: C6H7BrN2

To a cooled (13 C) mixture of 3-amino-2-bromo-4-picoline (4.5 g, 24.06 mmol, Combi-Blocks) and potassium acetate (3.09 g, 31.5 mmol) in AcOH (100 mL) was added a solution of sodium nitrite (2.01 g, 29.1 mmol) in water (10 mL) dropwise. Upon complete addition the reaction mixture was allowed to slowly warm to rt for 66 h. A solution of NaN02 (706 mg) in water (3 mL) was added to the reaction mixture and the reaction mixture was stirred for 5 h. The solvent was removed under reduced pressure and the residue was basified with saturated NaHC03. The aqueous layer was extracted with EtOAc (3x) and the combined organic layers were washed with water then brine, and dried over MgS04. The filtrate was purified by silica gel flash chromatography, eluting with EtOAc:hexanes (0: 1? 1 :1) to give a white crystalline solid (1.38 g, 7.0 mmol, 29%).MS m/z=198 [M+H]+. Calculated for C6H4BrN3: 198

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 126325-50-6, 3-Amino-2-bromo-4-picoline.

Reference:
Patent; AMGEN INC.; MINATTI, Ana Elena; LOW, Jonathan, D.; ALLEN, Jennifer, R.; AMEGADZIE, Albert; BROWN, James; FROHN, Michael, J.; GUZMAN-PEREZ, Angel; HARRINGTON, Paul, E.; LOPEZ, Patricia; MA, Vu Van; NISHIMURA, Nobuko; QIAN, Wenyuan; RUMFELT, Shannon; RZASA, Robert, M.; SHAM, Kelvin; SMITH, Adrian, L.; WHITE, Ryan; XUE, Qiufen; WO2014/138484; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 34392-85-3, Adding some certain compound to certain chemical reactions, such as: 34392-85-3, name is 3-Amino-2-chloro-6-methoxypyridine,molecular formula is C6H7ClN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 34392-85-3.

Bring a solution of 2-chloro-6-methoxy-3-nitro-pyridine (2. 8 g, 0. 018 mol) in 75% H2SO4 (15 mL) to 0C using an ice bath. Slowly add a solution of NaN02 in water (5 mL) to the reaction mixture and stir for 30 minutes. Add three molar equivalents of CuCI in concentrated HCl and stir for 15 minutes. Heat the mixture at 80C for 30 minutes. Pour onto ice, extract the aqueous with ethyl acetate, dry the organic layer (NA2SO4) and concentrate under reduced pressure. Purify using flash column chromatography (hexanes to 10% ethyl acetate/hexanes eluent) to afford the title compound.

According to the analysis of related databases, 34392-85-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NEUROGEN CORPORATION; WO2005/7648; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 76469-41-5 ,Some common heterocyclic compound, 76469-41-5, molecular formula is C5H2F3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

6.65 g of the compound obtained in Step 3 and 4.6 ml of hydrazine monohydrate were added to 100 ml of n-propanol. The resulting mixture was refluxed for 6 hours, and distilled under a reduced pressure to remove the solvent. The residue thus obtained was dissolved in 80 ml of chloromethane, washed with water, and dried over anhydrous magnesium sulfate. The resulting organic layer was concentrated under a reduced pressure to obtain 6.20 g (yield: 85.6%) of the title compound.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 76469-41-5, 2,3,5-Trifluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Park, Tae-Ho; Zhao, Long-Xuan; Lee, Sang-Ho; US2006/47124; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 72587-15-6, 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine, blongs to pyridine-derivatives compound. name: 2-Chloro-3-nitro-5-(trifluoromethyl)pyridine

Compound WXOO2-1 (295.68 mg, 662.13 tmol) and compound WXOO1-2 (354.9 mg, 1.30 nmol) weredissolved in acetonitrile (3.00 mE) at room temperature,followed by the addition of potassium carbonate (183.03mg, 1.32 mmol). The reaction mixture was heated at roomtemperature and stirred for 2 hours. After the reaction, themixture was diluted with water (10 mE) and extracted withethyl acetate (5 mEx2). The organic phases were combinedand dried over anhydrous sodium sulfate, followed byfiltration. The filtrate was concentrated under reduced pressure to remove the solvent. The obtained residue wasisolated by column chromatography (eluent: petroleumether/ethyl acetate=1 0/1-2/1, volume ratio) to obtain thetarget product WXOO2-2. MS-ESI mlz: 464.0 [M+H].

The synthetic route of 72587-15-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SHIJIAZHUANG SAGACITY NEW DRUG DEVELOPMENT CO., LTD.; LUO, Yunfu; YANG, Chundao; LEI, Maoyi; LIU, LING; HU, Guoping; LI, Jian; CHEN, Shuhui; US2019/177318; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1121-60-4, name is Picolinaldehyde, molecular formula is C6H5NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of Picolinaldehyde

2-Pyridylbenzaldehyde (10.7 g, 0.1 mol), malonic acid (25.5 g, 0.25 mol) was added to a 100 ml round bottom flask.30 ml of pyridine was added as a solvent, magnetically stirred, and after all of it was dissolved, 1.6 g of piperidine was injected into the system.The oil bath was heated to 65 C and reacted for 3 h.The reaction was followed by thin layer chromatography, and after the reaction was completed, the reaction solution was cooled to 0-5 C.Pour into a mixture of ice and water containing concentrated hydrochloric acid (12 mol / l, 50 ml), a large amount of white solids precipitated, suction filtration,The desired 2-pyridine acrylic acid was obtained in a molar yield of 78%.

With the rapid development of chemical substances, we look forward to future research findings about 1121-60-4.

Reference:
Patent; Danyang Ning David Fang To Detect Co., Ltd.; Wei Qian; (4 pag.)CN109748851; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5346-38-3, Pyridine-2-carbothioamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 5346-38-3, blongs to pyridine-derivatives compound. Computed Properties of C6H6N2S

Pyridinecarbothioamides 26-28 (1 eq.) and dichloroacetone(1 eq.) were dissolved in toluene (1 M) and heated to reflux (110 C).After completion of the reaction, the mixture was cooled to roomtemperature and extracted with EtOAc (3 times) and the organiclayer was washed (brine), dried (MgSO4), filtered and concentratedin vacuo. The product was purified by column chromatography.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,5346-38-3, its application will become more common.

Reference:
Article; Louvel, Julien; Guo, Dong; Soethoudt, Marjolein; Mocking, Tamara A.M.; Lenselink, Eelke B.; Mulder-Krieger, Thea; Heitman, Laura H.; Ijzerman, Adriaan P.; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 681 – 691;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 36052-24-1 , The common heterocyclic compound, 36052-24-1, name is Methyl 6-aminonicotinate, molecular formula is C7H8N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Compound 15 (1.0 equiv., 3.94 mmol, 0.600 g) was added portion wise to a suspension OfLiAlH4 (3.00 equiv., 11.83 mmol, 0.449 g) in dry THF (17 ml) at 00C. The reaction mixture was stirred at room temperature overnight. Excess LiAlH4 was destroyed by addition of methanol (while cooling on ice), the reaction mixture was filtered over Celite and the filtrate concentrated under reduced pressure. The crude product was purified by column chromatography (dichloromethane / methanol 75:25) to give 6-amino-3-pyridinemethanol (16) (0.330 g, yield = 67%) as a white solid. 1H NMR (delta, CD3OD): 4.43 (2H, s), 6.58 (IH, d, J = 8.5 Hz), 7.48 (IH, dd, J = 8.5, ~ 2 Hz) 7.86 (IH, d, J ~ 2 Hz)

The synthetic route of 36052-24-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tibotec Pharmaceuticals Ltd.; WO2007/113290; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 38533-61-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 38533-61-8, name is 2-Chloro-6-methoxy-3-nitropyridine, molecular formula is C6H5ClN2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A suspension of 2-chloro-6-methoxy-3-nitropyridine (20.85 g, 110.57 mmol) in concentrated hydrochloric acid (37%) (171 mL, 5528.49 mmol) was stirred at 90 0C for 3 hours and allowed to cool to ambient temperature. The suspension was adjusted to pH 5 with 2M NaOH and the aqueous mixture was then continually extracted with EtOAc (250 mL). The organics were concentrated to afford a yellow solid which was filtered off and washed with Et2theta (200 mL). The solid was stirred in EtOAc (200 mL) and the green insoluble solid filtered off. Both filtrates were combined and dried (MgSO4) before concentrating to yield as 6-chloro-5-nitropyridin-2-ol a yellow solid (14.7 g, 84.22 mmol, 76 %).1R NMR (400 MHz, DMSOd6) delta 6.52 (IH, d), 8.26 (IH, d), no OH peak observed, m/z 173 (M-H)”

According to the analysis of related databases, 38533-61-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/24821; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem