Day: March 16, 2022

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 619331-71-4, name is 4,7-Dibromo-1H-pyrrolo[2,3-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 619331-71-4

A mixture of 4,7-dibromo-lH-pyrrolo[2,3-c]pyridine (946 mg, 3.43 mmol), Nal (2.08 g, 13.7 mmol), Cul (33 mg, 0.17 mmol), and trans-N,N’-dimethylcyclohexane-l, 2-diamine (51 mg, (1779) 0.35 mmol) in l,4-dioxane (10 mL) was stirred at 90 C under argon for 4 h. LC/MS showed complete conversion was achieved (LC-MS 323.0, 325.0 [M+H]+, RT 1.30 min). The solvent was removed and the residue was suspended in ethyl acetate and filtered. The filtrate was washed with NH4CI (aq.), water and brine, dried over anhydrous Na2S04 and concentrated. The material obtained was dissolved in dichloromethane (20 mL) and treated with di-tert-butyl dicarbonate (1.20 mL, 5.1 mmol) and a few crystals of 4-dimethylaminopyridine. After stirring at room temperature for 2 h, the mixture was concentrated and chromatographed on a silica gel column (ethyl acetate in hexames, 0 – 50%) to provide tert-butyl 4-bromo-7-iodo-pyrrolo[2,3-c]pyridine- l-carboxylate (1.41 g, 97%) as a pink oil. LC-MS 423.3, 425.3 [M+H]+, RT 1.69 min.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 619331-71-4, 4,7-Dibromo-1H-pyrrolo[2,3-c]pyridine.

Reference:
Patent; PTC THERAPEUTICS, INC.; CHEN, Guangming; BHATTACHARYYA, Anuradha; JIANG, Yao; KARP, Gary, Mitchell; NARASIMHAN, Jana; TURPOFF, Anthony; ZHANG, Nanjing; (0 pag.)WO2020/5882; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 1589541-56-9 ,Some common heterocyclic compound, 1589541-56-9, molecular formula is C6H3Cl2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a stirred solution of compound 6-amino-2,4-dichloronicotinonitrile (0.26 g, 1.37mmol) in chloroform (7.0 mL) was added diisopropylethylamine (0.49 mL, 2.75 mmol)followed by imidazole (0.47 g, 6.87 mmol) and CDI (1.15 g, 6.87 mmol) at 0 C and allowed to stir at room temperature for 12 h. After the clear solution is formed (R)-(+)-phenyl ethyl amine (1.08 g, 8.9 mmol) was added at room temperature and stirred for 2 h. After confirming the completion of starting material by TLC, the reaction mixture was concentrated underreduced pressure and dissolved in ethyl acetate and then washed with water. The organic layer was washed with brine, dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure to get crude product which was purified by column chromatography (hexanes:ethyl acetate=7:3) to afford desired product. 1H NMR (ppm, 400 MHz, DMSO-d6): delta 10.07 (s, 1H), 8.03 (s, 1H), 7.37-7.32 (m, 5H), 7.28-7.24 (m, 1H), 4.84 (t, J= 8.00 Hz, 1H), 1.41 (d, J= 8.00Hz, 3H). MS ES calc?d. for C15H12Cl2N4O [M+H]+ 335; Found 335.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1589541-56-9, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WILSON, Kevin, J.; WITTER, David, J.; SILIPHAIVANH, Phieng; LIPFORD, Kathryn; SLOMAN, David; FALCONE, Danielle; O’BOYLE, Brendan; MANSOOR, Umar Faruk; LIM, Jongwon; METHOT, Joey, L.; BOYCE, Christopher; CHEN, Lei; DANIELS, Matthew, H.; FEVRIER, Salem; HUANG, Xianhai; KURUKULASURIYA, Ravi; TONG, Ling; ZHOU, Wei; KOZLOWSKI, Joseph; MALETIC, Milana, M.; SHINKRE, Bidhan, A.; THATAI, Jayanth Thiruvellore; BAKSHI, Raman Kumar; KARUNAKARAN, Ganesh Babu; WO2014/52563; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 167837-43-6, Adding some certain compound to certain chemical reactions, such as: 167837-43-6, name is (E)-3-(6-Aminopyridin-3-yl)acrylic acid,molecular formula is C8H8N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 167837-43-6.

e) 3-(6-amino-pyridin-3-yl)-N-(3-cyano-lH-indol-2-yhnethyl)-N-methyl-acrylamide; EDC (250 mg, 1.3 mmol) was added to a solution of (£)-3-(6-Amino-pyridin-3-yl)- acrylic acid (172 mg, 1.05 mmol), 2-methylaminomethyl-lH-indole-3-carbonitrile (186 mg, 1.0 mmol), HOBf H2O (135 mg, 1.0 mmol) and DPEA (510 muL, 3.0 mmol) in dry DMF (4 mL). After 3 days of stirring, the mixture was diluted with water (50 mL) at 100C. The resulting precipitate was filtered, washed with water and dried to afford the title compound (277 mg, 84%). 1H NMR (300 MHz, DMSO-d6, delta): 12.1 (m, IH), 8.16 (s, IH), 7.84 (s, IH), 7.5 (m, 3H), 7.2 (m, 2H), 6.97 (m, IH), 6.44 (s, 2H), 5.08 and 4.88 (rotamers, 2s, 2H), 3.22 and 2.96 (rotamers, 2s, 3H). MS (ESI): m/e 332 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 167837-43-6, (E)-3-(6-Aminopyridin-3-yl)acrylic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; AFFINIUM PHARMACEUTICALS, INC.; WO2007/53131; (2007); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1254073-41-0, name is 5-Fluoropicolinohydrazide, the common compound, a new synthetic route is introduced below. Recommanded Product: 1254073-41-0

The title compound was prepared in an analogous method to that described in E1 11. To a solution of 4-[(2-chlorophenyl)carbonyl]-2-piperazinone (I4) (225 mg, 0.943 mmol) in Dichloromethane (5 ml) stirred under argon at room temp was added solid triethyloxonium tetrafluoroborate (179 mg, 0.943 mmol). The reaction mixture was stirred at RT for 2 hr. Solid 5-fluoro-2-pyridinecarbohydrazide (I24) (161 mg, 1.037 mmol) was added and the reaction mixture stirred at RT for 18 hr. The solvent was evaporated in vacuo, and the residue dissolved in n-butanol (5 ml) and stirred at 120 0C for 4 hr. The reaction mixture was cooled to room temperature and partitioned between Dichloromethane (~ 25 ml) and saturated brine (~ 25 ml). The aqueous phase was extracted wih Dichloromethane (2 x 25 ml) and the combined organic extracts washed with saturated brine (~ 25 ml), dried over sodium sulphate, and evaporated in vacuo to afford the crude product as a yellow oil. This was dissolved in 1 :1 MeOH:DMSO and purified by Open Access Mass Directed AutoPrep on Sunfire C18 column using Acetonitrile Water with a Formic acid modifier. The solvent was evaporated in vacuo and the residue dried overnight in a vacuum oven at 40 0C to give the required product as a white powder in 126.4 mg.LCMS: 2 minute run in MeCN. MH+ m/z = 358.03; RT = 0.80-0.82 min.

The synthetic route of 1254073-41-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 149142-67-6, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione. This compound has unique chemical properties. The synthetic route is as follows. Formula: C7H3BrN2O2

An appropriate amount of 1.82 g (10 mmol) of 5-chloro-7-N erythropoose was dissolved in 50 mL of ethanol, placed in a Erlenmeyer flask,Was slowly added dropwise to 50 mL of an ethanol solution containing 0.75 g (15 mmol) of hydrazine hydrate and heated to 80 C for 6 hours. Thin layerChromatography method to track the reaction to complete, the reaction system of the mixture before the hot filter, washed with ethanol, the filtrate was static crystallizationIntermediates. The resulting intermediate was placed in a reactor with 2.26 g (10 mmol) of 5-bromo-7-Nindalene, 50 mL of ethanol was added,Heated and stirred, and refluxed at 80 C for 4 hours. TCL tracking to the reaction is complete, stop heating, remove the condensing device. Will reactThe solid-liquid mixture of the system was concentrated under reduced pressure, cooled to room temperature and filtered. The filter cake was washed with warm water to give 5-chloro-5′-bromo-Double 7-N hetero-aldehyde Schiff base (2) crude. The crude product was added to the reactor, and 25 mL of ethanol was added for recrystallization,Dried to give a yellowish brown color crystalline powder (3.11 g) in a total yield of 76.9%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 149142-67-6, 5-Bromo-1H-pyrrolo[2,3-b]pyridine-2,3-dione.

Reference:
Patent; Shaanxi University of Science and Technology; Liang Chengyuan; Jia Minyi; Tian Danni; Ju Weihui; Pei Shaomeng; (17 pag.)CN106632407; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 139585-48-1, name is 2-Chloro-5-methoxypyridine. This compound has unique chemical properties. The synthetic route is as follows. COA of Formula: C6H6ClNO

Carboxylic acid XIIIAcid XIII-I5 ‘-Methoxy-3,4,5,6-tetrahydro-2H- [ 1 ,2 ‘] bipyridinyl-4-carboxylic acida) 5′-Methoxy-3,4,5,6-tetrahydro-2H-[l,2’]bipyridinyl-4-carboxylic acid ethyl esterTo a stirred solution of piperidine-4-carboxylic acid ethyl ester (0.52 g, 3.34 mmol) and 2- chloro-5-methoxy-pyridine in 10 mL of toluene was added (13 mg, 0.057 mmol) of Pd(II) acetate, (17 mg, 0.027 mmol) of BINAP and tBuOK (0.44 g, 3.90 mmol). The mixture was heated at 1200C for two hours, concentrated under vacuo and the residue was directly purified on column chromatography (SiO2, EtOAc/Hept 1 :2) yielding 0.17 g (24 %) of the title compound as a light yellow oil. ES-MS m/e: 265.3 (M+H+).

With the rapid development of chemical substances, we look forward to future research findings about 139585-48-1.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; JABLONSKI, Philippe; KNUST, Henner; NETTEKOVEN, Matthias; PATINY-ADAM, Angelique; RATNI, Hasane; RIEMER, Claus; WO2011/23626; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1256811-02-5, name is 1-(5-Bromo-2-methoxypyridin-3-yl)ethanone. This compound has unique chemical properties. The synthetic route is as follows. Formula: C8H8BrNO2

Step 4-Synthesis of 2-bromo-1-(5-bromo-2-hydroxypyridin-3-yl)ethanone To a solution of 1-(5-bromo-2-methoxypyridin-3-yl)ethanone (2.0 g, 8.69 mmol) in HBr (20 mL, HOAc solution), Br2 (1.4 g, 8.76 mmol) was added dropwise at room temperature. The reaction mixture was stirred at room temperature for 5 hours. Then the reaction mixture was filtered to collect the HBr salt. The solid was suspended with Na2CO3 solution, extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2SO4, filtered and concentrated in vacuo to provide 2-bromo-1-(5-bromo-2-hydroxypyridin-3-yl)ethanone (2.0 g, yield: 74%). 1H-NMR (DMSO, 400 MHz) delta 12.83 (br s, 1H), 8.11?8.13 (m, 2H), 4.85 (s, 2H). MS (M+H)+: 295.

With the rapid development of chemical substances, we look forward to future research findings about 1256811-02-5.

Reference:
Patent; Liverton, Nigel J.; McComas, Casey Cameron; Habermann, Joerg; Koch, Uwe; Narjes, Frank; Li, Peng; Peng, Xuanjia; Soll, Richard; Wu, Hao; Palani, Anandan; He, Shuwen; Dai, Xing; Liu, Hong; Lai, Zhong; London, Clare; Xiao, Dong; Zorn, Nicolas; Nargund, Ravi; US2014/213571; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 52311-20-3, 2-Amino-4-ethoxypyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of 2-Amino-4-ethoxypyridine, blongs to pyridine-derivatives compound. Safety of 2-Amino-4-ethoxypyridine

4-Ethoxy-pyridin-2-ylamine (15 g, 109 mmol) is dissolved in HOAc (100 mL) and cooled to 0 C. Bromine is added dropwise with vigorous stirring. The mixture is allowed to stir at RT for 30 minutes at which point a precipitate forms. The mixture is stirred for 30 min and the solids collected by filtration, washed with EtOAc in dried in a vacuum oven to give 5-bromo-4-ethoxy-pyridin-2-ylamine hydrobromide (23.3 g, 78.2 mmol).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,52311-20-3, 2-Amino-4-ethoxypyridine, and friends who are interested can also refer to it.

Reference:
Patent; Boehringer Ingelheim International GmbH; LIU, Pingrong; MILLER, Craig Andrew; YU, Maolin; ZHANG, Zhonghua; (93 pag.)US2018/72717; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 38222-83-2 , The common heterocyclic compound, 38222-83-2, name is 2,6-Di-Tert-butyl-4-methylpyridine, molecular formula is C14H23N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a mixture of 2, 6-di-/Patent; MASARYKOVA UNIVERZITA; PARUCH, Kamil; CARBAIN, Benoit; HAVEL, Stepan; DAMBORSKY, Jiri; BREZOVSKY, Jan; DANIEL, Lukas; SISAKOVA, Alexandra; NIKULENKOV, Fedor; KREJCI, Lumir; (190 pag.)WO2019/201865; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 52378-63-9, Adding some certain compound to certain chemical reactions, such as: 52378-63-9, name is (3-Aminopyridin-2-yl)methanol,molecular formula is C6H8N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52378-63-9.

(i) A solution sodium nitrite (2.38 g.) in water (10 ml.) was added dropwise to a stirred mixture of 3-amino-2-hydroxymethylpyridine (4.8 g.) in aqueous hydrobromic acid (48%, 10 ml) and water (5 ml) at 0-5 C. This solution of the diazonium salt was added to a hot solution of cuprous bromide (2.5 g.) in 60% hydrobromic acid and following cessation of nitrogen evolution the mixture was heated on the steam bath for 0.5 hours, diluted with water and saturated with hydrogen sulphide. Filtration, concentration to low bulk and extraction with chloroform yielded 3-bromo-2-hydroxymethyl-pyridine (4.8 g.).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 52378-63-9, (3-Aminopyridin-2-yl)methanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4025527; (1977); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem