Day: December 9, 2021

Authors Du, JY; Li, YM; Xu, JC; Huang, MQ; Wang, J; Chao, JF; Wu, JH; Sun, HB; Ding, HM; Ye, H in ELSEVIER SCI LTD published article about in [Du, Jingyi; Huang, Mingquan; Wang, Juan; Wu, Jihong; Ye, Hong] Beijing Technol & Business Univ BTBU, China Light Ind, Key Lab Brewing Mol Engn, Beijing 100048, Peoples R China; [Li, Yueming; Xu, Jianchun; Chao, Jinfu; Sun, Huibin; Ding, Haimei] Qingdao Langyatai Grp Ltd, Qingdao 266500, Peoples R China in 2021, Cited 44. HPLC of Formula: C8H9NO2. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

A study was carried out to determine systematically the key aroma-active compounds of Langyatai Baijiu with Jian flavour (LBJF) using sensory omics analysis (SOA). A total of 56 odorants were screened out using gas chromatography-olfactometry-mass spectrometry (GC-O-MS)/Osme analysis. Among them, 15 aroma-active components were first identified. After quantitation, 30 odorants had odour activity values (OAVs) > 1.0 in LBJF. Recombinant and omission experiments proved that the esters, alcohols, acids, especially ethyl hexanoate, gamma psi psi-nonalactone, and dimethyl trisulfide, were critical to the flavour of LBJF. The basic and commercial liquors had obvious differences in the skeleton compositions of esters and acids. This study uncovers the characteristics of Jian flavour Baijiu (JFB) and provides a scientific basis for the quality control of JFB, which is helpful for the development of Chinese Baijiu flavour styles.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Oxyfunctionalization of Alkanes Based on a Tricobalt(II)-Substituted Dawson-Type Rhenium Carbonyl Derivative as Catalyst WOS:000548456300009 published article about HETEROPOLYTUNGSTATE DERIVATIVES; HETEROGENEOUS CATALYSTS; CYCLOHEXANE OXIDATION; W-183 NMR; METAL; KEGGIN; PERFORMANCE; FUNCTIONALIZATION; HYDROCARBONS; OXYGENATION in [Ma, Xinyi; Wang, Ping; Liu, Zhihao; Xin, Changhui; Wang, Siyu; Jia, Jiage; Ma, Pengtao; Niu, Jingyang; Wang, Jingping] Henan Univ, Henan Key Lab Polyoxometalate Chem, Coll Chem & Chem Engn, Kaifeng 475004, Henan, Peoples R China in 2020.0, Cited 61.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Category: pyridine-derivatives

POM-supported metal carbonyl derivatives (PMCDs) represent a family of tremendous potential catalysts owing to their peculiar physical and chemical properties. Yet low-valence transition metal-substituted Dawson-type PMCD catalysts are uncommon. Hence, we synthesized a tricobalt-substituted PMCDs by conventional aqueous solution method, [Na(H2O)(5)](NH4)(7)[P2W15O56Co3(H2O)(3)(OH)(3)Re(CO)(3)]center dot 13H(2)O (1), and characterized by single crystal X-ray diffraction crystallography, IR, and thermogravimetric analyses (TGA), etc. The obtained compound 1 was employed as a catalyst for the oxidation of diphenylmethane (DPM) to benzophenone, giving 96.8% yield in the presence of tert-butyl hydroperoxide (TBHP) and pyridine. The control experiments indicate that Co metal ion plays an important role in the catalytic reactions. As a side note, the electrospray ionization mass spectrometry (ESI-MS) and UV spectroscopy showed that 1 can retain its integrity in solution, and magnetic measurements indicated that 1 exhibited a weaker ferromagnetic interaction at low temperature.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis, characterization, in vitro antimicrobial and anticancer studies of new platinum N-heterocyclic carbene (NHC) complexes and unexpected nickel complexes WOS:000485103500021 published article about STRUCTURAL-CHARACTERIZATION; BIOLOGICAL-ACTIVITY; CRYSTAL-STRUCTURES; METAL-COMPLEXES; DNA-BINDING; LIGANDS; IMIDAZOLIUM; PYRIDINE; ANTIBACTERIAL; CYTOTOXICITY in [Choo, Kar Bee; Lee, Sui Mae; Lee, Wai Leng; Cheow, Yuen Lin] Monash Univ Malaysia, Sch Sci, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor, Malaysia in 2019.0, Cited 74.0. Recommanded Product: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A series of bidendate pyridine-functionalized metal N-heterocyclic carbene (NHC) complexes with various wingtip substituents (R = methyl, phenyl and tert-butyl) had been prepared from silver oxide-mediated transmetalation method. The basic backbone of the NHC ligands were prepared in two step-wise reactions: reduction of the commercially available 2-benzoylpyridine, followed by halogenation to yield 2-(chloro(phenyl) methyl) pyridine. Subsequent reactions with different imidazoles gave the desired imidazolium salts (or NHC precursors) with different R groups at the N wingtip (R = Me, Ph, t-Bu). Transmetalation of the imidazolium salts into platinum NHC complexes were achieved by using Ag2O mediated method with Pt(cod)Cl-2 as the transmetalating agent. On the other hand, nickel NHC complexes were obtained via one pot synthesis method with nickel chloride as the transmetalating agent and reflux in the presence of a base. Following recrystallisation, the molecular structure of Pt NHC complex (+/-)-5a had been successfully elucidated via single crystal X ray diffraction (XRD) analysis. The six-membered ring of the platinum NHC complexes adopted a boat conformation with the phenyl ring arranged at the axial position. Meanwhile, two unexpected nickel complexes, i.e. a simple nickel coordination complex and a nickelate complex, were obtained and studied using XRD. These Pt NHC complexes and unexpected Ni complexes were evaluated for their in vitro antimicrobial and anticancer activities against a panel of pathogenic microorganisms and three selected human cancer cell lines, including breast (MCF7), colon (HCT116) and oral (H103) cancer cells. Generally, the Pt NHC complexes displayed enhanced antimicrobial activities upon coordination to metals, as compared to the corresponding imidazolium salts i.e. NHC precursors, with minimum inhibitory concentration (MIC) values in micromolar (mM) range. A couple of platinum NHC complexes synthesized exhibited antimicrobial activities with MIC as low as 2 mM, which are comparable to silver NHC complexes with renowned antimicrobial profiles. Similarly, upon coordination to the metals, the cytotoxic effects of the platinum NHC complexes increased significantly as compared to the imidazolium salts. Among all, platinum NHC complex (+/-)-5c displayed significant cytotoxicities towards the cancer cells with IC50 values that are two to three times lower than that of the anticancer drug cisplatin. In summary, evidences for influence of both wingtip substituents and metals on the biological activities of the complexes have been found. (C) 2019 Elsevier B.V. All rights reserved.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. In 2020 GREEN CHEM published article about C DOUBLE-BOND; MOLECULAR-OXYGEN; FREE CATALYST; PHOTOOXIDATIVE CLEAVAGE; ALPHA-METHYLSTYRENE; SINGLET-OXYGEN; ALCOHOLS; GREEN; CO2; TRANSFORMATION in [Zhang, Yu; Das, Shoubhik] Univ Antwerp, Dept Chem, ORSY Div, Gronenborgerlaan 171, B-2020 Antwerp, Belgium; [Zhang, Yu; Hatami, Nareh; Lange, Niklas Simon; Schilling, Waldemar] Georg August Univ Gottingen, Inst Biomol & Organ Chem, Tammannstr 2, D-37077 Gottingen, Germany; [Ronge, Emanuel; Jooss, Christian] Georg August Univ Gottingen, Inst Materialphys, Friedrich Hund Pl 1, D-37077 Gottingen, Germany in 2020, Cited 68. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Selective cleavage of C & xe001;C bonds is highly important for the synthesis of carbonyl containing fine chemicals and pharmaceuticals. Novel methodologies such as ozonolysis reactions, Lemieux-Johnson oxidation reactionetc. already exist. Parallel to these, catalytic methods using homogeneous catalysts also have been discovered. Considering the various advantages of heterogeneous catalysts such as recyclability and stability, couple of transition metal-based heterogeneous catalysts have been applied for this reaction. However, the pharmaceutical industries prefer to use metal-free catalysts (especially transition metal-free) to avoid further leaching in the final products. This is for sure a big challenge to an organic chemist and to the pharmaceutical industries! To make this feasible, a mild and efficient protocol has been developed using polymeric carbon nitrides (PCN) as metal-free heterogeneous photocatalysts to convert various olefins into the corresponding carbonyls. Later, this catalyst has been applied in the gram scale synthesis of pharmaceutical drugs using direct solar energy. Detailed mechanistic studies revealed the actual role of oxygen, the catalyst, and the light source.

COA of Formula: C12H9NO. Welcome to talk about 91-02-1, If you have any questions, you can contact Zhang, Y; Hatami, N; Lange, NS; Ronge, E; Schilling, W; Jooss, C; Das, S or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article A new zinc(II) complex with N2O2-tetradentate schiff-base derived from pyridoxal-S-methylthiosemicarbazone: Synthesis, characterization, crystal structure, DFT, molecular docking and antioxidant activity studies WOS:000645617700015 published article about TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; GROWTH-FACTOR RECEPTOR; THIOSEMICARBAZONE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; COPPER(II) COMPLEXES; LIGANDS; NICKEL(II); ANTITUMOR in [Poladian, Qumars; Ilhan-Ceylan, Berat; Kurt, Yasemin] Istanbul Univ Cerrahpasa, Engn Fac, Dept Chem, TR-34320 Istanbul, Turkey; [Sahin, Onur] Sinop Univ, Fac Hlth Sci, Dept Occupat Hlth & Safety, TR-57000 Sinop, Turkey; [Karakurt, Tuncay] Kirsehir Ahi Evran Univ, Fac Engn Architecture, Dept Chem & Proc Engn, TR-40100 Kirsehir, Turkey in 2021.0, Cited 69.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Recommanded Product: 65-22-5

A new unsymmetrical N2O2-tetradentate Schiff-base complex of zinc(II) was synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2-hydroxy-4-methoxy-benzaldehyde as starting compounds. S-methylthiosemicarbazone (1) and zinc(II) complex [Zn(L)CH3OH] ( 2) were characterized by elemental analysis, FT-IR, UV-visible, H-1, and C-13 NMR spectra. The molecular structure of the complex (2) was determined by single crystal X-ray diffraction technique. The structure consists of a distorted square-pyramidal geometry around the central metal, Zn(II). Quantum chemical calculations were carried out using density functional theory DFT/B3LYP, 6-31G (d), and LanL2DZ basis sets for theoretical characterization of the compounds. The experimental and theoretical data were compared comprehensively. The potential energy distribution (PED) analysis was performed for the assignment of vibration frequencies. In order to support in vitro studies, molecular docking studies have been carried out so that the title compound can be an inhibitor of Epidermal Growth Factor Receptor (1 m17), and the relationship between calculated HOMO energies and docking studies has been examined. In addition, the total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds were determined by Cupric Reducing Antioxidant Capacity (CUPRAC) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) methods, respectively. (C) 2021 Elsevier Ltd. All rights reserved.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C8H9NO2. Shpanko, IV; Sadovaya, IV in [Shpanko, I. V.] V Stus Donetsk Natl Univ, UA-21021 Vinnitsa, Ukraine; [Sadovaya, I. V.] Donetsk Natl Univ, Donetsk, Ukraine published Isoenthalpy Catalytic Effects of Pyridines in Reactions of Phenyloxyrane with N-Aroylbenzenesulfonamides in 2019, Cited 21. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

Additive nature of the combined effect of the structure (X, Y substituents) and temperature on the rate and free activation energy has been established for the reactions of phenyloxirane with Y-substituted N-aroylbenzenesulfonamides catalyzed by X-substituted pyridines. The cross reaction series is isoenthalpic with respect to the structural effects. The mechanism of the catalytic process has been discussed.

Welcome to talk about 614-18-6, If you have any questions, you can contact Shpanko, IV; Sadovaya, IV or send Email.. COA of Formula: C8H9NO2

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Solvent-free microwave-assisted synthesis of imidazo[1,5-a]pyridine and -quinoline derivatives WOS:000481164400001 published article about RATIOMETRIC FLUORESCENT-PROBE; COMPLEXES; EFFICIENT; LIGHT; TRANSANNULATION; ALDEHYDES; EMISSION; LIGANDS; IMIDAZO; SHIFT in [Herr, Jasmin Martha; Roessiger, Carina; Goettlich, Richard] Justus Liebig Univ Giessen, Inst Organ Chem, Heinrich Buff Ring 17, D-35392 Giessen, Germany; [Herr, Jasmin Martha; Roessiger, Carina; Albrecht, Georg; Goettlich, Richard] Justus Liebig Univ Giessen, Ctr Mat Res LaMa, Giessen, Germany; [Albrecht, Georg] Justus Liebig Univ Giessen, Inst Appl Phys, Giessen, Germany; [Yanagi, Hisao] NAIST, Dept Mat Sci, Nara, Japan in 2019.0, Cited 39.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A quick and highly efficient microwave-assisted preparation of imidazopyridines and -quinolines is described, starting from the corresponding ketones and amines. The method requires no solvent and uses activated MnO2 as an oxidant. A mechanism for the cyclization is proposed and discussed.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 J MED CHEM published article about NATURAL-PRODUCTS; INTRACELLULAR ZINC; CORRELATION-ENERGY; IRON CHELATORS; CELL-GROWTH; DNA-DAMAGE; APOPTOSIS; COMPLEXES; DEPLETION; ANALOGS in [Galiana-Rosello, Cristina; Gonzalez, Jorge; Martinez-Camarena, Alvaro; Garcia-Espana, Enrique] Univ Valencia, Inst Ciencia Mol ICMol, Dept Quim Inorgan, Valencia 46980, Spain; [Galiana-Rosello, Cristina; Eugenia Gonzalez-Rosende, Maria] Univ CEU Cardenal Herrera, Fac Ciencias Salud, Dept Farm, C Ramon y Cajal S-N, Valencia 46115, Spain; [Galiana-Rosello, Cristina; Fernandez de Mattos, Silvia; Villalonga, Priam] Univ Illes Balears, Inst Univ Invest Ctencies Salut IUNICS, Canc Cell Biol Lab, Illes Balears 07122, Spain; [Galiana-Rosello, Cristina; Fernandez de Mattos, Silvia; Villalonga, Priam] Inst Invest Sanitaria Illes Balears IdISBa, Illes Balears 07122, Spain; [Villalonga, Ruth] Univ Illes Balears, Dept Quim, Illes Balears 07122, Spain; [Fernandez de Mattos, Silvia] Univ Illes Balears, Dept Biol Fonamental, Illes Balears 07122, Spain; [Soriano, Concepcion; Llinares, Jose] Univ Valencia, Dept Quim Organ, E-46100 Valencia, Spain in 2020.0, Cited 79.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Category: pyridine-derivatives

In vitro viability assays against a representative panel of human cancer cell lines revealed that polyamines L1a and L5a displayed remarkable activity with IC50 values in the micromolar range. Preliminary research indicated that both compounds promoted G1 cell cycle arrest followed by cellular senescence and apoptosis. The induction of apoptotic cell death involved loss of mitochondrial outer membrane permeability and activation of caspases 3/7. Interestingly, L1a and L5a failed to activate cellular DNA damage response. The high intracellular zinc-chelating capacity of both compounds, deduced from the metal specific Zinquin assay and ZnL2+ stability constant values in solution, strongly supports their cytotoxicity. These data along with quantum mechanical studies have enabled to establish a precise structure-activity relationship. Moreover, L1a and L5a showed appropriate drug-likeness by in silico methods. Based on these promising results, L1a and L5a should be considered a new class of zinc-chelating anticancer agents that deserves further development.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Chemical synthesis of 5 ‘-beta-glycoconjugates of vitamin B-6 WOS:000519529400008 published article about PYRIDOXINE-BETA-GLUCOSIDE; PARTICULATE GLUCOSYLTRANSFERASE; PROTEIN GLYCOSYLATION; GROWING CULTURE; N-GLYCOSYLATION; FUSARIUM TOXINS; RICE BRAN; SEEDLINGS; GLUCURONIDATION; BIOAVAILABILITY in [Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael] Tech Univ Munich, Chair Analyt Food Chem, Maximus von Imhof Forum 2, D-85354 Freising Weihenstephan, Germany in 2020.0, Cited 107.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Formula: C8H10ClNO3

Various 5′-beta-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chemically according to KOENIGS-KNORR conditions using alpha 4,3-O-iso-propylidene pyridoxine and the respective acetobromo glycosyl donors with AgOTf (3.0 eq.) and NIS (3.0 eq.) as promoters at 0 degrees C. Furthermore, 5′-beta-[C-13(6)]-labeled pyridoxine glucoside (PNG) was prepared starting from [C-1(3)6]-glucose and pyridoxine. Additionally, two strategies were examined for the synthesis of 5′-beta-pyridoxal glucoside (PLG).

Formula: C8H10ClNO3. Bye, fridends, I hope you can learn more about C8H10ClNO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation WOS:000510109900013 published article about RUTHENIUM(II) ARENE COMPLEXES; VITRO ANTICANCER ACTIVITY; IN-VITRO; RIBONUCLEOTIDE REDUCTASE; ZN(II) COMPLEXES; DNA CLEAVAGE; PHASE-II; 3-AMINOPYRIDINE-2-CARBOXALDEHYDE THIOSEMICARBAZONE; SPECTRAL CHARACTERIZATION; CYTOTOXIC ACTIVITIES in [Saswati; Mohanty, Monalisa; Banerjee, Atanu; Biswal, Sonaleen; Dinda, Rupam] Natl Inst Technol, Dept Chem, Rourkela 769008, Odisha, India; [Horn, Adolfo, Jr.] Univ Estadual Norte Fluminense, Lab Ciencias Quim, Campos Dos Goytacaces, RJ, Brazil; [Schenk, Gerhard] Univ Queensland, Sch Chem & Mol Biosci, St Lucia, Qld 4072, Australia; [Brzezinski, Krzysztof] Univ Bialystok, Inst Chem, Ciolkowskiego 1K, PL-15245 Bialystok, Poland; [Sinn, Ekkehard] Western Michigan Univ, Dept Chem, Kalamazoo, MI 49008 USA; [Reuter, Hans] Univ Osnabruck, Inst Chem New Mat, Barbarastr 6, D-49069 Osnabrucks, Germany in 2020.0, Cited 98.0. Quality Control of Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Two new dimeric Zn(II) ([{ZnL1(DMSO2)}(2)]center dot DMSO (1), [{(ZnLCl)-Cl-2}(2)] (2)) and a novel tetrameric Zn(II) complex ([(Zn2L3)(2)(mu-OAc)(2)(mu(3)-O)(2)] (3)), where H2L1 = 4-(p-methoxyphenyl) thiosemicarbazone of o-hydroxynapthaldehyde, HL2 = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H2L3 = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal X-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10(12)M(-1)), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, circular dichroism and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10(3) to 10(4) M-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line.

Quality Control of Phenyl(pyridin-2-yl)methanone. About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Saswati; Mohanty, M; Banerjee, A; Biswal, S; Horn, A; Schenk, G; Brzezinski, K; Sinn, E; Reuter, H; Dinda, R or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem