Day: September 15, 2021

Reference of 1235342-53-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1235342-53-6, name is 3-(Bromomethyl)-5-methylpyridine hydrobromide. A new synthetic method of this compound is introduced below.

An inert atmosphere N2 was passed through a 1 L three-necked round bottom flask and held.3-Bromomethyl-5-methylpyridine hydrobromide (Compound A, 20 g, 74.92 mmol) was added.Dichloromethane (200ml) and water (40g),Then, sodium hydrogencarbonate (27.1 g, 322.58 mmol) was added dropwise with stirring at 0 C.Aqueous solution (40ml)And m-CPBA (37.1g, 214.99mmol)A solution of dichloromethane (200 ml).Stir at room temperature for 2 hours.The resulting solution was extracted with 5 x 200 ml of dichloromethane.Combine the organic layers,Dry with anhydrous sodium sulfate,Concentrate in vacuo.The residue was applied to a silica gel column eluting with dichloromethane/methanol.Get 7.5g (50%)Compound B3-bromomethane-5-methylpyridine-N-oxide pale yellow solid,The test results are shown in Figure 1.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1235342-53-6, 3-(Bromomethyl)-5-methylpyridine hydrobromide, and friends who are interested can also refer to it.

Reference:
Patent; Hangzhou Aoyi Baoling Pharmaceutical Co., Ltd.; Fang Yuan; Jin Yukun; Gong Wen; Li Fugao; Sun Xiaoyan; Ling Jue; Yu Yingmin; (15 pag.)CN109678841; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 117519-09-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 117519-09-2, name is 3-Amino-2-chloro-6-(trifluoromethyl)pyridine, molecular formula is C6H4ClF3N2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

PREPARATION 173; 4-Bromo-2-chloro-6-trifluoromethyl-pyridin-3-ylamine; 6-Trifluoromethyl-pyridin-3-ylamine (150 g, 925 mmol) was suspended in 500 ml acetonitrile. Added to the solution was N-Chlorosuccinimide (124 g, 925 mmol) and the mixture heated at 80 C. for 2 h after which N-bromosuccinimide (165 g, 925 mmol) was added and the mixture heated at 80 C. for a further 3 h. The rm was cooled to ambient temperature, concentrated in vacuo and triturated in 100 ml diethyl ether, removing the precipitate by filtration. The resulting filtrate was concentrated in vacuo and purified by column chromatography on silica, eluting with Hept:EtOAc, 4:1 to give the title compound as a dark red oil (220 g, 86%).1H NMR (CDCl3) 4.90 (bs, 2H), 7.67(s, 1H); LRMS (ES) m/z 275/277 [MH]+

According to the analysis of related databases, 117519-09-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; US2007/197478; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 71469-93-7, Methyl 4-aminopyridine-2-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 71469-93-7, blongs to pyridine-derivatives compound. Formula: C7H8N2O2

To a solution of 2-(2-methoxyphenyl)acetic acid (218 mg, 1.31 mmol) in DMF (4 mL) was added HOAt (179 mg, 1.31 mmol), EDCI (328 mg, 1.71 mmol), DIPEA (574 muL, 3.29 mmol) and methyl 4-aminopyridine-2-carboxylate (200 mg, 1.31 mmol) and the mixture was stirred at room temperature for 6 hours 15 minutes. The resulting mixture was partitioned between H2O (30 mL) and DCM (30 mL) and the two phases separated. The aqueous was further extracted with DCM (30 mL) and the combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The crude product was purified by chromatography on silica eluting with EtOAc in heptane to afford the titled compound as a pale yellow gum.1H NMR (500 MHz, Chloroform-d) delta 8.58 (d, J = 5.5 Hz, 1H), 8.10 (s, 1H), 7.92 (dd, J = 5.5, 2.2 Hz, 1H), 7.84 (d, J = 2.1 Hz, 1H), 7.37- 7.32 (m, 1H), 7.29 (dd, J = 7.4, 1.5 Hz, 1H), 7.04- 6.97 (m, 2H), 3.98 (s, 3H), 3.97 (s, 3H), 3.75 (s, 2H).LC-MS (Method E): Rt 0.96 mins; MS m/z 301.1 = [M+H]+ (99% 215nm)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,71469-93-7, its application will become more common.

Reference:
Patent; ENTERPRISE THERAPEUTICS LIMITED; COLLINGWOOD, Stephen; MCCARTHY, Clive; HARGRAVE, Jonathan, David; HAY, Duncan, Alexander; SCHOFIELD, Thomas, Beauregard; ELLAM, Sarah; BUXTON, Craig; HABGOOD, Matthew; INGRAM, Peter; MA, Chun Yan; NAPIER, Spencer; SHAIKH, Abdul; SMITH, Matthew; STIMSON, Christopher; WALKER, Edward; (401 pag.)WO2019/145726; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 183208-35-7 ,Some common heterocyclic compound, 183208-35-7, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step 1: (0558) To a solution containing compound 6 (2.0 g, 10.15 mmol) dissolved in N,N-dimethylformamide (78.93 mL, 1015.05 mmol) was added 1-iodopyrrolidine-2,5-dione (2.28 g, 10.15 mmol) and the solution was allowed to stir at room temperature for 2 hours. Upon completion, the reaction mixture was poured into a saturated aqueous sodium thiosulfate solution and extracted with ethyl acetate (3×150 mL). The organic layers were combined, washed with brine, dried over anhydrous sodium sulfate, filtered, and then evaporated to dryness to give 3.15 grams of compound 7 in about 95% purity.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,183208-35-7, its application will become more common.

Reference:
Patent; Plexxikon Inc.; Lin, Jack; Pham, Phuongly; Buell, John; Dong, Ken; Ibrahim, Prabha; Spevak, Wayne; Tsang, Garson; Wu, Guoxian; Zhang, Ying; (183 pag.)US2016/326162; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 70201-43-3, 3-Bromoisonicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H4BrNO, blongs to pyridine-derivatives compound. Formula: C6H4BrNO

[0068] To a solution of 3-bromo-4-pyridinecarboxaldehyde 3 (3.0 g, 16.2 mmol) in absolute methanol (40 mL) was added NaBH4 (0.736 g 19.5 mmol) at 0C. The mixture was stirred at 0C for 2 hours under nitrogen. The solvent was then removed under vacuum. Water and ethyl acetate were added and the organic layer was washed with water, dried over Na2SO4 and evaporated under vacuum to afford the compound 4 (3.021 g, 100%) as a white powder. 1H NMR (CDCl3, 300 MHz, 298 K, delta ppm): 8.61 (s, 1 H), 8.51 (d, 1H, J = 4.8 Hz), 7.55 (d, 1H, J = 4.8 Hz), 4.76 (s, 2 H), 2.89 (s, 1H). 13C NMR (CDCl3, 75.5 MHz, 298 K, delta ppm): 151.14, 149.45, 148.54, 122.47, 119.90, 63.47. GC/MS (m/z): 188 IR (KBr, v, cm-1): 3152, 2894, 2829, 1593, 1447, 1401, 1333, 1223, 1170, 1070, 1024, 834, 705, 599

The synthetic route of 70201-43-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSA (Institut National des Sciences Appliquees) de Rouen; Centre National de la Recherche Scientifique (CNRS); Universite de Rouen; VFP Therapies; Marsais, Francis; Levacher, Vincent; Papamicael, Cyril; Bohn, Pierre; Peauger, Ludovic; Gembus, Vincent; Le Fur, Nicolas; Dumartin-Lepine, Marie-Laurence; EP2759536; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 116632-24-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 116632-24-7, name is 2-Amino-4,6-dichloropyridine. A new synthetic method of this compound is introduced below.

Reference Example 4 6-chloro-4-fluoropyridin-2-amine (0375) 7.46 g (49.11 mmol) of cesium fluoride were added at room temperature to a mixed solution of 2.00 g (12.27 mmol) of 4,6-dichloropyridin-2-amine and 30 ml dimethyl sulfoxide. After completion of the addition, said reaction mixture liquid was stirred for 12 hours at 170 C. After completion of the stirring, the reaction was stopped by addition of 100 ml of water, and said reaction liquid was extracted with ethyl acetate (2×300 ml). The organic layer obtained was dried with anhydrous sodium sulfate, and the solvent distilled off under reduced pressure. The residue obtained was purified by silica gel chromatography (n-hexane:ethyl acetate=9:1 to 5:5), and 95 mg of the desired compound were obtained as a white solid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116632-24-7, its application will become more common.

Reference:
Patent; SYNGENTA PARTICIPATIONS AG; NAKAYA, Yoshihiko; MASUZAWA, Yoshihide; FURUHASHI, Takamasa; MIYAKADO, Yuuki; HOTTA, Hiroyasu; INABA, Masamitsu; (76 pag.)US2016/221998; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 104508-24-9 ,Some common heterocyclic compound, 104508-24-9, molecular formula is C7H5BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Racemic 2,2-difluoro-8-(1-hydroxyethyl)-2H-1 ,4-benzoxazin-3(4H)-one (50 mg; may be prepared as described in intermediate 4), 6-(bromomethyl)-2-pyridinecarbonitrile (64.5 mg, may be prepared as described in intermediate 39), potassium carbonate (60.3 mg, 0.436 mmol) and potassium iodide (0.362 mg, 2.182 mumol) were dissolved in DMF (2000 mul) in a 10 ml. round-bottomed flask open to the atmosphere and stirred at room temperature overnight. The reaction mixture was evaporated to dryness, redissolved in EtOAc (30ml) and treated with saturated aqueous sodium bicarbonate (30ml). The aqueous layer was extracted with EtOAc (2x30ml) and the organic layers were combined, washed with brine (30ml), dried over magnesium sulfate, fiitered and evaporated to dryness to give the crude product (94mg) as a pale yellow oil. The crude product was purified on a 25+S Biotage silica cartridge, eluting with a 0 to 70 % mixture of EtOAc in hexane to give a colourless oil (67 mg). 53 mg of this racemic mixture was resolved using a Chiralpak IA column eluting with heptane: ethanol (80:20) v/v pump- mixed. Using these conditions the faster-running enantiomer (18 mg, Compound 61 or 62) and the slower-running enantiomer (17 mg, Compound 61 or 62) were obtained in >98% enantiomeric excess as white solids. 1H NMR (CD3OD) delta: 1.45 (3H, d), 5.24 (1 H, q), 5.43 (2H, s), 7.10 (1 H, dd), 7.20 (1 H, t), 7.39, (1 H, d), 7.65 (1 H, d), 7.78 (1 H, d), 7.98 (1 H, t). m/z [M+H]+: 346.2. Retention time 0.91 min (LC/MS method 3).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,104508-24-9, its application will become more common.

Reference:
Patent; GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan; WO2011/12622; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 15128-82-2, 2-Nitropyridin-3-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C5H4N2O3, blongs to pyridine-derivatives compound. Computed Properties of C5H4N2O3

Preparation 3; Preparation of 3-Oxo-3,4-dihydro-2/-/-pyridoF3,2-d1f 1 ,41oxazine-6-carboxaldehvde; (a) 2-Bromo-5-hydroxy-6-nitropyridine; 3-Hydroxy-2-nitropyridine (20 g, 0.143 mole) was dissolved in methanol (400 ml_) and a solution of 25% sodium methoxide in methanol (33 ml_, 0.13 mole) was added at – room temperature. The mixture was stirred for 30 min, then was cooled to 0 0C, and bromine (7.2 ml_, 0.14 mole) was added slowly. The reaction was stirred at 0 0C for 30 min, then was quenched with glacial AcOH (2.5 ml_). The solvent was removed in vacuo to afford material (30 g, 96%), which was used without further purification: MS (ES) m/z219.0 (M + H)+.

The synthetic route of 15128-82-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/81179; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 15128-82-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 15128-82-2, name is 2-Nitropyridin-3-ol, molecular formula is C5H4N2O3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Hydroxy-2-nitropyridine (175 mg, 1.21 mmol) and triphenylphosphine (440 mg, 1.65 mmol) were added sequentially to a stirred solution of (1S)-1-(2,6-dichloro-3-fluorophenyl)ethanol (229.8 mg, 1.1 mmol) in THF (10 mL) under a nitrogen atmosphere. The reaction mixture was maintained at room temperature for 1 h and then diisopropyl azo-dicarboxylate (0.34 mL, i.65 mmol) was added at 0C. The mixture was stirred for an additional 12 h. The reaction mixture was evaporated under vacuum to give an oil. The residue was purified by flash chromatography (eluting with 20->25% EtOAc in hexanes) to give the title compound as a white solid (321.5 mg; 0.97 mmol; 88.3% yield); MS (APCI) (M+H)+ 331; SFC-MS: 99.5%ee. 1H NMR (400 MHz, chloroform-D) 8 ppm 1.85 (d, J=6.6 Hz, 3 H) 6.10 (q, J=6.6 Hz, 1 H) 7.04 -7.13 (m, 1 H) 7.21 (dd, J=8.5, 1.14 Hz, 1 H) 7.30 (dd, ^=9.0, 4.9 Hz, 1 H) 7.37 (dd, J=Q.6, 4.6 Hz, 1 H) 8.04 (dd, Jt4.6, 1.3 Hz, 1 H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 15128-82-2, 2-Nitropyridin-3-ol.

Reference:
Patent; PFIZER INC.; WO2006/21886; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 849937-96-8, 5-Bromo-2,4-dichloropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, COA of Formula: C5H2BrCl2N, blongs to pyridine-derivatives compound. COA of Formula: C5H2BrCl2N

Example 123 N-[l-cyclopropyl-2-(5-methyl-l,2,4-oxadiazol-3-yl)propan-2-yl]-5-(3-hydroxyoxetan- 3-yl)-4-(2,2,2-trifluoroethoxy)pyridine-2-carboxamide 3-(4,6-dichloro-3-pyridyl)oxetan-3-ol To a solution of 5-bromo-2,4-dichloropyridine (CAN 849937-96-8, 15 g, 66.1 mmol) in dry THF (300 ml) cooled down to -15C under an argon atmosphere was added isopropyl magnesium chloride, lithium chloride complex (53.4 ml, 69.4 mmol) and the mixture was stirred at -15C for 1 hour. Then oxetan-3-one (5.24 g, 72.7 mmol) was added neat to the reaction mixture cooled at -15C, reaction mixture was stirred and let to warm up to room temperature overnight. Reaction was quenched by addition of water and stirred for 5 minutes. Reaction was diluted with ethyl acetate and was transfered into a separatory funnel. The organic phase was extracted with a saturated aqueous solution of ammonium chloride and the organic phase was collected. The aqueous phase was back-extracted with ethyl acetate. The combined organic phases were dried over sodium sulfate and evaporated down to dryness. The crude material was purified by flash chromatography on silica eluting with a heptane/ethyl acetate gradient to yield the title compound (10.5mg, 72%). MS (ESI, m/z): 220.4 (M+H+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,849937-96-8, 5-Bromo-2,4-dichloropyridine, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; GRETHER, Uwe; KIMBARA, Atsushi; NETTEKOVEN, Matthias; RICKLIN, Fabienne; ROEVER, Stephan; ROGERS-EVANS, Mark; ROMBACH, Didier; SCHULZ-GASCH, Tanja; WESTPHAL, Matthias; WO2014/86805; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem