Sep-21 News Simple exploration of 186593-43-1

According to the analysis of related databases, 186593-43-1, the application of this compound in the production field has become more and more popular.

Related Products of 186593-43-1, Adding some certain compound to certain chemical reactions, such as: 186593-43-1, name is 5-Amino-3-bromo-2-methylpyridine,molecular formula is C6H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 186593-43-1.

General procedure: 1.2.2.1. General method Bl To a stirred solution of Intermediate Gen-1 (1 to 1.2 eq.), and amine derivative (1 eq.) in DCM or DMF are added TBTU or HATU (1 to 1.2 eq.) followed by TEA or NMM (2 to 3 eq.) at room temperature under argon, the reaction mixture is stirred at room temperature until completion. Then the reaction is quenched with water, the layers are separated. The organic layer is dried over Na2SO i, filtered and evaporated to dryness. Alternatively, the reaction is concentrated in vacuo, the residue is partionned between EtOAc or a mixture of EtOAc/nBuOH and a saturated aqueous NH4C1 solution or water. The layers are separated, the organic layer is dried over Na2S04, filtered and evaporated to dryness. Then the residue is purified by chromatography on silica gel to afford the expected Intermediate.

According to the analysis of related databases, 186593-43-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GALAPAGOS NV; SANIERE, Laurent Raymond Maurice; HUCK, Jacques; DYKES, Graeme James; SCHMITT, Benoit Antoine; BLANC, Javier; BUTLER, Anna Sara; BEAUMONT, Stephane Nicolas Alain; BONNATERRE, Florence Marie-Emilie; WO2015/24905; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sep-21 News A new synthetic route of 15128-82-2

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15128-82-2, its application will become more common.

Synthetic Route of 15128-82-2 ,Some common heterocyclic compound, 15128-82-2, molecular formula is C5H4N2O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

(S)-1-(2,6-dichloro-3-fluorophenyl)ethanol (20.9 g, 0.10 mol) was dissolved in 200 mL anhydrous tetrahydofuran, to which 3-hydroxy-2-nitropyridine (16.0 g, 0.11 mol) and triphenylphosphine (40.0 g, 0.15 mol) were sequentially added under a nitrogen atmosphere, and the reaction solution was stirred at room temperature for 1 hour, cooled to 0 C. and diisopropyl azodicarboxylate (40 mL, 0.15 mol) was added dropwise. After the addition was complete, stirring was continued at 0 C. for 12 hours. The solvent was distilled off to obtain an oily material, which was separated by silica gel column chromatography, to give (R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine (20.2 g). Yield: 61%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,15128-82-2, its application will become more common.

Reference:
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; LIANYUNGANG RUNZHONG PHARMACEUTICAL CO., LTD.; CENTAURUS BIOPHARMA CO., LTD.; GONG, Feng; LI, Xinlu; ZHAO, Rui; ZHANG, Xiquan; XU, Xinhe; LIU, Xijie; XIAO, Dengming; HAN, Yongxin; (22 pag.)US2018/244649; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

9/24/21 News Sources of common compounds: 626-05-1

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-05-1, 2,6-Dibromopyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 626-05-1, 2,6-Dibromopyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 626-05-1, blongs to pyridine-derivatives compound. Recommanded Product: 626-05-1

n-Butyl magnesium chloride (2.0 M in THF, 2.25 ml, 45 mmol) was added to a stirred solution of w-butyl lithium (1.6 M in hexanes, 5.56 ml, 8.9 mmol) at 0C under argon. After 10 minutes at 0C the mixture was cooled to -10C. A solution of 2,6-dibromopyridine (3.0 g, 12.7 mmol) in toluene (35 ml) was added over 10 minutes and the mixture was stirred at -10 for 2 hours. After cooling to -40C, sulfur dioxide gas was bubbled into the mixture for 5 minutes and the reaction was stirred at -40C for 30 minutes. Sulfuryl chloride (1.1 ml, 13.6 mmol) was added and the mixture was allowed to warm to room temperature. The resulting mixture was added over 5 minutes to a stirred mixture of phenol (1.25 g, 13.3 mmol) and triethylamine (7.0 ml, 50.6 mmol) in acetonitrile (30 ml) at 0C. The mixture was stirred at 0C for 30 minutes and then at room temperature for 2 hours. The mixture was concentrated in vacuo and the residue partitioned between ethyl acetate and dilute sodium bicarbonate solution. The organic phase was washed with water, brine, dried over anhydrous magnesium sulfate and concentrated in vacuo to afford the title product (D7). MS(ES+) m/e 314/316 [M+H]+.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,626-05-1, 2,6-Dibromopyridine, and friends who are interested can also refer to it.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/10629; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

9/24/21 News Introduction of a new synthetic route about 107504-08-5

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107504-08-5, its application will become more common.

Synthetic Route of 107504-08-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 107504-08-5, name is 5-Fluoro-2-picolinic acid. A new synthetic method of this compound is introduced below.

General procedure: 5-fluoropicolinic acid (8.0 g, 56.7 mmol) was dissolved in methanol (50 mL),Dichlorosulfoxide (13.5 g, 113.4 mmol) was added, heated to 70 C. for 16 hours, and concentrated, and the residue was used directly in the next step. (8.0g, yield: 90.9%)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,107504-08-5, its application will become more common.

Reference:
Patent; Shandong Xuanzhu Pharmaceutical Technology Co., Ltd.; Wang Tingzhong; Liu Bin; (31 pag.)CN110698471; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

09/24/21 News A new synthetic route of 137640-84-7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137640-84-7, 6-(3-(Trifluoromethyl)phenoxy)picolinic acid.

Synthetic Route of 137640-84-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 137640-84-7, name is 6-(3-(Trifluoromethyl)phenoxy)picolinic acid. This compound has unique chemical properties. The synthetic route is as follows.

To a 500 mL three-necked flask was added 2-(3-trifluoromethylphenoxy)-6-pyridinecarboxylic acid 28.3 g (0.1 mol),Bis(trichloromethyl) carbonate 11.9 g (0.04 mol) and150 mL of ethyl acetate, magnetically stirred and heated to 35 C.0.3 g of triethylamine was added dropwise, and the reaction was kept at 50 C for 2 h after the addition.Until the bubble stops, the reaction solution is clarified by white turbidity.Then purge the residual hydrogen chloride and phosgene with nitrogen.Standby after cooling.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 137640-84-7, 6-(3-(Trifluoromethyl)phenoxy)picolinic acid.

Reference:
Patent; Hebei University; Li Wan; Yang Zihui; Yang Fenglin; (6 pag.)CN108794390; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

09/24/21 News A new synthetic route of 1136-52-3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1136-52-3, its application will become more common.

Application of 1136-52-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1136-52-3, name is (2,2,8-Trimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methanol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of alpha4,3-O-isopropylidene pyridoxine, the respective saccharideand molecular sieves (4 A) was stirred under argon atmospherein dry solvent (5 mL) at rt for 1 h before it was cooled to the respectivetemperature T. The promoter was added and the reaction mixture allowedto reach rt overnight. The mixture was diluted with dichloromethane(10 mL) and filtered through a pad of celite. Afterwards,the filtrate was washed with Na2S2O3 (10% in water, 30 mL) and theaqueous phase was extracted with dichloromethane (3 × 40 mL). Thecombined organic layers were washed with distilled water (1×50 mL),brine (1 × 50 mL) and dried over Na2SO4. The solvent was evaporatedunder reduced pressure and the crude product subjected to columnchromatography using SiO2 (pentane/ethyl acetate 1/1 to 1/4, gradientelution) followed by C18 (methanol, isocratic) to afford the glucoside.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1136-52-3, its application will become more common.

Reference:
Article; Bachmann, Thomas; Rychlik, Michael; Carbohydrate Research; vol. 489; (2020);,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

09/24/21 News The origin of a common compound about 832735-56-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,832735-56-5, 4-Bromo-2-(difluoromethoxy)pyridine, and friends who are interested can also refer to it.

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.832735-56-5, name is 4-Bromo-2-(difluoromethoxy)pyridine, molecular formula is C6H4BrF2NO, molecular weight is 224.0029, as common compound, the synthetic route is as follows.category: pyridine-derivatives

A mixture of C41 (120 mg, 0.467 mmol), C49 (105 mg, 0.469 mmol), tn’s(dibenzylideneacetone)dipalladium(0) (12.8 mg, 14.0 pmol), 4,5- bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos; 17.8 mg, 30.8 pmol), and cesium carbonate (608 mg, 1 .87 mmol) in 1 ,4-dioxane (5 mL) was stirred at 100 C for 16 hours. After cooling to room temperature, the reaction mixture was filtered, and the filtrate was concentrated in vacuo. The residue was purified using silica gel chromatography (Eluent: 20: 1 petroleum ether / ethyl acetate) to provide the product as a yellow oil. Yield: 50 mg, 0.17 mmol, 36%. 1 H NMR (400 MHz, CDCI3) delta 7.81 (d, J=5.9 Hz, 1 H), 7.42 (t, JHF=73.7 HZ, 1 H), 6.08 (dd, J=5.8, 2.1 Hz, 1 H), 5.75 (d, J=2.0 Hz, 1 H), 4.20-4.1 1 (m, 4H), 3.66 (dd, J=8.0, 5.5 Hz, 2H), 3.20-3.09 (m, 1 H), 2.71 (d, J=7.9 Hz, 2H), 1 .28 (t, J=7.1 Hz, 3H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,832735-56-5, 4-Bromo-2-(difluoromethoxy)pyridine, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; ZHANG, Lei; BUTLER, Christopher Ryan; BECK, Elizabeth Mary; BRODNEY, Michael Aaron; BROWN, Matthew Frank; MCALLISTER, Laura Ann; LACHAPELLE, Erik Alphie; GILBERT, Adam Matthew; (170 pag.)WO2018/2760; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

24-Sep-21 News The origin of a common compound about 56055-54-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56055-54-0, Methyl 5,6-dichloronicotinate, and friends who are interested can also refer to it.

Application of 56055-54-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 56055-54-0, name is Methyl 5,6-dichloronicotinate. A new synthetic method of this compound is introduced below.

Step B: Methyl 5-chloro-6- (2, 2, 2-trifluoro-1-methylethoxy) nicotinate; To a solution of 630 mg (3.06 mmol) of methyl 5,6-dichloronicotinate (from Step A) and 349 muL (3.06 mmol) of 1, 1, l-trifluoro-2-propanol in 10 mL of THF at-78 C was added 3.1 mL (3.06 mmol) of sodium bis (trimethylsilyl) amide (1.0 M in THF). After stirring at-78 C for 30 min and at 0 C for 5 h, the reaction was quenched by adding 10 mL of saturated NH4Cl. The mixture was poured into brine and extracted with CH2C12 (3 x 20 mL). Organic layers were combined, dried over MgS04, and concentrated. Chromatography on a Biotage 40M cartridge using 3: 97 v/v Et20/hexanes as the eluant gave 627 mg of the title compound : 1H NMR (500 MHz, CDC13) 8 1.56 (d, J = 6.4, 3H), 3.93 (s, 3H), 5.86 (m, 1H), 8.27 (d, J = 2.1, 1H), 8. 67 (d, J = 2.0, 1H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,56055-54-0, Methyl 5,6-dichloronicotinate, and friends who are interested can also refer to it.

Reference:
Patent; MERCK & CO., INC.; WO2005/58848; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

24-Sep-21 News Extended knowledge of 1008-91-9

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1008-91-9, 1-(Pyridin-4-yl)piperazine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1008-91-9, 1-(Pyridin-4-yl)piperazine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C9H13N3, blongs to pyridine-derivatives compound. Computed Properties of C9H13N3

The crude material (1.15 g, 7.06 mmol) from Step B was dissolved in dichloromethane (50 mL). After addition of diisopropylethylamine (4.7 mL, 42.4 mmol), 3-nitrosali-cylic acid (1.94 g, 10.6 mmol), and PyBrOP (5.78 g, 12.3 mmol), the resulting mixture was stirred over night at room temperature before being put into IN sodium hydroxide (300 mL). Extraction with dichloromethane (2×100 mL) removed all PyBrOP products. The aqueous phase was carefully acidified to pH~5-6 with 3N HC1 and extracted with dichloromethane (3×100 mL). The combined organic layers of the neutral extraction were dried over sodium sulfate, concentrated, and finally purified by column chromatography (dichloromethane/methanol/NH4OH=10/l/0.1) to yield the desired product (850 mg, 37% for 2 steps).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1008-91-9, 1-(Pyridin-4-yl)piperazine, and friends who are interested can also refer to it.

Reference:
Patent; Schering Corporation and Pharmacopeia, Inc.; US2004/147559; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

9/24 News Extracurricular laboratory: Synthetic route of 15862-34-7

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15862-34-7, 5-Bromo-2-hydroxy-3-nitropyridine.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 15862-34-7, name is 5-Bromo-2-hydroxy-3-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C5H3BrN2O3

To a solution of 5-Bromo-3-nitro-pyridin-2-ol (10.0 g, 45.66 mmol) in 70 ml of toluene and 7 ml of DMF was added PBr3 (6.60 ml, 68.49 mmol) and the reaction mixture was heated at 12O0C for 20 min under nitrogen atmosphere. After the completion of the reaction mixture (TLC monitoring), water (100 mL) was added and extracted with ethyl acetate (3 x 200 mL). The combined organics was washed with water, brine, dried (Na2SO4), filtered and concentrated to get the desired product (10.30 g, 80.03%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 15862-34-7, 5-Bromo-2-hydroxy-3-nitropyridine.

Reference:
Patent; PROLYSIS LTD; WO2007/107758; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem