Day: August 18, 2021

Adding a certain compound to certain chemical reactions, such as: 93683-65-9, 6-Chloro-3-nitropicolinonitrile, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 93683-65-9, blongs to pyridine-derivatives compound. Product Details of 93683-65-9

Example 6b 3-nitro-6-thioxo-1,6-dihydropyridine-2-carbonitrile One equivalent of NaSH:H2O is added to a solution of 6-chloro-3-nitropicolinonitrile (5.45 mmol, 1 g) in 20 ml of EtOH. The color turns orange. The reaction medium is stirred at room temperature for 30 minutes. The crude reaction product is then concentrated, redissolved in ethyl acetate and extracted several times using an acidic aqueous phase (1 N HCl) and then a neutral phase. The organic phase is concentrated and the crude reaction product recrystallized in acetone to yield 0.64 g (79%) of yellow crystals. 1H NMR: deltaH ppm (400 MHz, DMSO): 8.71 (1H, d, CHarom), 8.27 (1H, d, CHarom).

The synthetic route of 93683-65-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PIERRE FABRE MEDICAMENT; KALOUN, El Bachir; BEDJEGUELAL, Karim; RABOT, Remi; KRUCZYNSKI, Anna; SCHMITT, Philippe; PEREZ, Michel; RAHIER, Nicolas; US2013/85144; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.104408-24-4, name is 6-Hydrazinylnicotinonitrile, molecular formula is C6H6N4, molecular weight is 134.1386, as common compound, the synthetic route is as follows.Safety of 6-Hydrazinylnicotinonitrile

[1086] a mixture of ethyl 2-(methoxyimino)-4-oxopentanoate (558.2 mg, 2.98 mmol) and 6-hydrazinylnicotinonitrile (400 mg, 2.98 mmol) in AcOH (5 ml) was stirred at 118 C for 5 hours. The reaction mixture was cooled to 25 C and concentrated under reduced pressure to give a residue, which was diluted with ch2ci2 (100 ml). The organic phase was washed with saturated aqueous NaHCO3 (20 ml), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure to give a residue, which was purified by column chromatography (SiO2, petroleum ether/ethyl acetate = 1 :0 to 5: 1) to afford compound 208a (160 mg, 19.09% yield) as a white solid, but structure (proposed structure) could not be confirmed by n-h hmbc. 1H NMR (400 mhz, CDCl3): delta 8.66 (dd, = 0.8, 2.4 hz, 1h), 8.07 (dd, j = 2.4, 8.4 hz, 1h), 7.88 (dd, j = 0.8, 8.4 hz, 1h), 6.67 (s, 1h), 4.35 (q, j = 6.8 hz, 2h), 2.37 (s, 3h), 1.32 (t, j = 7.2 hz, 3h). MS (ESI) m/z (m+l)+ 257.1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,104408-24-4, 6-Hydrazinylnicotinonitrile, and friends who are interested can also refer to it.

Reference:
Patent; BLADE THERAPEUTICS, INC.; BUCKMAN, Brad, Owen; YUAN, Shendong; ADLER, Marc; EMAYAN, Kumaraswamy; MA, Jingyuang; (687 pag.)WO2018/64119; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 886364-86-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 886364-86-9, name is 5-Bromo-4-methylpicolinonitrile, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine:To a mixture of 5-bromo-4-methylpicolinonitrile (2.5 g, 12.7 mmol, Eq: 1.00), sodium azide (1.07 g, 16.5 mmol, Eq: 1.3) and triethylamine hydrochloride (2.27 g, 16.5 mmol, Eq: 1.3) was added xylene (25 ml). The reaction mixture was heated at 140 C. overnight, and upon cooling was concentrated under reduced pressure. To the white residue was added water and an aq. HCl solution. These solids were filtered, washed with water, and dried to give 5-bromo-4-methyl-2-(2H-tetrazol-5-yl)-pyridine (2.43 g, 80% yield) as an off-white solid.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 886364-86-9, 5-Bromo-4-methylpicolinonitrile.

Reference:
Patent; Hoffmann-La Roche Inc; Bhagirath, Niala; Brameld, Kenneth Albert; Kennedy-Smith, Joshua; US2013/90334; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 183208-35-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 183208-35-7 as follows.

Into a 500 mL round bottomed flask were added 5-bromo-1H-pyrrolo[2,3-b]rhoyridine (10.11 g, 51.3 mmol) and 250 ml acetone. N-iodosuccinimide (NIS, 12.7 g, 56.4 mmol) was added, and the reaction mixture was stirred at room temperature for 1 hour. The precipitate was collected and washed with cold acetone to afford 12. 2 g (74%) of the title compound as a tan powder. 1H-NMR (500 MHz, ^6-DMSO) J= 12.35 (br.s, 1H), 8.29 (d, J=2.0 Hz, 1H), 7.84 (d, J=2.0 Hz 1 H), 7.79 (s, 1H); MS: m/z 322.8/324.8 [MH+].

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183208-35-7, its application will become more common.

Reference:
Patent; SGX PHARMACEUTICALS, INC.; WO2008/124849; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 17228-64-7, name is 2-Chloro-6-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 17228-64-7

General procedure: A heating reaction vessel was charged with the prescribed amount of catalyst, naphthylpyrimidine (0.5 mmol), aryl chloride (0.6 mmol), K2CO3 (1.5 mmol), KO2CR (0.1 mmol), PAr3 (0.1 mmol) and water (3 mL) under nitrogen. The vessel was sealed and heated at 120 C (oil bath temperature) for 24 h. The resulting mixture was cooled to room temperature, and the aqueous layer was extracted with ethyl acetate, then the combined organic layers were washed with water, dried over MgSO4, filtered, and the solvent was removed on a rotary evaporator. The resulting residue was purified by flash chromatography to give the corresponding products 1-34.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 17228-64-7, 2-Chloro-6-methoxypyridine.

Reference:
Article; Li, Hong-Mei; Tu, Tian-Yong; Han, Xin; Wang, Zhi-Qiang; Fu, Wei-Jun; Hao, Xin-Qi; Song, Mao-Ping; Xu, Chen; Synlett; vol. 29; 13; (2018); p. 1729 – 1734;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 78607-36-0 ,Some common heterocyclic compound, 78607-36-0, molecular formula is C5H3ClIN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Dissolve 2-chloro-3-iodopyridine (2.0 g, 8.37 mmol) in toluene (7 mL). Add piperazine-1-carboxylic acid t-butyl ester (1.2 g, 6.4 mmol), followed by the addition of tris(dibenzylideneacetone)dipalladium(0) (0.12 g, 0.13 mmol), 4,5-bis(diphenyl- phosphino)-9,9-dimethylxanthene (0.23 g, 0.39 mmol), and sodium t-butoxide (0.93 g, 9.7 mmol). Heat at 100 0C for 3.5 hr. Concentrate and partition the residue between EtOAc and water. Extract the aqueous phase twice with ethyl acetate. Wash combined organic layers with brine. Dry the organic extracts (sodium sulfate), filter, concentrate and purify (silica gel chromatography, eluting with 0: 100 to 20:80 ethyl acetate:hexanes), to give the title preparation (95%). MS (ES): m/z = 298 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,78607-36-0, its application will become more common.

Reference:
Patent; ELI LILLY AND COMPANY; WO2009/29439; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 174669-74-0, name is 2-Fluoropyridin-3-ol, molecular formula is C5H4FNO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Safety of 2-Fluoropyridin-3-ol

To a suspension of sodium hydride (0.129 g, 3.21 mmol) in DMF (10 mL) at 0 C was dropwise added a stuffing solution of 2-fluoropyridin-3-ol (0.363 g, 3.21 mmol) in DMF (5 mL), then followed by the dropwise addition of the solution of 2-(2-(2-(2- azidoethoxy)ethoxy)ethoxy)ethyl 4-methylbenzenesulfonate (1.00 g, 2.68 mmol) in DMF (5 mL). The suspension was held at 0 C for 10 mm, then brought to ambient temperature for 1 hour, followed by additional heating at 60 C for 4 hours. The solvent was removed in vacuo. 100 ml of ethyl acetate was added followed by 3 separate wash extractions with concentrated brine solution. The organic layer was dried over sodium sulfate, filtered, and concentrated. The crude material was purified using flash chromatography (IscoCombiFlash – eluted with 10 – 50% EtOAc in Hex) to give a colorless oil. 3-(2-(2-(2-(2- azidoethoxy)ethoxy)ethoxy)ethoxy)-2-fluoropyridine (702 mg, 2.233 mmol, 83 % yield) was isolated as a clear oil. ?H NMR (400MHz, CHLOROFORM-d) oe 7.75 (dt, 1=4.9, 1.6 Hz, 1H), 7.33 (ddd, 1=10.0, 8.1, 1.5 Hz, 1H), 7.10 (ddd, 1=7.9, 4.9, 0.7 Hz, 1H), 4.30 – 4.16 (m, 2H),3.95 – 3.83 (m, 2H), 3.80 – 3.61 (m, 1OH), 3.38 (t, 1=5.1 Hz, 2H) 13C NMR (101MHz, CHLOROFORM-d) d 142.3, 137.7, 137.5, 123.4, 123.4, 121.7, 121.6, 77.3, 76.7, 70.9, 70.7, 70.6, 70.0, 69.4, 69.0, 50.6 19F NMR (400MHz, CHLOROFORM-d) oe -83.55. HRMS (ESI) Theory:C 1 3H20FN404+ mlz 315.464; found 315.1463.

With the rapid development of chemical substances, we look forward to future research findings about 174669-74-0.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; MORIN, Paul, E.; DONNELLY, David; LIPOVSEK, Dasa; GOKEMEIJER, Jochem; JURE-KUNKEL, Maria, N.; FABRIZIO, David; WRIGHT, Martin, C.; DISCHINO, Douglas; BONACORSI, Samuel, J.; SMITH, Ralph, Adam; LAFONT, Virginie; (0 pag.)WO2016/86021; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 55314-16-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 55314-16-4 as follows.

A mixture of 65 g (0.156 moles) of 4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl-5-(trifluoromethyl)phenyl]-3-guanidino-benzamide from step (c), 30.0 g (0.171 moles) of 3-dimethylamino-1-(3-pyridyl)-2-propen-1-one of the formula (VIII) in 650 ml n-butanol was heated at 110-115 C. for 9 hours. Reaction mass was brought to room temperature and the separated solid (70 g) was filtered off. Wet solid was leached with hot water (700 ml) and hot methanol (700 ml) successively. The wet product was dried at 60-65 C. under vacuum to yield compound of formula (I). Yield: 52.1 g (63%) MR: 235-236 C. Purity: 99.0% (by HPLC)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,55314-16-4, its application will become more common.

Reference:
Patent; Natco Pharma Limited; Kompella, Amala; Bhujanga Rao, Adibhatla Kali Satya; Rachakonda, Sreenivas; Gampa, Venugopala Krishna; Nannapaneni, Venkaiah Chowdary; US2013/210847; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1513-66-2 ,Some common heterocyclic compound, 1513-66-2, molecular formula is C5H3F2N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

500 g of DMF was added to a 1000 mL four-necked flask, 100 g of compound A was charged,113.6 g of potassium carbonate and 5 g of tetrabutylammonium bromide, the temperature was raised to 60 C, and 92.6 g of the product was added dropwise2,3-difluoropyridine in 50 g of DMF in a mixed solution at a controlled temperature of 65 to 70 C,The reaction is about 2 hours, the reaction is completed, added to 1000 g of water, the pH is adjusted to 7 to 8 with hydrochloric acid,Stirring for 1 hour, filtering, solid is the etherification (compound I), drying.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1513-66-2, 2,3-Difluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu Fuding Chemical Co., Ltd.; Liu Dongwei; Cheng Lizhong; Chang Qing; Dong Hailong; Zhu Ruiyu; Gu Junkun; (16 pag.)CN106632045; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 128071-98-7, 4-Bromo-2-fluoropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 128071-98-7, blongs to pyridine-derivatives compound. HPLC of Formula: C5H3BrFN

Compound 41.1. 4-Bromo-2-hydrazinylpyridine. To a solution of 4-bromo-2- fluoropyridine (2.0 g, 1 1.4 mmol) in pyridine (10 mL) was added hydrazine (5 mL, 159 mmol). The mixture was heated at 70 C for 2 hours, then cooled to room temperature. The volatile organics were removed under reduced pressure, then water (60 mL) was added to the residue and an off-white solid precipitated. The solid was filtered, washed with water, and dried under reduced pressure at 50 C to give 1.77 g (84%) of the title compound as an off- white solid, m/z (ES+) 188, 190 (M+H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,128071-98-7, its application will become more common.

Reference:
Patent; 3-V BIOSCIENCES, INC.; OSLOB, Johan D.; MCDOWELL, Robert S.; JOHNSON, Russell; YANG, Hanbiao; EVANCHIK, Marc; ZAHARIA, Cristiana A.; CAI, Haiying; HU, Lily W.; WO2014/8197; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem