Day: August 25, 2021

Related Products of 766-16-5, Adding some certain compound to certain chemical reactions, such as: 766-16-5, name is 4-Fluoro-2-methylpyridine,molecular formula is C6H6FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 766-16-5.

4-Fluoro-2-methylpyridine(4.32 g, 4.01 mL, 38.9 mmol), NBS (6 g, 33.7 mmol) and AIBN(0.56 g, 3.4 mmol) were mixed and CCl 4 (50 mL) was added, followed by heating to 80 C. for 3 h. After cooling the reaction mixture with diatomaceous earthThe filtrate was concentrated under reduced pressure and the crude product was purified by silica gel column chromatography (eluent: PE / EtOAc (v / v) = 9/1) to giveTo 1.3 g of product as a brown oil, yield: 16%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 766-16-5, 4-Fluoro-2-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Liu Bing; Bai Shun; Zhou Youbo; Yang Tiping; He Wei; Zhang Yingjun; Zheng Changchun; (103 pag.)CN106749268; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 15862-37-0, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.15862-37-0, name is 2,5-Dibromo-3-nitropyridine, molecular formula is C5H2Br2N2O2, molecular weight is 281.89, as common compound, the synthetic route is as follows.

In a 250 mL thick-walled flask was added (2-chloropyrimidin-5-yl)boronic acid (1 g, 6.32 mmol),2,5-dibromo-3-nitropyridine (1.780 g, 6.32 mmol) in 90 mL of THF. Added tripotassium phosphate (2.68 g, 12.6 mmol)and PdChidppO-CLhChAdduct (0.103 g, 0.126 mmol) . Bubbled in argon through the mixture while sonicating for 1 min. Capped flask and heated in an oil bath at 65 C overnight. Concentrated to afford a brown solid. The crude material was purified on a 120 g ISCO column, eluting with 20% EtOAc/hexanes to 50% EtOAc/hexanes over 20 column volumes. The fractions containing the title compound were concentrated to afford 0.72 g (36% yield) of a yellow solid. NMR (400MHz, CDCh) delta 9.04 (d, J=2.0 Hz, 1H), 8.83 (s, 2H), 8.58 (d, J=2.0 Hz, 1H).

Statistics shows that 15862-37-0 is playing an increasingly important role. we look forward to future research findings about 2,5-Dibromo-3-nitropyridine.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; NORRIS, Derek J.; VACCARO, Wayne; DEBENEDETTO, Mikkel V.; DEGNAN, Andrew P.; DELUCCA, George V.; DESKUS, Jeffrey A.; HAN, Wen-Ching; KUMI, Godwin Kwame; SCHMITZ, William D.; STARRETT, John E., JR.; HILL, Matthew D.; HUANG, Hong; (563 pag.)WO2016/183118; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H8N2O3, blongs to pyridine-derivatives compound. Computed Properties of C7H8N2O3

Step 1: A solution of commercially available 6-methoxy-2-methyl-3-nitropyridine (183 mg, 1.19 mmol), [5-cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl]methanol (see preparation 1, 320 mg,1.13 mmol) and PPh3 (563 mg, 2.15 mmol) in toluene (30 ml) was cooled to 0C, DIAD (434 mg, 2.15 mmol) was added and the mixture was stirred at room temperature for 12 h. The solution was concentrated under reduced pressure to give a crude residue which was purified by flash chromagraphy to give 5-cyclopropyl-3-(2,6-dichlorophenyl)-4-((6-methyl-5-nitropyridin-2-yloxy)methyl) isoxazole (340 mg, 0.810 mmol; 68% yield).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,5467-69-6, 6-Methoxy-2-methyl-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Phenex Pharmaceuticals AG; EP2128158; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 183610-70-0, name is 2-Amino-3-(trifluoromethyl)pyridine. A new synthetic method of this compound is introduced below., Formula: C6H5F3N2

To a stirred solution of R-10 (2.70 g, 16.66 mmol) in DMF (15 ml) is added N- bromosuccinimide (3.00 g, 16.85 mmol) as a DMF solution (15 ml, dropwise). After 4 h the reaction is poured onto ice. The resulting precipitate is collected via filtration to give the product as an off-white solid. Dissolved into DCM and washed with brine. The layers are separated and the organic phase is dried (MgS04), filtered and concentrated to give the title intermediate (3.8 g); m/z 241.2/243.2 [M/M+2H] .

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 183610-70-0, 2-Amino-3-(trifluoromethyl)pyridine.

Reference:
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BARTOLOZZI, Alessandra; BOSANAC, Todd; CHEN, Zhidong; DE LOMBAERT, Stephane; HUBER, John; LO, Ho Yin; LOKE, Pui Leng; LIU, Weimin; MORWICK, Tina Marie; OLAGUE, Alan; RIETHER, Doris; TYE, Heather; WU, Lifen; ZINDELL, Renee; WO2012/24150; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1206979-33-0, 6-Chloro-1H-pyrazolo[4,3-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 1206979-33-0, blongs to pyridine-derivatives compound. category: pyridine-derivatives

At r.t. to a suspension of 6-chloro-1H-pyrazolo[4,3-c]pyridine (0.5 g, 3 mmol) (Frontier Cat. No. Z13659) in methylene chloride (3 mL) and THF (1 mL) was added methanesulfonic acid (42 muL, 0.65 mmol), followed by dihydropyran (0.89 mL, 9.8 mmol). The mixture was stirred at r.t. for 2 h., and then at 50 C. overnight. After cooling the mixture was concentrated under reduced pressure. The residue was purified by flash chromatography on a silica gel column with ethyl acetate in hexanes (0-50%) to afford the desired product (0.8 g). LCMS (M+H)+=238.0; LCMS (M-84+H)+=154.0/156.0.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1206979-33-0, its application will become more common.

Reference:
Patent; Incyte Corporation; Zhuo, Jincong; Xu, Meizhong; Qian, Ding-Quan; US2014/171405; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1658-42-0, Adding some certain compound to certain chemical reactions, such as: 1658-42-0, name is Methyl 2-(pyridin-2-yl)acetate,molecular formula is C8H9NO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1658-42-0.

To a stirred solution of methyl 2-(pyridin-2-yl)acetate (190 g, 1.260 mol) in 1,4- dioxane (1.9 L) was added Triton-B (Benzyl Trimethyl ammonium hydroxide) (46 mL, 0.252 mol) at room temperature and stirred for 10 min. Acrylonitrile (49.7 mL, 0.760 mol) was dissolved in 1,4-dioxane (0.9 L) and was added drop wise over period of 30 minutes. The resulting reaction mixture was stirred for 16 hr at room temperature. The reaction progress was monitored by TLC. After completion of the reaction (TLC), the reaction mixture was concentrated under reduced pressure to afford the crude title compound. Purification by column chromatography was by using (100-200 silica gels) using 15 percent ethyl acetate and pet. ether as the eluent afforded pure compound.

According to the analysis of related databases, 1658-42-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MANDAL, Mihir; TANG, Haifeng; XIAO, Li; SU, Jing; LI, Guoqing; YANG, Shu-Wei; PAN, Weidong; TANG, Haiqun; DEJESUS, Reynalda; HICKS, Jacqueline; LOMBARDO, Matthew; CHU, Hong; HAGMANN, William; PASTERNAK, Alex; GU, Xin; JIANG, Jinlong; DONG, Shuzhi; DING, Fa-Xiang; LONDON, Clare; BISWAS, Dipshikha; YOUNG, Katherine; HUNTER, David, N.; ZHAO, Zhiqiang; YANG, Dexi; WO2015/112441; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13362-78-2 , The common heterocyclic compound, 13362-78-2, name is (E)-1,2-Di(pyridin-4-yl)ethene, molecular formula is C12H10N2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of (E)-1,2-di(4-pyridyl)ethylene (91 mg, 0.5 mmol) and sodium 2-bromoethanesulfonate (317 mg, 1.5 mmol) (Aldrich) in abs. EtOH (3 mL) was refluxed with stirring for 50 h. The insoluble substance was filtered, washed with benzene, MeOH, and acetone, and re-crystallized from water-EtOH (2.8:1 (v/v), 2.7 mL) to yield 128 mg (64percent) of (E)-3a as a pinkish powder.

The synthetic route of 13362-78-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vedernikov, Artem I.; Lobova, Natalia A.; Kuz’mina, Lyudmila G.; Howard, Judith A.K.; Strelenko, Yuri A.; Alfimov, Michael V.; Gromov, Sergey P.; Journal of Molecular Structure; vol. 989; 1-3; (2011); p. 114 – 121;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 628691-85-0, Adding some certain compound to certain chemical reactions, such as: 628691-85-0, name is 2,4-Dichloro-3-fluoropyridine,molecular formula is C5H2Cl2FN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 628691-85-0.

Step 2: Synthesis of 2-chloro-3-fluoro-4-(4-aminophenoxy)pyridine A solution of 4-aminophenol (24.8 g, 227 mmol) in anhydrous dimethyl sulfoxide (210 mL) was bubbled with nitrogen gas for 10 minutes, and potassium tert-butoxide (26.80 g, 238.8 mmol) was then added to get a reaction mixture. The reaction mixture was stirred at room temperature for 30 minutes, and then 2-chloro-3-fluoro-4-chloropyridine (37.68 g, 227 mmol) was added. The reaction mixture was stirred at room temperature for 5 h, and then diluted with water (1000 mL) and extracted with ethyl acetate (500 mL*3). The organic phases were combined. The combined organic phases were washed with saline solution (500 mL*2), dried with anhydrous sodium sulfate, filtrated, and concentrated. The residue was purified by column chromatography (silica gel, petroleum ether:ethyl acetate=5:1, v/v) to get product as light yellow solid (15.0 g, yield: 28%). 1H NMR (300 MHz, DMSO-d6): delta 5.22 (br s, 2H), 6.62 (d, J=9.0 Hz, 2H), 6.75 (t, J=5.7 Hz, 1H), 6.92 (d, J=9.0 Hz, 2H), 8.05 (d, J=5.7 Hz, 1H) MS (ESI+): m/z 239.1 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 628691-85-0, 2,4-Dichloro-3-fluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PEKING UNIVERSITY FOUNDER GROUP CO., LTD.; PKUCARE PHARMACEUTICAL R&D CENTER; PKU HEALTHCARE INDUSTRY GROUP CO., LTD.; YI, Chongqin; XU, Heng; TAO, Jing; LIN, Songwen; HAN, Fangbin; (42 pag.)US2017/29404; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 13534-97-9, 6-Bromopyridin-3-amine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 13534-97-9, blongs to pyridine-derivatives compound. SDS of cas: 13534-97-9

To a solution of 6-bromopyridin-3-amine (500 mg, 2.89 mmol) in CH3CN:DMF (3:2 mL) was added CuI (219 mg, 1.15 mmol) and triethylamine (2 mL, 14.4 mmol) and the solution was purged with argon for 15 min. Ethynyltrimethylsilane (1.2 mL, 8.67 mmol) and tetrakis(triphenyl phosphine)Pd(0) (100 mg, 0.086 mmol) were added and the solution was purged for another 30 min. The reaction mixture was heated to 45C for 2.5 h. Then, the reaction mixture was diluted with ethyl acetate (100 mL) and washed with saturated NaHCO3 solution (50 mL). The aqueous layer was re-extracted with ethyl acetate (3 X 50 mL). The combined organic layer was washed with water (2 X 50 mL), followed by brine and dried over sodium sulphate and concentrated in vacuo to afford 6-((trimethylsilyl)ethynyl)pyridin-3-amine 5 (776mg, 70percent).1H NMR (400 MHz, CDCl3) delta 8.04 (s, 1H), 7.25 (d, J=7.8 Hz, 1H), 6.91(d, J=7.8 Hz, 1H), 3.85 (br s, 2H), 0.24 (s, 9H). ES-MS m/z 191.00 (M+H)+.

The synthetic route of 13534-97-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LYSOSOMAL THERAPEUTICS INC.; SKERLJ, Renato, T.; LANSBURY, Peter, T.; GOOD, Andrew, C.; BOURQUE, Elyse Marie, Josee; (134 pag.)WO2016/73889; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1215387-58-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1215387-58-8, name is 5-Bromo-1H-pyrrolo[2,3-c]pyridine, molecular formula is C7H5BrN2, molecular weight is 197.03, as common compound, the synthetic route is as follows.

To a stirred solution of 5-bromo-1H-pyrrolo[2,3-c]pyiidine (2.5 g, 12.75 mmol) in DMF (20 mL), 60% NaH (0.57 g, 15.30 mmol) was slowly added portionwise at 0 C. The resulting suspension was stirred at RT for 1h. The reaction mixture was cooled to 0 C and 2-(chloromethoxy)ethyl)trimethylsilane (2.55 g, 15.30 mmol) was added. The reaction mixture was allowed to stir at RT for 2h. The reaction mixture was quenched with water (70 mL), extracted with EtOAc (2 x 100 mL) and the combined organic layers were dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude compound was purified by flash column chromatography and eluted with 15% EtOAc/pet ether to afford the title compound (2.7 g, 66%) as a liquid compound. LC-MS (method 1): R, = 2.73 min; m/z = 329.41 (M+H*+2).

Statistics shows that 1215387-58-8 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-1H-pyrrolo[2,3-c]pyridine.

Reference:
Patent; ORYZON GENOMICS, S.A.; SALAS SOLANA, Jorge; CARCELLER GONZALEZ, Elena; ORTEGA MUNOZ, Alberto; (195 pag.)WO2018/149986; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem