Day: March 18, 2022

Adding a certain compound to certain chemical reactions, such as: 144657-66-9, tert-Butyl 3-formyl-1H-pyrrolo[2,3-b]pyridine-1-carboxylate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 144657-66-9, blongs to pyridine-derivatives compound. SDS of cas: 144657-66-9

To a solution of 1-(tert-butoxycarbonyl)-3-formyl-7-azaindole (2.5g, 10.2 mmol) in 16 mL EtOH was added NaBH4 (115mg, 3.05 mmol). The reaction was stirred at ambient temperature for 4h, concentrated and triturated with IN NaOH. The basic solution was extracted with ether and ethylacetate. The organics were washed with water and brine, then dried over Na2S04, filtered and concentrated. The filtrate was concentrated and purified by silica gel chromatography (50% ethylacetate/hexanes) to give tert-butyl 3-(hydroxymethyl)-lH- pyrrolo[2,3-b]pyridine-l-carboxylate (44%). LCMS [M-tert-Bu]+ = 191.1.

The synthetic route of 144657-66-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; STACHEL, Shawn, J.; EGBERTSON, Melissa; BRNARDIC, Edward; JONES, Kristen; SANDERS, John, M.; HENZE, Darrell, A.; WO2013/176970; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 849068-61-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 849068-61-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid. A new synthetic method of this compound is introduced below.

A mixture of 5-bromo-lH-pyrrolo[2,3-b]pyridine-3-carboxylic acid (480 mg, 2 mmol, 1.0 eq) and cone. H2S04 (0.5 mL, cat.) in methanol was refluxed for 24 h. After the reaction was complete, the solvent was concentrated. The resulting residue was dissolved with EA, washed with aq. NaHC03., dried over Na2S04, filtered and concentrated to provide methyl 5-bromo-lH-pyrrolo[2,3-b]pyridine-3-carboxylate (450 mg, 85%) as a white solid. LCMS (M+H+) m/z calculated 256.1 found 256.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,849068-61-7, its application will become more common.

Reference:
Patent; LIFESCI PHARMACEUTICALS, INC.; MCDONALD, Andrew; QIAN, Shawn; (346 pag.)WO2018/11628; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 153034-88-9, name is 2-Chloro-4-iodo-3-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows. category: pyridine-derivatives

The mixture of 234 mg of 2-chloro-4-iodo picoline, 17.6 mg of copper iodide, 33.3 mg of 1,10-phenanthroline, 601 mg of cesium carbonate, 230 muL of 4-methoxybenzyl alcohol, and 0.5 mL of toluene, was stirred at 110C for 4 hours. After adding water and a saturated aqueous solution of sodium hydrogen carbonate, the mixture was extracted with chloroform, and the organic layer was washed with saturated brine. The thus-obtained organic layer was dried over anhydrous sodium sulfate, insolubles were filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by preparative thin-layer chromatography, and 207 mg of 2-chloro-4-[(4-methoxybenzyl)oxy]-3-methylpyridine [64-1] as a white solid.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 153034-88-9, 2-Chloro-4-iodo-3-methylpyridine.

Reference:
Patent; BANYU PHARMACEUTICAL CO., LTD.; EP1790650; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 60186-13-2, 2,4,6-Trichloro-3-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Product Details of 60186-13-2, blongs to pyridine-derivatives compound. Product Details of 60186-13-2

(7) (R)-1-(2,6-dichloro-3-nitropyridin-4-yl)piperidine-3-tert-butyl carbamate To 30 mL solution of 2,4,6-trichloro-3-nitropyridine (1.14 g, 5.0 mmol) in ethanol was added triethylamine (1.4 mL, 10 mmol) at -10C, and stirred in an ice bath. After 15 mL solution of (R)-tert-butylpiperidin-3-yl-carbamate (1 g, 5.0 mmol) in ethanol was slowly added dropwise with a constant pressure funnel, the reaction solution was stirred for 1 h at -10C, and concentrated. The resultant crude product was subjected to silica gel column chromatography (ethyl acetate : petroleum ether = 1:2) to afford 0.78 g titled product with a yield of 39.9%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,60186-13-2, 2,4,6-Trichloro-3-nitropyridine, and friends who are interested can also refer to it.

Reference:
Patent; Xuanzhu Pharmaco., Ltd.; EP2524917; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 7471-05-8, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.7471-05-8, name is 2-(4,5-Dihydro-1H-imidazol-2-yl)pyridine, molecular formula is C8H9N3, molecular weight is 147.1772, as common compound, the synthetic route is as follows.

General procedure for dehydrogenation of imidazolines with NaIO4 catalyzed by [Mn(TPP)Cl]: All of the reactions were carried out at room temperature under air in a 25 mL flask equipped with a magnetic stirrer bar. A solution of NaIO4 (2 mmol) in H2O (10 mL) was added to a mixture of 2-imidazolines (1 mmol), [Mn(TPP)Cl] (0.05 mmol) in CH3CN (5 mL). The progress of reaction was monitored by TLC (eluent: EtOAc/MeOH 4:1). After the reaction was completed, water (30 mL) was added and the corresponding imidazoles were extracted with CH2Cl2 (2 x 20 mL). The imidazole derivatives were obtained after evaporation of solvent. IR and 1H NMR spectral data confirmed the identities of the products.

The chemical industry reduces the impact on the environment during synthesis 7471-05-8, I believe this compound will play a more active role in future production and life.

Reference:
Article; Kargar, Hadi; Moghadam, Majid; Mirkhani, Valiollah; Tangestaninejad, Shahram; Mohammadpoor-Baltork, Iraj; Nameni, Iman; Bioorganic and Medicinal Chemistry Letters; vol. 21; 7; (2011); p. 2146 – 2148;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3998-90-1, name is Methyl 2-chloro-6-picoline-4-carboxylate. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C8H8ClNO2

A mixture of methyl 2-chloro-6-methyl-pyridine-4-carboxylate (1.8 g, 10 mmol) and 10% palladium-on-charcoal catalyst (200 mg) in methanol (100 ml) was stirred under hydrogen at 5 atmospheres pressure. The catalyst was removed by filtration and the volatiles removed from the filtrate by evaporation. The residue was treated with 10% aqueous sodium hydroxide solution and extracted with ether (3*30 ml). The combined extracts were dried (MgSO4) and the solvent removed by evaporation to give methyl 2-methyl-pyridine-4-carboxylate (800 mg, 53%) as an oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 3998-90-1, Methyl 2-chloro-6-picoline-4-carboxylate.

Reference:
Patent; Zeneca Limited; Zeneca Pharma S.A.,; US5962458; (1999); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 163658-33-1, (6-Ethylpyridin-2-yl)methanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 163658-33-1, blongs to pyridine-derivatives compound. Recommanded Product: 163658-33-1

EXAMPLE 3 N-[1-(6-ethyl-2-pyridylmethyl)piperidin-4-yl]-2-cyclopentyl-2-hydroxy-2-phenylacetamide STR7 To a solution of 22 mg of 6-ethyl-2-pyridine-methanol in 3 ml of ethyl acetate, 0.1 ml of triethylamine and 50 mul of methanesulfonylchloride were added at room temperature, followed by 30 minutes’ stirring at the same temperature. Saturated aqueous sodium hydrogencarbonate solution was added to the reaction mixture, followed by an hour’s stirring. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The extract was combined with the organic layer, washed with saturated saline solution, dried over anhydrous magnesium sulfate and removed of the solvent by reduced pressure distillation. The residue was dissolved in 3 ml of N,N-dimethylformamide, and to the solution 32 mg of N-(piperidin-4-yl)-2-cyclopentyl-2-hydroxy-2-phenylacetamide as obtained in Step (2) of Example 2, 12 mg of sodium bromide and 85 mg of potassium carbonate were added, followed by 4 hours’ stirring at room temperature. The reaction mixture was poured into water and extracted with diethyl ether. The extract was sequentially washed with water and saturated saline solution, dried over anhydrous magnesium sulfate and removed of the solvent by reduced pressure distillation. The residue was purified by preparative thin layer chromatography [Kieselgel 60F254, Art 5744 (Merck), chloroform/methanol=12/1] to give 14.5 mg of the title compound as a white solid. FAB-MS (m/e, (C26 H35 N3 O2 +H)+) 422 1 H-NMR(CDCl3) delta: 1.15-1.34 (1H, m), 1.29 (3H, t, J=7.5 Hz), 1.38-1.92 (11H, m), 2.17-2.30 (2H, m), 5 2.70-2.89 (2H, m), 2.81 (2H, q, J=7.5 Hz), 2.97-3.22 (2H, m), 3.63 (2H, s), 3.67-3.81 (1H, m), 6.35 (1H, brd, J=7.7 Hz), 7.04 (1H, d, J=7.3 Hz), 7.21 (1H, d, J=7.9 Hz), 7.24-7.40 (3H, m), 7.53-7.65 (3H, m)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,163658-33-1, (6-Ethylpyridin-2-yl)methanol, and friends who are interested can also refer to it.

Reference:
Patent; Banyu Pharmaceutical Coaltd; US6130232; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 880870-13-3 ,Some common heterocyclic compound, 880870-13-3, molecular formula is C6H5BrClNO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step B: 6-chloro-4-methoxypyridine-3 -carbonitrile: A solution of 5 -bromo-2-chloro-4- methoxypyridine (5.0 g, 22.48 mmol) in DMF (80 mL) was purged with nitrogen for 15 mm. Atthis point, Zn(CN)2 (3.96 g, 33.7 mmol) and Pd(Ph3P)4 (2.60 g, 2.25 mmol) were added, successively. The resulting suspension was stirred at 95 C for 12 h under nitrogen atm. The reaction mixture was cooled to ambient temperature, filtered to remove inorganic solid. The solvent (DMF) was evaporated to provide the crude residue as an oil, which was purified on silica gel and eluted with 0-30% ethyl acetate/hexane to afford the product.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,880870-13-3, its application will become more common.

Reference:
Patent; MERCK SHARP & DOHME CORP; TANG, Haifeng; PIO, Barbara; JIANG, Jinlong; PASTERNAK, Alexander; DONG, Shuzhi; FERGUSON, Ronald Dale, II; GUO, Zack Zhiqiang; CHOBANIAN, Harry; FRIE, Jessica; GUO, Yan; WU, Zhicai; YU, Yang; WANG, Ming; WO2015/17305; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 197376-47-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 197376-47-9, name is Ethyl 6-Chloropyridine-3-acetate, molecular formula is C9H10ClNO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A solution of lithium bis(trimethylsilyl)amide in THF (1 M, 14 mL, 14.0 mmol) was added to a solution of ethyl 2-(6-chloropyridin-3-yl)acetate (2.5 g, 12.5 mmol) in THF at -78 C under nitrogen. After stirred at -78 C for 2 h, methyl iodide (1.94 g, 13.7 mmol) was added. The mixture was stirred at 20 C for another 8 h. Worked up, concentrated and purified with silica gelcolumn chromatography, eluting with 0%-40% EA/PE, to give the title compound (1.5 g, 83% purity in LCMS, yield 46%) as yellow oil. MS (ES+) C10H12C1N02 requires: 213, 215, found:214, 216 [M+H].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 197376-47-9, Ethyl 6-Chloropyridine-3-acetate.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; BROOIJMANS, Natasja; BRUBAKER, Jason, D.; FLEMING, Paul, E.; HODOUS, Brian, L.; KIM, Joseph, L.; WAETZIG, Josh; WILLIAMS, Brett; WILSON, Douglas; WILSON, Kevin, J.; (347 pag.)WO2017/181117; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176526-00-4, name is 2-(Pyridin-4-yl)benzaldehyde. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2-(Pyridin-4-yl)benzaldehyde

General procedure: A mixture of 4-hydroxycoumarine 1 (162 mg, 1 mmol), thearomatic aldehydes 2a-l (1 mmol; 106, 185, 141, 175, 131, 122,136, 120, 151, 96, 107, and 112 mg, respectively), 6-amino-1,3-dimethyluracil 3 (155 mg, 1 mmol), and Fe3O4TiO2 NPs(0.02 g), in H2O (2 mL) were stirred at ambient temperaturefor 2-3 h (see Table 2). After completion of the reactionas indicated by thin layer chromatography (eluent/ethyl acetate-petrol = 3:1), the reaction mixture was dilutedwith DMF (1 mL) and the catalyst was recovered from thereaction mixture by simply using an external magnet. Forreuse, the catalyst was washed with EtOH and dried in airat ambient temperature for several hours. The remainingsolution was diluted with H2O (1 mL), to yield the pureproducts by recrystallization from this solution.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 176526-00-4, 2-(Pyridin-4-yl)benzaldehyde.

Reference:
Article; Fakheri-Vayeghan, Sakineh; Abdolmohammadi, Shahrzad; Kia-Kojoori, Reza; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 73; 8; (2018); p. 545 – 551;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem