Month: November 2021

An article Efficient Synthesis of 1,4-Bis(5-aryl-1,3,4-oxadiazol-2-yl)-2,3,5,6-tetrafluorobenzenes WOS:000567893800031 published article about ONE-POT SYNTHESIS; 2,5-DISUBSTITUTED-1,3,4-OXADIAZOLES; 1,3,4-OXADIAZOLES; DESIGN; ACIDS in [Dhotre, B. K.] Swami Vivekanand Sr Coll, Mantha 431504, India; [Raut, S. V.; Pathan, A.] Maulana Azad Coll & Res Ctr Rouza Bagh, Aurangabad 431001, Maharashtra, India; [Khandebharad, A. U.] JES Coll, Dept Chem, Jalna 431203, India in 2020, Cited 21. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6. Formula: C8H9NO2

An efficient acid-catalyzed condensation between substituted benzohydrazides and 2,3,5,6-tetrafluoroterephthalic acid to form 1,4-bis(5-aryl-1,3,4-oxadiazol-2-yl)-2,3,5,6-tetrafluorobenzenes is reported. The products were isolated in 74-87% yield and were characterized by(1)H NMR, IR, and mass spectra.

About Ethyl nicotinate, If you have any questions, you can contact Dhotre, BK; Raut, SV; Khandebharad, AU; Pathan, A or concate me.. Formula: C8H9NO2

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 DYES PIGMENTS published article about AGGREGATION-INDUCED EMISSION; POLYMERIC NANOPARTICLES; ORGANIC NANOPARTICLES; LIQUID-CHROMATOGRAPHY; HYDROGEN-SULFIDE; CLICK REACTION; HUMAN PLASMA; AIE; HOMOCYSTEINE; THIOLS in [Sheng, Huace; Hu, Yonghong; Zhao, Xinxin; Yang, Wenge] Nanjing Tech Univ, Sch Pharmaceut Sci, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China; [Hu, Yonghong; Fan, Shimin] Nanjing Tech Univ, Synerget Innovat Ctr Adv Mat, 30 South Puzhu Rd, Nanjing 211816, Jiangsu, Peoples R China; [Zhou, Yi] Nanjing Tech Univ, Coll Chem & Mol Engn, Nanjing 211816, Jiangsu, Peoples R China; [Cao, Yang] Jiangsu Prov Hosp, Nanjing 210000, Jiangsu, Peoples R China in 2019.0, Cited 58.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. COA of Formula: C12H9NO

A new imidazo [1,5-alpha]pyridine-based fluorescent probe, named MZC-AC, is developed for the detection of cysteine (Cys) based on an excited state intramolecular proton transfer (ESIPT) mechanism. The probe MZC-AC uses an acrylate moiety as the ESIPT blocking group as well as the recognition site. Upon the treatment with Cys, MZC-AC exhibits a dramatic fluorescence enhancement (85-fold) and a large Stokes shift (166 nm). The limit of detection obtained from fluorescent titration was as low as 0.07 mu M. MZC-AC displays highly sensitive and selective response to Cys over homocysteine (Hcy) and glutathione (GSH). Significantly, MZC-AC could be used to detect Cys in living cells.

COA of Formula: C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Sheng, HC; Hu, YH; Zhou, Y; Fan, SM; Cao, Y; Zhao, XX; Yang, WG or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A new zinc(II) complex with N2O2-tetradentate schiff-base derived from pyridoxal-S-methylthiosemicarbazone: Synthesis, characterization, crystal structure, DFT, molecular docking and antioxidant activity studies WOS:000645617700015 published article about TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; GROWTH-FACTOR RECEPTOR; THIOSEMICARBAZONE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; COPPER(II) COMPLEXES; LIGANDS; NICKEL(II); ANTITUMOR in [Poladian, Qumars; Ilhan-Ceylan, Berat; Kurt, Yasemin] Istanbul Univ Cerrahpasa, Engn Fac, Dept Chem, TR-34320 Istanbul, Turkey; [Sahin, Onur] Sinop Univ, Fac Hlth Sci, Dept Occupat Hlth & Safety, TR-57000 Sinop, Turkey; [Karakurt, Tuncay] Kirsehir Ahi Evran Univ, Fac Engn Architecture, Dept Chem & Proc Engn, TR-40100 Kirsehir, Turkey in 2021.0, Cited 69.0. Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

A new unsymmetrical N2O2-tetradentate Schiff-base complex of zinc(II) was synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2-hydroxy-4-methoxy-benzaldehyde as starting compounds. S-methylthiosemicarbazone (1) and zinc(II) complex [Zn(L)CH3OH] ( 2) were characterized by elemental analysis, FT-IR, UV-visible, H-1, and C-13 NMR spectra. The molecular structure of the complex (2) was determined by single crystal X-ray diffraction technique. The structure consists of a distorted square-pyramidal geometry around the central metal, Zn(II). Quantum chemical calculations were carried out using density functional theory DFT/B3LYP, 6-31G (d), and LanL2DZ basis sets for theoretical characterization of the compounds. The experimental and theoretical data were compared comprehensively. The potential energy distribution (PED) analysis was performed for the assignment of vibration frequencies. In order to support in vitro studies, molecular docking studies have been carried out so that the title compound can be an inhibitor of Epidermal Growth Factor Receptor (1 m17), and the relationship between calculated HOMO energies and docking studies has been examined. In addition, the total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds were determined by Cupric Reducing Antioxidant Capacity (CUPRAC) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) methods, respectively. (C) 2021 Elsevier Ltd. All rights reserved.

Quality Control of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Poladian, Q; Sahin, O; Karakurt, T; Ilhan-Ceylan, B; Kurt, Y or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 65-22-5. Recently I am researching about NATURAL-PRODUCTS; MITOCHONDRIAL; DESIGN, Saw an article supported by the Ministry of Education and Science of the Russian FederationMinistry of Education and Science, Russian Federation [4.5821.2017/8.9]. Published in ELSEVIER in AMSTERDAM ,Authors: Morkovnik, AS; Zubenko, AA; Divaeva, LN; Kartsev, VG; Borodkin, GS; Klimenko, AI. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

A simple method for pyridoxal structural modification via furan ring closure was developed resulting in 2-acyl- and 2-heteroarylfuro[2,3-c]pyridines. The reaction products can be proposed as pyridoxal mimetics to inhibit pyridoxal 5′-phosphate-dependent enzymes.

SDS of cas: 65-22-5. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Morkovnik, AS; Zubenko, AA; Divaeva, LN; Kartsev, VG; Borodkin, GS; Klimenko, AI or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Rawat, J; Gadgil, M in ELSEVIER published article about MONOCLONAL-ANTIBODY PRODUCTION; AMINO-ACIDS; METABOLISM; GLUCOSE; GROWTH; PRODUCTIVITY; STRATEGIES; PROTEIN; DESIGN; MEDIA in [Rawat, Jyoti; Gadgil, Mugdha] CSIR Natl Chem Lab, Chem Engn & Proc Dev, Pune 411008, Maharashtra, India; [Rawat, Jyoti; Gadgil, Mugdha] CSIR Natl Chem Lab Campus, Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2020.0, Cited 40.0. Formula: C8H10ClNO3. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Small-scale culture of animal cells in suspension is of importance for many applications. At a small-scale, fed-batch is achieved either by manual bolus feeding or the use of liquid handling robots. In this study, we report an alternate application of a hydrogel for in situ continuous delivery of a nutrient feed comprising 18 amino acids, vitamins, antioxidants, and trace elements. We show that amino acid release is sustained for at least seven days. Importantly, release rates of individual amino acids can be independently modulated by changing their loading. We demonstrate the application of this hydrogel for complete in situ feeding of nutrients to a suspension adapted CHO cell line expressing IgG leading to 2.7-fold and 4-fold improvement in integral viable cell density (IVCD) and volumetric productivity respectively. This is similar to improvements obtained by bolus liquid feeding. Further, supplying glucose from the same hydrogel to eliminate manual feeding led to a 1.8-fold increase in IVCD accompanied by a 3-fold increase in volumetric productivity as compared to batch culture. In summary, this study provides a proof-of-concept that hydrogels can enable completely closed in situ feeding for mammalian cell culture requiring no external intervention. Such continuous in situ delivery can potentially enable closed culture systems maintaining nutrients at low levels mimicking physiological concentrations.

Formula: C8H10ClNO3. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Rawat, J; Gadgil, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Hwang, S; Ryu, JY; Jung, SH; Park, HR; Lee, J in PERGAMON-ELSEVIER SCIENCE LTD published article about CYCLOHEXENE OXIDE; HIGHLY EFFICIENT; METAL-CATALYSTS; COPOLYMERIZATION; CO2; EPOXIDES in [Hwang, Saem; Ryu, Ji Yeon; Jung, Sung Hoo; Park, Hyoung-Ryun; Lee, Junseong] Chonnam Natl Univ, Dept Chem, 300 Yongbong Dong, Gwangju 500757, South Korea in 2020.0, Cited 33.0. Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Cobalt complexes containing a salen-type pyridoxal ligand with pyridine were synthesized as a new Co (III) catalytic system for the cycloaddition of carbon dioxide. Two cobalt(III) complexes possessing a salen-type pyridoxyl ligand were synthesized by the reaction of pyridoxal ligands (pyr(2)en = (N,N’-bis (pyridoxylideneiminato)ethylene) and pyr(2)cy = (N,N’-bis(pyridoxylideneiminato)cyclohexane)) and Co (OAc)(2) and characterized by various analytical methods, including infrared spectroscopy and high-resolution mass analysis. Single-crystal X-ray crystallography analysis confirmed that the cobalt pyr(2)en complex had a distorted octahedral structure: the tetradentate Schiff base ligand binds the cobalt metal in one plane, and the metal center adopts an octahedral geometry by the additional coordination of acetate and dimethyl sulfoxide. The synthesized complexes were used as catalysts in the cycloaddition of carbon dioxide (CO2) to propylene oxide. The catalysts showed high activity for cycloaddition between CO2 and epoxides, even at a low loading (0.5 mol%), in the presence of various cocatalysts. (C) 2020 Elsevier Ltd. All rights reserved.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Hwang, S; Ryu, JY; Jung, SH; Park, HR; Lee, J or concate me.. Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 ADV SYNTH CATAL published article about ACTIVE ALPHA-PHENYLPYRIDYLMETHANOLS; ARYL HETEROARYL KETONES; ENANTIOSELECTIVE REDUCTION; ASYMMETRIC-SYNTHESIS; KLUYVEROMYCES-MARXIANUS; BIOCATALYTIC SYNTHESIS; CARBONYL REDUCTASE; CELL-CULTURES; SUBSTRATE; BIOREDUCTION in [Li, Zhining; Wang, Zexu; Wang, Yuhan; Huang, Zedu; Chen, Fener] Fudan Univ, Engn Ctr Catalysis & Synth Chiral Mol, Dept Chem, 220 Handan Rd, Shanghai 200433, Peoples R China; [Li, Zhining; Wang, Zexu; Huang, Zedu; Chen, Fener] Shanghai Engn Res Ctr Ind Asymmetr Catalysis Chir, 220 Handan Rd, Shanghai 200433, Peoples R China; [Wu, Xiaofan] Fuzhou Univ, Coll Chem Engn, 2 Xueyuan Rd, Fuzhou 350100, Fujian, Peoples R China; [Lu, Hong] Fudan Univ, Sch Life Sci, State Key Lab Genet Engn, 2005 Songhu Rd, Shanghai 200438, Peoples R China; [Lu, Hong] Shanghai Engn Res Ctr Ind Microorganisms, 2005 Songhu Rd, Shanghai 200438, Peoples R China in 2019.0, Cited 63.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Formula: C12H9NO

We report here the discovery of a novel ketoreductase (KRED), named KmCR2, with a broad substrate spectrum on bioreduction of sterically bulky diaryl- and aryl(heteroaryl)methanones. The position of the substituent on aromatic rings (meta versus para or ortho) was revealed to control the stereospecificity of KmCR2. The stereoselective preparation of both enantiomers of diaryl- or aryl(heteroaryl)methanols using strategically engineered substrates with a traceless directing group (bromo group) showcased the potential application of this substrate-controlled bioreduction reaction. The combined use of substrate engineering and protein engineering, was demonstrated to be a useful strategy in efficiently improving stereoselectivity or switching stereopreference of enzymatic processes.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Li, ZN; Wang, ZX; Wang, YH; Wu, XF; Lu, H; Huang, ZD; Chen, F or concate me.. Formula: C12H9NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Krishna; Kumari, S; Yadav, D; Sharma, SK in [Krishna; Kumari, Shweta; Yadav, Deepak; Sharma, Sunil K.] Univ Delhi, Dept Chem, Delhi 110007, India; [Yadav, Deepak] Cent Univ Haryana, Dept Chem, Mahendergarh 123031, India published Cu (II) Schiff base complex grafted guar gum: Catalyst for benzophenone derivatives synthesis in 2020.0, Cited 79.0. Computed Properties of C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

In this study Guar gum based Cu(II) Schiff’s base complex (GG-Cu) has been synthesized and characterized by FTIR, PXRD, UV-vis, TGA, XPS, FESEM, TEM, EDAX, solid-state NMR, Elemental mapping, CHNS and AAS analysis. This moiety has been found to be an efficient heterogeneous catalyst for selective oxidation reactions. Fifteen model reactions have been carried to establish the catalytic behavior of GG-Cu, and five of these yield novel products. The ease of separation of catalyst from the reaction mixture simply by filtration is an added advantage; furthermore the catalyst can be reused up to five times without significant loss of catalytic activity. The overall concept of developing newer, efficient and environmental benign catalysts with ease of separation and recycling ability has been successfully demonstrated. All of the isolated products were fully characterized on the basis of their physical and spectral data.

Computed Properties of C12H9NO. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Krishna; Kumari, S; Yadav, D; Sharma, SK or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article High-Pressure-Mediated Thiourea-Organocatalyzed Asymmetric Michael Addition to (Hetero)aromatic Nitroolefins: Prediction of Reaction Parameters by PCP-SAFT Modelling WOS:000544057700023 published article about ION-EXCHANGE-RESIN; ACETIC-ACID; CATALYZED ESTERIFICATION; LACTIC-ACID; CHEMICAL-EQUILIBRIUM; COSOLVENT INFLUENCE; REACTION-KINETICS; SOLVENTS; NITROMETHANE; REDUCTION in [Weinbender, Thomas; Reiser, Oliver] Univ Regensburg, Inst Organ Chem, Univ Str 31, D-93053 Regensburg, Germany; [Knierbein, Michael; Bittorf, Lukas; Held, Christoph; Sadowski, Gabriele] TU Dortmund Univ, Lab Thermodynam, Emil Figge Str 70, D-44227 Dortmund, Germany; [Siewert, Riko; Verevkin, Sergey P.] Univ Rostock, Dept Phys Chem, Dr Lorenz Weg 1, D-18059 Rostock, Germany in 2020.0, Cited 74.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

Thiourea-organocatalyzed Michael additions of diethyl malonate to various heteroaromatic nitroolefins (13 examples) have been studied under high-pressure (up to 800 MPa) and ambient pressure conditions. High pressure was conducive to enhanced product yields by a factor of 2-12 at a given reaction time, high reaction rates (reaction times were decreased from 72-24 h down to 4-24 h) and high enantioselectivity. Elucidating the effects of solvents for maximizing reaction rates and yields has been carried out using the Perturbed-Chain Polar Statistical Associating Fluid Theory (PCP-SAFT), allowing for the first time a prediction of the kinetic profiles under high-hydrostatic-pressure conditions.

About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Weinbender, T; Knierbein, M; Bittorf, L; Held, C; Siewert, R; Verevkin, SP; Sadowski, G; Reiser, O or concate me.. Recommanded Product: 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about AEROBIC ALCOHOL OXIDATION; PALLADIUM NANOPARTICLES; COUPLING REACTIONS; HIGHLY EFFICIENT; SELECTIVITY; SURFACE; SUZUKI, Saw an article supported by the . Published in WILEY in HOBOKEN ,Authors: Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Quality Control of Phenyl(pyridin-2-yl)methanone

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or concate me.. Quality Control of Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem