Day: September 27, 2021

Related Products of 885588-03-4, Adding some certain compound to certain chemical reactions, such as: 885588-03-4, name is 3-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid,molecular formula is C12H8FIN2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 885588-03-4.

2.7 N-[(3aS,4R,7aR)-2,2-dimethylhexahydro-1 ,3-benzodioxol-4-yl]-3-[(2-fluoro-4- odophenyl) amino]isoicotinamide (31); A suspension of 3-[(2-fluoro-4-iodophenyl) amino] isonicotinic acid (10.46 g, 29.2 mmol), (3aS,4fi,7afi)-2,2-dimethylhexahydro-1 ,3-benzodioxol-4-amine (21 ) (5.00 g, 29.2 mmol), 1 – hydroxybenzotriazole (4.41 g, 29.2 mmol) and EDCI (5.6 g, 29.2 mmol) in DMF (100 mL) was stirred at room temperature overnight. The reaction was quenched with water (150 mL) and extracted with ethyl acetate (150 mL). Emulsion was formed and collected, filtered and the filtrate was combined to the organic layer. The organic layer was washed with saturated NaHCO3 solution (150 mL) and water (2×150 mL), brine and dried over Na2SO4 and concentrated to give brown foam. The crude was purified by crystallization from IPA. The mother liquor was concentrated and purified by flash chromatography to afford the desired product (12 g. 80% yield). LC/MS [Method A: rt:7.35 min; m/z: 512 (M+1 )].

According to the analysis of related databases, 885588-03-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SERONO S.A.; GOUTOPOULOS, Andreas; YU, Henry; ASKEW, Benny, C.; LIU-BUJALSKI, Lesley; WO2010/17051; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1190319-59-5, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1190319-59-5, name is 1H-Pyrrolo[2,3-c]pyridine-4-carbonitrile, molecular formula is C8H5N3, molecular weight is 143.1454, as common compound, the synthetic route is as follows.

a) To a suspension of NaH 60% (19 mg, 0.47 mmol) in dry DMF (1 mL) at 0 5C was added dropwise a solution of 1 H-pyrrolo[2,3-c]pyridine-4-carbonitrile (67 mg, 0.45 mmol) in DMF (1 mL). After 10 min a solution of 2-(bromomethyl)-4- chloro-1 -((2,4-difluorobenzyl)oxy)benzene (162 mg, 0.47 mmol) in 1 mL of DMF was added dropwise. After 16 h at 0 5C water was added and extracted with EtAcO (x3). Combined organic extracts were washed with water, brine and dried over Na2S04. Column chromatography on silica gel eluting with DCM:MeOH (95:5) gave the desired compound as a slightly brown solid (159 mg, 87% yield).1 H NMR (400 MHz, CDCI3) ? 8.83 (s, 1 H), 8.55 (s, 1 H), 7.37 (d, J = 3.1 Hz, 1 H), 7.29 (dd, J = 8.8, 2.6 Hz, 1 H), 7.22 – 7.14 (m, 1 H), 6.99 (d, J = 2.6 Hz, 1 H), 6.94 (d, J = 8.8 Hz, 1 H), 6.90 – 6.82 (m, 2H), 6.70 (dd, J = 3.1 , 0.8 Hz, 1 H), 5.37 (s, 2H), 5.04 (s, 2H).

The chemical industry reduces the impact on the environment during synthesis 1190319-59-5, I believe this compound will play a more active role in future production and life.

Reference:
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; DRACONIS PHARMA, S.L.; ALMIRALL, S.A.; TORRENS JOVER, Andoni; MERCE VIDAL, Ramon; CALDENTEY FRONTERA, Francesc Xavier; RODRIGUEZ GARRIDO, Antonio, David; CARCELLER GONZALEZ, Elena; SALAS SOLANA, Jordi; WO2013/37960; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 88912-26-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 88912-26-9 as follows.

THF (25 ml_), 2-{4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2- fluorophenyl}acetohydrazide (700 mg, 1.98 mmol), 2,5-dichloro-4-pyridinecarboxylic acid (380 mg, 1.98 mmol), HATU (380 mg, 1.98 mmol) and DIPEA (0.700 ml_, 3.96 mmol) were combined and stirred at rt for 45 min. Burgess Reagent (2.36 g, 9.90 mmol) was added and the reaction stirred overnight. The reaction mixture was diluted with ethyl acetate and washed with water. The solvent was removed and the crude material purified via silica gel chromatography to give 340 mg of the title compound. 1H NMR (DMSO-d6) delta 8.74 (s, 1 H), 7.98 (s, 1 H), 7.77 (m, 1 H), 7.50 (m, 3 H), 7.46 (m, 1 H), 4.50 (s, 2 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,88912-26-9, its application will become more common.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/157273; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 74420-15-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 74420-15-8, name is 3-Bromo-1H-pyrrolo[2,3-b]pyridine. This compound has unique chemical properties. The synthetic route is as follows.

A. 3-Bromo-1H-pyrrolo[2,3-b]pyridine and ammonia (0.5M in 1,4-dioxane) is heated to reflux. After 5 h the solution is concentrated. The residue is chromatographed on a silica gel plug to give 1H-pyrrolo[2,3-b]pyridin-3-ylamine.

According to the analysis of related databases, 74420-15-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Calvo, Raul R.; Cheung, Wing S.; Player, Mark R.; US2006/116368; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 6635-90-1, 2-Methoxy-4-methyl-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives

1. The mixture of 2-methoxy-4-methyl-5-nitropyridine (1.68g, 10.0 mmol) and 1,1- dimethoxy-N,N-dimethylmethanamine (14 Ml, 103 mmol) in 10 mL of DMF was heated at 130C overnight, cooled to RT, diluted with EtOAc, washed with water and brine, dried (MgS04), and concentrated. The residue was dissolved in 70 mL of EtOH. To this solution was added 1.06 g of 10% Pd/C. The mixture was stirred under 1 atm of hydrogen atmosphere over 4 days, filtered through a pad of Celite, and washed with EtOH. The filtrate was concentrated to give crude 5-methoxy-lH-pyrrolo[2,3-c]pyridine (quant). H NMR (399 MHz, DMSO-d6) delta ppm 11.26 (1 H, br. s.), 8.33 (1 H, s), 7.53 (1 H, d, 7=2.7 Hz), 6.73 – 6.88 (1 H, m), 6.32 (1 H, d, 7=3.1 Hz), 3.30 (3 H, s).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6635-90-1, 2-Methoxy-4-methyl-5-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; SRI INTERNATIONAL; JONG, Ling; CHANG, Chih-Tsung; PARK, Jaehyeon; (71 pag.)WO2016/114816; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 89466-18-2, Adding some certain compound to certain chemical reactions, such as: 89466-18-2, name is 6-Bromo-2-methoxypyridin-3-amine,molecular formula is C6H7BrN2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89466-18-2.

Example Al 4 a) Preparation of intermediate 31A mixture of formic acid (12.8 ml, 340 mmol) and acetic acid anhydride (8.54 ml, (91 mmol) was stirred at r.t. for 40 min. Subsequently, a solution of 3-amino-6-bromo- 2-methoxy-pyridine (5 g, 24.6 mmol) in THF (30 ml) was added dropwise to the mixture. The resulting r.m. was stirred overnight at 60 0C, and was then cooled and poured into ice-water, resulting in the precipitation of a solid. The solid was filtered off, washed with water, and dried. Yield: 5.2 g of intermediate 31 (76 %).

According to the analysis of related databases, 89466-18-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC; BISCHOFF, Francois, Paul; GIJSEN, Henricus, Jacobus, Maria; PIETERS, Serge, Maria, Aloysius; MINNE, Garrett, Berlond; WO2010/145883; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 74420-15-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 74420-15-8, name is 3-Bromo-1H-pyrrolo[2,3-b]pyridine, molecular formula is C7H5BrN2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

22.0 g (111.66 mmol) of the intermediate product (A) is dissolved in 350 ml of THF, and n-BuLi (49.13 mL, 122.82 mmol) is slowly added at -78 C. After 1 hour, TsCl (25.55 g, 133.99 mmol) was added and stirred for 4 hours under a stream of nitrogen

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 74420-15-8, 3-Bromo-1H-pyrrolo[2,3-b]pyridine.

Reference:
Patent; Cheil Industries Co., Ltd.; Hong, Jin Suk; Yu, Dong Gyu; Yu, Uhn Sun; Lee, Han Ir; Kang, Dong Min; Lee, Sang Sin; Jang, Yuna; Jung, Su Young; Han, Su Jin; (31 pag.)KR2015/15252; (2015); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 5315-25-3, name is 2-Bromo-6-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Formula: C6H6BrN

At room temperature, m-chloroperbenzoic acid (82 g, 475 mmol) was added to a solution of 2-bromo-6-methylpyridine 28 (40 g, 232.5 mmol) in chloroform (400 mL). The mixture was heated at 65 C. for 20 h and then was cooled to 0 C. for 3 h. After filtration of the precipitate, the filtrate was concentrated under reduced pressure. An aqueous solution of sodium hydroxide 2 M (100 mL) was added to this residue and this solution was extracted with dichloromethane (4×100 mL). The organic phases were combined, dried over magnesium sulfate, filtered and concentrated under reduced pressure to give compound 29 in the form of a yellow solid, which was used in the rest of the synthesis without additional purification (35.48 g, 81%). M.p.: 48-55 C. 1H NMR (400 MHz, CDCl3) delta: 7.55 (dd, J=7.9; 1.6 Hz, 1H), 7.23 (dd, J=7.9; 1.6 Hz, 1H), 7.01 (t, J=7.9 Hz, 1H), 2.57 (s, 3H); 13C NMR (100 MHz, CDCl3) delta: 151.2, 133.5, 128.7, 125.3, 125.2, 19.3. HRMS (ESI+) calculated for C6H7NOBr [M+H]+, m/z 187.9711. found: 187.9698. Rf=0.33 (silica, dichloromethane-methanol 96:4).

With the rapid development of chemical substances, we look forward to future research findings about 5315-25-3.

Reference:
Patent; CISBIO BIOASSAYS; LAMARQUE, Laurent; PARKER, David; BUTLER, Stephen J.; DELBIANCO, Martina; US2015/361116; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 157402-44-3 ,Some common heterocyclic compound, 157402-44-3, molecular formula is C12H9NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a vigorously-stirred solution of 6-phenyl-2-pyhdine aldehyde (0.50 g, 2.73 mmol) in 30 mL of anhydrous Et2O under N2, was added a solution of methyllithium (1.7 mL of 1.6 M solution in Et2O, 3.0 mmol) at ambient temperature. After 12 h, the reaction was quenched with 5 mL saturated aqueous ammonium chloride. This solution was extracted with 3 x 10 mL EtOAc. The organic fractions were pooled, dried over Na2SO4 and concentrated. After removing the volatiles in vacuo, the resultant yellow oil was chromatographed on silica with 10% EtOAc/hexanes. Clean fractions were combined and the volatiles were removed to provide 0.25 g of the product as a yellow oil (50%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 157402-44-3, 6-Phenylpicolinaldehyde, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; EXXONMOBIL CHEMICAL PATENTS INC.; WO2008/85658; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 18087-99-5, (4,6-Dimethylpyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 18087-99-5, blongs to pyridine-derivatives compound. Quality Control of (4,6-Dimethylpyridin-2-yl)methanol

b) Preparation of 4,6-dimethyl-pyridme-2-carbaldehyde Manganese dioxide (3.17 g, 36.5 mmol) was added to a solution of (4,6- dimethyl-pyridin-2-yl)-methanol (1.0 g, 7.30 mmol) in chloroform (30 mL) and heated at reflux overnight. The reaction mixture was cooled to 0 C and filtered over celite, washing with further chloroform. The filtrate was evaporated to give a residue which was purified by column chromatography over silica gel (60-120 mesh) using 10 % ethyl acetate in hexane as eluent to afford 4,6-dimethyl-pyridine-2-carbaldehyde (0.5 g, 51 %) as a light brown liquid.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,18087-99-5, its application will become more common.

Reference:
Patent; F2G LTD; WO2008/62182; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem