Day: September 15, 2021

Reference of 70201-43-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.70201-43-3, name is 3-Bromoisonicotinaldehyde, molecular formula is C6H4BrNO, molecular weight is 186.0061, as common compound, the synthetic route is as follows.

To a solution of 5-methoxy-1-indanone (0.32 mmol) and 3-bromo-4-pyridinecarboxaldehyde (0.36 g, 2 mmol) in toluene (30 mL) was added p-toluenesulfonic acid (0.45 g, 2.4 mmol). After heated atreflux using a Dean-Stark for 4h, the mixture was cooled to room temperature and the solvent was removed in vacuum, then 5% sodium bicarbonate solution was added until pH 8. After extraction with dichloromethane (4x), the organic layer was dried over magnesium sulfate and concentrated to dryness. The residue was taken up with EtOAc and the solid was filtered, rinsed with EtOAc to afford the title compound 91 as a yellow solid (Yield 330 mg, 50%).1fl NMR (300 MHz, CDC13, 6): 3.91 (br s, 5H), 6.96-7.00 (m, 2H), 7.49 (d, 1H, J 5,1 Hz), 7.74(t, 1H, J= 2.4 Hz), 7.87 (d, 1H, J= 8.4 Hz), 8.58 (d, 1H, J= 5.1 Hz), 8.82 (s, 1H).?3C NMR (75 MHz, CDCI3, 6): 31.7, 55.8, 109.8, 115.8, 123,5, 126.7, 128.2, 131.1, 141.2, 143.1, 148.3, 152.3, 153.0, 165.8, 191.3.

The chemical industry reduces the impact on the environment during synthesis 70201-43-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; INSA (INSTITUT NATIONAL DES SCIENCES APPLIQUEES) DE ROUEN; CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS); UNIVERSITE DE ROUEN; VFP THERAPIES; MARSAIS, Francis; LEVACHER, Vincent; PAPAMICAEL, Cyril; BOHN, Pierre; PEAUGER, Ludovic; GEMBUS, Vincent; LE FUR, Nicolas; DUMARTIN-LEPINE, Marie-Laurence; WO2014/114742; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 10592-27-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10592-27-5, name is 2,3-Dihydro-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

General procedure: Indoles 1 (0.5 mmol), DMSO (3mL) and I2O5 (1 mmol) were added into a flask and vigorously stirred at 80oC under air. The reaction was stopped until indoles were completely consumed as monitored by TLC analysis. After the completion of reaction, saturated Na2S2O3 solution (20 mL) was added to the mixture. The mixture was extracted with EtOAc (3×20 mL) and the organic layer was dried over anhydrous sodium sulfate, filtered and concentrated on a rotary evaporator. Then, the crude product was purified by column chromatography on silica gel using ethyl acetate and petroleum ether as the eluent to give the products 2.

According to the analysis of related databases, 10592-27-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Wang, Ci-Ping; Jiang, Guo-Fang; Tetrahedron Letters; vol. 58; 18; (2017); p. 1747 – 1750;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 586-95-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 586-95-8, name is 4-Pyridinemethanol, molecular formula is C6H7NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a solution of 4-pyridylcarbinol (15 g, 137.4 mmol) in DCM (200 ml) was added thionyl chloride (43.6 ml) and the resulting reaction mixture was stirred at room temperature for 4 h. The mixture was cooled to room temperature and the solvent was evaporated in vacuo. The residue was diluted with DCM and washed with a saturated solution Of NaHCO3. The combined organic layers were dried over Na2SO4 and con- centrated in vacuo to yield intermediate compound 29 (17.18 g, 99 %).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 586-95-8, 4-Pyridinemethanol.

Reference:
Patent; JANSSEN PHARMACEUTICA N.V.; ADDEX PHARMACEUTICALS S.A.; WO2007/104783; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 38749-79-0, 3-Bromo-2-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C6H6BrN, blongs to pyridine-derivatives compound. HPLC of Formula: C6H6BrN

Lithium hexamethyldisilazane (436 mL, 0.44 mmol, 1 M solution in hexanes) was dissolved in diethyl ether (1 L). Compound 26, 3-bromo-2-methylpyridine, (25.0 g, 0.14 mmol) was added. The solution was stuffed for 1 h. Diethyl carbonate (26.0 mL, 0.22 mol) was added and the solution was stirred overnight. The reaction solution was washed three times with half-saturated aqueous sodium chloride (3 x 250 mL) and dried with magnesium sulfate. The solvent was evaporated and the reminder was dissolved in hexanes (200 mL). The solution was filtered through silica pad (10 g), the pad was rinsed with additional hexanes (100 mL) and the solvent was evaporated. The remaining oil was stirred in high vacuum for 1 hour till there were no further bubbles visible. The product was a yellow liquid(37.7 g). LCMS: [M + Hj = 244.1.

The synthetic route of 38749-79-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; KALA PHARMACEUTICALS, INC.; KIM, Jinsoo; NGUYEN, Minh N.; ENLOW, Elizabeth; ONG, Winston Z.; NOWAK, Pawel W.; FEUTRILL, John T.; WO2014/201127; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10235-65-1, name is 4,6-Dichloro-2-(pyridin-2-yl)pyrimidine, the common compound, a new synthetic route is introduced below. HPLC of Formula: C9H5Cl2N3

Intermediate 134: 4-chloro-2-(2-pyridi vdro-2-naphthalenyloxy)pyrimidine1 ,2,3,4-tetrahydro-2-naphthalenol (164.0 mg, 1 .1 1 mmol) was added to a cold (0C) solution of sodium hydride (48.7 mg, 1 .22 mmol) in A/,A/-dimethylformamide (10 ml_). After 30 min of stirring under nitrogen at 0 C, 4,6-dichloro-2-(2-pyridinyl)pyrimidine (250.0 mg, 1 .1 1 mmol) was added. After 16 hr of stirring at r.t., the reaction mixture was cooled at 0 C and sodium hydride (24.0 mg, 0.60 mmol) was added. After 2 hr of stirring under nitrogen at room temperature, water (50 ml_) was added to the reaction mixture, followed by EtOAc (50 ml_). The aqueous layer was further extracted with EtOAc (50 ml_). The combined organic layers was dried through a hydrophobic frit and concentrated to dryness to give a brown oil. The crude was purified by column chromatography eluting with a gradient from 0-50% of EtOAc-cyclohexane to give the impure product (278.0 mg). 168 mg of the impure product was dissolved in 1 :1 MeOH:DMSO (2 mL) and purified by MDAP (Method E). The solvent was evaporated in vacuo to give the title compound as a yellow oil, 64.2 mg (17%).LCMS (Method A): Rt = 1 .25 min, MH+ 338.1 .

The synthetic route of 10235-65-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; ATKINSON, Stephen John; BARKER, Michael David; CAMPBELL, Matthew; HUMPHREYS, Philip; LIDDLE, John; SHEPPARD, Robert John; WILSON, David; WO2012/52390; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1446507-38-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1446507-38-5, name is 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione. A new synthetic method of this compound is introduced below.

POCl3 (175.0 mL) is charged into the reaction vessel at 20-35 C., and 6-(6-trifluoromethyl-pyridin-2-yl)-1H-1,3,5-triazine-2,4-dione (35.0 g, 0.1355 mol) was added in portions at below 50 C. The reaction mixture was de-gassed 5-20 minutes by purging with N2 gas. Phosphorous pentachloride (112.86 g, 0.542 mol) was added while stirring at below 50 C., the resulting slurry was heated to reflux (105-110 C.) and maintained for 3-4 h. The reaction mixture was cooled to 50-55 C., concentrated at below 55 C. then cooled to 20-30 C. The reaction mixture was rinsed with ethyl acetate and the ethyl acetate layer was slowly added to cold water (temperature 5 C.) while stirring and maintaining the temperature below 10 C. The mixture was stirred 3-5 minutes at a temperature between 10 to 20 C. and the ethyl acetate layer was collected. The reaction mixture was rinsed with sodium bicarbonate solution and dried over anhydrous sodium sulphate. The material was dried 2-3 h under vacuum at below 45 C. to provide 2, 4-dichloro-6-(6-trifluoromethyl-pyridin-2-yl)-1, 3, 5-triazine.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1446507-38-5, 6-(6-(Trifluoromethyl)pyridin-2-yl)-1,3,5-triazine-2,4(1H,3H)-dione, and friends who are interested can also refer to it.

Reference:
Patent; Agios Pharmaceuticals, Inc.; Agresta, Samuel V.; (34 pag.)US2018/311249; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 603305-89-1, 7-Bromothieno[3,2-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 603305-89-1, blongs to pyridine-derivatives compound. Recommanded Product: 603305-89-1

General procedure: A dry Schlenk tube was charged under Ar with dry toluene (3 mL), the fluoro or methoxyanilines (1.1 equiv.), Pd(OAc)2 (6 mol%), BINAP (8 mol%), Cs2CO3 (2 equiv.) and compound 1. The mixture was heated with stirring under Ar at 100 C for 2 h. After cooling water (5 mL) and ethyl acetate (5 mL) were added. The phases were separated and the aqueous phase was extracted with more ethyl acetate (2 × 5 mL). The organic phase was dried (MgSO4) and filtered. Removal of the solvent gave a solid which was submitted to a dry flash in silica using ether or AcOEt and a solid was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,603305-89-1, its application will become more common.

Reference:
Article; Queiroz, Maria-Joao R.P.; Peixoto, Daniela; Calhelha, Ricardo C.; Soares, Pedro; Dos Santos, Tiago; Lima, Raquel T.; Campos, Joana F.; Abreu, Rui M.V.; Ferreira, Isabel C.F.R.; Vasconcelos, M. Helena; European Journal of Medicinal Chemistry; vol. 69; (2013); p. 855 – 862;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4021-11-8, name is 2-Methylisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 4021-11-8

A suspension of 2-methyl-pyridine-4-carboxylic acid (1.0 g, 7.29 mmol) in methanol (50 ml_) and H2SO4 (0.5 ml_) is heated to 700C. The solid material dissolves and stirring is continued at 700C for 18 h. The mixture is cooled to rt, filtered, and the filtrate is evaporated. The remaining solid is washed with diethyl ether and dried to give methyl 2-methyl-pyridine-4-carboxylate; LC-MS: tR = 0.39 min, [IVM]+ = 152.05. This material is dissolved in 7 N NH3 in methanol (25 ml_) and the mixture is stirred in a sealed vial for 20 h at 60C before it is filtered. The filtrate is evaporated to give crude 2-methyl-isonicotinamide (2.12 g) as a brownish solid. To a solution of this material in DCM (25 ml_), pyridine (5.24 g, 54.0 mmol) is added. The mixture is cooled to 00C before trifluoroacetic anhydride (8.10 g, 38.6 mmol) is added portionwise. Stirring is continued at 00C for 2 h before the reaction is quenched with water. The mixture is diluted with DCM and the org. phase is separated and washed with 5% aq. citric acid solution followed by sat. aq. NaHCO3 solution. The washings are extracted back twice with DCM. The combined org. extracts are dried over MgSO4, filtered and concentrated. The crude product is purified on prep. TLC plates with heptane:EA 4:1 to give 2-methyl-isonicotinonitrile (330 mg); LC-MS: tR = 0.55 min, [M+1]+ = 119.13.

With the rapid development of chemical substances, we look forward to future research findings about 4021-11-8.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/24905; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 911434-05-4, Adding some certain compound to certain chemical reactions, such as: 911434-05-4, name is 5-Bromo-2-methyl-3-nitropyridine,molecular formula is C6H5BrN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 911434-05-4.

0208] Step 1. 5-Bromo-2-methyl-pyridin-3-ylamine. To a stirred mixture of iron filings (5 g, 89.29 mmol, 3.88 equiv) and ammonium chloride (1 g, 18.70 mmol, 0.81 equiv) in ethanol (66 mL) and water (33 mL) was added a solution of 5-bromo-2-methyl-3- nitropyridine (5 g, 23.04 mmol, 1.00 equiv) in ethanol (50 mL) dropwise at 90 C. The reaction mixture was stirred for 10 min at 90 C and then cooled to rt. The solid material was removed by filtration. The filtrate was concentrated under vacuum and the residue was purified on a silica gel column eluted with ethyl acetate/petroleum ether (1:2) to yield 1.6 g (37%) of the title compound as a yellow solid. LC/MS (Method I, ESI): RT= 0.81 min, m/z = 187.0; 189.0 [M+H

According to the analysis of related databases, 911434-05-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; FORMA TM, LLC; BAIR, Kenneth, W.; BAUMEISTER, Timm, R.; BUCKMELTER, Alexandre, J.; CLODFELTER, Karl, H.; GUNZNER-TOSTE, Janet; HAN, Bingsong; LIN, Jian; REYNOLDS, Dominic, J.; SMITH, Chase, C.; WANG, Zhongguo; ZAK, Mark; ZHENG, Xiaozhang; ZHAO, Guiling; WO2013/130943; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 130658-65-0, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 130658-65-0, name is 1-(Pyridin-4-yl)piperidin-4-ol, molecular formula is C10H14N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

EXAMPLE 31 Azodicarbonyldipiperidine (20.03 g), tributylphosphine (16.06 g) and 1-(4-pyridyl)-4-piperidin-1-ol (9.43 g) were added to a stirred solution of N-t-butyloxycarbonyl-4-aminophenol (11.08 g) in dry THF (300 ml), cooled under a blanket of nitrogen to 10 C. A thick precipitate formed and the mixture was stirred at ambient temperature for 20 hours during which time the mixture slowly thinned. The precipitated tributylphosphine oxide was removed by filtration and the residue concentrated in vacuo. The residue was purified by flash chromatography on silica gel using ethyl acetate followed by dichloromethane containing an increasing amount of methanol (up to 5% methanol) as eluent to give a solid (7.38 g). mp 192-195 C. A solution of this solid (4.22 g) in dichloromethane (400 ml) was treated with a saturated solution of hydrogen chloride in ether (50 ml) and the mixture was stirred for 64 hours. The mixture concentrated in vacuo and the residue crystallized from methanol/ether to give 1-(4-pyridyl)-4-(4-aminophenyloxy)piperidine hydrochloride (2.85 g), mp. 289-291 C. NMR: 1.73 (m,2H), 2.06 (m,2H), 3.64 (m,2H), 3.94(m,2H), 4.76 (m,1H), 7.12(d,2H), 7.24(d,2H), 7.34(d,2H), 8.23(d,2H), 10.32 (broad, 2H); MS: m/z 270 (MH)+. This solid (1.5 g) was dissolved in water (10 ml) and 2M sodium hydroxide added until precipitation was complete.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 130658-65-0, 1-(Pyridin-4-yl)piperidin-4-ol.

Reference:
Patent; Zeneca Limited; US6313127; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem