Day: October 15, 2021

Product Details of 65-22-5. Poladian, Q; Sahin, O; Karakurt, T; Ilhan-Ceylan, B; Kurt, Y in [Poladian, Qumars; Ilhan-Ceylan, Berat; Kurt, Yasemin] Istanbul Univ Cerrahpasa, Engn Fac, Dept Chem, TR-34320 Istanbul, Turkey; [Sahin, Onur] Sinop Univ, Fac Hlth Sci, Dept Occupat Hlth & Safety, TR-57000 Sinop, Turkey; [Karakurt, Tuncay] Kirsehir Ahi Evran Univ, Fac Engn Architecture, Dept Chem & Proc Engn, TR-40100 Kirsehir, Turkey published A new zinc(II) complex with N2O2-tetradentate schiff-base derived from pyridoxal-S-methylthiosemicarbazone: Synthesis, characterization, crystal structure, DFT, molecular docking and antioxidant activity studies in 2021.0, Cited 69.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5.

A new unsymmetrical N2O2-tetradentate Schiff-base complex of zinc(II) was synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2-hydroxy-4-methoxy-benzaldehyde as starting compounds. S-methylthiosemicarbazone (1) and zinc(II) complex [Zn(L)CH3OH] ( 2) were characterized by elemental analysis, FT-IR, UV-visible, H-1, and C-13 NMR spectra. The molecular structure of the complex (2) was determined by single crystal X-ray diffraction technique. The structure consists of a distorted square-pyramidal geometry around the central metal, Zn(II). Quantum chemical calculations were carried out using density functional theory DFT/B3LYP, 6-31G (d), and LanL2DZ basis sets for theoretical characterization of the compounds. The experimental and theoretical data were compared comprehensively. The potential energy distribution (PED) analysis was performed for the assignment of vibration frequencies. In order to support in vitro studies, molecular docking studies have been carried out so that the title compound can be an inhibitor of Epidermal Growth Factor Receptor (1 m17), and the relationship between calculated HOMO energies and docking studies has been examined. In addition, the total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds were determined by Cupric Reducing Antioxidant Capacity (CUPRAC) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) methods, respectively. (C) 2021 Elsevier Ltd. All rights reserved.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Poladian, Q; Sahin, O; Karakurt, T; Ilhan-Ceylan, B; Kurt, Y or concate me.. Product Details of 65-22-5

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Triazole-based ligands functionalized silica: Effects of ligand denticity and donors on catalytic oxidation activity of Pd nanoparticles WOS:000498386100012 published article about AEROBIC ALCOHOL OXIDATION; PALLADIUM NANOPARTICLES; COUPLING REACTIONS; HIGHLY EFFICIENT; SELECTIVITY; SURFACE; SUZUKI in [Ampawa, Supanan; Krittametaporn, Nuttaporn; Sangtrirutnugul, Preeyanuch] Mahidol Univ, Ctr Excellence Innovat Chem PERCH CIC, Ctr Catalysis, Dept Chem,Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand; [Ungpittagul, Thasanaporn; Phomphrai, Khamphee] Vidyasirimedhi Inst Sci & Technol, Sch Mol Sci & Engn, Dept Mat Sci & Engn, Rayong 21210, Thailand in 2019.0, Cited 32.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. HPLC of Formula: C12H9NO

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

HPLC of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 91-02-1. Recently I am researching about FUNCTIONALIZATION; ARENES; DECARBONYLATION; SULFONATION; ACTIVATION; AMIDATION; MILD, Saw an article supported by the Program of Science and Technology Innovation Talents of Henan Province [19HASTIT035]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, G; Jia, CQ; Cai, XF; Zhong, L; Zou, L; Cui, XL. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

The first example of meta-selective C-Ar-H bond functionalization of aryl 2-pyridyl ketones has been developed using [Ru(p-cymene)Cl-2](2) as the catalyst and alkyl bromide as the coupling reagent. This development provides an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone skeletons, which are found in various functional molecules.

Recommanded Product: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Li, G; Jia, CQ; Cai, XF; Zhong, L; Zou, L; Cui, XL or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019 RUSS J GEN CHEM+ published article about ENTHALPY-ENTROPY COMPENSATION; ISOPARAMETRICITY; TRANS-2,3-DIARYLOXIRANES; MECHANISM; PHANTOM in [Shpanko, I. V.] V Stus Donetsk Natl Univ, UA-21021 Vinnitsa, Ukraine; [Sadovaya, I. V.] Donetsk Natl Univ, Donetsk, Ukraine in 2019, Cited 21. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6. Quality Control of Ethyl nicotinate

Additive nature of the combined effect of the structure (X, Y substituents) and temperature on the rate and free activation energy has been established for the reactions of phenyloxirane with Y-substituted N-aroylbenzenesulfonamides catalyzed by X-substituted pyridines. The cross reaction series is isoenthalpic with respect to the structural effects. The mechanism of the catalytic process has been discussed.

Quality Control of Ethyl nicotinate. About Ethyl nicotinate, If you have any questions, you can contact Shpanko, IV; Sadovaya, IV or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Towards in situ continuous feeding via controlled release of complete nutrients for fed-batch culture of animal cells WOS:000518148400014 published article about MONOCLONAL-ANTIBODY PRODUCTION; AMINO-ACIDS; METABOLISM; GLUCOSE; GROWTH; PRODUCTIVITY; STRATEGIES; PROTEIN; DESIGN; MEDIA in [Rawat, Jyoti; Gadgil, Mugdha] CSIR Natl Chem Lab, Chem Engn & Proc Dev, Pune 411008, Maharashtra, India; [Rawat, Jyoti; Gadgil, Mugdha] CSIR Natl Chem Lab Campus, Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020.0, Cited 40.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. COA of Formula: C8H10ClNO3

Small-scale culture of animal cells in suspension is of importance for many applications. At a small-scale, fed-batch is achieved either by manual bolus feeding or the use of liquid handling robots. In this study, we report an alternate application of a hydrogel for in situ continuous delivery of a nutrient feed comprising 18 amino acids, vitamins, antioxidants, and trace elements. We show that amino acid release is sustained for at least seven days. Importantly, release rates of individual amino acids can be independently modulated by changing their loading. We demonstrate the application of this hydrogel for complete in situ feeding of nutrients to a suspension adapted CHO cell line expressing IgG leading to 2.7-fold and 4-fold improvement in integral viable cell density (IVCD) and volumetric productivity respectively. This is similar to improvements obtained by bolus liquid feeding. Further, supplying glucose from the same hydrogel to eliminate manual feeding led to a 1.8-fold increase in IVCD accompanied by a 3-fold increase in volumetric productivity as compared to batch culture. In summary, this study provides a proof-of-concept that hydrogels can enable completely closed in situ feeding for mammalian cell culture requiring no external intervention. Such continuous in situ delivery can potentially enable closed culture systems maintaining nutrients at low levels mimicking physiological concentrations.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Rawat, J; Gadgil, M or concate me.. COA of Formula: C8H10ClNO3

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 614-18-6. Rechitskaya, ED; Kuratieva, NV; Lider, EV; Eremina, JA; Klyushova, LS; Eltsov, IV; Kostin, GA in [Rechitskaya, E. D.; Kuratieva, N., V; Lider, E., V; Eremina, J. A.; Kostin, G. A.] Nikolaev Inst Inorgan Chem SB RAS, Lavrentieva 3, Novosibirsk, Russia; [Rechitskaya, E. D.; Kuratieva, N., V; Lider, E., V; Eremina, J. A.; Eltsov, I., V; Kostin, G. A.] Novosibirsk State Univ, Pirogova 2, Novosibirsk, Russia; [Klyushova, L. S.] Inst Mol Biol & Biophys, Subdiv FRC FTM, 2-12 Timakova Str, Novosibirsk 630060, Russia; [Klyushova, L. S.] Sci Inst Clin & Expt Lymphol, Branch ICG SB RAS, 2 Timakova Str, Novosibirsk 630117, Russia published Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes in 2020, Cited 37. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

Three novel ruthenium nitrosyl complexes [Ru(NO)Cl-3(InicMe)(2)] (1b), [RuNOCl3(NicEt)(2)] (1c) and [RuNOCl3(NicMe)(2)] (1d) (InicMe = methyl isonicotinate, NicEt = ethyl nicotinate, NicMe = methyl nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD analysis. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: pi(arene)-pi(arene) and pi(COO)-pi(arene) stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)(2)Cl-3] (L = Py, gamma-Pic, beta-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex. (C) 2020 Elsevier B.V. All rights reserved.

Product Details of 614-18-6. About Ethyl nicotinate, If you have any questions, you can contact Rechitskaya, ED; Kuratieva, NV; Lider, EV; Eremina, JA; Klyushova, LS; Eltsov, IV; Kostin, GA or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about ISONICOTINOYL HYDRAZONE; IRON CHELATORS; IN-VITRO; VITAMIN-B-6; EXPRESSION; APOPTOSIS; ANALOGS; TARGETS; GROWTH; AGENTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31671183]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A030307005]. Published in KARGER in BASEL ,Authors: Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. SDS of cas: 65-22-5

Background/Aims: Hydrazone and acylhydrazone derivatives, which are produced from aldehyde reacting with hydrazine or acylhydrazine, have been reported to exhibit antitumor activities. However, the angionenic effects of this kind of derivatives haven’t been elucidated. Here, we synthesized 12 pyridoxal hydrazone and acylhydrazone compounds and investigated their antiangiogenic effects and the underlying mechanisms. Method: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay was used to screen the inhibitory effects of the synthesized compounds on endothelial cells (ECs) proliferation. The compound with best inhibitory effect was further evaluated with wound-healing assay and tube formation assay. Calcein-Am assay was carried out to determine the content of intracellular labile iron pool (LIP). Intracellular reduced glutathione (GSH) was determined by spectrophotometry. Flow cytometry was used to determine cell cycle and apoptosis. Results: Compound 10 (3-hydroxy-5-[hydroxymethyl]-2-methyl-pyridine-4-carbaldehyde-2-naphthalen-1-acetyl hydrazone) showed the best inhibitory effect on human umbilical vascular ECs proliferation, with IC50 value of 25.4 mu mol/L. It not only inhibited wound-healing and tube formation of ECs, but also decreased the content of intracellular LIP and GSH. Furthermore, it arrested ECs cycle at S phase and induced cell apoptosis. Conclusions: Compound 10 exhibits antiangiogenic effects by reducing the content of intracellular LIP and GSH, and subsequently arresting cell cycle and inducing cell apoptosis.

SDS of cas: 65-22-5. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C6H5NO. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Introducing of potent cytotoxic novel 2-(aroylamino)cinnamamide derivatives against colon cancer mediated by dual apoptotic signal activation and oxidative stress published in 2020.0, Reprint Addresses Omar, AM (corresponding author), King Abdulaziz Univ, Fac Pharm, Dept Pharmaceut Chem, Jeddah 21589, Saudi Arabia.; Ahmed, HEA (corresponding author), Taibah Univ, Coll Pharm, Pharmacognosy & Pharmaceut Chem, Al Madinah Al Munawarah 47114, Saudi Arabia.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

Curcumin and trans-cinnamaldehyde are acrolein-based Michael acceptor compounds that are commonly found in domestic condiments, and known to cause cancer cell death via redox mechanisms. Based on the structural features of these compounds we designed and synthesized several 2-cinnamamido-N-substituted-cinnamamide (bis-cinnamamide) compounds. One of the derivatives, (Z)-2-[(E)-cinnamamido]-3-phenyl-N-propylacrylamide 8 showed a moderate antiproliferative potency (HCT-116 cell line inhibition of 32.0 mu M), no inhibition of normal cell lines C-166, and proven cellular activities leading to apoptosis. SAR studies led to more than 10-fold increase in activity. Our most promising compound, [(Z)-3-(1H-indol-3-yl)-N-propyl-2-[(E)-3-(thien-2-yl)propenamido) propenamide] 45 killed colon cancer cells at IC50 = 0.89 mu M (Caco-2), 2.85 mu M (HCT-116) and 1.65 mu M (HT -29), while exhibiting much weaker potency on C-166 and BHK normal cell lines (IC50 = 71 mu M and 77.6 mu M, respectively). Cellular studies towards identifying the compounds mechanism of cytotoxic activities revealed that apoptotic induction occurs in part as a result of oxidative stress. Importantly, the compounds showed inhibition of cancer stem cells that are critical for maintaining the potential for self-renewal and stemness. The results presented here show discovery of covalently acting Michael addition compounds that potently kill cancer cells by a defined mechanism, with prominent selectivity profile over non-cancerous cell lines.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Omar, AM; El-Araby, ME; Abdelghany, TM; Safo, MK; Ahmed, MH; Boothello, R; Patel, BB; Abdel-Bakky, MS; Malebari, AM; Ahmed, HEA; Elhaggar, RS or concate me.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Name: Ethyl nicotinate. In 2021 SCI REP-UK published article about PREDICTION; MOLECULES in [Zeng, Ruolan; Deng, Jiyong; Dang, Limin; Yu, Xinliang] Hunan Inst Engn, Hunan Prov Key Lab Environm Catalysis & Waste Reg, Coll Mat & Chem Engn, Xiangtan 411104, Hunan, Peoples R China in 2021, Cited 23. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

A three-descriptor quantitative structure-activity/toxicity relationship (QSAR/QSTR) model was developed for the skin permeability of a sufficiently large data set consisting of 274 compounds, by applying support vector machine (SVM) together with genetic algorithm. The optimal SVM model possesses the coefficient of determination R-2 of 0.946 and root mean square (rms) error of 0.253 for the training set of 139 compounds; and a R-2 of 0.872 and rms of 0.302 for the test set of 135 compounds. Compared with other models reported in the literature, our SVM model shows better statistical performance in a model that deals with more samples in the test set. Therefore, applying a SVM algorithm to develop a nonlinear QSAR model for skin permeability was achieved.

About Ethyl nicotinate, If you have any questions, you can contact Zeng, RL; Deng, JY; Dang, LM; Yu, XL or concate me.. Name: Ethyl nicotinate

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Formula: C8H10ClNO3. Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH in [Chen, Xuyang; Li, Hui; Luo, Hongjun; Lin, Zhexuan; Luo, Wenhong] Shantou Univ, Coll Med, Bioanalyt Lab, Xinling Rd 22, Shantou, Guangdong, Peoples R China published Synthesis and Evaluation of Pyridoxal Hydrazone and Acylhydrazone Compounds as Potential Angiogenesis Inhibitors in 2019.0, Cited 45.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5.

Background/Aims: Hydrazone and acylhydrazone derivatives, which are produced from aldehyde reacting with hydrazine or acylhydrazine, have been reported to exhibit antitumor activities. However, the angionenic effects of this kind of derivatives haven’t been elucidated. Here, we synthesized 12 pyridoxal hydrazone and acylhydrazone compounds and investigated their antiangiogenic effects and the underlying mechanisms. Method: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay was used to screen the inhibitory effects of the synthesized compounds on endothelial cells (ECs) proliferation. The compound with best inhibitory effect was further evaluated with wound-healing assay and tube formation assay. Calcein-Am assay was carried out to determine the content of intracellular labile iron pool (LIP). Intracellular reduced glutathione (GSH) was determined by spectrophotometry. Flow cytometry was used to determine cell cycle and apoptosis. Results: Compound 10 (3-hydroxy-5-[hydroxymethyl]-2-methyl-pyridine-4-carbaldehyde-2-naphthalen-1-acetyl hydrazone) showed the best inhibitory effect on human umbilical vascular ECs proliferation, with IC50 value of 25.4 mu mol/L. It not only inhibited wound-healing and tube formation of ECs, but also decreased the content of intracellular LIP and GSH. Furthermore, it arrested ECs cycle at S phase and induced cell apoptosis. Conclusions: Compound 10 exhibits antiangiogenic effects by reducing the content of intracellular LIP and GSH, and subsequently arresting cell cycle and inducing cell apoptosis.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH or concate me.. Formula: C8H10ClNO3

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem