Day: December 15, 2021

An article Design, synthesis, and biological evaluation of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as novel Nur77 modulators WOS:000573916100021 published article about CELL-DEATH; ENDOPLASMIC-RETICULUM; DUAL ROLES; APOPTOSIS; EXPRESSION; STRESS; UBIQUITINATION; METABOLISM; ACTIVATION; INDUCTION in [Li, Baicun; Yao, Jie; Guo, Kaiqiang; He, Fengming; Chen, Kun; Lin, Zongxin; Liu, Shunzhi; Huang, Jiangang; Wu, Qiaoqiong; Fang, Meijuan; Zeng, Jinzhang; Wu, Zhen] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China; [Li, Baicun; Yao, Jie; Guo, Kaiqiang; He, Fengming; Chen, Kun; Lin, Zongxin; Liu, Shunzhi; Huang, Jiangang; Wu, Qiaoqiong; Fang, Meijuan; Zeng, Jinzhang; Wu, Zhen] Xiamen Univ, Sch Pharmaceut Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Peoples R China; [Li, Baicun] Chinese Acad Med Sci, Inst Basic Med Sci, Dept Physiol, State Key Lab Med Mol Biol, Beijing 100005, Peoples R China; [Li, Baicun] Peking Union Med Coll, Sch Basic Med, Beijing 100005, Peoples R China in 2020.0, Cited 74.0. Recommanded Product: 500-22-1. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Nur77 is a potential target for the treatment of cancer such as HCC. Herein, we detailed the discovery of a novel series of 5-((8-methoxy-2-methylquinolin-4-yl)amino)-1H-indole-2-carbohydrazide derivatives as potential Nur77 modulators. The studies of antiproliferative activity and Nur77-binding affinity of target compounds resulted in the discovery of a lead candidate (10g), which was a good Nur77 binder (K-D = 3.58 +/- 0.16 mu M) with a broad-spectrum antiproliferative activity against all tested hepatoma cells (IC50 < 2.0 mu M) and was low toxic to normal LO2 cells. 10g could up-regulate Nur77 expression and mediate sub-cellular localization of Nur77 to induce apoptosis in hepatocellular carcinoma cell lines, which relied on 10g inducing Nur77-dependent autophagy and endoplasmic reticulum stress as the upstream of apoptosis. Moreover, the in vivo assays verified that 10g significantly inhibited xenograft tumor growth. These results indicate that 10g has the potential to be developed as a novel Nur77-targeting anti-hepatoma drug. (C) 2020 Elsevier Masson SAS. All rights reserved. Recommanded Product: 500-22-1. About 3-Pyridinecarboxaldehyde, If you have any questions, you can contact Li, BC; Yao, J; Guo, KQ; He, FM; Chen, K; Lin, ZX; Liu, SZ; Huang, JG; Wu, QQ; Fang, MJ; Zeng, JZ; Wu, Z or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Xu, JH; Wu, WB; Wu, J in [Xu, Jin-hui; Wu, Wen-bin; Wu, Jie] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore published Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with Alkynes under Anaerobic and Aerobic Conditions in 2019.0, Cited 47.0. SDS of cas: 91-02-1. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Ortho-alkylated and ortho-acylated pyridines have been conveniently synthesized from pyridine N-oxides and alkynes under visible-light-mediation in a metal-free manner. The alkynes served as both alkylating and acylating agents via switching between anaerobic and aerobic conditions. The overall strategy accommodates a broad scope of substituted pyridine N-oxides and alkynes, with excellent regioselectivity in a number of cases.

SDS of cas: 91-02-1. Welcome to talk about 91-02-1, If you have any questions, you can contact Xu, JH; Wu, WB; Wu, J or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Product Details of 91-02-1. Recently I am researching about CHEMISTRY; REAGENTS; SCALE; TOOL, Saw an article supported by the project Italian Ministry for Economic Development (MISE), Horizon 2020 [338]; University of Bari; Austrian COMET Program by the Austrian Federal Ministry of Transport, Innovation and Technology (BMVIT) [FFG 862766]; Austrian Federal Ministry for Digital and Economic Affairs (BMDW); State of Styria (Styrian Funding Agency SFG). Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Musci, P; von Keutz, T; Belaj, F; Degennaro, L; Cantillo, D; Kappe, CO; Luisi, R. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Strained compounds are privileged moieties in modern synthesis. In this context, 1-azabicyclo[1.1.0]butanes are appealing structural motifs that can be employed as click reagents or precursors to azetidines. We herein report the first telescoped continuous flow protocol for the generation, lithiation, and electrophilic trapping of 1-azabicyclo[1.1.0]butanes. The flow method allows for exquisite control of the reaction parameters, and the process operates at higher temperatures and safer conditions with respect to batch mode. The efficiency of this intramolecular cyclization/C3-lithiation/electrophilic quenching flow sequence is documented with more than 20 examples.

Welcome to talk about 91-02-1, If you have any questions, you can contact Musci, P; von Keutz, T; Belaj, F; Degennaro, L; Cantillo, D; Kappe, CO; Luisi, R or send Email.. Product Details of 91-02-1

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

SDS of cas: 91-02-1. In 2020 ANGEW CHEM INT EDIT published article about OLD YELLOW ENZYME; COMBINING PHOTOCATALYSIS; BIOCATALYTIC REDUCTION; RADICALS; BOND; DISSOCIATION; REDOX; HETEROCYCLES; BIOREDUCTION; COMPLEXES in [Nakano, Yuji; Black, Michael J.; Meichan, Andrew J.; Sandoval, Braddock A.; Chung, Megan M.; Biegasiewicz, Kyle F.; Hyster, Todd K.] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA; [Zhu, Tianyu] CALTECH, Div Chem & Chem Engn, Pasadena, CA 91125 USA; [Nakano, Yuji] Monash Univ, Monash Inst Pharmaceut Sci, Parkville, Vic 3052, Australia; [Biegasiewicz, Kyle F.] Arizona State Univ, Sch Mol Sci, Tempe, AZ 85287 USA in 2020, Cited 61. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Flavin-dependent ‘ene’-reductases (EREDs) are highly selective catalysts for the asymmetric reduction of activated alkenes. This function is, however, limited to enones, enoates, and nitroalkenes using the native hydride transfer mechanism. Here we demonstrate that EREDs can reduce vinyl pyridines when irradiated with visible light in the presence of a photoredox catalyst. Experimental evidence suggests the reaction proceeds via a radical mechanism where the vinyl pyridine is reduced to the corresponding neutral benzylic radical in solution. DFT calculations reveal this radical to be dynamically stable, suggesting it is sufficiently long-lived to diffuse into the enzyme active site for stereoselective hydrogen atom transfer. This reduction mechanism is distinct from the native one, highlighting the opportunity to expand the synthetic capabilities of existing enzyme platforms by exploiting new mechanistic models.

SDS of cas: 91-02-1. Welcome to talk about 91-02-1, If you have any questions, you can contact Nakano, Y; Black, MJ; Meichan, AJ; Sandoval, BA; Chung, MM; Biegasiewicz, KF; Zhu, TY; Hyster, TK or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

I found the field of Chemistry very interesting. Saw the article [(CN)-N-boolean AND]-Alkenyl Gold(III) Complexes by Proximal Ring-Opening of (2-Pyridyl)alkylidenecyclopropanes: Mechanistic Insights published in 2020.0. Safety of Phenyl(pyridin-2-yl)methanone, Reprint Addresses Nevado, C (corresponding author), Univ Zurich, Dept Chem, Winterthurerstr 190, CH-8057 Zurich, Switzerland.; Mascarenas, JL; Lopez, F (corresponding author), Univ Santiago de Compostela, Ctr Singular Invest Quim Biol & Mat Mol CIQUS, Santiago De Compostela, A Coruna, Spain.; Mascarenas, JL; Lopez, F (corresponding author), Univ Santiago de Compostela, Dept Quim Organ, Santiago De Compostela, A Coruna, Spain.; Lopez, F (corresponding author), CSIC, Inst Quim Organ Gen, Madrid, Spain.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Pyridine-substituted alkylidenecyclopropanes (Py-ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring-opening pathway, to generate highly appealing, catalytically active pyridine alkenyl [C<^>N]-gold(III) species. Mechanistic studies reveal that the activation of the C-C bond of the ACP takes place through an unusual concerted, sigma-bond metathesis type-process.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of 3-Pyridinecarboxaldehyde. Authors Gein, VL; Rubtsova, DD; Bobyleva, AA; Yankin, AN in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Gein, V. L.; Rubtsova, D. D.; Bobyleva, A. A.] Perm State Pharmaceut Acad, Perm 614990, Russia; [Yankin, A. N.] Natl Res Univ ITMO, St Petersburg 197101, Russia in 2020.0, Cited 5.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

5-Aryl(heteryl)-1-hydroxyethyl-4-(furyl-2-carbonyl)-3-hydroxy-3-pyrroline-2-ones were synthesized via reactions of methyl ester of furyl-2-carbonylpyruvic acid with a mixture of aromatic or heterocyclic aldehyde and ethanolamine in dioxane. Antibacterial and antifungal activities of the synthesized compounds was studied.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Bjelogrlic, SK; Todorovic, TR; Kojic, M; Sencanski, M; Nikolic, M; Visnjevac, A; Araskov, J; Miljkovic, M; Muller, CD; Filipovic, NR in ELSEVIER SCIENCE INC published article about 3-DIMENSIONAL CELL-CULTURE; HUMAN SERUM-ALBUMIN; DNA-DAMAGE; CRYSTAL-STRUCTURE; TOPOISOMERASE-I; PALLADIUM(II) COMPLEXES; MITOCHONDRIAL-MEMBRANE; DOWN-REGULATION; CANCER; CISPLATIN in [Bjelogrlic, Snezana K.] Natl Canc Res Ctr Serbia, Pasterova 14, Belgrade 11000, Serbia; [Bjelogrlic, Snezana K.; Muller, Christian D.] Univ Strasbourg, Inst Pluridisciplinaire Hubert Curien, UMR 7178, CNRS, F-67401 Illkirch Graffenstaden, France; [Todorovic, Tamara R.; Nikolic, Milan; Araskov, Jovana] Univ Belgrade, Fac Chem, Studentski Trg 12-16, Belgrade 11000, Serbia; [Kojic, Milan; Miljkovic, Marija] Univ Belgrade, Inst Mol Genet & Genet Engn, V Stepe 444a,POB 23, Belgrade 11010, Serbia; [Sencanski, Milan] Univ Belgrade, Ctr Multidisciplinary Res, Inst Nucl Sci Vinca, Belgrade 11000, Serbia; [Visnjevac, Aleksandar] Rudjer Boskovic Inst, Phys Chem Div, Bijenicka C 54, HR-10000 Zagreb, Croatia; [Filipovic, Nenad R.] Univ Belgrade, Fac Agr, Nemanjina 6, Belgrade 11000, Serbia in 2019.0, Cited 103.0. Recommanded Product: Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Anticancer activity of Pd complexes 1-5 with bidentate N-heteroaromatic hydrazone ligands was investigated on human acute monocytic leukemia (THP-1; cells in a suspension) and human mammary adenocarcinoma (MCF-7; two-dimensional layer and three-dimensional spheroid tumor model) cell lines. For the Pd(II) complexes with condensation products of ethyl hydrazainoacetate and quinoline-8-carboxaldehyde (complex 1) and 2-for-mylpyridine (complex 3), for which apoptosis was determined as a mechanism of anticancer activity, further investigation revealed that they arrest the cell cycle in G0/G1 phase, induce generation of reactive oxygen species and inhibit Topoisomerase I in vitro. In silico studies corroborate experimental findings that these complexes show topoisomerase inhibition activity in the micromolar range and indicate binding to a DNA’s minor groove as another potential target. Based on the results obtained by circular dichroism and fluorescence spectroscopy measurements, the most active complexes are suitable to be delivered to a blood stream via human serum albumin.

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Bjelogrlic, SK; Todorovic, TR; Kojic, M; Sencanski, M; Nikolic, M; Visnjevac, A; Araskov, J; Miljkovic, M; Muller, CD; Filipovic, NR or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 TETRAHEDRON published article about HYPOPHOSPHITE COMBINATION SYSTEM; PHENYL SULFONE; NUCLEOPHILIC DIFLUOROMETHYLATION; CARBONYL-COMPOUNDS; SULFIDE OXIDATION; RANEY-NICKEL; REDUCTIVE DESULFURIZATION; STEREOSELECTIVE-SYNTHESIS; HIGH ENANTIOSELECTIVITY; REFORMATSKY REACTION in [Batisse, Chloe; Davila, Maria F. Cespedes; Messara, Amelia; Panossian, Armen; Hanquet, Gilles; Leroux, Frederic R.] Univ Strasbourg, Univ Haute Alsace, CNRS, ECPM,UMR LIMA 7042, 25 Rue Becquerel, F-67087 Strasbourg, France; [Castello, Marco] Univ Basilicata, Dipartimento Sci, Via Nazario Sauro 85, I-85100 Potenza, Italy; [Davila, Maria F. Cespedes; Vivet, Bertrand; Marciniak, Gilbert] Sanofi Aventis R&D, 16 Rue Ankara, F-67080 Strasbourg, France in 2019.0, Cited 143.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

The -CHF2 moiety has shown a growing interest in pharmaceutical and agrochemical applications over the last few years. Its introduction is therefore a current research topic for organic chemists. Several groups have reported the synthesis of difluoromethylated compounds. However, the more challenging enantioselective introduction of the difluoromethyl group has been scarcely described yet. We recently developed a new strategy, based on the use of an enantiopure difluoromethyl sulfoxide used as chiral and traceless auxiliary, for the synthesis of highly enantioenriched alpha-difluoromethyl alcohols. The first method developed in our laboratory aims to access highly stereoenriched alpha,alpha-difluoro-beta-hydroxysulfoxides through the condensation of the enantiopure difluoromethyl sulfoxide on carbonyl derivatives. It is noteworthy that highly diastereo- and enantioenriched alpha,alpha-difluoro-beta-hydroxysulfoxides can also be accessed after the diastereoselective reduction of highly enantioenriched alpha,alpha-difluoro-beta-ketosulfoxides. Finally, the expected difluoromethyl-substituted alcohols can be obtained after removal of the chiral auxiliary with complete retention of stereoenrichment at carbon. (C) 2019 Elsevier Ltd. All rights reserved.

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Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Recently I am researching about SUPEROXIDE-DISMUTASE ACTIVITY; PARAMAGNETIC-RESONANCE SPECTRA; DENSITY-FUNCTIONAL THEORY; AB-INITIO HF; CRYSTAL-STRUCTURES; X-RAY; ACTIVE-SITE; SPECTROSCOPIC CHARACTERIZATION; INTERMOLECULAR INTERACTIONS; NICKEL(II) COMPLEXES, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Singh, Y; Patel, RN; Patel, SK; Jadeja, RN; Patel, AK; Patel, N; Roy, H; Kumar, P; Butcher, RJ; Jasinski, JP; Cortijo, M; Herrero, S. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

A series of two new mono- and one binuclear m-nitrato bridged copper(II) complexes [Cu(L)(HL)]ClO4 (1), [Cu(HL)(NO3)(H2O)](2)NO3 center dot H2O (2) and [Cu-2(L-2)(mu-NO3)(2)] (3), with an unsymmetrical NNO donor Schiff base (HL) have been synthesized and characterized by elemental analysis, FTIR, CV, UV-vis and EPR spectroscopy. Their molecular structures were also determined by single crystal X-ray crystallography. In the binuclear complex 3, the Cu center dot center dot center dot Cu distance is 3.494 angstrom. In 1, 2 and 3, the Cu(II) centers have distorted square pyramidal geometry (tau(5) = 0.05-0.17). Evidence of weak pi center dot center dot center dot pi stacking intermolecular interactions along with other non-covalent interactions (hydrogen bonding) was observed by analyzing the respective crystal structures of the complexes. Thus, these hydrogen bonds, pi center dot center dot center dot pi stacking interactions and other weak intermolecular interactions establish in the form of supramolecular architectures a crystalline network environment. The non-covalent interactions were also investigated by employing Hirshfeld Analysis. The room temperature magnetic moments of the mononuclear complexes are less than the spin only values which are indicative of small interactions. Also, significant magnetic interactions were not exhibited by binuclear copper(II) complex 3 in the variable temperature magnetic measurements. The X-band EPR spectra of all three complexes exhibit copper(II) hyperfine structures as well as zero-field splitting which are appropriate for the triplet states of dimers. In complexes 1 and 2, the presence of pseudo dipolar interactions is proposed. Quantum chemical calculations (DFT) were carried out on complexes 1-3 to explore the electronic and spectral properties of these newly synthesized complexes. These complexes show significant antiproliferative and SOD activity. The SOD activity measured in terms of kMcCF is in the range 4.94-12.31 (mol L)(-1)s(-1))x 10(4). (C) 2021 Elsevier Ltd. All rights reserved.

Application In Synthesis of Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Galli, U; Hysenlika, R; Meneghetti, F; Del Grosso, E; Pelliccia, S; Novellino, E; Giustiniano, M; Tron, GC in [Galli, Ubaldina; Hysenlika, Rejdia; Del Grosso, Erika; Tron, Gian Cesare] Univ Piemonte Orientale, Dipartimento Sci Farmaco, I-28100 Novara, Italy; [Meneghetti, Fiorella] Univ Milan, Dipartimento Sci Farmaceut, I-20133 Milan, Italy; [Pelliccia, Sveva; Novellino, Ettore; Giustiniano, Mariateresa] Univ Napoli Federico II, Dipartimento Farm, I-80131 Naples, Italy published Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines in 2019.0, Cited 38.0. Category: pyridine-derivatives. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitrogen atom was able to intercept the nascent nitrilium ion, channeling the reaction toward to the sole formation of imidazopyrazines, suppressing the competitive formation of other possible side products deriving from the reaction with the high-energy nitrilium ion. The number of examples and the variability of the nature of isocyanides, aldehydes, and amine components herein employed, witness the robustness of this novel methodology.

Category: pyridine-derivatives. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem