Day: September 24, 2021

Application of 109-09-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.109-09-1, name is 2-Chloropyridine, molecular formula is C5H4ClN, molecular weight is 113.54, as common compound, the synthetic route is as follows.

Synthesis of pyridin-2-yl-hydrazine (2): To a stirredsolution of 1 (20 g, 0.176 mol, 1 equiv) in hydrazine hydrate (200 mL, 10 vol) was stirred at 100 C for 48 h. When TLC (8:2 EtOAc and methanol) showed complete consumption of the starting material, the reaction mixture was diluted with water (200 mL) and extracted with ethyl acetate (5 × 500 mL), dried over Na2SO4 evaporated to dryness under reduced pressure to afford 2 (15.0 g, 78 %) as a red oil; 1H NMR (300 MHz,CDCl3): delta 8.14 (1H, d, J = 3 Hz, Ar-H), 7.51-7.45 (1H, m, Ar-H), 6.71-6.66 (2H, m, Ar-H), 5.78 (1H, brs, -NH), 3.81 (2H,brs, -NH2); LCMS calculated for C5H7N3: 109.13; Found 110.1,[M+H]+

The chemical industry reduces the impact on the environment during synthesis 109-09-1, I believe this compound will play a more active role in future production and life.

Reference:
Article; Gandikota, N. Murthy; Bolla, R. Sekhar; Viswanath, I. V. Kasi; Bethi, Sridharreddy; Asian Journal of Chemistry; vol. 29; 9; (2017); p. 1920 – 1924;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 106047-17-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 106047-17-0 as follows.

REFERENTIAL EXAMPLE 239 4-[4-(Methoxycarbonyl)phenyl]pyridine N-oxide: The compound (1.49 g) obtained in Referential Example 238 was dissolved in methylene chloride (30 ml), 70% m-chloroperbenzoic acid (3.46 g) was added, and the mixture was stirred at room temperature for 1 hour. An aqueous solution of sodium sulfite was added to conduct liquid separation. The resultant organic layer was washed with a saturated aqueous solution of sodium hydrogencarbonate and then dried over anhydrous sodium sulfate. The solvent was distilled off to obtain the title compound (1.33 g). 1H-NMR (DMSO) delta: 3.88(3H,s), 7.86(2H,d,J=7.2 Hz), 7.94(2H,d,J=8.3 Hz), 8.05(2H,d,J=8.3 Hz), 8.30(2H,d,J=7.2 Hz). MS (FAB) m/z: 230(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,106047-17-0, its application will become more common.

Reference:
Patent; DAIICHI PHARMACEUTICAL CO., LTD.; US2005/20645; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 882499-87-8 ,Some common heterocyclic compound, 882499-87-8, molecular formula is C7H7BrN2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A mixture of compound 14-1 (10.0 g, 43.28 mmol) and LiOH (5.46 g, 129.8 mmol) in THF (400 mL), MeOH (200 mL) and water (100 mL) was stirred at 70 C for 2 hrs under an atmosphere of N2. Subsequently, the reaction mixture was cooled to 0 C and adjusted its pH value to 6 by adding coned, aq. HC1. The resulting suspension was filtered and the solid was dried in vacuo to give compound 14-2 (7.8 g, 83% yield). LC-MS (ESI): m/z 211 [M+H]+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,882499-87-8, its application will become more common.

Reference:
Patent; PRESIDIO PHARMACEUTICALS, INC.; ZHONG, Min; LI, Leping; WO2012/58125; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 139022-25-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.139022-25-6, name is Imidazo[1,2-a]pyridine-6-carboxylic acid, molecular formula is C8H6N2O2, molecular weight is 162.15, as common compound, the synthetic route is as follows.

To a stirred solution of compound D (2.5 g,15.4 mmol, 1 eq) in DMF (50 mL) were added compound E (2.3g, 23.1 mmol, 1.5 eq), triethylamine (15.6 g, 154.3 mmol, 10 eq) and T3P (-50% in ethyl acetate, 14.8 g, 23.1 mmol, 1.5 eq) at 23 C and the resulting mixture was heated at 120 C for 18 h. The reaction mixture was cooled to RT, quenched with water and the organic components were extracted with 10% methanol/ CH2CI2. The organic layer was concentrated in vacuo and the crude material was purified by flash chromatography (Combiflash) using 100-200 mesh silica gel eluting with 10% MeOH/ CH2CI2 to obtain the compound F (600 mg, 20%) as off white solid. (0302) [0292] lH NMR (400 MHz, OMSO-d6) delta 9.03 (s, 1 H), 8.06 (s, 1 H), 7.64 (m, 1 H), 7.59 (d, / = 8 Hz, 1 H), 7.47-7.44 (m, 1 H), 3.61 (s, 3 H), 3.32 (s, 3 H); (0303) [0293] LCMS : m/z = 206.2 [M+H], RT = 0.54 minutes; (Program Rl , Column W).

Statistics shows that 139022-25-6 is playing an increasingly important role. we look forward to future research findings about Imidazo[1,2-a]pyridine-6-carboxylic acid.

Reference:
Patent; ASANA BIOSCIENCES, LLC; THOMPSON, Scott, K.; PRIESTLEY, Tony; KUNDU, Mrinalkanti; SAHA, Ashis; NATH, Suvadeep; (126 pag.)WO2018/64135; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100-26-5, name is 2,5-Pyridinedicarboxylic acid. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,5-Pyridinedicarboxylic acid

To a mixture containing Cu(ClO4)2·6H2O (0.190 g, 0.5 mmol) and tris(3-aminopropyl)amine, trpn (0.0.094 g, 0.5 mmol) dissolved in MeOH (20 mL), an aqueous solution (5 mL) of pyridine-2,5-dicarboxylic acid disodium salt (0.053 g, 0.25 mmol) was added. The solution was then heated on a steam-bath for 10 min, filtered through celite and the resulting blue solution was allowed to stand at room temperature. The crude solid, which separated was collected by filtration. Crystallization of the product from H2O afforded tiny blue crystals suitable for X-ray analysis. These were collected by filtration, washed by propan-2-ol, Et2O and dried in air (overall yield: 0.150 g, 82% based on Cu(ClO4)2·6H2O). Characterization: C32H54Cl2Cu3N10O16 (1096.37 g/mol): Calcd: C, 35.06; H, 4.96; N, 12.78. Found: C, 34.88; H, 5.01; N,12.63%. Selected IR bands (ATR, cm1): 3323 (m), 3285 (m) nu(NeH) stretching; 2934 (w), 2889 (w) nu(CeH) stretching; 1594 (s), 1436 (vs)[nu(C]O+C]C+C]N)]; 1070 (vs, b) nu(CleO). UV-Vis (H2O): lambdamax, nm (epsilonmax M-1 cm-1 per Cu atom)=562 (sh), 679 (85), 906 (sh).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 100-26-5, 2,5-Pyridinedicarboxylic acid.

Reference:
Article; Louka, Febee R.; Haq, Sabriah J.; Guidry, Hollie R.; Williams, Bailey R.; Henary, Maher M.; Fischer, Roland C.; Torvisco, Ana; Massoud, Salah S.; Mautner, Franz A.; Inorganica Chimica Acta; vol. 500; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 113124-09-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 113124-09-7, name is 5,6-Dimethylnicotinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

13,0 g of trifluoromethane sulfonic acid was added dropwise to a mixture of 0,91 g (7,0 mmol)2,3-dimethylpyridi ne-5-carbonitrile and 2,0 g (9,0 mmol) I -(2-fluorophenyl)-2-(2-pyridyl)propan-2-olin 40 ml dichloroethane at 0 – 5C. After 2 days at room temperature the reaction mixture was poured onto sodium carbonate solution, the organic layer was separated and the aqueous layer was extracted with dichloromethane. The combined organic extracts were extracted withsodium hydrogen carbonate and water, evaporated and the residue was purified via MPLC with water/acetonitrile mixtures to yield 0,11 g (4 %) of the title compound as a light yellow oil. 1H.NMR (CDCI3, 6 in ppm): 8,7 (s, 1H); 8,6 (d, 1H); 7,8 (m, 2H); 7,6 (m, 1H); 7,3-7,1 (m, 4H);3,4 (d, IH); 3,3, (d, IH); 2,6 (s, 3H); 2,4 (s, 3H); 1,6 (s, 6H).*HPLCMS: Rt = 0,743 mm; M+H = 346,1

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 113124-09-7, 5,6-Dimethylnicotinonitrile.

Reference:
Patent; BASF SE; MUELLER, Bernd; CAMBEIS, Erica; LOHMANN, Jan Klaas; ESCRIBANO CUESTA, Ana; WOLF, Antje; FEHR, Marcus; RIEDIGER, Nadine; TERTERYAN-SEISER, Violeta; GRAMMENOS, Wassilios; WINTER, Christian; (151 pag.)WO2018/54721; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1195-59-1 , The common heterocyclic compound, 1195-59-1, name is 2,6-Pyridinedimethanol, molecular formula is C7H9NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A) Synthesis of 2,6-bis-(chloromethyl)pyridine To thionyl chloride (11.6 ml, 158 mmoles), cooled at 0 C., 2,6-bis-(hydroxymethyl)pyridine (4 g, 28 mmoles) is added very slowly. The obtained solution is left under stirring for 2 hours at room temperature, then the thionyl chloride in excess is evaporated at a reduced pressure. The obtained residue is treated with chloroform and it is evaporated again at a reduced pressure to remove the thionyl chloride residues. The raw product is treated with chloroform and washed with water. The organic phase is anhydrified with sodium sulphate and dried obtaining 4.81 g of the product as white solid having melting point=76-78 C.

The synthetic route of 1195-59-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Del Soldato, Piero; Benedini, Francesca; Antognazza, Patrizia; US2004/23933; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 142404-69-1, Adding some certain compound to certain chemical reactions, such as: 142404-69-1, name is 2-(Chloro(4-chlorophenyl)methyl)pyridine,molecular formula is C12H9Cl2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 142404-69-1.

General procedure: To a stirred solution of (1-(2-phenoxyethyl)piperidin-4-yl)methanol (0.3 g, 1.27 mmol) in THF (5 mL) was added sodium hydride (0.046 g, 1.9 mmol, 1.5 equiv) and 10 minutes later, 2-(chloro(4-chlorophenyl)methyl)pyridine (0.304 g, 1.27 mmol, 1.0 equiv) at room temperature. The reaction mixture was heated at 80 C and stirred for 16 h. After completion,water was added to the reaction mixture and extracted with EtOAc. The combined organic extract was washed with brine, dried over sodium sulphate, filtered and concentrated under reduced pressure. Purification using prep HPLC purification to furnish 0.0 12 g of 2-((4- chlorophenyl)(( 1 -(2-phenoxyethyl)piperidin-4-yl)methoxy)methyl)pyridine (Yield = 2%). 1H NMR (400 MHz, CD3OD-d4): 8.45-8.43 (m, 1H), 7.86-7.82 (m, 1H), 7.62-7.60 (m, 1H),7.39-7.36 (m, 2H), 7.32-7.23 (m, 5H), 6.93-6.89 (m, 3H), 5.42 (s, 1H), 4.12 (t, 2H, J =5.6Hz), 3.36 (d, 2H, J = 6.0Hz), 3.07 (d, 2H, J = 11.6Hz), 2.82 (t, 2H, J = 5.6Hz), 2.22-2.16 (m, 2H), 1.89-1.69 (m, 3H), 1.46-1.36 (m, 2H); ESI+ MS: m/z: 437 ([M + Hj).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 142404-69-1, 2-(Chloro(4-chlorophenyl)methyl)pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE BROAD INSTITUTE, INC.; MASSACHUSETTS INSTITUTE OF TECHNOLOGY; HOLSON, Edward; WAGNER, Florence, Fevrier; WEIWER, Michel; SCOLNICK, Edward; PALMER, Michelle; LEWIS, Michael; PAN, Jennifer, Q.; ZHANG, Yan-Ling; XU, Qihong; (323 pag.)WO2016/100823; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 958358-00-4 ,Some common heterocyclic compound, 958358-00-4, molecular formula is C8H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Di-tert-butyl dicarbonate (2.45 g) was added in one portion to a mixture of 5-bromo- 6-methyl-lH-pyrrolo[2,3-b]pyridine (1.97g) and methylene chloride (100 ml). 4-Dimethylaminopyridine (0.011 g) was added and the reaction mixture was stirred at ambient temperature for 16 hours. The resultant mixture was evaporated and the residual oil was purified by column chromatography on silica using a 5:1 mixture of isohexane and methanol as eluent. There was thus obtained 5-bromo-l-fert-butoxycarbonyl-6-methyl- lH-rhoyrrolo[2,3-b]rhoyridine as a solid (2.34 g); 1H NMR Spectrum: (DMSOd6) 1.62 (s, 9H), 2.66 (s, 3H), 6.63 (d, IH), 7.75 (d, IH), 8.27 (s, IH); Mass Spectrum: M+H1″ 309.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,958358-00-4, its application will become more common.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/135398; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 133627-45-9, name is 2-Chloro-4-methylpyridin-3-amine, molecular formula is C6H7ClN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C6H7ClN2

(1) Synthesis of 3-bromo-2-chloro-4-methylpyridine 3-amino-2-chloro-4-methylpyridine (2 g) was added to a mixed solvent of a 48% aqueous hydrogen bromide solution (17 mL) and water (12 mL). Sodium nitrite (2.5 g) was added to the solution at 0 C. Further, bromine (22 mL) was added. The reaction mixture was warmed to room temperature and stirred for 12 hours. The reaction mixture was partitioned by adding a 5 N aqueous sodium hydroxide solution and ethyl acetate. The organic layer was washed with brine and then dried over anhydrous magnesium sulfate. The desiccant was removed by filtration. The filtrate was concentrated under reduced pressure to give the title compound (1.7 g). 1H-NMR (400 MHz, CDCl3) delta (ppm): 2.51 (s, 3H), 7.01-7.24 (m, 1H), 8.06-8.35 (m, 1H).

With the rapid development of chemical substances, we look forward to future research findings about 133627-45-9.

Reference:
Patent; EISAI R&D MANAGEMENT CO., LTD.; Norimine, Yoshihiko; Takeda, Kunitoshi; Hagiwara, Koji; Suzuki, Yuichi; Ishihara, Yuki; Sato, Nobuaki; US2013/143907; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem