Day: March 10, 2022

Related Products of 51173-05-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 51173-05-8, name is 5-Fluoro-2-hydroxypyridine. This compound has unique chemical properties. The synthetic route is as follows.

a) 5-Fluoro-3-nitropyridin-2-ol A mixture of concentrated sulphuric acid (1 mL) and fuming nitric acid (1 mL) was added dropwise to a stirred, cooled (ice-bath) mixture of 5-fluoropyridin-2-ol (1.20 g, 10.6 mmol) and concentrated sulphuric acid (2.7 mL). The mixture was warmed to ambient temperature and then to 85 C. After 2 hours, the mixture was cooled and poured onto ice-water. The precipitate was filtered and dried to give the title compound (0.72 g, 43%) as a yellow solid. LRMS (m/z): 157 (M-1)+. 1H NMR delta (300 MHz, DMSO-d6): 8.28 (s, 1H), 8.67 (s, 1H).

According to the analysis of related databases, 51173-05-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Almirall, S.A.; EP2527344; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 17322-91-7, 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one, blongs to pyridine-derivatives compound. Quality Control of 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one

Dissolve 5-hydroxy-1H-pyrrole [3,2] pyridine (10 mmol) in 40 ml of dichloromethane solution.10 ml of triethylamine was added thereto, and the temperature was controlled below 10 C.A solution of 2-chloroacetyl chloride (12 mmol) in dichloromethane was added dropwise to the system.After the addition was completed, the temperature was returned to room temperature, and the mixture was stirred at room temperature for 10 hours.The reaction system was then washed with 50 ml of a 5% aqueous solution of sodium carbonate and the organic phase was dried over anhydrous Na2SO4.After evaporating the solvent, the obtained solid was separated by flash column chromatography.1.9 g of pale yellow 2-chloro-1-(5-hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid were obtained in a yield of 90%.

The synthetic route of 17322-91-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sang Qi; (10 pag.)CN108456207; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59020-10-9, name is 3-(Tributylstannyl)pyridine. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 59020-10-9

Example 54 (Sp) -8-(3-Pyridinyl)adenosine-2’O-(tert- butyldimethylsilyl)-3′,5′-cyclic N-phenylphosphoramidate (5j); A mixture of Pd (OAc)2 0.166 mmol) and PPh3 (91mg, 0.348 mmol) in NMP (4 ml) was stirred at 50 C until the solution had turned dark red. A solution of (Sp)-8- bromoadenosine-2’O-(tert-butyldimethylsilyl)-3′,5′-cyclic N-phenylphosphoramidate (4) (0.500 g, 0.83 mmol) in NMP (2 ml) and 3- (tributylstannyl)pyridine g, 1.66 mmol) were added. The reaction mixture was stirred at 110 C for 10 h before the NMP was removed at reduced pressure and the residual material subjected to flash chromatography on silica gel using 7.5% MeOH in CH2Cl2. The product was a white solid contaminated with traces of organotin residues which were removed by dissolution of the the coupling product in CH2Cl2 and reprecipitation by hexane; yield 0.280 g (57%); HRMS (electrospray) : M+H 596.2211. Calc. for C27H34N7O5PSi+H: 596.2201. ¹H NMR (CDC1,, 300 MHz) : No. (CDCl3)-0.16 (3H, s, CH3),-0.15 (3H, s, CH,) , 0.60 (9H, s, C(CH3)3) , 4.30 – 4.43 (lH, m, H-4′), 4.60 – 4.68 (2H, m, OCH,), 5.15 (lH, d, J 5.2 Hz, H-2′), 5.69 (lH, s, H-1′), 5.75 – 5.82 (lH, m, H-3′), 6.37 (2H, bs, NH2), 6.58 (lH, d, J 9.2 Hz, NH), 6.99 – 7.10 (3H, m, 3 x H-Ph), 7.17 – 7.24 (2H, t, J 7.4 Hz, 2 x H-Ph), 7.42 – 7.48 (lH, m, H-pyr), 8.02 – 8.06 (lH, m, H-pyr), 8.37 (lH, s, H-2), 8.76 – 8.79 (lH, m, H-pyr), 8.97 (lH, d, J 1.7 Hz, H-pyr); ¹3C NMR (CDCl3,75 MHz) : 8 -5.5 and -4.8 (2 x CH3) , 18. 0 (Si-C), 25.4 (3 x CH3), 68.9 (d, J 6.8 Hz, OCH,), 71.3 (d, J 4 .5 Hz, CH-4′), 73.3 (d. J 8.8 Hz, CH-2′), 77.5 (d, J 3.8 Hz, CH-3′), 94.2 (CH-1′), 119.4,119.5, 119.6,122.9, 123.5, 125.0,129.1, 129.1,136.8, 138.5,148.1, 149.8,150.3, 151.4,153.5, 155.9.

With the rapid development of chemical substances, we look forward to future research findings about 59020-10-9.

Reference:
Patent; LAURAS AS; COCKBAIN, Julian; WO2005/123755; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1018505-59-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1018505-59-3, name is 5-(4-Ethylpiperazin-1-yl)pyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows.

The 4 – (2 – dimethyl carbonyl -2 – carbonyl – ethylamine) -2 – pyrimidine formic acid (1.26 g 1.2 eq), 5 – (4 – ethyl – piperazine -1 – yl) – piperidine -2 – amino (0.81 g 1 eq) and triethylamine (500 mul) in DMF (15 ml) in, then added HBTU (1.51 g 1.5 eq). The mixture stirring at room temperature to 16 hours, then EtOAc (50 ml) and saturated NaHCO3Solution (15 ml), and for separating each layer of EtOAc (2 × 15 ml) extraction the aqueous layer, the combined organic layer drying (MgSO4), Filtering and evaporation to dryness, the residue through the column chromatography purification, and to obtain white solid compound of 1.04 g (yield: 47%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1018505-59-3, 5-(4-Ethylpiperazin-1-yl)pyridin-2-amine.

Reference:
Patent; Jiangxi Runze Pharmaceutical Co., Ltd.; Liao Niansheng; Zou Mingming; Hu Xiande; Sui Rongchun; Xu Man; (14 pag.)CN108689997; (2018); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 6945-67-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 6945-67-1, name is 2-Bromo-4-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

To a solution of sodium (480mg, 21mmol) dissolved in 1-propanol (45mL), was added 2-bromo-4-nitropyridine [(3.2g, 19.2mmol), J. Med. Chem. 46(7), 1273-1276; 2003] and the mixture was heated at 95C for 2 hours. The solvent was then evaporated under reduced pressure and the residue was suspended in chloroform and filtered. The filtrate was washed with water, dried over magnesium sulfate, and concentrated in vacuo to give an oily residue. The residue was distilled and title product was obtained during a temperature range of 145-150C, as a solid in 58% yield, 2.67g. 1H-NMR(CDCl3, 400MHz) delta: 0.70(t, 3H), 1.58(m, 2H), 3.95(t, 2H), 6.65(m, 1H), 6.83(d, 1H), 8.02(d, 1H) Micro analysis found (%); C(44.10), H(4.70), N(6.80); C8H10BrNO requires (%); C(44.50), H(4.70), N(6.50)

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 6945-67-1, 2-Bromo-4-nitropyridine.

Reference:
Patent; Pfizer Limited; EP1595881; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1093879-46-9, name is 2-(6-Bromopyridin-2-yl)acetic acid. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C7H6BrNO2

Into a mixture of 2-(6-bromopyridin-2-yl)acetic acid (54 mg, 0.24 mmol) and (2S,4R)-N-(2′-chloro-2-fluoro-[l, -biphenyl]-3-yl)-4-fluoropyrrolidine-2-carboxamide hydrochloride (91 mg, 0.24 mmol) in DMF (2 mL), TBTU (116 mg, 0.36 mmol) was added followed by DIEA (0.083 mL, 0.48 mmol) with stirring. After the reaction was finished, NaHCO3 solution (10 mL) was added and the resulting solid precipitation was collected by filtration, washed with water, and purified by silica gel column chromatography to afford (2S,4R)- 1 -(2-(6-bromopyridin-2-yl)acetyl)-N-(2′-chloro-2-fluoro-[ 1 , 1 ‘-biphenyl]-3 -yl)-4- fluoropyrrolidine-2-carboxamide (124 mg) (41).1H NMR (400 MHz, Chloroform-d) delta 9.33 – 9.18 (m, 1H), 8.21 (ddd, J = 1.7, 7.3, 8.7 Hz, 1H), 7.53 – 7.42 (m, 2H), 7.31 (dddd, J = 4.1, 7.3, 9.6, 12.7 Hz, 6H), 7.14 (td, J = 1.1, 8.0 Hz, 1H), 7.01 (ddd, J = 1.7, 6.8, 7.8 Hz, 1H), 5.30 (d, J = 53.0 Hz, 1H), 4.95 (dd, J = 7.1, 8.4 Hz, 1H), 4.13 (ddt, J = 1.7, 12.6, 19.7 Hz, 1H), 3.92 (d, J = 2.0 Hz, 2H), 3.67 (ddd, J = 3.5, 12.6, 33.0 Hz, 1H), 2.86 – 2.71 (m, 1H), 2.45 (dddt, J = 2.0, 8.4, 14.8, 21.8 Hz, 1H). LC (method A): =3.08 min. LC/MS (EI) mlz: [M + H]+ 534.

With the rapid development of chemical substances, we look forward to future research findings about 1093879-46-9.

Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WILES, Jason, Allan; PHADKE, Avinash, S.; DESHPANDE, Milind; AGARWAL, Atul; CHEN, Dawei; GADHACHANDA, Venkat, Rao; HASHIMOTO, Akihiro; PAIS, Godwin; WANG, Qiuping; WANG, Xiangzhu; GREENLEE, William; (447 pag.)WO2017/35408; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 78427-26-6, name is 1-(4-Aminophenyl)pyridin-1-ium chloride, the common compound, a new synthetic route is introduced below. Recommanded Product: 1-(4-Aminophenyl)pyridin-1-ium chloride

To a 250 mL Erlenmeyer flask were added 14.6 g of l-(4-aminophenyl)pyridine-l-ium chloride (“PyCI”), 20 g deionized ice water, and 80 g of deionized water under stirring. After all PyCI solids were dissolved, 40 mL of 2M sodium nitrite was added to this solution, which was then put into an ice-water bath and cooled to [0062] In a separate 2L vessel, 22.89 g of N-(5-chloro-2-methoxyphenyl)-3-hydroxy-2-naphthamide (available from TCI as Naphthol AS-CA) was dissolved in a solution 37.5 mL of 2M NaOH and 250 ml of ethanol. The resulting solution was cooled to 5C. To this solution was added the diazo-PyCI solution dropwise with vigorous stirring over a time period of 40 min to 1 hour. Since the solution became very viscous during the addition period, another 200 mL of ethanol and 300 mL of methanol were added to ensure a good mixing. During the whole addition period, approximately 50 mL of 2M NaOH was added to the reaction mixture to maintain a pH > 12. The reaction mixture was allowed to warm back to room temperature gradually and then stirred at room temperature overnight. The resulting red precipitate was removed by filtration, washed with deionized water, and dried in the vacuum oven at 60C to yield 32.4 g of the Cationic Synergist I.

The synthetic route of 78427-26-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cabot Corporation; Xu, Jinqi; (21 pag.)CN106062087; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1211517-76-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1211517-76-8, name is 3-Bromo-5-fluoro-4-methylpyridine, molecular formula is C6H5BrFN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 2: A solution of the intermediate from step 1 (3.0 g, 15.8 mmol) and [1 ,1-Bis(diphenylphosphino)- ferrocene]dichloropalladium(ll) ( 0,7 g, 0.95 mmol) in ethylene glycol (70 mL) was purged with N2 before 1-(vinyloxy)butane (3.2 g, 31.6 mmol) and NEt3 (4.4 mL, 31.6 mmol) were added. The RM was stirred at 140C for 4 h. Water was added and the mixture extracted with CH2CI2. The combined organic layers were concentrated in vacuo, a solution of HCI (3 M, 30 mL) and THF (10 mL) added and the resulting solution stirred overnight. Water was added and the mixture extracted several times with EtOAc. The combined organic layers were dried, volatiles removed under reduced pressure and the residue purified by CC (Si02, Cy/EtAc) to yield the desired compound (0.77 g, 32%).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211517-76-8, 3-Bromo-5-fluoro-4-methylpyridine.

Reference:
Patent; GRUeNENTHAL GMBH; VOSS, Felix; RITTER, Stefanie; NORDHOFF, Sonja; WACHTEN, Sebastian; OBERBOeRSCH, Stefan; KLESS, Achim; WO2015/22073; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 885326-88-5, name is Methyl 6-amino-4-bromopicolinate. This compound has unique chemical properties. The synthetic route is as follows. Safety of Methyl 6-amino-4-bromopicolinate

A mixture of Example 106C (644 mg, 2.79 mmol, 1 eq), 2- chloroacetaldehyde (40 % in H20, 1.63 mL, 23.33 eq) and NaHC03 (398 mg, 4.74 mmol, 1.7 eq) in EtOH (10 mL) was heated to 80 C 12 hours. The mixture was cooled to 20 C and basified with aq. Na2C03. The aqueous phase was extracted with ethyl acetate (30 mL*2). The combined organic phase was washed with brine (10 mL*2), dried with anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (gradient 5 to 50% EA in PE). Example 106D (600 mg crude) was obtained as a brown oil and used directly in next step.

With the rapid development of chemical substances, we look forward to future research findings about 885326-88-5.

Reference:
Patent; CHRYSALIS, INC.; GWALTNEY, Stephen; (147 pag.)WO2017/214413; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1214326-89-2, name is 3-Bromo-5-fluoropyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C5H4BrFN2

To a solution of 3-bromo-5- fluoro-pyridin-4-amine (20.0 mmol, 3.82 g) in DMF (40 niL) was added NaH (40.0 mmol, 1.6 g).The mixture was stirred at room temperature for 30 min, then cooled to 0 C. A soluntion of 2-chloro-6-fluoro-benzoyl chloride (30.0 mmol, 5.79 g) in DCM (10 niL) was then added dropwise. The reaction mixture was stirred at room temperature for 16 hours. The reaction was then quenched with ice water, extracted with EtOAc. The combined organics were dried (Na2S04), filtered and concentrated.The resultant oil was dissolved in MeOH (40 mL) and THF (40 mL). 2N NaOH (30 mL) was added. The mixture was stirredat room temperature for 16 hours. The volatile solvents were then removed under reduced pressure. Water (100 mL) was added. The aqueous layer was saturated with NaCl, extracted with CHCL/zPrOH (3/1). The combined organics were dried (Na2S04), filtered and concentrated. The crude product was purified by silica gel chromatography (0-8% EtOAc/DCM) to give the title compound as an off- white solid (3.4 g, 49% yield). ¾ NMR (400 MHz, DMSO) delta 11.07 (s, IH), 8.74 (s, IH), 8.71 (s, IH), 7.59 (dd, J= 14.8, 7.8 Hz, IH), 7.47 (d, J= 8.1 Hz, IH), 7.40 (t, J= 8.6 Hz, IH). LCMS (ESI) m z 348.9 [M+H+].

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 1214326-89-2, 3-Bromo-5-fluoropyridin-4-amine.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; BLENCH, Toby; ELLWOOD, Charles; GOODACRE, Simon; LAI, Yingjie; LIANG, Jun; MACLEOD, Calum; MAGNUSON, Steven; TSUI, Vickie; WILLIAMS, Karen; ZHANG, Birong; WO2012/35039; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem