Day: October 19, 2021

Ibrahim, GR; Shah, I; Gariballa, S; Yasin, J; Barker, J; Ashraf, SS in [Ibrahim, Ghada Rashad; Shah, Iltaf] UAE Univ, Coll Sci, Dept Chem, POB 15551, Al Ain, U Arab Emirates; [Gariballa, Salah; Yasin, Javed] UAE Univ, Coll Med, Dept Internal Med, POB 15551, Al Ain, U Arab Emirates; [Barker, James] Kingston Univ, Dept Chem & Pharmaceut Sci, Penrhyn Rd, Kingston Upon Thames KT1 2EE, Surrey, England; [Ashraf, Syed Salman] Khalifa Univ, Coll Arts & Sci, Dept Chem, POB 127788, Abu Dhabi, U Arab Emirates published Significantly Elevated Levels of Plasma Nicotinamide, Pyridoxal, and Pyridoxamine Phosphate Levels in Obese Emirati Population: A Cross-Sectional Study in 2020.0, Cited 48.0. Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5.

Water-soluble vitamins like B3 (nicotinamide), B6 (pyridoxine), and B9 (folic acid) are of utmost importance in human health and disease, as they are involved in numerous critical metabolic reactions. Not surprisingly, deficiencies of these vitamins have been linked to various disease states. Unfortunately, not much is known about the physiological levels of B6 vitamers and vitamin B3 in an ethnically isolated group (such as an Emirati population), as well as their relationship with obesity. The aim of the present study was to quantify various B6 vitamers, as well as B3, in the plasma of obese and healthy Emirati populations and to examine their correlation with obesity. A sensitive and robust HPLC-MS/MS-based method was developed for the simultaneous quantitation of five physiologically relevant forms of vitamin B6, namely pyridoxal, pyridoxine, pyridoxamine, pyridoxamine phosphate, and pyridoxal phosphate, as well as nicotinamide, in human plasma. This method was used to quantify the concentrations of these vitamers in the plasma of 57 healthy and 57 obese Emirati volunteers. Our analysis showed that the plasma concentrations of nicotinamide, pyridoxal, and pyridoxamine phosphate in the obese Emirati population were significantly higher than those in healthy volunteers (p< 0.0001,p= 0.0006, andp= 0.002, respectively). No significant differences were observed for the plasma concentrations of pyridoxine and pyridoxal phosphate. Furthermore, the concentrations of some of these vitamers in healthy Emirati volunteers were significantly different than those published in the literature for Western populations, such as American and European volunteers. This initial study underscores the need to quantify micronutrients in distinct ethnic groups, as well as people suffering from chronic metabolic disorders. Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Ibrahim, GR; Shah, I; Gariballa, S; Yasin, J; Barker, J; Ashraf, SS or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Nian, SF; Ling, F; Chen, JC; Wang, Z; Shen, HW; Yi, X; Yang, YF; She, YB; Zhong, WH in [Nian, Sanfei; Ling, Fei; Chen, Jiachen; Wang, Ze; Shen, Haiwei; Yi, Xiao; Zhong, Weihui] Zhejiang Univ Technol, Coll Pharmaceut Sci, Minist Educ, Key Lab Green Pharmaceut Technol & Related Equipm, Hangzhou 310014, Zhejiang, Peoples R China; [Yang, Yun-Fang; She, Yuanbin] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China; [Yang, Yun-Fang] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA published Highly Enantioselective Hydrogenation of Non-ortho-Substituted 2-Pyridyl Aryl Ketones via Iridium-f-Diaphos Catalysis in 2019.0, Cited 44.0. Product Details of 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

This work disclosed a highly enantioselective hydrogenation of non-ortho-substituted 2-pyridyl aryl ketones via Ir/f-diaphos catalysis. This catalytic system allows for full control over the configuration of the stereocenter, affording two enantiomers of the desired products with extremely high enantioselectivity (up to >99% ee in most cases) and excellent reactivity (TON of up to 19600, TOF of 1633 h(-1)) under mild conditions. Density functional theory calculations and control experiments revealed that the relay hydrogen bonding among the solvent isopropanol, substrate, and ligand is crucial for high ee’s.

Product Details of 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Nian, SF; Ling, F; Chen, JC; Wang, Z; Shen, HW; Yi, X; Yang, YF; She, YB; Zhong, WH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Phenyl(pyridin-2-yl)methanone. In 2019.0 CHEMISTRYSELECT published article about CATALYZED DENITROGENATIVE TRANSANNULATION; METAL-ORGANIC FRAMEWORK; ONE-POT SYNTHESIS; H BONDS; COUPLING REACTION; BENZYLIC HALIDES; GENERAL-METHOD; ARYL BROMIDES; ARYLATION; FUNCTIONALIZATION in [Chandrasekar, Selvaraj; Sangeetha, Subramani; Sekar, Govindasamy] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India in 2019.0, Cited 78.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A simple, effortless, and efficacious protocol for the synthesis of highly fluorescing imidazo[1,5-a]pyridines via copper catalyzed inter-/intramolecular C-N bond formation between readily available pyridyl alcohols with either benzyl amines or amino acids has been developed. This domino reaction is involved with alcohol oxidation/condensation/oxidative amination sequence to synthesize imidazo[1,5-a]pyridines in good to excellent yields. The fluorescence studies of these compounds indicated a bathochromic shift for the electron donating substituents, whereas a hypsochromic shift for the electron withdrawing substituents. Synthetic modification of the groups attached to the heterocyclic core showed a profound impact on the emission properties when subjected to pH and solvent polarity change.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Chandrasekar, S; Sangeetha, S; Sekar, G or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Phenyl(pyridin-2-yl)methanone. Recently I am researching about ONE-POT SYNTHESIS; ARYL HALIDES; DERIVATIVES; ALCOHOLS; FLUORIDE; MECHANOCHEMISTRY; NANOPARTICLES; HYDROCARBONS; ACTIVATION; VINYLATION, Saw an article supported by the US Department of Energy, Office of Science, Basic Energy Sciences, Materials Sciences and Engineering DivisionUnited States Department of Energy (DOE) [DE-AC02-76SF00515]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Hosseini, A; Schreiner, PR. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Ball milling of calcium carbide (CaC2) enables the reaction of its ethynyl moiety with organic electrophiles. This was realized simply by co-milling CaC(2)with organic substrates in a sealed jar without the need for an additive or a catalyst. Various ketones including those bearing alpha-hydrogens were ethynylated in good yields at short reaction times. Aryl halides are also amenable substrates for this protocol as they furnish aryl ethynes through a benzyne intermediate. This method offers a practical and cheap alternative to the established procedures for introducing ethynyl functionalities.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Hosseini, A; Schreiner, PR or concate me.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Bachmann, T; Schnurr, C; Zainer, L; Rychlik, M in ELSEVIER SCI LTD published article about PYRIDOXINE-BETA-GLUCOSIDE; PARTICULATE GLUCOSYLTRANSFERASE; PROTEIN GLYCOSYLATION; GROWING CULTURE; N-GLYCOSYLATION; FUSARIUM TOXINS; RICE BRAN; SEEDLINGS; GLUCURONIDATION; BIOAVAILABILITY in [Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael] Tech Univ Munich, Chair Analyt Food Chem, Maximus von Imhof Forum 2, D-85354 Freising Weihenstephan, Germany in 2020.0, Cited 107.0. SDS of cas: 65-22-5. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Various 5′-beta-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chemically according to KOENIGS-KNORR conditions using alpha 4,3-O-iso-propylidene pyridoxine and the respective acetobromo glycosyl donors with AgOTf (3.0 eq.) and NIS (3.0 eq.) as promoters at 0 degrees C. Furthermore, 5′-beta-[C-13(6)]-labeled pyridoxine glucoside (PNG) was prepared starting from [C-1(3)6]-glucose and pyridoxine. Additionally, two strategies were examined for the synthesis of 5′-beta-pyridoxal glucoside (PLG).

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Bachmann, T; Schnurr, C; Zainer, L; Rychlik, M or concate me.. SDS of cas: 65-22-5

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids WOS:000505596300034 published article about SELECTIVE COX-2 INHIBITORS; BIOLOGICAL EVALUATION; AMINOSALICYLIC ACID; DUAL INHIBITORS; CYCLOOXYGENASE; DERIVATIVES; DESIGN; DOCKING; IDENTIFICATION; STRATEGY in [Abdu-Allah, Hajjaj H. M.; Abdelmoez, Alshaimaa A. B.] Assiut Univ, Fac Pharm, Dept Pharmaceut Organ Chem, Assiut 71526, Egypt; [Tarazi, Hamadeh; El-Shorbagi, Abdel-Nasser A.; El-Awady, Raafat] Univ Sharjah, Sharjah Inst Med Res, Sharjah 27272, U Arab Emirates; [Tarazi, Hamadeh; El-Shorbagi, Abdel-Nasser A.; El-Awady, Raafat] Univ Sharjah, Coll Pharm, Sharjah 27272, U Arab Emirates in 2020.0, Cited 53.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. COA of Formula: C6H5NO

Eicosanoids like leukotrienes and prostaglandins that produced within the arachidonic acid cascade are involved in the pathogenesis of pain, acute and chronic inflammatory diseases. A promising approach for an effective anti-inflammatory therapy is the development of inhibitors targeting more than one enzyme of this cascade. Aiming to develop balanced COX/LOX inhibitors; 4-aminosalicylate based thiazolinones having different substituents at the 5th position of the 4-thiazolinone ring (2-22) were designed, synthesized, characterized and evaluated in vitro and in vivo for their anti-inflammatory activity. Most of the investigated compounds showed high COX-2 inhibitory potencies (IC(50)( )39-200 mu M) with selectivity indexes (30-84). Two compounds, 19 and 21, (IC50 = 41 and 44 mu M), are equipotent to celecoxib (IC50, = 49 mu M), while compound 22 (IC50 = 39 mu M) was the most potent. For 15-LOX, compounds 5, 11, 19, 21 and 22 revealed higher potency (IC50 1.5-2.2 mu M) than zileuton (IC50 15 mu M). Thus, compounds 5, 11, 19, 21 and 22 are potent dual inhibitors of COX-2 and 15-LOX. In vivo anti-inflammatory testing of these compounds revealed that, compounds 5 and 21 had an anti-inflammatory activity similar to indomethacin and celecoxib (% inhibition of oedema = 60 +/- 9) and higher than diclofenac potassium (% inhibition = 52 +/- 29), while compound 22 (% inhibition = 63 +/- 5) was more active than the reference drugs. The results showed that the activity is controlled by the bulkiness and lipophilicity of the substituent at the 5th position. The cytotoxicity results revealed that all compounds are not cytotoxic, additionally, in an experimental model of ulcerogenic effect, the most active compounds 21 and 22 showed better safety profile than indomethacin. Further, at the active sites of the COX-1, COX-2 and 15-LOX co-crystal, 19, 21, and 22 showed high binding forces in free binding energy study, which is consistent with in vitro and in vivo results. In conclusion, these compounds are good candidates for further biological investigation as potential anti-inflammatory drugs with dual balanced inhibition of COX and 15-LOX and good safety profile.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Abdu-Allah, HHM; Abdelmoez, AAB; Tarazi, H; El-Shorbagi, ANA; El-Awady, R or concate me.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Chemical synthesis of 5 ‘-beta-glycoconjugates of vitamin B-6 WOS:000519529400008 published article about PYRIDOXINE-BETA-GLUCOSIDE; PARTICULATE GLUCOSYLTRANSFERASE; PROTEIN GLYCOSYLATION; GROWING CULTURE; N-GLYCOSYLATION; FUSARIUM TOXINS; RICE BRAN; SEEDLINGS; GLUCURONIDATION; BIOAVAILABILITY in [Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael] Tech Univ Munich, Chair Analyt Food Chem, Maximus von Imhof Forum 2, D-85354 Freising Weihenstephan, Germany in 2020.0, Cited 107.0. Computed Properties of C8H10ClNO3. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Various 5′-beta-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chemically according to KOENIGS-KNORR conditions using alpha 4,3-O-iso-propylidene pyridoxine and the respective acetobromo glycosyl donors with AgOTf (3.0 eq.) and NIS (3.0 eq.) as promoters at 0 degrees C. Furthermore, 5′-beta-[C-13(6)]-labeled pyridoxine glucoside (PNG) was prepared starting from [C-1(3)6]-glucose and pyridoxine. Additionally, two strategies were examined for the synthesis of 5′-beta-pyridoxal glucoside (PLG).

Computed Properties of C8H10ClNO3. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Bachmann, T; Schnurr, C; Zainer, L; Rychlik, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Proximity Effect in Uranyl Coordination of the Cucurbit[6]uril-Bipyridinium Pseudorotaxane Ligand for Promoting Host-Guest Synergistic Chelating WOS:000675430900047 published article about METAL-ORGANIC FRAMEWORK; POLYROTAXANES; INCLUSION; DESIGN in [Li, Fei-Ze; Liu, Ning] Sichuan Univ, Inst Nucl Sci & Technol, Minist Educ, Key Lab Radiat Phys & Technol, Chengdu 610064, Peoples R China; [Li, Fei-Ze; Geng, Jun-Shan; Hu, Kong-Qiu; Yu, Ji-Pan; Chai, Zhi-Fang; Mei, Lei; Shi, Wei-Qun] Chinese Acad Sci, Inst High Energy Phys, Lab Nucl Energy Chem, Beijing 100049, Peoples R China; [Chai, Zhi-Fang] Chinese Acad Sci, Ningbo Inst Ind Technol, Engn Lab Adv Energy Mat, Ningbo 315201, Zhejiang, Peoples R China in 2021, Cited 43. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6. HPLC of Formula: C8H9NO2

behavior of cucurbituril-bipyridinium pseudorotaxane ligand by utilizing meta-functionalized bipyridinium dicarboxylate guest. A tailored pseudorotaxane precursor involving 1,1′-(hexane-1,6-diyl)bis(3-cyanopyridin-1-ium) bromide (C6BPCN3) and cucurbit[6]uril (CB[6]) has designed and synthesized. Through in situ hydrolysis of the pseudorotaxane ligands and their coordination assembly with uranyl cations, seven new uranyl-rotaxane coordination polymers URCP1-URCP7 have been obtained under hydrothermal conditions in the presence of different anions. It is demonstrated that the variation of carboxylate groups from para- to meta-position greatly affected the coordination behaviors of the metafunctionalized pseudorotaxane linkers, which are enriched from simple guest-only binding to host-guest simultaneous coordination and synergistic chelating. This effective regulation on uranyl coordination of supramolecular pseudorotaxane can be attributed to the proximity effect, which refers to the meta-position carboxyl group being spatially closer to the portal carbonyl group of CB[6]. Moreover, by combining other regulation methods such as introducing competing counterions and modulating solution acidity, the nuclearity of the uranyl center and the coordination patterns of the pseudorotaxane ligand can be diversely tuned, which subsequently exert great influence on the final dimensionality of resultant uranyl compounds. This work presents a large diversity of uranyl-based coordination polyrotaxane compounds with fascinating mechanically interlocked components and, most importantly, provides a feasible approach to adjust and control the metal coordination behavior of the pseudorotaxane ligand that might expand the scope of application of such supramolecular ligands.

About Ethyl nicotinate, If you have any questions, you can contact Li, FZ; Geng, JS; Hu, KQ; Yu, JP; Liu, N; Chai, ZF; Mei, L; Shi, WQ or concate me.. HPLC of Formula: C8H9NO2

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis and Evaluation of Pyridoxal Hydrazone and Acylhydrazone Compounds as Potential Angiogenesis Inhibitors WOS:000507320500005 published article about ISONICOTINOYL HYDRAZONE; IRON CHELATORS; IN-VITRO; VITAMIN-B-6; EXPRESSION; APOPTOSIS; ANALOGS; TARGETS; GROWTH; AGENTS in [Chen, Xuyang; Li, Hui; Luo, Hongjun; Lin, Zhexuan; Luo, Wenhong] Shantou Univ, Coll Med, Bioanalyt Lab, Xinling Rd 22, Shantou, Guangdong, Peoples R China in 2019.0, Cited 45.0. Recommanded Product: 65-22-5. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Background/Aims: Hydrazone and acylhydrazone derivatives, which are produced from aldehyde reacting with hydrazine or acylhydrazine, have been reported to exhibit antitumor activities. However, the angionenic effects of this kind of derivatives haven’t been elucidated. Here, we synthesized 12 pyridoxal hydrazone and acylhydrazone compounds and investigated their antiangiogenic effects and the underlying mechanisms. Method: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay was used to screen the inhibitory effects of the synthesized compounds on endothelial cells (ECs) proliferation. The compound with best inhibitory effect was further evaluated with wound-healing assay and tube formation assay. Calcein-Am assay was carried out to determine the content of intracellular labile iron pool (LIP). Intracellular reduced glutathione (GSH) was determined by spectrophotometry. Flow cytometry was used to determine cell cycle and apoptosis. Results: Compound 10 (3-hydroxy-5-[hydroxymethyl]-2-methyl-pyridine-4-carbaldehyde-2-naphthalen-1-acetyl hydrazone) showed the best inhibitory effect on human umbilical vascular ECs proliferation, with IC50 value of 25.4 mu mol/L. It not only inhibited wound-healing and tube formation of ECs, but also decreased the content of intracellular LIP and GSH. Furthermore, it arrested ECs cycle at S phase and induced cell apoptosis. Conclusions: Compound 10 exhibits antiangiogenic effects by reducing the content of intracellular LIP and GSH, and subsequently arresting cell cycle and inducing cell apoptosis.

Recommanded Product: 65-22-5. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C12H9NO. In 2019.0 ACTA CRYSTALLOGR C published article about SUPEROXIDE-DISMUTASE ACTIVITY; DOT-N INTERACTIONS; COPPER(II) COMPLEXES; CRYSTAL-STRUCTURE in [Araujo, Vinicius Oliveira; Schwade, Vania Denise] Fundacao Univ Fed Grande Dourados, Fac Ciencias Exatas & Tecnol, Rodovia Dourados Itahum,Km 12, BR-79804970 Dourados, MS, Brazil; [Tirloni, Brbara] Univ Fed Santa Maria, Dept Quim, Ave Roraima 1000, BR-97105900 Santa Maria, RS, Brazil; [Streit, Livia] Univ North Georgia, Dept Chem & Biochem, 3820 Mundy Mill Rd, Oakwood, GA 30566 USA in 2019.0, Cited 22.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Semicarbazones can exist in two tautomeric forms. In the solid state, they are found in the keto form. This work presents the synthesis, structures and spectroscopic characterization (IR and NMR spectroscopy) of four such compounds, namely the neutral molecule 4-phenyl-1-[phenyl(pyridin-2-yl)methylidene] semicarbazide, C19H16N4O, (I), abbreviated as HBzPyS, and three different hydrated salts, namely the chloride dihydrate, C19H17N4O+center dot Cl-center dot 2H(2)O, (II), the nitrate dihydrate, C19H17N4O+center dot NO3-center dot 2H(2)O, (III), and the thiocyanate 2.5-hydrate, C19H17N4O+center dot SCN-center dot 2.5H(2)O, (IV), of 2-[phenyl({[(phenylcarbamoyl) amino]imino})methyl]pyridinium, abbreviated as [H(2)BzPyS](+)center dot X-center dot nH(2)O, with X = Cl- and n = 2 for (II), X= NO3- and n = 2 for (III), and X = SCN- and n = 2.5 for (IV), showing the influence of the anionic form in the intermolecular interactions. Water molecules and counter-ions (chloride or nitrate) are involved in the formation of a two-dimensional arrangement by the establishment of hydrogen bonds with the N-H groups of the cation, stabilizing the E isomers in the solid state. The neutral HBzPyS molecule crystallized as the E isomer due to the existence of weak pi-pi interactions between pairs of molecules. The calculated IR spectrum of the hydrated [H(2)BzPyS](+) cation is in good agreement with the experimental results.

HPLC of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Araujo, VO; Tirloni, B; Streit, L; Schwade, VD or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem