Day: December 24, 2021

An article Non-covalent interactions governing the supramolecular assembly of copper(II) complexes with hydrazone-type ligand: Experimental and quantum chemical study WOS:000640386000003 published article about SUPEROXIDE-DISMUTASE ACTIVITY; PARAMAGNETIC-RESONANCE SPECTRA; DENSITY-FUNCTIONAL THEORY; AB-INITIO HF; CRYSTAL-STRUCTURES; X-RAY; ACTIVE-SITE; SPECTROSCOPIC CHARACTERIZATION; INTERMOLECULAR INTERACTIONS; NICKEL(II) COMPLEXES in [Singh, Y.; Patel, Ram N.; Patel, Satish K.] APS Univ, Dept Chem, Rewa 486003, MP, India; [Jadeja, R. N.; Patel, Abhay K.; Patel, Neetu] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India; [Roy, H.] Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Zool, Vadodara 390002, India; [Kumar, P.] VBS Purvanchal Univ, Rajju Bhaiya Inst Phys Sci Study & Res, Dept Chem, Jaunpur 222203, UP, India; [Butcher, R. J.] Howard Univ, Dept Inorgan & Struct Chem, Washington, DC 22031 USA; [Jasinski, Jerry P.] Keene State Coll, Dept Chem, 229 Main St, Keene, NH 03435 USA; [Cortijo, M.; Herrero, S.] Univ Complutense Madrid, Fac Ciencias Quim, Dept Quim Inorgan, Madrid 28040, Spain in 2021.0, Cited 133.0. COA of Formula: C12H9NO. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

A series of two new mono- and one binuclear m-nitrato bridged copper(II) complexes [Cu(L)(HL)]ClO4 (1), [Cu(HL)(NO3)(H2O)](2)NO3 center dot H2O (2) and [Cu-2(L-2)(mu-NO3)(2)] (3), with an unsymmetrical NNO donor Schiff base (HL) have been synthesized and characterized by elemental analysis, FTIR, CV, UV-vis and EPR spectroscopy. Their molecular structures were also determined by single crystal X-ray crystallography. In the binuclear complex 3, the Cu center dot center dot center dot Cu distance is 3.494 angstrom. In 1, 2 and 3, the Cu(II) centers have distorted square pyramidal geometry (tau(5) = 0.05-0.17). Evidence of weak pi center dot center dot center dot pi stacking intermolecular interactions along with other non-covalent interactions (hydrogen bonding) was observed by analyzing the respective crystal structures of the complexes. Thus, these hydrogen bonds, pi center dot center dot center dot pi stacking interactions and other weak intermolecular interactions establish in the form of supramolecular architectures a crystalline network environment. The non-covalent interactions were also investigated by employing Hirshfeld Analysis. The room temperature magnetic moments of the mononuclear complexes are less than the spin only values which are indicative of small interactions. Also, significant magnetic interactions were not exhibited by binuclear copper(II) complex 3 in the variable temperature magnetic measurements. The X-band EPR spectra of all three complexes exhibit copper(II) hyperfine structures as well as zero-field splitting which are appropriate for the triplet states of dimers. In complexes 1 and 2, the presence of pseudo dipolar interactions is proposed. Quantum chemical calculations (DFT) were carried out on complexes 1-3 to explore the electronic and spectral properties of these newly synthesized complexes. These complexes show significant antiproliferative and SOD activity. The SOD activity measured in terms of kMcCF is in the range 4.94-12.31 (mol L)(-1)s(-1))x 10(4). (C) 2021 Elsevier Ltd. All rights reserved.

COA of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recently I am researching about SELECTIVE OXIDATION; AEROBIC OXIDATION; DIRECT AMIDATION; BRONSTED ACID; METHYL-GROUP; COPPER; PYRIDINE; FUNCTIONALIZATION; OXYGENATION; KETONES, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21172200, 21702191]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gao, XY; Han, SJ; Zheng, ML; Liang, A; Li, JY; Zou, DP; Wu, YS; Wu, YJ. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone. Category: pyridine-derivatives

A novel oxidation of benzylic C H bonds for the synthesis of diverse six-membered N-heteroaromatic aldehydes and ketones has been developed. The obvious advantages of this approach are the simple operation, mild reaction conditions, and without use of toxic reagent and transition metal. The present method should provide a useful access for the synthesis and modification of N-heterocycles.

About Phenyl(pyridin-2-yl)methanone, If you have any questions, you can contact Gao, XY; Han, SJ; Zheng, ML; Liang, A; Li, JY; Zou, DP; Wu, YS; Wu, YJ or concate me.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020 BEILSTEIN J ORG CHEM published article about COUPLED ELECTRON-TRANSFER; VICINAL DIAMINES; METAL-FREE; RADICAL-ADDITION; CATALYSIS; IMINES; DERIVATIVES; ARYLATION; REAGENTS; KETONES in [Tambe, Shrikant D.; Min, Kwan Hong; Iqbal, Naeem; Cho, Eun Jin] Chung Ang Univ, Dept Chem, 84 Heukseok Ro, Seoul 06974, South Korea in 2020, Cited 65. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

A simple photocatalytic method was developed for the synthesis of unsymmetrical 1,2-diamines by the unprecedented reductive coupling of N-benzylidene-[1,1′-biphenyl]-2-amines with an aliphatic amine. The presence of a phenyl substituent in the aniline moiety of the substrate was critical for the reactivity. The reaction proceeded via radical-radical cross-coupling of alpha-amino radicals generated by proton-coupled single-electron transfer in the presence of an Ir photocatalyst. On the other hand, symmetrical 1,2-diamines were selectively produced from the same starting materials by the judicious choice of the reaction conditions, showcasing the distinct reactivity of N-benzylidene-[1,1′-biphenyl]-2-amines. The developed method can be employed for the synthesis of various bulky vicinal diamines, which are potential ligands in stereoselective synthesis.

Welcome to talk about 500-22-1, If you have any questions, you can contact Tambe, SD; Min, KH; Iqbal, N; Cho, EJ or send Email.. Application In Synthesis of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Ramaiah, MM; Shubha, PB; Prabhala, PK; Shivananju, NS in [Ramaiah, Manjunatha M.; Shubha, Priya Babu] Univ Mysore, Dept Studies Chem, Synthet Lab, Mysore 570006, Karnataka, India; [Prabhala, Pavan Kumar] Acharya Nagarjuna Univ, SVRM Coll, Dept Chem, Guntur, Andhra Pradesh, India; [Shivananju, Nanjunda Swamy] JSS Sci & Technol Univ, Dept Biotechnol, Mysore, Karnataka, India published 1,8-Diazabicyclo[5.4.0]undec-7-ene-mediated formation of N-sulfinyl imines in 2020.0, Cited 31.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.

A facile and efficient method was developed for the preparation of a variety of aryl, heteroaryl, and alkyl N-sulfinyl imines using 1,8-diazabicyclo[5.4.0]undec-7-ene. In addition to tert-butanesulfinamide, the condensation is also effective with p-toluenesulfinamide. The reaction was performed at room temperature and produces the corresponding N-sulfinyl imines in excellent yields in the absence of acids, metals, and additives. This methodology is also useful for the preparation of N-sulfinyl imines on gram scale. A one-pot synthesis was developed using aryl and heteroaryl alcohols with both tert-butanesulfinamide and p-toluenesulfinamide at room temperature, resulting in the corresponding N-sulfinyl imines with good yields.

Welcome to talk about 500-22-1, If you have any questions, you can contact Ramaiah, MM; Shubha, PB; Prabhala, PK; Shivananju, NS or send Email.. COA of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Synthesis of novel quinoline-based thiadiazole, evaluation of their antileishmanial potential and molecular docking studies WOS:000462472500011 published article about ALPHA-GLUCOSIDASE INHIBITORS; IN-VITRO EVALUATION; DERIVATIVES; BENZOTHIADIAZOLE; COMPLEXES; POLYMERS; DESIGN in [Almandil, Noor Barak; Taha, Muhammad; Ibrahim, Mohamed; Mosaddik, Ashik] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Pakistan; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Imran, Syahrul] Univ Teknol MARA UiTM, Atta ur Rahman Inst Nat Prod Discovery, Puncak Alam Campus, Bandar Puncak Alam 42300, Selangor De, Malaysia; [Alqahtani, Mohammed A.; Bamarouf, Yasser A.; Gollapalli, Mohammed] Imam Abdulrahman Bin Faisal Univ, CCSIT, POB 1982, Dammam 31441, Saudi Arabia in 2019.0, Cited 54.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Safety of 3-Pyridinecarboxaldehyde

New series of quinoline-based thiadiazole analogs (1-20) were synthesized, characterized by EI-MS, H-1 NMR and C-13 NMR. All synthesized compounds were subjected to their antileishmanial potential. Sixteen analogs 1-10, 12, 13, 16, 17, 18 and 19 with IC50 values in the range of 0.04 +/- 0.01 to 5.60 +/- 0.21 mu M showed tremendously potent inhibition as compared to the standard pentamidine with IC50 value 7.02 +/- 0.09 mu M. Analogs 11, 14, 15 and 20 with IC50 8.20 +/- 0.35, 9.20 +/- 0.40, 7.20 +/- 0.20 and 9.60 +/- 0.40 mu M respectively showed good inhibition when compared with the standard. Structure-activity relationships have been also established for all compounds. Molecular docking studies were performed to determine the binding interaction of the compounds with the active site target.

Safety of 3-Pyridinecarboxaldehyde. Welcome to talk about 500-22-1, If you have any questions, you can contact Almandil, NB; Taha, M; Rahim, F; Wadood, A; Imran, S; Alqahtani, MA; Bamarouf, YA; Ibrahim, M; Mosaddik, A; Gollapalli, M or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors WOS:000613505100025 published article about EPITHELIAL OVARIAN CARCINOMAS; NITRIC-OXIDE SYNTHASE; HYDROXY-L-ARGININE; PROGNOSTIC VALUE; CANCER; EXPRESSION; RECEPTOR; MICROENVIRONMENT; THERAPIES; SURVIVAL in [Mohan, Srinidi; Patel, Seema; Barlow, David; Rojas, Augusto Cardenas] Univ New England, Coll Pharm, Dept Pharmaceut Sci, Portland, ME USA in 2020.0, Cited 28.0. Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Purpose: We investigated Nw-hydroxy L-Arginine (NOHA) predictive response in serous ovarian carcinoma based on estrogen-hormone receptor expression status; and assessed the distinctive NOHA response between estrogen-receptor-negative (ER-) tumor subtypes of ovarian and breast cancer. Materials/methods: Three-dimensional (3D) spheroids models of ER- and estrogen-receptor-positive (ER+) from breast and ovarian tumor, cultured for 9 weeks, were assayed for cellular levels of inducible nitric oxide synthase (NOS2), nitric oxide (as total nitrite) and L-Arginine, and compared to NOHA in culture medium. Statistical difference was set at p < 0.01. Results: Nine-week in vitro studies showed a progressive NOHA reduction in culture medium by at least 0.4-0.8 fold, and 0.65-0.92 fold only in the ER-breast tumor and ER-ovarian tumor 3D spheroids, respectively; with increases in cellular NOS2 and nitric-oxide levels, by at least 1.0-2.45 fold in both ER-tumor subtype 3D spheroids (p < 0.01; n = 6). Within ER-subtypes, medium NOHA decreased by >= 38.9% in ovarian cancer over breast cancer 3D-spheroids, with cellular increases in NOS2 (by >= 17.4%), and nitric oxide (by >= 18.8%). Cellular L-Arginine to medium NOHA ratio was higher, and by at least 6.5-22.5 fold in ER-breast tumor 3D-spheroids, and at least 10-70 fold in ER-ovarian tumor 3D spheroids, than in ER+ and control conditions; and was >= 48% higher in ER-ovarian cancer than in ER-breast cancer 3D-spheroids. Conclusions: The present study shows NOHA as a sensitive and selective indicator differentiating and distinguishing ER-subtypes based on the tumor grade.

About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Mohan, S; Patel, S; Barlow, D; Rojas, AC or concate me.. Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 65-22-5. Bachmann, T; Schnurr, C; Zainer, L; Rychlik, M in [Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael] Tech Univ Munich, Chair Analyt Food Chem, Maximus von Imhof Forum 2, D-85354 Freising Weihenstephan, Germany published Chemical synthesis of 5 ‘-beta-glycoconjugates of vitamin B-6 in 2020.0, Cited 107.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5.

Various 5′-beta-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chemically according to KOENIGS-KNORR conditions using alpha 4,3-O-iso-propylidene pyridoxine and the respective acetobromo glycosyl donors with AgOTf (3.0 eq.) and NIS (3.0 eq.) as promoters at 0 degrees C. Furthermore, 5′-beta-[C-13(6)]-labeled pyridoxine glucoside (PNG) was prepared starting from [C-1(3)6]-glucose and pyridoxine. Additionally, two strategies were examined for the synthesis of 5’-beta-pyridoxal glucoside (PLG).

Recommanded Product: 65-22-5. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Bachmann, T; Schnurr, C; Zainer, L; Rychlik, M or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 65-22-5. Recently I am researching about ISONICOTINOYL HYDRAZONE; IRON CHELATORS; IN-VITRO; VITAMIN-B-6; EXPRESSION; APOPTOSIS; ANALOGS; TARGETS; GROWTH; AGENTS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31671183]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2018A030307005]. Published in KARGER in BASEL ,Authors: Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Background/Aims: Hydrazone and acylhydrazone derivatives, which are produced from aldehyde reacting with hydrazine or acylhydrazine, have been reported to exhibit antitumor activities. However, the angionenic effects of this kind of derivatives haven’t been elucidated. Here, we synthesized 12 pyridoxal hydrazone and acylhydrazone compounds and investigated their antiangiogenic effects and the underlying mechanisms. Method: 3-(4,5-Dimethylthiazol-2-yl)-2, 5-dipheyltetrazolium bromide assay was used to screen the inhibitory effects of the synthesized compounds on endothelial cells (ECs) proliferation. The compound with best inhibitory effect was further evaluated with wound-healing assay and tube formation assay. Calcein-Am assay was carried out to determine the content of intracellular labile iron pool (LIP). Intracellular reduced glutathione (GSH) was determined by spectrophotometry. Flow cytometry was used to determine cell cycle and apoptosis. Results: Compound 10 (3-hydroxy-5-[hydroxymethyl]-2-methyl-pyridine-4-carbaldehyde-2-naphthalen-1-acetyl hydrazone) showed the best inhibitory effect on human umbilical vascular ECs proliferation, with IC50 value of 25.4 mu mol/L. It not only inhibited wound-healing and tube formation of ECs, but also decreased the content of intracellular LIP and GSH. Furthermore, it arrested ECs cycle at S phase and induced cell apoptosis. Conclusions: Compound 10 exhibits antiangiogenic effects by reducing the content of intracellular LIP and GSH, and subsequently arresting cell cycle and inducing cell apoptosis.

Welcome to talk about 65-22-5, If you have any questions, you can contact Chen, XY; Li, H; Luo, HJ; Lin, ZX; Luo, WH or send Email.. Recommanded Product: 65-22-5

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: Phenyl(pyridin-2-yl)methanone. I found the field of Chemistry; Crystallography very interesting. Saw the article Copper(II) hydrazone complexes with different nuclearities and geometries: Synthesis, structural characterization, antioxidant SOD activity and antiproliferative properties published in 2020.0, Reprint Addresses Jadeja, RN (corresponding author), Maharaja Sayajirao Univ Baroda, Fac Sci, Dept Chem, Vadodara 390002, India.. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone.

New copper(II) hydrazone complexes with (Z)-2-(phenyl(2-(pyridin-2-yl)hydrazono)methyl)pyridine (L) were synthesized and characterized using various physicochemical methods. The geometries of the complexes can be classified as mononuclear and binuclear. The complex 1, [Cu(L)(Cl)(2)], is mononuclear whereas the solid-state structure of complex 2 contain a mixture of co-crystals of the mono- and binuclear complexes 2a, [Cu(L)(H2O)(SO4)], and 2b, [Cu-2(L)(2)(mu-SO4)(2)]. The unit cell of 2 contains two units of the mononuclear complex 2a and one units of the binuclear complex 2b. The copper atoms contained in all the mono- and binuclear complexes are in a distorted square pyramidal geometry. The present study indicates that complexes having different nuclearities and geometries can be achieved by changing the synthetic conditions and methods. Variable temperature magnetic susceptibility measurements of the complexes have shown the presence of weak anti-ferromagnetic interactions. These interactions are mediated by intermolecular hydrogen bonding in 1 and through a symmetric sulfate bridge in 2. The EPR spectra in the polycrystalline state for 1 and 2 exhibited a broad signal at similar to 2.149 due to spin-spin interactions between two copper(II) ions. The cyclic voltammograms of complexes 1 and 2 in DMSO gave two irreversible redox waves. Density functional theory (DFT) calculations were evaluated in the study, involving the molecular specification with the use of B3LYP/LANL2DZ formalism for the copper atoms and B3LYP/6-31G for the remaining atoms. Both complexes catalyzed the dismutation of superoxide (O-2(center dot-)). Furthermore, the copper complexes and the ligand were tested to explore their anticancer properties. Promising cytotoxicity of the synthesized compounds was observed against the selected cancerous cell lines of neuroblastoma, lung carcinoma, hepatocellular carcinoma and breast cancer. (C) 2020 Elsevier Ltd. All rights reserved.

Recommanded Product: Phenyl(pyridin-2-yl)methanone. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Quality Control of Phenyl(pyridin-2-yl)methanone. Recently I am researching about VISIBLE-LIGHT; ELECTRON; PHOTOEXCITATION; ENERGY; STATE; ACIDS, Saw an article supported by the University of Hamburg; Alexander von Humboldt FoundationAlexander von Humboldt Foundation. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Cardinale, L; Konev, MO; von Wangelin, AJ. The CAS is 91-02-1. Through research, I have a further understanding and discovery of Phenyl(pyridin-2-yl)methanone

Functionalization with C1-building blocks are key synthetic methods in organic synthesis. The low reactivity of the most abundant C-1-molecule, carbon dioxide, makes alternative carboxylation reactions with CO2-surrogates especially important. We report a photoredox-catalyzed protocol for alkene carbamoylations. Readily accessible 4-carboxamido-Hantzsch esters serve as convenient starting materials that generate carbamoyl radicals upon visible light-mediated single-electron transfer. Addition to various alkenes proceeded with high levels of regio- and chemoselectivity.

Quality Control of Phenyl(pyridin-2-yl)methanone. Welcome to talk about 91-02-1, If you have any questions, you can contact Cardinale, L; Konev, MO; von Wangelin, AJ or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem