Day: August 23, 2021

Adding a certain compound to certain chemical reactions, such as: 100367-39-3, 4-Bromo-2-methoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C6H6BrNO, blongs to pyridine-derivatives compound. COA of Formula: C6H6BrNO

EXAMPLE 22: Synthesis of N1-(7-chloroquinolin-4-vn-N2-(2-((2-methoxypyridin-4- yl)amino)ethyl)-N2-methylethane- 1 ,2-diamine. Pd(OAc)2, BINAP, K3PO4, dioxane [00257] A mixture of 4-bromo-2-methoxypyridine (0.188 g, 0.997 mmol), Nx-(2- aminoethyl)-N2-(7-chloroquinolin-4-yl)-N1-methylethane-l,2-diamine (0.278 g, 0.997 mmol), Pd(OAc)2 (24.5 mg), BINAP (0.135 g), and K3PO4 (1.14 g) in 1,4-dioxane (10 mL) was degassed with argon for 5 min and then stirred at 100 C for 20 h in a sealed tube. The reaction mixture was cooled to room temperature, filtered through Celite, and concentrated in vacuo. Purification by silica gel chromatography using CH2CI2/CH3OH/NH4OH (270:9: 1, and 180:9: 1) afforded N1-(7-chloroquinolin-4-yl)-N2-(2-((2-methoxypyridin-4- yl)amino)ethyl)-N2-methylethane-l,2-diamine (0.26 g, 67%) as a pale-yellow solid after lyophilization with CH3CN/H20. 1H NMR (300 MHz, DMSO-d6) delta 2.31 (s,3H); 2.60 (t, J = 6.3, 2H); 2.69 (t, J = 6.6, 2H); 3.12 (q, J = 5.9, 2H); 3.38 (q, J = 6.0, 2H); 3.72 (s, 3H); 5.78 (d, J = 2.1, 1H); 6.20 (dd, J = 2.0, 5.9, 1H); 6.26 (t, J = 5.0, 1H); 6.50 (d, J = 5.4, 1H); 7.14 (br t, 1H); 7.41 (dd, J = 2.1, 9.0, 1H); 7.62 (d, J = 5.7, 1H); 7.78 (d, J = 2.4, 1H); 8.17 (d, J = 9.0, 1H); 8.39 (d, J = 5.4, 1H). Mass spectrum (ESI) m/e = 386.6 (M+l).

The synthetic route of 100367-39-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; PRESAGE BIOSCIENCES, INC.; DECKWERTH, Thomas; KLEINMAN, Edward; RUAN, Fuqiang; BAKER, William; KLINGHOFFER, Richard; (126 pag.)WO2016/196393; (2016); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 799293-85-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 799293-85-9, name is 3-Bromothieno[3,2-c]pyridin-4-amine. A new synthetic method of this compound is introduced below.

To a solution of 3-bromo-thieno[2,3-c]pyridine-4-yl-amine (1.00 g, 4.38 mmol) in DMF (15 mL) was added NIS (1.08 g, 4.81 mmol). The resulting solution was stirred at room temperature overnight. Approximately half of the solvent was removed in vacuo and the resulting slurry was poured into sodium thiosulfate (5% solution in water, 100 mL). The resulting precipitate was collected and washed with water (2 x 30 mL) to afford 4-amino-7- biphenyl-3-yl-thieno[3,2-c]pyridine carboxylic acid as a tan solid (1.55 g, 4.38 mmol); RP- HPLC (Table 1, Method i) Rt 2.72 min; m/z: (M + H) + 357.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,799293-85-9, its application will become more common.

Reference:
Patent; ABBOTT LABORATORIES; WO2005/110410; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 103-74-2, 2-(2-Hydroxyethyl)pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 103-74-2, blongs to pyridine-derivatives compound. Recommanded Product: 103-74-2

To a solution of 2-(2-hydroxyethyl)pyridine (3 ml, 26.6 mmol) was added 30 ml of 33% HBr in acetic acid. The yellow solution was heated in the capped vial at 78 C. for 2 days. The reaction was evaporated under high vacuum to produce a brown solid. The solid was re-crystallized from hot isopropanol to produce a light tan solid (73%). 1H NMR (500 MHz, dMSO): delta 3.62-3.65 (t, 2H), 3.95-3.98 (t, 2H), 7.95 (t, 1H), 8.09-8.10 (d, 1H), 8.58 (t, 1H), 8.90 (d, 1H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,103-74-2, its application will become more common.

Reference:
Patent; Tachdjian, Catherine; Lebl-Rinnova, Marketa; Wallace, David; US2006/263411; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 677728-92-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 677728-92-6, name is 2-Fluoropyridine-5-carbaldehyde. A new synthetic method of this compound is introduced below.

General procedure: A solution containing the corresponding 4-fluoro aryl aldehyde (20.0mmol) and 4-hydroxy aryl aldehyde (20.0mmol) in DMAC (20 mL) was added to K2CO3(24.0mmol) and stirred at 100 C for 4 h under N2. The progress of the reaction was monitored by TLC (eluent: petroleum ether /ethyl acetate 5:1). Following the disappearance of the starting material, the mixture was washed with 1mol/LHCl(30 mL), 5% solution of NaHCO3(30 mL), and brine. The organic layer was dried over anhydrous sodium sulfate and concentrated to yield the crude material used for the subsequent reaction.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,677728-92-6, its application will become more common.

Reference:
Article; Bian, Cong; Chen, Xiaofang; Hu, Laixing; Hu, Xinxin; Liu, Yonghua; Wang, Chong; Wu, Yanbin; You, Xuefu; Zhang, Yongzhong; Bioorganic and medicinal chemistry letters; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 607373-83-1 , The common heterocyclic compound, 607373-83-1, name is 2-Chloro-4-methoxy-5-nitropyridine, molecular formula is C6H5ClN2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a suspension of 2-chloro-4-methoxy-5-nitropyridine (300 mg, 1.59 mmol), prepared according to a literature procedure (PCT Int. Appl. (2003), WO 2003080610 Al 20031002) in EtOH (3 mL) was added SnCl2.2H20 (1.44g, 6.36 mmol) and the the mixture heated at 90C for lhr. The solvents were evaporated and the residue partitioned between 3M NaOH (50 mL) and DCM (lOOmL). The phases were separated and the organic phase was washed with brine (20 mL), dried (Na2SC>4), the mixture filtered and the filtrate evaporated to dryness to afford the title compound as a yellow oil (174 mg, 69%); m z=158.9, 160.8 (MH)+.

The synthetic route of 607373-83-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTIVE BIOTECH AB; FRITZSON, Ingela; LIBERG, David; EAST, Stephen; MACKINNON, Colin; PREVOST, Natacha; WO2014/184234; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 41667-95-2, 5,6-Dichloronicotinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

A mixture of 5,6-dichloronicotinic acid (5 g) and sulfurous dichloride (3.10 g) in methanol (20 mL) was stirred overnight at 25C. Cold water (100 mL) was added and the resulting mixture was neutralized with sat. NaHCO3 solution. The aqueous layer was extracted with DCM (2x 100 mL) and the combined organic layers were dried over Na2SO4. Aftet filtration, the filtrate was concentrated in vacuo to give the title compound (5 g) as white solid. MS (ESI): C7H5C12NO2requires 205; found 206 [M+H].

The synthetic route of 41667-95-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; GLAXOSMITHKLINE (CHINA) R & D COMPANY LIMITED; DENG, Jing; LEI, Hui; MA, Xin; REN, Feng; CAI, Wei; LIN, Xichen; WO2015/180613; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 55304-75-1, Adding some certain compound to certain chemical reactions, such as: 55304-75-1, name is 2,6-Dichloro-3-(trifluoromethyl)pyridine,molecular formula is C6H2Cl2F3N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 55304-75-1.

General procedure: A DMF/water solution (1:1, 2 mL per 1 mmol of 1) of K3PO4 (1.5 mmol), Pd(OAc)2(2 mol %), and arylboronic acid 2 (2.2 mmol) was stirred at room temperaturefor 8-12 h (tlc control). After completion of the reaction, the mixture wasextracted with CH2Cl2 and the combined organic layers were dried (Na2SO4), filtered and the filtrate was concentrated in vacuo. The residue was purified bycolumn chromatography (silica gel, EtOAc/heptane = 1:4). Starting with 1(216 mg, 1.0 mmol), K3PO4 (345 mg, 2.5 mmol), Pd(OAc)2 (2 mol %), arylboronic acid (334 mg, 2.20 mmol), and solution of DMF andwater (1:1) (2 mL), 4a-f was isolated as a yield.

According to the analysis of related databases, 55304-75-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Ahmed, Shahzad; Sharif, Muhammad; Shoaib, Khurram; Reimann, Sebastian; Iqbal, Jamshed; Patonay, Tamas; Spannenberg, Anke; Langer, Peter; Tetrahedron Letters; vol. 54; 13; (2013); p. 1669 – 1672;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 571188-59-5, Adding some certain compound to certain chemical reactions, such as: 571188-59-5, name is tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate,molecular formula is C14H22N4O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 571188-59-5.

600 mg of Compound 5 was dissolved in 3 mL of toluene solution. 2 mL of a 1 mol/L solution of LiHMDS in tetrahydrofuran was added at 0 to 10 C and stirred for 1 h. At 0 to 10 C, 292 mg of a toluene solution of Compound 2 was added, and the reaction was slowly returned to room temperature for 5 hours.After the end of the reaction was monitored by HPLC, the reaction was quenched with 6 mL of saturated ammonium chloride. The organic phase was separated and dried over anhydrous sodium sulfate. An off-white solid with a yield of 54%.

According to the analysis of related databases, 571188-59-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Suzhou Pengxu Pharmaceutical Technology Co., Ltd.; Li Pixu; Wang Peng; Wei Qiang; (7 pag.)CN109553621; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 374633-36-0, Adding some certain compound to certain chemical reactions, such as: 374633-36-0, name is 2-Bromo-3-fluoro-6-picoline,molecular formula is C6H5BrFN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 374633-36-0.

Potassium permanganate (2.50 g, 15.8 mmol) was added portionwise to asuspension of 2-bromo-3-fluoro-6-methylpyridine (1 g, 5.26 mmol) in water (22 ml) at 90 00The reaction was stirred for 3 hours and then filtered through Celite while hot, washing with hot water. The filtrate was acidified to pH 1 via addition of 6 N HCI. The resultant precipitate was collected by filtration to give the title compound (0.15 g, 13 % yield). MS (mlz) 219.9 (M+H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 374633-36-0, 2-Bromo-3-fluoro-6-picoline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; DOWDELL, Sarah E.; EIDAM, Hilary Schenck; ELBAN, Mark; FOX, Ryan Michael; HILFIKER, Mark A.; HOANG, Tram H.; KALLANDER, Lara S.; LAWHORN, Brian Griffin; MANNS, Sharada; PHILP, Joanne; WASHBURN, David G.; YE, Guosen; (274 pag.)WO2017/6295; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 126325-47-1, name is 6-Bromo-2-methylpyridin-3-amine, molecular formula is C6H7BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Application In Synthesis of 6-Bromo-2-methylpyridin-3-amine

Isoamyl nitrite (215 muL, 1.61 mmol) was added to a mixture of corhoper(II) chloride (173 mg, 1.28 mmol) in dry CH3CN (3 mL) at room temperature under N2. A solution of 5-amino-2-bromo-6-picoline (200 mg, 1.07 mmol) in dry CH3CN (2.4 mL) was added via cannula. The resulting mixture was heated at 65 0C under N2 for 4 h. The reaction mixture was diluted with EtOAc and washed with water. The aqueous layer was extracted with EtOAc (Ix). The combined organic extracts were dried (Na2SO4) and concentrated in vacuo. The residue was purified by flash chromatography (Si, 1% of EtOAc in hexanes) to afford 6-bromo-3-chloro-2-methylpyridine. LCMS calc. = 206.0; found = 206.0 (M+l)+. 1H NMR (500 MHz, CDCl3) delta 7.48 (d, J- 8.2 Hz, 1 H); 7.29 (d, J= 8.2 Hz 1 H); 2.62 (s, 3 H).

With the rapid development of chemical substances, we look forward to future research findings about 126325-47-1.

Reference:
Patent; MERCK & CO., INC.; WO2007/81569; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem