Day: November 1, 2021

I found the field of Chemistry very interesting. Saw the article Triazole-based ligands functionalized silica: Effects of ligand denticity and donors on catalytic oxidation activity of Pd nanoparticles published in 2019.0. Product Details of 91-02-1, Reprint Addresses Sangtrirutnugul, P (corresponding author), Mahidol Univ, Ctr Excellence Innovat Chem PERCH CIC, Ctr Catalysis, Dept Chem,Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

Product Details of 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Bal-Demirci, T; Guveli, S; Yesilyurt, S; Ozdemir, N; Ulkuseven, B in [Bal-Demirci, Tulay; Guveli, Sukriye; Ulkuseven, Bahri] Istanbul Univ Cerrahpasa, Engn Fac, TR-34320 Istanbul, Turkey; [Yesilyurt, Saffet] Maltepe Univ, Fac Engn & Nat Sci, TR-34857 Istanbul, Turkey; [Ozdemir, Namik] Ondokuz May S Univ, Fac Educ, Dept Math & Sci Educ, TR-55139 Samsun, Turkey published Thiosemicarbazone ligand, nickel(II) and ruthenium(II) complexes based on vitamin B6 vitamer: The synthesis, different coordination behaviors and antioxidant activities in 2020.0, Cited 79.0. COA of Formula: C8H10ClNO3. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5.

Mixed ligand nickel(II) and ruthenium(II) complexes were synthesized from pyridoxal-N-allyl-thiosemicarbazone hydrochloride and triphenylphosphine. The structures of the complexes have been characterized by elemental analysis, IR, H-1 and P-31 NMR, conductivity, magnetic moment measurements and single-crystal X-ray diffraction technique. Based on X-ray crystallographic studies, a square-planar structure has been proposed for the Ni(II) complex, in which the thiosemicarbazone ligand acts as dianionic tridentate ONS ligand. In the case of the Ru(II) complex, the thiosemicarbazone is coordinated to metal atom as a monoanionic bidentate NS donor ligand in an octahedral geometry. Antioxidant activities of the ligand and its metal complexes were calculated as their trolox equivalent antioxidant capacities (TEAC) by CUPRAC method and DPPH assay. Both the ligand and its metal complexes were found to be antioxidant and are much more antioxidant at least 2.1 times than trolox, even, ligand is 3.5 times greater than that of trolox according to CUPRAC. A linear correlation (correlation coefficient R-2 = 0.9997) appeared between the obtained TEAC values by the two antioxidant assays.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Bal-Demirci, T; Guveli, S; Yesilyurt, S; Ozdemir, N; Ulkuseven, B or concate me.. COA of Formula: C8H10ClNO3

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, characterization, in vitro antimicrobial and anticancer studies of new platinum N-heterocyclic carbene (NHC) complexes and unexpected nickel complexes WOS:000485103500021 published article about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY in [Choo, Kar Bee; Lee, Sui Mae; Lee, Wai Leng; Cheow, Yuen Lin] Monash Univ Malaysia, Sch Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia in 2019.0, Cited 74.0. HPLC of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Choo, KB; Lee, SM; Lee, WL; Cheow, YL or concate me.. HPLC of Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Designing of novel zinc(ii) Schiff base complexes having acyl hydrazone linkage: study of phosphatase and anti-cancer activities WOS:000527529300029 published article about NI-II COMPLEXES; MOLECULAR-STRUCTURE; HYDROLYSIS; MECHANISM; LIGANDS; ESTERS; DRUGS; COBALT(III); DERIVATIVES; KINETICS in [Dasgupta, Sanchari; Karim, Suhana; Das, Debasis] Univ Calcutta, Dept Chem, 92 APC Rd, Kolkata 700009, India; [Banerjee, Saswati; Saha, Moumita; Saha, Krishna Das] CSIR Indian Inst Chem Biol, Canc Biol & Inflammatory Disorder Div, 4 Raja SC Mullick Rd, Kolkata 700032, India in 2020.0, Cited 48.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Three asymmetric tridentate acyl hydrazone Schiff base ligands namely L1, L2 and L3 were prepared via condensation of 4-methoxybenzohydrazide with picolinaldehyde, 1-(pyridin-2-yl)ethanone and phenyl(pyridin-2-yl)methanone respectively. Three bio-relevant mononuclear zinc(ii) complexes [Zn(L1)Cl-2]2H(2)O (1), [Zn(L2)Cl-2] (2) and [Zn(L3)Cl-2] (3) were synthesized by treatment of zinc(ii) chloride with the corresponding Schiff base ligands and characterised by the usual physicochemical techniques. The solid state structures of complexes 1 and 3 were evaluated by single crystal X-ray analysis. All complexes were able to hydrolyse the P-O bond of the phosphate monoester in 90% (v/v) DMSO-water medium using 4-nitrophenylphosphate (4-NPP) as the model substrate and the trend in their activity is 1 approximate to 2 > 3. On considering the highly efficient hydrolysis properties, complexes 1-3 were tested as potential therapeutic agents for cancer using HCT116 (human colorectal carcinoma), HepG2 (human hepatocellular carcinoma) and A549 (human non-small lung carcinoma) cells. Complex 2 showed the highest IC50 values for anti-cancer activity towards all three cell lines among the three complexes and complex 3 showed the least activity as observed in the phosphatase activity study. The internucleosomal degradation of DNA during apoptosis can be detected by cell death detection ELISA. DNA fragmentation that leads to cell death was examined and when induced by complex 2 in HepG2 cells a significant level of DNA fragmentation was observed at regular intervals of time.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Dasgupta, S; Karim, S; Banerjee, S; Saha, M; Saha, KD; Das, D or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry; Science & Technology – Other Topics; Engineering very interesting. Saw the article Ultralow Loading Cobalt-Based Nanocatalyst for Benign and Efficient Aerobic Oxidation of Allylic Alcohols and Biobased Olefins published in 2019.0. Recommanded Product: 500-22-1, Reprint Addresses Tao, DJ (corresponding author), Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China.; Li, CZ (corresponding author), Chinese Acad Sci, Dalian Inst Chem Phys, State Key Lab Catalysis, Dalian 116023, Peoples R China.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

The synthesis of alpha,beta-unsaturated ketones from aerobic oxidation of allylic alcohols and biobased olefins serves as an important topic in green and sustainable chemistry. In this work, we report the utilization of a sacrificial template ZIF-8 for preparation of mesoporous Co-0.05/N-C material with an ultralow cobalt loading of 0.05 wt %, in which the excellent catalytic performance in aerobic oxidation of alpha-pinene and cinnamyl alcohol was achieved with an 85% yield of verbenone and a yield of cinnamaldehyde, respectively. The results of control experiments and several characterization investigations further illustrate that the sacrificial template ZIF-8 plays a key role to disperse well metallic cobalt in the Co-0.05/N-C-800 catalyst and an appropriate cobalt content of 0.05 wt % is beneficial for benign and efficient aerobic oxidation of various allylic alcohols and biobased olefins. In addition, the Co0.05/N-C-800 catalyst also exhibited good stability and reusability for recovering and reusing at least six times without obvious decrease in catalytic activity. The presented efficient nanocatalyst thus triggers facile synthesis of a series of alpha,beta-unsaturated aldehydes/ketones in high yields.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Zhao, X; Zhou, Y; Huang, K; Li, CZ; Tao, DJ or concate me.. Recommanded Product: 500-22-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 ORG PROCESS RES DEV published article about HIGHLY EFFICIENT SYNTHESIS; FUNCTIONALIZED INDOLIZINES; SUBSTITUTED INDOLIZINES; PROPARGYLIC ALCOHOLS; ONE-POT; CYCLOISOMERIZATION; S(N)2′-SUBSTITUTION; 2-ALKYLAZAARENES; DERIVATIVES; ACTIVATION in [Martinez, Thibaut; Alahyen, Ismail; Lemiere, Gilles; Mouries-Mansuy, Virginie; Fensterbank, Louis] Sorbonne Univ, Paris, France in 2020.0, Cited 43.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

A metal-free access to 2-iodo-1,3-disubstituted indolizines has been developed. The proposed synthesis is relatively simple and efficient and involves the iodine-triggered 5-endo-trig cyclization of 2-pyridylallene precursors. While it can be conducted on a gram scale, the preparation of the precursors is straightforward and does not always require intermediate purifications. The obtained 2-iodoindolizines can be further functionalized through cross-coupling reactions.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Martinez, T; Alahyen, I; Lemiere, G; Mouries-Mansuy, V; Fensterbank, L or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Reductive Activation and Hydrofunctionalization of Olefins by Multiphoton Tandem Photoredox Catalysis WOS:000649106200047 published article about TRANSFER HYDROGENATION; RADICAL IONS; LIGHT; ALKENES; MARKOVNIKOV; FUNCTIONALIZATION; PHOTOCHEMISTRY; PHOTOCATALYSIS; GENERATION; COMPLEXES in [Czyz, Milena L.; Taylor, Mitchell S.; Horngren, Tyra H.; Polyzos, Anastasios] Univ Melbourne, Sch Chem, Parkville, Vic 3010, Australia in 2021.0, Cited 86.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Recommanded Product: 91-02-1

The conversion of olefin feedstocks to architecturally complex alkanes represents an important strategy in the expedient generation of valuable molecules for the chemical and life sciences. Synthetic approaches are reliant on the electrophilic activation of unactivated olefins, necessitating functionalization with nucleophiles. However, the reductive functionalization of unactivated and less activated olefins with electrophiles remains an ongoing challenge in synthetic chemistry. Here, we report the nucleophilic activation of inert styrenes through a photoinduced direct single electron reduction to the corresponding nucleophilic radical anion. Central to this approach is the multiphoton tandem photoredox cycle of the iridium photocatalyst [Ir(ppy)(2)(dtb-bpy)]PF6, which triggers in situ formation of a high-energy photoreductant that selectively reduces styrene olefinic it bonds to radical anions without stoichiometric reductants or dissolving metals. This mild strategy enables the chemoselective reduction and hydrofunctionalization of styrenes to furnish valuable alkane and tertiary alcohol derivatives. Mechanistic studies support the formation of a styrene olefinic radical anion intermediate and a Birch-type reduction involving two sequential single electron transfers. Overall, this complementary mode of olefin activation achieves the hydrofunctionalization of less activated alkenes with electrophiles, adding value to abundant olefins as valuable building blocks in modern synthetic protocols.

Recommanded Product: 91-02-1. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Czyz, ML; Taylor, MS; Horngren, TH; Polyzos, A or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Teng, QQ; Ng, PS; Leung, JN; Huynh, HV in [Teng, Qiaoqiao; Ng, Ping Siang; Leung, Jia Nuo; Han Vinh Huynh] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore; [Teng, Qiaoqiao] Changzhou Univ, Sch Petrochem Engn, Changzhou 213164, Peoples R China published Donor Strengths Determination of Pnictogen and Chalcogen Ligands by the Huynh Electronic Parameter and Its Correlation to Sigma Hammett Constants in 2019.0, Cited 37.0. SDS of cas: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

The suitability and accuracy of the Huynh electronic parameter (HEP) was further tested to reveal remote substituent effects in pyridines, which are located five or six bonds away from the reporter probe. These values show an excellent correlation to Hammett sigma-constants of the respective substituents with coefficients of R-2=0.9856 (sigma(m)) and R-2=0.9857 (sigma(p)). Based on this observation, a methodology for the re-evaluation of certain Hammett constants with larger uncertainties has been proposed and demonstrated. Moreover, the scope of HEP was extended to various neutral pnictogen and chalcogen donors during which transphobia effects were revealed for mixed NHC complexes containing phosphites, arsine and stibine for the first time.

SDS of cas: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Teng, QQ; Ng, PS; Leung, JN; Huynh, HV or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis and Evaluation of Pyridoxal Hydrazone and Acylhydrazone Compounds as Potential Angiogenesis Inhibitors WOS:000507320500005 published article about ISONICOTINOYL HYDRAZONE; IRON CHELATORS; IN-VITRO; VITAMIN-B-6; EXPRESSION; APOPTOSIS; ANALOGS; TARGETS; GROWTH; AGENTS in [Chen, Xuyang; Li, Hui; Luo, Hongjun; Lin, Zhexuan; Luo, Wenhong] Shantou Univ, Coll Med, Bioanalyt Lab, Xinling Rd 22, Shantou, Guangdong, Peoples R China in 2019.0, Cited 45.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Product Details of 65-22-5

Background/Aims: Hydrazone and acylhydrazone derivatives, which are produced from aldehyde reacting with hydrazine or acylhydrazine, have been reported to exhibit antitumor activities. However, the angionenic effects of this kind of derivatives haven’t been elucidated. Here, we synthesized 12 pyridoxal hydrazone and acylhydrazone compounds and investigated their antiangiogenic effects and the underlying mechanisms. Method: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay was used to screen the inhibitory effects of the synthesized compounds on endothelial cells (ECs) proliferation. The compound with best inhibitory effect was further evaluated with wound-healing assay and tube formation assay. Calcein-Am assay was carried out to determine the content of intracellular labile iron pool (LIP). Intracellular reduced glutathione (GSH) was determined by spectrophotometry. Flow cytometry was used to determine cell cycle and apoptosis. Results: Compound 10 (3-hydroxy-5-[hydroxymethyl]-2-methyl-pyridine-4-carbaldehyde-2-naphthalen-1-acetyl hydrazone) showed the best inhibitory effect on human umbilical vascular ECs proliferation, with IC50 value of 25.4 mu mol/L. It not only inhibited wound-healing and tube formation of ECs, but also decreased the content of intracellular LIP and GSH. Furthermore, it arrested ECs cycle at S phase and induced cell apoptosis. Conclusions: Compound 10 exhibits antiangiogenic effects by reducing the content of intracellular LIP and GSH, and subsequently arresting cell cycle and inducing cell apoptosis.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH or concate me.. Product Details of 65-22-5

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article The novel structural modification of pyridoxal via its cyclization into 2-acyl- and 2-heteroarylfuro[2,3-c]pyridines WOS:000460711400040 published article about NATURAL-PRODUCTS; MITOCHONDRIAL; DESIGN in [Morkovnik, Anatolii S.; Divaeva, Ludmila N.; Borodkin, Gennadii S.] Southern Fed Univ, Inst Phys & Organ Chem, Rostov Na Donu 344090, Russia; [Zubenko, Alexander A.] North Caucasian Zonal Sci Vet Inst, Novocherkassk 346406, Rostov On Don R, Russia; [Kartsev, Victor G.] InterBioScreen Ltd, Chernogolovka 142432, Moscow Region, Russia; [Klimenko, Alexander I.] Don State Agr Univ, Novocherkassk 346493, Rostov On Don R, Russia in 2019.0, Cited 34.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Category: pyridine-derivatives

A simple method for pyridoxal structural modification via furan ring closure was developed resulting in 2-acyl- and 2-heteroarylfuro[2,3-c]pyridines. The reaction products can be proposed as pyridoxal mimetics to inhibit pyridoxal 5′-phosphate-dependent enzymes.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Morkovnik, AS; Zubenko, AA; Divaeva, LN; Kartsev, VG; Borodkin, GS; Klimenko, AI or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem