Day: January 20, 2022

Recently I am researching about TRANSITION-METAL-COMPLEXES; EFFECTIVE CORE POTENTIALS; GROWTH-FACTOR RECEPTOR; THIOSEMICARBAZONE DERIVATIVES; BIOLOGICAL-ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; COPPER(II) COMPLEXES; LIGANDS; NICKEL(II); ANTITUMOR, Saw an article supported by the . Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Poladian, Q; Sahin, O; Karakurt, T; Ilhan-Ceylan, B; Kurt, Y. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

A new unsymmetrical N2O2-tetradentate Schiff-base complex of zinc(II) was synthesized by the template reaction of pyridoxal-S-methylthiosemicarbazone and 2-hydroxy-4-methoxy-benzaldehyde as starting compounds. S-methylthiosemicarbazone (1) and zinc(II) complex [Zn(L)CH3OH] ( 2) were characterized by elemental analysis, FT-IR, UV-visible, H-1, and C-13 NMR spectra. The molecular structure of the complex (2) was determined by single crystal X-ray diffraction technique. The structure consists of a distorted square-pyramidal geometry around the central metal, Zn(II). Quantum chemical calculations were carried out using density functional theory DFT/B3LYP, 6-31G (d), and LanL2DZ basis sets for theoretical characterization of the compounds. The experimental and theoretical data were compared comprehensively. The potential energy distribution (PED) analysis was performed for the assignment of vibration frequencies. In order to support in vitro studies, molecular docking studies have been carried out so that the title compound can be an inhibitor of Epidermal Growth Factor Receptor (1 m17), and the relationship between calculated HOMO energies and docking studies has been examined. In addition, the total antioxidant capacity (as TEAC value) and free radical scavenging activity of the compounds were determined by Cupric Reducing Antioxidant Capacity (CUPRAC) and 1,1-diphenyl-2-picryl hydrazyl (DPPH) methods, respectively. (C) 2021 Elsevier Ltd. All rights reserved.

Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Welcome to talk about 65-22-5, If you have any questions, you can contact Poladian, Q; Sahin, O; Karakurt, T; Ilhan-Ceylan, B; Kurt, Y or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Assessing the predictive response of a simple and sensitive blood-based biomarker between estrogen-negative solid tumors WOS:000613505100025 published article about EPITHELIAL OVARIAN CARCINOMAS; NITRIC-OXIDE SYNTHASE; HYDROXY-L-ARGININE; PROGNOSTIC VALUE; CANCER; EXPRESSION; RECEPTOR; MICROENVIRONMENT; THERAPIES; SURVIVAL in [Mohan, Srinidi; Patel, Seema; Barlow, David; Rojas, Augusto Cardenas] Univ New England, Coll Pharm, Dept Pharmaceut Sci, Portland, ME USA in 2020.0, Cited 28.0. Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Purpose: We investigated Nw-hydroxy L-Arginine (NOHA) predictive response in serous ovarian carcinoma based on estrogen-hormone receptor expression status; and assessed the distinctive NOHA response between estrogen-receptor-negative (ER-) tumor subtypes of ovarian and breast cancer. Materials/methods: Three-dimensional (3D) spheroids models of ER- and estrogen-receptor-positive (ER+) from breast and ovarian tumor, cultured for 9 weeks, were assayed for cellular levels of inducible nitric oxide synthase (NOS2), nitric oxide (as total nitrite) and L-Arginine, and compared to NOHA in culture medium. Statistical difference was set at p < 0.01. Results: Nine-week in vitro studies showed a progressive NOHA reduction in culture medium by at least 0.4-0.8 fold, and 0.65-0.92 fold only in the ER-breast tumor and ER-ovarian tumor 3D spheroids, respectively; with increases in cellular NOS2 and nitric-oxide levels, by at least 1.0-2.45 fold in both ER-tumor subtype 3D spheroids (p < 0.01; n = 6). Within ER-subtypes, medium NOHA decreased by >= 38.9% in ovarian cancer over breast cancer 3D-spheroids, with cellular increases in NOS2 (by >= 17.4%), and nitric oxide (by >= 18.8%). Cellular L-Arginine to medium NOHA ratio was higher, and by at least 6.5-22.5 fold in ER-breast tumor 3D-spheroids, and at least 10-70 fold in ER-ovarian tumor 3D spheroids, than in ER+ and control conditions; and was >= 48% higher in ER-ovarian cancer than in ER-breast cancer 3D-spheroids. Conclusions: The present study shows NOHA as a sensitive and selective indicator differentiating and distinguishing ER-subtypes based on the tumor grade.

Welcome to talk about 65-22-5, If you have any questions, you can contact Mohan, S; Patel, S; Barlow, D; Rojas, AC or send Email.. Recommanded Product: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2020.0 CARBOHYD RES published article about PYRIDOXINE-BETA-GLUCOSIDE; PARTICULATE GLUCOSYLTRANSFERASE; PROTEIN GLYCOSYLATION; GROWING CULTURE; N-GLYCOSYLATION; FUSARIUM TOXINS; RICE BRAN; SEEDLINGS; GLUCURONIDATION; BIOAVAILABILITY in [Bachmann, Thomas; Schnurr, Christian; Zainer, Laura; Rychlik, Michael] Tech Univ Munich, Chair Analyt Food Chem, Maximus von Imhof Forum 2, D-85354 Freising Weihenstephan, Germany in 2020.0, Cited 107.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Various 5′-beta-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chemically according to KOENIGS-KNORR conditions using alpha 4,3-O-iso-propylidene pyridoxine and the respective acetobromo glycosyl donors with AgOTf (3.0 eq.) and NIS (3.0 eq.) as promoters at 0 degrees C. Furthermore, 5′-beta-[C-13(6)]-labeled pyridoxine glucoside (PNG) was prepared starting from [C-1(3)6]-glucose and pyridoxine. Additionally, two strategies were examined for the synthesis of 5′-beta-pyridoxal glucoside (PLG).

Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Bye, fridends, I hope you can learn more about C8H10ClNO3, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Significantly Elevated Levels of Plasma Nicotinamide, Pyridoxal, and Pyridoxamine Phosphate Levels in Obese Emirati Population: A Cross-Sectional Study WOS:000569735200001 published article about CHRONIC DISEASE PREVENTION; EXTENDED-RELEASE NIACIN; LIQUID-CHROMATOGRAPHY; B-6 VITAMERS; FOLIC-ACID; HUMAN-MILK; VITAMIN-B-6; SUPPLEMENTATION; FOLATE; INFLAMMATION in [Ibrahim, Ghada Rashad; Shah, Iltaf] UAE Univ, Coll Sci, Dept Chem, POB 15551, Al Ain, U Arab Emirates; [Gariballa, Salah; Yasin, Javed] UAE Univ, Coll Med, Dept Internal Med, POB 15551, Al Ain, U Arab Emirates; [Barker, James] Kingston Univ, Dept Chem & Pharmaceut Sci, Penrhyn Rd, Kingston Upon Thames KT1 2EE, Surrey, England; [Ashraf, Syed Salman] Khalifa Univ, Coll Arts & Sci, Dept Chem, POB 127788, Abu Dhabi, U Arab Emirates in 2020.0, Cited 48.0. Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Water-soluble vitamins like B3 (nicotinamide), B6 (pyridoxine), and B9 (folic acid) are of utmost importance in human health and disease, as they are involved in numerous critical metabolic reactions. Not surprisingly, deficiencies of these vitamins have been linked to various disease states. Unfortunately, not much is known about the physiological levels of B6 vitamers and vitamin B3 in an ethnically isolated group (such as an Emirati population), as well as their relationship with obesity. The aim of the present study was to quantify various B6 vitamers, as well as B3, in the plasma of obese and healthy Emirati populations and to examine their correlation with obesity. A sensitive and robust HPLC-MS/MS-based method was developed for the simultaneous quantitation of five physiologically relevant forms of vitamin B6, namely pyridoxal, pyridoxine, pyridoxamine, pyridoxamine phosphate, and pyridoxal phosphate, as well as nicotinamide, in human plasma. This method was used to quantify the concentrations of these vitamers in the plasma of 57 healthy and 57 obese Emirati volunteers. Our analysis showed that the plasma concentrations of nicotinamide, pyridoxal, and pyridoxamine phosphate in the obese Emirati population were significantly higher than those in healthy volunteers (p< 0.0001,p= 0.0006, andp= 0.002, respectively). No significant differences were observed for the plasma concentrations of pyridoxine and pyridoxal phosphate. Furthermore, the concentrations of some of these vitamers in healthy Emirati volunteers were significantly different than those published in the literature for Western populations, such as American and European volunteers. This initial study underscores the need to quantify micronutrients in distinct ethnic groups, as well as people suffering from chronic metabolic disorders. Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. About 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride, If you have any questions, you can contact Ibrahim, GR; Shah, I; Gariballa, S; Yasin, J; Barker, J; Ashraf, SS or concate me.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Recommanded Product: 614-18-6. Yu, HY; Xie, T; Qian, XH; Ai, LZ; Chen, C; Tian, HX in [Yu, Haiyan; Xie, Tong; Qian, Xinhua; Chen, Chen; Tian, Huaixiang] Shanghai Inst Technol, Dept Food Sci & Technol, Shanghai, Peoples R China; [Ai, Lianzhong] Univ Shanghai Sci & Technol, Sch Med Instrument & Food Engn, Shanghai, Peoples R China published Characterization of the volatile profile of Chinese rice wine by comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry in 2019, Cited 35. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6.

BACKGROUND Chinese rice wine (CRW) is a kind of traditional fermentation wine in China. Aged CRW is more popular among consumers owing to its harmonious and pleasant flavor. The volatile profile of CRW has been extensively studied using gas chromatography/mass spectrometry (GC/MS). However, flavor components in CRW are far richer than those detected by GC/MS. To obtain more information about the volatile profile of fresh (5-year) and aged (10-year) CRW, a method based on comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry (GCxGC/qMS) was developed. The major volatile compounds contributing to the characteristic aroma of fresh and aged CRW were identified by surrogate odor activity value (OAV). RESULTS Ninety-eight volatile compounds were detected in the 5-year CRW samples and 107 in the 10-year samples by GCxGC/qMS. The numbers of compounds detected by GCxGC/qMS for the 5-year and 10-year samples were 71.4 and 65.4% higher than those detected by GC/MS. The aged wine had a more complex volatile profile than the fresh wine, with an increase in esters and aldehydes and a decrease in alcohols and organic acids. There were 22 volatile compounds with surrogate OAV > 1. Nine were the potent key aroma compounds in CRW: ethyl isovalerate (OAV 500-33 500), ethyl butyrate (OAV 84-334), ethyl isobutyrate (OAV 49-170), 2-nonenal (OAV 20-100), ethyl heptanoate (OAV 1-74), ethyl hexanoate (OAV 60-77), phenylethyl alcohol (OAV 2-18), benzaldehyde (OAV 28-30) and hexanal (OAV 4-11). CONCLUSION GCxGC/qMS showed better separation than GC/MS. The presented GCxGC/qMS method was suitable for characterization of the volatile profile of CRW. (c) 2019 Society of Chemical Industry

Recommanded Product: 614-18-6. Bye, fridends, I hope you can learn more about C8H9NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Mohan, S; Patel, S; Barlow, D; Rojas, AC in ELSEVIER URBAN & PARTNER SP Z O O published article about EPITHELIAL OVARIAN CARCINOMAS; NITRIC-OXIDE SYNTHASE; HYDROXY-L-ARGININE; PROGNOSTIC VALUE; CANCER; EXPRESSION; RECEPTOR; MICROENVIRONMENT; THERAPIES; SURVIVAL in [Mohan, Srinidi; Patel, Seema; Barlow, David; Rojas, Augusto Cardenas] Univ New England, Coll Pharm, Dept Pharmaceut Sci, Portland, ME USA in 2020.0, Cited 28.0. Recommanded Product: 65-22-5. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5

Purpose: We investigated Nw-hydroxy L-Arginine (NOHA) predictive response in serous ovarian carcinoma based on estrogen-hormone receptor expression status; and assessed the distinctive NOHA response between estrogen-receptor-negative (ER-) tumor subtypes of ovarian and breast cancer. Materials/methods: Three-dimensional (3D) spheroids models of ER- and estrogen-receptor-positive (ER+) from breast and ovarian tumor, cultured for 9 weeks, were assayed for cellular levels of inducible nitric oxide synthase (NOS2), nitric oxide (as total nitrite) and L-Arginine, and compared to NOHA in culture medium. Statistical difference was set at p < 0.01. Results: Nine-week in vitro studies showed a progressive NOHA reduction in culture medium by at least 0.4-0.8 fold, and 0.65-0.92 fold only in the ER-breast tumor and ER-ovarian tumor 3D spheroids, respectively; with increases in cellular NOS2 and nitric-oxide levels, by at least 1.0-2.45 fold in both ER-tumor subtype 3D spheroids (p < 0.01; n = 6). Within ER-subtypes, medium NOHA decreased by >= 38.9% in ovarian cancer over breast cancer 3D-spheroids, with cellular increases in NOS2 (by >= 17.4%), and nitric oxide (by >= 18.8%). Cellular L-Arginine to medium NOHA ratio was higher, and by at least 6.5-22.5 fold in ER-breast tumor 3D-spheroids, and at least 10-70 fold in ER-ovarian tumor 3D spheroids, than in ER+ and control conditions; and was >= 48% higher in ER-ovarian cancer than in ER-breast cancer 3D-spheroids. Conclusions: The present study shows NOHA as a sensitive and selective indicator differentiating and distinguishing ER-subtypes based on the tumor grade.

Bye, fridends, I hope you can learn more about C8H10ClNO3, If you have any questions, you can browse other blog as well. See you lster.. Recommanded Product: 65-22-5

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Quantum dots enable direct alkylation and arylation of allylic C(sp(3))-H bonds with hydrogen evolution by solar energy WOS:000652330400010 published article about SP(3) C-H; LIGHT PHOTOREDOX CATALYSIS; TRANSITION-METAL; FUNCTIONALIZATION; ALLYLATION; CARBONYL; PHOTOCATALYSIS; SELECTIVITY; ACTIVATION; ALDEHYDES in [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Tech Inst Phys & Chem, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China; [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100190, Peoples R China; [Huang, Cheng; Qiao, Jia; Ci, Rui-Nan; Wang, Xu-Zhe; Wang, Yang; Wang, Jing-Hao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu] Univ Chinese Acad Sci, Sch Future Technol, Beijing 100049, Peoples R China in 2021, Cited 67. Application In Synthesis of Ethyl nicotinate. The Name is Ethyl nicotinate. Through research, I have a further understanding and discovery of 614-18-6

Direct alkylation and arylation of allylic C(sp3)-H bonds are straight-forward approaches for accessing allylic C-C products. However, the engagement of allylic C-C bond- forming reaction without introducing extraneous functional groups and stoichiometric oxidant or reductant has proved difficult. Here, we report a general and mild strategy using semiconductor quantum dots (QDs) as photocatalysts for coupling a broad range of available allylic C(sp(3))-H bonds with alpha- amino C-H bonds or heteroarenes, respectively, under sunlight irradiation (> 85 examples). The protocol bypasses stoichiometric oxidant or reductant and pre-functionalization of both the coupling partners and produces hydrogen (H-2) as the byproduct. The outstanding efficiency and selectivity and step- and atom-economy represents the first direct alkylation and arylation of allylic C(sp(3))-H bonds with hydrogen evolution powered by solar energy.

Bye, fridends, I hope you can learn more about C8H9NO2, If you have any questions, you can browse other blog as well. See you lster.. Application In Synthesis of Ethyl nicotinate

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 J MED CHEM published article about H-3 RECEPTOR; NEURONAL HISTAMINE; H3 RECEPTOR; AGONIST; PROTEIN; SYSTEM; DISCOVERY; TARGET; 2-AMINOPYRIMIDINES; IDENTIFICATION in [Kumar, Ajeet; Yadav, Anubhav; Dogra, Shalini; Sona, Chandan; Umrao, Deepmala; Yadav, Prem N.] Cent Drug Res Inst, Pharmacol Div, Lucknow 226031, Uttar Pradesh, India; [Pasam, Venkata Reddy; Thakur, Ravi Kumar; Singh, Kartikey; Tripathi, Rama Pati] Cent Drug Res Inst, Med & Proc Chem Div, Lucknow 226031, Uttar Pradesh, India; [Singh, Maninder; Siddiq, Mohammad Imran] Cent Drug Res Inst, Mol & Struct Biol Div, Lucknow 226031, Uttar Pradesh, India; [Shukla, Mahendra; Jaiswal, Swati; Ahmad, Hafsa; Rashid, Mamunur; Singh, Sandeep K.; Wahajuddin, Muhammad; Dwivedi, Anil Kumar; Lal, Jawahar] Cent Drug Res Inst, Pharmaceut & Pharmacokinet Div, Lucknow 226031, Uttar Pradesh, India; [Shukla, Mahendra; Jaiswal, Swati; Ahmad, Hafsa; Rashid, Mamunur; Singh, Sandeep K.; Wahajuddin, Muhammad; Dwivedi, Anil Kumar; Lal, Jawahar] Cent Drug Res Inst, CSIR, Lucknow 226031, Uttar Pradesh, India; [Siddiq, Mohammad Imran; Tripathi, Rama Pati; Yadav, Prem N.] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India; [Tripathi, Rama Pati] Natl Inst Pharmaceut Educ & Res Raebareli, New Transit Campus,Bijnor Rd, Lucknow 226002, Uttar Pradesh, India in 2019.0, Cited 85.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Recommanded Product: 3-Pyridinecarboxaldehyde

The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several neurotransmitters including histamine and various essential physiological processes, such as feeding, arousal, cognition, and pain. The H3R is considered as a drug target for the treatment of several central nervous system disorders. We have synthesized and identified a novel series of 4-aryl-6-methyl-5,6,7,8-tetrahydroquinazolinamines that act as selective H3R antagonists. Among all the synthesized compounds, in vitro and docking studies suggested that the 4-methoxy-phenyl-substituted tetrahydroquinazolinamine compound 4c has potent and selective H3R antagonist activity (IC50 < 0.04 mu M). Compound 4c did not exhibit any activity on the hERG ion channel and pan-assay interference compounds liability. Pharmacokinetic studies showed that 4c crosses the blood brain barrier, and in vivo studies demonstrated that 4c induces anorexia and weight loss in obese, but not in lean mice. These data reveal the therapeutic potential of 4c as an anti-obesity candidate drug via antagonizing the H3R. Recommanded Product: 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

HPLC of Formula: C6H5NO. I found the field of Chemistry; Engineering very interesting. Saw the article A molybdenum based metallomicellar catalyst for controlled and chemoselective oxidation of activated alcohols in aqueous medium published in 2019, Reprint Addresses Chand, DK (corresponding author), Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India.. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde.

A surfactant based oxodiperoxo molybdenum complex, which could activate molecular oxygen, has been employed as a catalyst for controlled oxidation of benzylic alcohols to corresponding carbonyls. The oxidation reactions were carried out under aqueous environment, however, in the absence of any extraneous base or co-catalyst. Sensitive/oxidizable functional groups like cyano, sulfide, hydroxyl, aryl-hydroxyl, alkene (internal/terminal), alkyne (internal/terminal), and acetal were tolerated during the transformations. Such selectivity is attributed to the mild nature of the catalyst. The methodology could also be scaled-up for multi-gram synthesis and the protocol is likely to find practical use since it requires an inexpensive recyclable-catalyst and easily available oxidant (under green conditions). A plausible mechanism is proposed with the help of preliminary computational study. (C) 2019 Elsevier Inc. All rights reserved.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 NEW J CHEM published article about COORDINATION CHEMISTRY; FLUORESCENT SENSORS; CU(II) COMPLEXES; SYNAPTIC ZINC; MECHANISM; RUTHENIUM(II); VITAMIN-B-6; COPPER(II); INDUCTION; LIGANDS in [Mondal, Satyajit; Chakraborty, Moumita; Mondal, Antu; Pakhira, Bholanath; Chattopadhyay, Shyamal Kumar] Indian Inst Engn Sci & Technol, Dept Chem, Sibpur 711103, Howrah, India; [Mukhopadhyay, Subhra Kanti; Banik, Avishek] Univ Burdwan, Dept Microbiol, Burdwan 713104, W Bengal, India; [Sengupta, Swaraj] Birla Inst Technol, Dept Chem, Ranchi 835215, Jharkhand, India in 2019.0, Cited 67.0. The Name is 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride. Through research, I have a further understanding and discovery of 65-22-5. Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Herein we report, a mononuclear, highly fluorescent zinc(ii) complex Zn(L)(N-3)(H2O) (1) that was prepared by an easy one pot method, in which the tridentate Schiff base ligand (E)-4-((2-(dimethylamino)ethylimino)methyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol (HL) was generated in situ. The compound is characterized by various spectroscopic techniques, and its structure was determined by single crystal X-ray diffraction studies. DFT calculations were used to understand the electronic structures of the ligand and the complex, and TD-DFT calculations were performed to interpret the nature of the electronic transitions observed in their UV-vis spectra. In the complex, Zn(II) is found to be penta-coordinated with one azide ligand, an aqua ligand and a monoanionic tridentate N,N,O-donor ligand. In an aqueous methanol (1:9 by volume) solution, at the physiological pH (0.01 M Tris-HCl buffer, pH 7.4), compound 1 exhibits an intense greenish blue fluorescence (lambda(ex) 390 nm, lambda(em) 462 nm), whose intensity is about 17-fold stronger than that of the free ligand. Compound 1 is found to show significant DNA binding activity. The pyridoxal appended tridentate ligand can be used for the bio-imaging of Zn(II).

Bye, fridends, I hope you can learn more about C8H10ClNO3, If you have any questions, you can browse other blog as well. See you lster.. Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem