Day: February 16, 2022

An article Conformational Dynamics-Guided Loop Engineering of an Alcohol Dehydrogenase: Capture, Turnover and Enantioselective Transformation of Difficult-to-Reduce Ketones WOS:000484142600018 published article about THERMOANAEROBACTER-ETHANOLICUS; SATURATION MUTAGENESIS; MOLECULAR-DYNAMICS; DIRECTED EVOLUTION; SUBSTRATE-SPECIFICITY; ASYMMETRIC REDUCTION; BIOCATALYSIS; KETOREDUCTASE; MUTATION; ENZYME in [Liu, Beibei; Xu, Yan; Nie, Yao] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China; [Liu, Beibei; Qu, Ge; Li, Jun-Kuan; Fan, Wenchao; Sun, Zhoutong] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Tianjin Airport Econ Area, 32 West 7th Ave, Tianjin 300308, Peoples R China; [Li, Jun-Kuan; Ma, Jun-An] Tianjin Univ, Tianjin Key Lab Mol Optoelect Sci, Dept Chem, Tianjin 300072, Peoples R China; [Li, Jun-Kuan; Ma, Jun-An] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China in 2019, Cited 82. Category: pyridine-derivatives. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1

Directed evolution of enzymes for the asymmetric reduction of prochiral ketones to produce enantio-pure secondary alcohols is particularly attractive in organic synthesis. Loops located at the active pocket of enzymes often participate in conformational changes required to fine-tune residues for substrate binding and catalysis. It is therefore of great interest to control the substrate specificity and stereochemistry of enzymatic reactions by manipulating the conformational dynamics. Herein, a secondary alcohol dehydrogenase was chosen to enantioselectively catalyze the transformation of difficult-to-reduce bulky ketones, which are not accepted by the wildtype enzyme. Guided by previous work and particularly by structural analysis and molecular dynamics (MD) simulations, two key residues alanine 85 (A85) and isoleucine 86 (I86) situated at the binding pocket were thought to increase the fluctuation of a loop region, thereby yielding a larger volume of the binding pocket to accommodate bulky substrates. Subsequently, site-directed saturation mutagenesis was performed at the two sites. The best mutant, where residue alanine 85 was mutated to glycine and isoleucine 86 to leucine (A85G/I86L), can efficiently reduce bulky ketones to the corresponding pharmaceutically interesting alcohols with high enantioselectivities (similar to 99% ee). Taken together, this study demonstrates that introducing appropriate mutations at key residues can induce a higher flexibility of the active site loop, resulting in the improvement of substrate specificity and enantioselectivity.

Welcome to talk about 91-02-1, If you have any questions, you can contact Liu, BB; Qu, G; Li, JK; Fan, WC; Ma, JA; Xu, Y; Nie, Y; Sun, ZT or send Email.. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Tang, SJ; Wei, WJ; Yin, D; Poznik, MC; Chruma, AO in WILEY-V C H VERLAG GMBH published article about SUPER-ELECTRON-DONORS; COUPLING REACTION; DOUBLE-BLIND; REGIOSELECTIVITY; VIRIDENOMYCIN; DERIVATIVES; CARBONATES in [Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.] Sichuan Univ, Key Lab Green Chem & Technol, Coll Chem, Chengdu 610064, Sichuan, Peoples R China; [Tang, Shaojian; Wei, Wenjing; Yin, Dan; Poznik, Michal; Chruma, Jason J.] Sichuan Univ, Sino British Mat Res Inst, Coll Phys Sci & Technol, Chengdu 610064, Sichuan, Peoples R China in 2019.0, Cited 43.0. HPLC of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A palladium-catalyzed decarboxylative propargylation (DcPg) of propargyl 2,2-diphenylglycinate imines was developed. In this process, the nature of the propargyl ester and aryl imine components, as well as the catalyst system and solvent, had a significant impact on the ratio of desired propargylated products vs. allene and/or diene side products that arise via different modes of C-C bond formation. The resulting propargylated products can be transformed readily into useful (Z)-homoallylic amines. Moreover, the regioisomeric diene products could be converted to pharmaceutically-relevant diarylmethyl imines via a two-step Diels-Alder/oxidation process.

Welcome to talk about 500-22-1, If you have any questions, you can contact Tang, SJ; Wei, WJ; Yin, D; Poznik, MC; Chruma, AO or send Email.. HPLC of Formula: C6H5NO

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells WOS:000481615900014 published article about ACID; IDENTIFICATION; BIOSYNTHESIS; DERIVATIVES in [Mullarky, Edouard; Robin, Anita D.; Cantley, Lewis C.] Weill Cornell Med Coll, Meyer Canc Ctr, New York, NY 10065 USA; [Mullarky, Edouard; Robin, Anita D.; Cantley, Lewis C.] Weill Cornell Med Coll, Dept Med, New York, NY 10065 USA; [Xu, Jiayi; Huggins, David J.; Miller, Michael; Michino, Mayako; Stamford, Andrew W.; Meinke, Peter T.; Kargman, Stacia] Triinst Therapeut Discovery Inst, 413 East 69th St, New York, NY 10021 USA; [Huggins, David J.] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY USA; [Jennings, Andy] Andy Jennings Consulting LLC, San Diego, CA USA; [Noguchi, Naoyoshi; Tomita, Daisuke] Takeda Pharmaceut Co Ltd, Pharmaceut Res Div, Shonan Res Ctr, 26-1 Muraoka Higashi 2 Chome, Fujisawa, Kanagawa 2518555, Japan; [Olland, Andrea; Lakshminarasimhan, Damodharan] Xtal Biostruct, 12 Michigan Dr, Natick, MA 01760 USA; [Su, Taojunfeng; Zhang, Guoan] Weill Cornell Med, Prote & Metabol Core Facil, New York, NY 10021 USA in 2019.0, Cited 30.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1. Application In Synthesis of 3-Pyridinecarboxaldehyde

Cancer cells reprogram their metabolism to support growth and to mitigate cellular stressors. The serine synthesis pathway has been identified as a metabolic pathway frequently altered in cancers and there has been considerable interest in developing pharmacological agents to target this pathway. Here, we report a series of indole amides that inhibit human 3-phosphoglycerate dehydrogenase (PHGDH), the enzyme that catalyzes the first committed step of the serine synthesis pathway. Using X-ray crystallography, we show that the indole amides bind the NAD(+) pocket of PHGDH. Through structure-based optimization we were able to develop compounds with low nanomolar affinities for PHGDH in an enzymatic IC50 assay. In cellular assays, the most potent compounds inhibited de novo serine synthesis with low micromolar to sub-micromolar activities and these compounds successfully abrogated the proliferation of cancer cells in serine free media. The indole amide series reported here represent an important improvement over previously published PHGDH inhibitors as they are markedly more potent and their mechanism of action is better defined.

Application In Synthesis of 3-Pyridinecarboxaldehyde. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

An article 4-(3-Nitrophenyl)thiazol-2-ylhydrazone derivatives as antioxidants and selective hMAO-B inhibitors: synthesis, biological activity and computational analysis WOS:000457961800001 published article about MONOAMINE-OXIDASE-B; HIGH-POTENCY; IN-VITRO; MAO; SCAFFOLD; DESIGN; AGENTS; IDENTIFICATION in [Secci, Daniela; Guglielmi, Paolo; D’Ascenzio, Melissa; Chimenti, Paola] Sapienza Univ Rome, Dipartimento Chim & Tecnol Farmaco, Rome, Italy; [Carradori, Simone] G DAnnunzio Univ Chieti Pescara, Dept Pharm, Via Vestini 31, I-66100 Chieti, Italy; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Sch Pharm, Pharmaceut Chem, Potchefstroom, South Africa; [Petzer, Anel; Petzer, Jacobus P.] North West Univ, Ctr Excellence Pharmaceut Sci, Potchefstroom, South Africa; [Bagetta, Donatella; Alcaro, Stefano; Ortuso, Francesco] Magna Graecia Univ Catanzaro, Dipartimento Sci Salute, Catanzaro, Italy; [Zengin, Gokhan] Selcuk Univ, Sci Fac, Dept Biol, Konya, Turkey; [D’Ascenzio, Melissa] Univ Dundee, Sch Life Sci, DArcy Thompson Unit, Dundee DD1 4HN, Scotland in 2019.0, Cited 51.0. Quality Control of 3-Pyridinecarboxaldehyde. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

A new series of 4-(3-nitrophenyl)thiazol-2-ylhydrazone derivatives were designed, synthesised, and evaluated to assess their inhibitory effect on the human monoamine oxidase (hMAO) A and B isoforms. Different (un)substituted (hetero)aromatic substituents were linked to N1 of the hydrazone in order to establish robust structure-activity relationships. The results of the biological testing demonstrated that the presence of the hydrazothiazole nucleus bearing at C4 a phenyl ring functionalised at the meta position with a nitro group represents an important pharmacophoric feature to obtain selective and reversible human MAO-B inhibition for the treatment of neurodegenerative disorders. In addition, the most potent and selective MAO-B inhibitors were evaluated in silico as potential cholinesterase (AChE/BuChE) inhibitors and in vitro for antioxidant activities. The results obtained from molecular modelling studies provided insight into the multiple interactions and structural requirements for the reported MAO inhibitory properties.

Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.. Quality Control of 3-Pyridinecarboxaldehyde

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Authors Sapijanskaite-Banevic, B; Sovkovaja, B; Vaickelioniene, R; Siugzdaite, J; Mickeviciute, E in MDPI published article about N-ACYLHYDRAZONE DERIVATIVES; ANTIMICROBIAL EVALUATION; 2-AMINOTHIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; HIGH ANTIBACTERIAL; DESIGN; NMR; ISOMERIZATION; PYRIMIDINE; THIAZOLES in [Sapijanskaite-Banevic, Birute; Sovkovaja, Bozena; Vaickelioniene, Rita] Kaunas Univ Technol, Dept Organ Chem, Radvilenu Rd 19, LT-50254 Kaunas, Lithuania; [Siugzdaite, Jurate] Lithuanian Univ Hlth Sci, Dept Vet Pathobiol, Vet Acad, Tilzes Str 18, LT-47181 Kaunas, Lithuania; [Mickeviciute, Egle] Kaunas Univ Technol, Dept Informat Syst, Studentu Str 50, LT-51368 Kaunas, Lithuania in 2020.0, Cited 52.0. COA of Formula: C6H5NO. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1

Thiazole derivatives attract the attention of scientists both in the field of organic synthesis and bioactivity research due to their high biological activity. In the present study, thiazole ring was obtained by the interaction of 1-(4-(bromoacetyl)phenyl)-5-oxopyrrolidine-3-carboxylic acid with thiocarbamide or benzenecarbothioamide, as well as tioureido acid. A series of substituted 1-(3-(1,3-thiazol-2-yl)phenyl)-5-oxopyrrolidines with pyrrolidinone, thiazole, pyrrole, 1,2,4-triazole, oxadiazole and benzimidazole heterocyclic fragments were synthesized and their antibacterial properties were evaluated against Gram-positive strains of Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes and Gram-negative Pseudomonas aeruginosa, Escherichia coli and Salmonella enterica enteritidis. The vast majority of compounds exhibited between twofold and 16-fold increased antibacterial effect against the test-cultures when compared with Oxytetracycline.

COA of Formula: C6H5NO. Bye, fridends, I hope you can learn more about C6H5NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

Dong, C; Wang, X; Pei, ZB; Sheno, RW in [Dong, Chao; Wang, Xin; Pei, Zibo; Sheno, Ruwei] Nanjing Tech Univ, Coll Chem Engn, State Key Lab Mat Oriented Chem Engn, Nanjing 211800, Jiangsu, Peoples R China published Metal-Free Denitrogenative C-C Couplings of Pyridotriazoles with Boronic Acids To Afford alpha-Secondary and alpha-Tertiary Pyridines in 2019.0, Cited 84.0. Name: Phenyl(pyridin-2-yl)methanone. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

Pyridotriazoles are utilized as robust building blocks to access alpha-secondary and alpha-tertiary pyridines via the development of a simple yet practically useful metal-free denitrogenative C-C cross-coupling with boronic acids. The reaction shows a high level of functional tolerance, broad substrate scope, and facile scalability. The synthetic potential of the method is demonstrated by the strurctural modification of a bioactive molecule and concise synthesis of pheniramine analogs.

Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.. Name: Phenyl(pyridin-2-yl)methanone

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C12H9NO. You, SY; Yan, CY; Zhang, RL; Cai, MZ in [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Minist Educ, Key Lab Funct Small Organ Mol, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong; Zhang, Rongli; Cai, Mingzhong] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China; [Yan, Chenyu] Jiangxi Normal Univ, Affiliated Middle Sch, Nanchang 330022, Jiangxi, Peoples R China; [You, Shengyong] Jiangxi Acad Sci, Inst Appl Chem, Nanchang 330029, Jiangxi, Peoples R China published A convenient and practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with formic acid as carbon monoxide source in 2019.0, Cited 82.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1.

A practical heterogeneous palladium-catalyzed carbonylative Suzuki coupling of aryl iodides with arylboronic acids under carbon monoxide gas-free conditions has been developed using a bidentate phosphino-functionalized magnetic nanoparticle-immobilized palladium(II) complex as catalyst. Formic acid was utilized as the carbon monoxide source with dicyclohexylcarbodiimide as the activator, and a wide variety of biaryl ketones were generated in moderate to high yields. The new heterogeneous palladium catalyst can be prepared via a simple procedure and can easily be separated from a reaction mixture by simply applying an external magnet and recycled up to 10 times without any loss of activity.

COA of Formula: C12H9NO. Bye, fridends, I hope you can learn more about C12H9NO, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C8H10ClNO3. Recently I am researching about FLUORIDE-ION; ANION; FLUORESCENCE; AGGREGATION; METALLOGELS; DYE; CHEMOSENSORS; RECOGNITION; VITAMIN-B-6; DERIVATIVES, Saw an article supported by the UGC, New Delhi, IndiaUniversity Grants Commission, India; SERB, DST, New Delhi [EMR/2016/008005/OC]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Pati, C; Ghosh, K. The CAS is 65-22-5. Through research, I have a further understanding and discovery of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

A naphthalimide-pyridoxal conjugate 1 has been designed and synthesized. Compound 1 forms a stable greenish yellow colored gel in DMSO:H2O (8:1 v/v). Rheological study reveals that the gel is mechanically strong (G> G) over a wide range of applied strains. The morphology of the gel as determined by FESEM shows a highly cross-linked fibrous network. The gel is anion-responsive and is selectively transformed into a sol with a color change from greenish yellow to deep blue only in the presence of F- among other anions. In CH3CN, compound 1 was also sensitive to basic anions such as F- and AcO- ions. In solution, F- was differentiated from AcO- through a color change. While the yellow colored solution of 1 in acetonitrile was changed into deep blue in the presence of F-, AcO- ions gave a faint blue coloration. A similar colorimetric differentiation of F- from AcO- has been possible in CH3CN by a reusable Schiff base-linked Merrifield resin 1a or 1b.

Bye, fridends, I hope you can learn more about C8H10ClNO3, If you have any questions, you can browse other blog as well. See you lster.. COA of Formula: C8H10ClNO3

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

In 2019.0 APPL ORGANOMET CHEM published article about AEROBIC ALCOHOL OXIDATION; PALLADIUM NANOPARTICLES; COUPLING REACTIONS; HIGHLY EFFICIENT; SELECTIVITY; SURFACE; SUZUKI in [Ampawa, Supanan; Krittametaporn, Nuttaporn; Sangtrirutnugul, Preeyanuch] Mahidol Univ, Ctr Excellence Innovat Chem PERCH CIC, Ctr Catalysis, Dept Chem,Fac Sci, 272 Rama VI Rd, Bangkok 10400, Thailand; [Ungpittagul, Thasanaporn; Phomphrai, Khamphee] Vidyasirimedhi Inst Sci & Technol, Sch Mol Sci & Engn, Dept Mat Sci & Engn, Rayong 21210, Thailand in 2019.0, Cited 32.0. The Name is Phenyl(pyridin-2-yl)methanone. Through research, I have a further understanding and discovery of 91-02-1. Category: pyridine-derivatives

Triazole-based ligands, tris (triazolyl)methanol (Htbtm), bis (triazolyl)-phenylmethanol (Hbtm), and phenyl (pyridin-2-yl)(triazolyl)methanol (Hpytm), with differences in ligand denticity (i.e., bidentate and tridentate) and type of N donors (i.e., triazole and pyridine) were functionalized onto a silica support to produce the corresponding SiO2-L (L = tbtm, btm, pytm). Subsequent reactions with Pd (CH3COO)(2) in CH2Cl2 yielded Pd/SiO2-L. ICP-MS reveals that Pd loadings are higher with increased N loadings, resulting in the following trend: Pd/SiO2-tbtm (0.83 mmol Pd g(-1)) > Pd/SiO2-btm (0.65 mmol Pd g(-1)) ~ Pd/SiO2-pytm (0.63 mmol Pd g(-1)). Meanwhile, TEM images of the used Pd/SiO2-L catalysts after the first catalytic cycle show that the mean size of Pd NPs is highest with Pd/SiO2-pytm (8.5 +/- 1.5 nm), followed by Pd/SiO2-tbtm (6.4 +/- 1.6 nm) and Pd/SiO2-btm (4.8 +/- 1.3 nm). Based on TONs, catalytic studies toward aerobic oxidation of benzyl alcohol to benzaldehyde at 60 degrees C in EtOH showed that Pd/SiO2-pytm possessed the most active surface Pd(0) atoms, most likely as a result of more labile properties of the pyridine-triazole ligand compared to tris- and bis (triazolyl) analogs. ICP-MS and TEM analysis of Pd/SiO2-btm indicate minimal Pd leaching and similar average Pd NPs sizes after 1(st) and 5(th) catalytic runs, respectively, confirming that SiO2-btm is an efficient Pd NPs stabilizer. The Pd/SiO2-btm catalyst was also active toward aerobic oxidation of various benzyl alcohol derivatives in EtOH and could be reused for at least 7 reaction cycles without a significant activity loss.

Category: pyridine-derivatives. Welcome to talk about 91-02-1, If you have any questions, you can contact Ampawa, S; Krittametaporn, N; Ungpittagul, T; Phomphrai, K; Sangtrirutnugul, P or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem

COA of Formula: C6H5NO. Recently I am researching about POLO-BOX DOMAIN; ALPHA-AMINO; PD(II)-CATALYZED PHOSPHORYLATION; DEHYDROAMINO ACIDS; MICHAEL ADDITION; C BOND; ROUTE; ACCESS; DEHYDROTRYPTOPHAN; PHOSPHONATION, Saw an article supported by the National Key Research and Development Program of China [2019YFA0905100]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772142, 21901181, 21961142015]; Tianjin Municipal Science & Technology Commission [19JCQNJC04700]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Cao, HQ; Liu, HN; Liu, ZY; Qiao, BK; Zhang, FG; Ma, JA. The CAS is 500-22-1. Through research, I have a further understanding and discovery of 3-Pyridinecarboxaldehyde

A general and practical cross-dehydrogenative coupling protocol between readily available trisubstituted alpha,beta-dehydro alpha-amino carboxylic esters and H-phosphites is described. This C(sp(2))-H phosphorylation reaction proceeds with absolute Z-selectivity promoted by silver salt in a radical relay manner. The bulky tetrasubstituted beta-phosphonodehydroamino acids were obtained in grams and added new modules to the toolkit for peptide modifications.

COA of Formula: C6H5NO. Welcome to talk about 500-22-1, If you have any questions, you can contact Cao, HQ; Liu, HN; Liu, ZY; Qiao, BK; Zhang, FG; Ma, JA or send Email.

Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem