Day: March 17, 2022

Electric Literature of 62002-31-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 62002-31-7, name is 4,5,6,7-Tetrahydro-3H-imidazo[4,5-c]pyridine dihydrochloride, molecular formula is C6H11Cl2N3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

1-Hydroxy-7-azabenzotriazole (0.32 g, 2.4 mmol) was added to a solution of phenylpropiolic acid (0.34 g, 2.4 mmol) in dichloromethane (30 mL). The solution was cooled to 0 C. EDC (0.45 g, 2.4 mmol) was added. The reaction mixture was stirred at 0 C. for 20 min. 4,5,6,7-Tetrahydroimidazo[4,5-c]pyridine dihycrochloride (0.50 g, 2.3 mmol) was added. Ethyldiisopropylamine (0.40 mL, 2.3 mmol) was added. The reaction mixture was stirred for 16 h at room temperature. It was diluted with ethyl acetate (100 mL) and washed with 10% aqueous sodium hydrogensulfate solution (100 mL). The aqueous phase was extracted with ethyl acetate (3*60 mL): It was added a 1 N sodium hydroxide solution until pH 12 was obtained. It was extracted with ethyl acetate (3*90 mL). These extracts were combined and dried over magnesium sulfate. The solvent was removed in vacuo. The crude product was purified by flash chromatography on silica (40 g), using dichloromethane/methanol/25% aqueous ammonia (100:10:1) as eluent, to give 50 mg of the title compound. 1H NMR (CDCl3, 2 rotamers): delta2.75 and 2.85 (both t, together 2H); 4.03 and 4.15 (both t, together 2H); 4.75 and 4.92 (both s, together 1H); 7.10-7.70 (m, 6H).

According to the analysis of related databases, 62002-31-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Novo Nordisk A/S; US6908926; (2005); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 914942-88-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 914942-88-4, name is tert-Butyl (6-amino-7-iodo-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)(methyl)carbamate, molecular formula is C13H18IN5O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A101.3 (107mg, O.thetammol), A1.12 (164mg, 0.41 mmol) bis(triphenylphophine)palladium dichloride and triethylamine were degassed by bubbling nitrogen through the reaction for several minutes and then heated under a nitrogen atmosphere at 90 0C for 30 minutes. The mixture was concentrated under reduced pressure and the product purified by silica gel chromatography (hexane/ethyl acetate) to yield A101.4 (148mg, 80%). LCMS: Ret. Time – 3.53 min, M+it = 454.39.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 914942-88-4, tert-Butyl (6-amino-7-iodo-1-methyl-1H-imidazo[4,5-c]pyridin-4-yl)(methyl)carbamate.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WO2006/122137; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 22187-96-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 22187-96-8, name is 5-Methoxypicolinaldehyde, molecular formula is C7H7NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of 5-methoxypicolinaldehyde (326mgs, 2.36mmol) in MeOH (10 mL) was added NaBH4 (71.9 mg, 1.90 mmol) at O0C. The mixture was stirred at O0C for 10 min after concentration in vacuo, the residue was purified with ISCO MPLC (40-80% EtOAc/hexane) to yield the title compound as a colorless oil (298 mg, 90 %). 1H NMR (CDCl3) 68.28 (d, 1 H), 7.09 – 7.27 (m, 2 H), 4.73 (s, 2 H), 3.89 (s, 3 H). MS (M+H+) = 140.

According to the analysis of related databases, 22187-96-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/27746; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 52378-63-9 , The common heterocyclic compound, 52378-63-9, name is (3-Aminopyridin-2-yl)methanol, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

i. A solution sodium nitrite (2.38 g) in water (10 ml) was added dropwise to a stirred mixture of 3-amino-2-hydroxy-methylpyridine (4.8 g) in aqueous hydrochloric acid (48% 10 ml) and water (5 ml) at 0-5 C. This solution of the diazonium salt was added to a hot solution of cuprous chloride (2.5 g) in conc. hydrochloric acid and following cessation of nitrogen evolution the mixture was heated on the steam bath for 0.5 hours, diluted with water and saturated with hydrogen sulphide. Filtration, concentration to low bulk and extraction with chloroform yielded 3-chloro-2-hydroxy-methyl-pyridine (3.7 g), m.p. 42-44 (from n-pentane).

The synthetic route of 52378-63-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Smith Kline & French Laboratories Limited; US4013769; (1977); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 20970-75-6, name is 2-Cyano-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. Product Details of 20970-75-6

step 1:48 g of 2-cyano-3-methylpyridine was added to 650 ml of a mixed solvent of a 5% by mass aqueous solution of NaOH and acetone.Under stirring, 125 ml of 10% mass fraction of H2O2 was added dropwise in 15 min, and the temperature was raised to 50 C, and the reaction was further stirred for 3.5 h.Stop the reaction, distill off the acetone at 50 C, freeze, filter, dry,White solid 3-methyl-2-pyridinecarboxamide47g,The yield was 85.3%;

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 20970-75-6, 2-Cyano-3-methylpyridine.

Reference:
Patent; Zhao Ming; (5 pag.)CN109705030; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 4487-56-3, Adding some certain compound to certain chemical reactions, such as: 4487-56-3, name is 2,4-Dichloro-5-nitropyridine,molecular formula is C5H2Cl2N2O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4487-56-3.

A mixture of 2,4-dichloro-5-nitropyridine (450 mg, 2.332 mmol), potassium fluoride (406 mg, 7.00 mmol), and 18-Crown-6 (99 mg, 0.373 mmol) in NMP (2 mL) was heated at 100C under nitrogen for 2 h. The reaction mixture was transferred to a separatory funnel containing water (5 mL) and ether (50 mL). The layers were separated and the organic layer was washed with water (2 x 5 mL), brine (5 mL), dried over MgS04, filtered, and concentrated. The residue was purified by column chromatography on silica gel (10%? 20% ethyl acetate in hexanes; 40 g column) to afford 2,4-difluoro-5-nitropyridine (177 mg, 1.106 mmol, 47% yield) as a colorless solid: NMR (400MHz, CDCh) delta 9.07 (d, J=9.5 Hz, 1H), 6.95 (dd, J=9A, 2.4 Hz, 1H); 19 F NMR (376MHz, CDCh) delta -52.17 (d, J=27.7 Hz, IF), -98.12 (dt, J=29.5, 8.7 Hz, IF).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 4487-56-3, 2,4-Dichloro-5-nitropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; HARTZ, Richard A.; AHUJA, Vijay T.; SIVAPRAKASAM, Prasanna; DUBOWCHIK, Gene M.; MACOR, John E.; (104 pag.)WO2018/98411; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 175204-82-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 175204-82-7, name is Methyl 4-(trifluoromethyl)nicotinate, molecular formula is C8H6F3NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

3-Isopropyl-5-(4-trifluoromethyl-3-pyridyl)-1,2,4-oxadiazole (Table 1, No. 81) 2 g of methyl 4-trifluoromethylnicotinate and 1.56 g of isobutyramide oxime were initially charged in 15 ml of ethanol and cooled to 0 C. 10 ml of a 1.2 molar sodium ethoxide solution were added dropwise to this solution. The mixture was allowed to warm to room temperature over a period of two hours and stirring was then continued at this temperature until the reaction, according to TLC, had ended. The reaction mixture was concentrated and the residue was taken up in saturated ammonium chloride solution and extracted with diethyl ether. Chromatographic purification of the crude product gave the desired compound as a yellowish oil. 1H-NMR (CDCl3, 300 MHz): d=1.41 (d, J=6.9 Hz, 6H), 3.22 (m, 1H), 7.78 (d, J=5 Hz, 1H), 9.02 (d, J=5 Hz, 1H), 9.34 (s, 1H) ppm.

According to the analysis of related databases, 175204-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Hoechst Schering AgrEvo GmbH; US6239160; (2001); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 403-45-2, name is 6-Fluoronicotinic acid. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 403-45-2

Step G: 6-fluoro-nicotinic acid methyl ester A round bottom flask was charged with K2CO3 (191 g, 1380 mmol), 6-fluoronicotinic acid (77.8 g, 551 mmol) and dimethylformamide (551 mL). Methyl iodide (51.5 mL, 827 mmol) was then added in one portion at room temperature and mixture stirred overnight at room temperature. The reaction mixture was partitioned between ethyl acetate and water. The organic layer was washed three times with water and once with brine, and then dried over Na2SO4. Purification by silica gel flash chromatography (ethyl acetate/dichloromethane) gave 6-fluoro-nicotinic acid methyl ester (71.8 g, 84%) as a white solid. 1H NMR (400 MHz, CDCl3, delta): 3.96 (s, 3H) 7.01 (dd, J=8.58, 2.93 Hz, 1H) 8.41 (ddd, J=8.49, 7.61, 2.44 Hz, 1H) 8.89 (d, J=2.34 Hz, 1H); MS (M+1): 156.1.

With the rapid development of chemical substances, we look forward to future research findings about 403-45-2.

Reference:
Patent; Pfizer Inc.; US2012/165343; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1014631-89-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1014631-89-0, name is 1-(Pyridin-3-yl)-1H-pyrazole-4-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.

Stage 3: (Pyridin-3-yl)-1H-pyrazole-4-carbonyl chloride hydrochloride; 4.00 g (21.15 mmol) of 1-(pyridin-3-yl)-1H-pyrazole-4-carboxylic acid were initially charged in approx. 100 ml of dichloromethane, and admixed with 2 drops of dimethylformamide under argon. 7.783 g (61.32 mmol) of oxalyl chloride were added dropwise and, after the end of the addition, the mixture was stirred at room temperature for 1 hour. The solution was concentrated, and the residue was admixed with approx. 10 ml of toluene and concentrated. This gave a colourless solid which was converted further immediately.

According to the analysis of related databases, 1014631-89-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Bayer CropScience AG; US2011/118290; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem