Day: March 17, 2022

Electric Literature of 1160791-13-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1160791-13-8, name is 2-Amino-6-bromothiazolo[5,4-b]pyridine, molecular formula is C6H4BrN3S, molecular weight is 230.09, as common compound, the synthetic route is as follows.

Step 2: l-allyl-3- (6-bromothiazolo [5,4-b] pyridin-2-yl) urea (Intermediates). In a 25 ml round-bottomed flask, 6-bromothiazolo [5,4-b] pyridin-2-amine (0.575 g, 2.5 mmol) was suspended in tetrahydrofuran (15 mL). To this triethylamine (0.697 mL,5.00 mmol) was added in one portion and resulting reaction mixture was stirred at RT.Then allyl isocyanate (0.331 mL, 3.75 mmol) was added and stirred at RT for overnight.The reaction mixture was evaporated in vacuo, ice-cold water was added, sonicated well and the precipitated solid was filtered and dried under high vacuum. The crude product was triturated with acetonitrile gave the pure product as brown solid (0.650mg, 83%).MS (ES+): 314 for C10H9BrN4OS1H NMR (DMSO-d6) delta: 3.82 (t, 2H,CH2); 5.10 -5.25(m, 2H,CH2); 5.80 -5.95(m,IH5CH); 6.95 (t, IH5NH); 8.15 (bs, IH5NH); 8.23 (s, lH,Aro.); 8.48 (s, lH,Aro.).

The chemical industry reduces the impact on the environment during synthesis 1160791-13-8, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/147431; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 13472-84-9, name is 3-Chloro-2-methoxypyridine. A new synthetic method of this compound is introduced below., Recommanded Product: 3-Chloro-2-methoxypyridine

General procedure: An oven-dried reaction flask, equipped with a reflux condenser was charged with heteroaryl chloride (1.0 mmol), 4-(N-Boc-N-methyl)aminopiperidine (1.3 equiv.), Pd(OAc)2 (3 mol%), DavePhos (3 mol%), t-BuONa (1.2 equiv.). The flask was sealed, and was evacuated and backfilled with argon for three times. Then 3 mL toluene was added to the system with a syringe. The reaction mixture was stirred at 120 C for 12 h. After cooling to the room temperature, the resulting residue was filtered through a plug of silica gel and washed with ethyl acetate. The mixture was then poured into water and extracted. The combined organic layers were washed with brine, dried over MgSO4, and filtered. The solvent was removed under vacuum. The residue was purified by flash column chromatography to afford the desired product.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 13472-84-9, 3-Chloro-2-methoxypyridine.

Reference:
Article; Zhang, Kena; Li, Hui; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng; Tetrahedron Letters; vol. 58; 20; (2017); p. 1976 – 1979;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 135124-71-9, name is 5-(Hydroxymethyl)nicotinonitrile, the common compound, a new synthetic route is introduced below. name: 5-(Hydroxymethyl)nicotinonitrile

To a solution of 5-(hydroxymethyl)pyridine-3-carbonitrile (2 g, 14.91 mmol) in DCM (10 mL) was added hydrogen chloride in dioxane (4M, 5 mL) and concentrated. To the residue was added SOCl2(6.50 mL, 89.61 mmol) and stirred for 3 hr at 60 C. After cooling, toluene (200mL) was added and the mixture was filtered. The filtrate was adjusted to pH = 7 with sat. NaHCCh and extracted with DCM (3 x 50 mL). The organic phase was combined and dried over Na2S04and then concentrated under reduced pressure to give 5-(chloromethyl)pyridine-3- carbonitrile (l .7g, 74.72% yield) as a black solid.

The synthetic route of 135124-71-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ARBUTUS BIOPHARMA, INC.; BI, Yingzhi; DORSEY, Bruce D.; FAN, Yi; MOORE, Christopher Brooks; NGUYEN, Duyan; (169 pag.)WO2019/191624; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 63996-36-1 , The common heterocyclic compound, 63996-36-1, name is 2-(4-Bromophenyl)pyridine, molecular formula is C11H8BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

967 mg (4.10 mmoL) of Compound J, 759 mg (4.14 mmoL) of phenoxazine, 28 mg (0.123 mmoL) of Pd(OAc)2, 99 mg (0.492 mmoL) of P(t-Bu)3, and 569 mg (5.92 mmoL) of NaOt-Bu are dissolved in 40 mL of toluene, and the mixture is heated to 110 C., and the temperature is maintained until the reaction is terminated. When the reaction is terminated, the resultant is subjected to a work-up procedure and column chromatography to obtain Compound K (yield: 80%).

The synthetic route of 63996-36-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung Electronics Co., Ltd.; Yang, Hae Yeon; Son, Jun Mo; Ju, Won Jae; (34 pag.)KR101594129; (2016); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 884495-38-9, name is 6-Chloro-4-methylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 884495-38-9

General procedure: To a solution of Intermediate 47B (1.00g. 8.92 mrnol) and 6bromo4 methylnicotinonitrile (1.76 g, 8.92 mmol) in dioxane (20 mL) was added K2C03 (308 g. 22.30mmol) and XANTPHOS (1.03 g, 1.78 mmol) and the resulting reaction mixture was degassed with nitrogen for 5 minutes. Pd2(dha)3 (0.82 g, 089 mmol) was added and the resulting mixture was degassed again for 5 minutes then heated at 100 C for 16 h. The reaction mixture was cooled to ambient temperature, filtered t1i?ough Celite and the filtrate was concentrated under reduced pressure. The residue was purified by column chromatography (Redisep40 g, 22. 5%MeOHDCM) to obtain Intermediate 47C (120 g, 59.0%) as a pale yellow solid. 1H NMR (300 MHz, DMSO-d6) ppm 2.57 (s. 3 H) 2.65 (t, J= 6.61 Hz, 2 H) 3.55 3.67 (m, 2 H) 4.71 (br. s., I H) 7.80 (s, I H) 7.96 (d, J= 0.76 Hz, I H) 8.47 (s, I H) 8.82 (s, I H). LCMS Qvlethod-D):retention time 086 mm, [M±ij 229.3.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 884495-38-9, 6-Chloro-4-methylnicotinaldehyde.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; GUNAGA, Prashantha; BHIDE, Rajeev S.; BORA, Rajesh Onkardas; PANDA, Manoranjan; YADAV, Navnath Dnyanoba; PRIESTLEY, Eldon Scott; RICHTER, Jeremy; (321 pag.)WO2018/93569; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem