Day: March 18, 2022

Related Products of 58602-02-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.58602-02-1, name is 2,6-Difluoro-3-nitropyridine, molecular formula is C5H2F2N2O2, molecular weight is 160.0784, as common compound, the synthetic route is as follows.

EXAMPLE 4 1-(6-Fluoro-3-nitro-2-pyridinyl)-4-carbobenzoxypiperazine-2-carboxylic acid In a similar procedure to that described in Example 1, from 6.0 g. of 2,6-difluoro-3-nitropyridine, 9.0 g. of 4-carbobenzoxypiperazine-2-carboxylic acid, hydrochloride, 20 ml. of triethylamine and 150 ml. of dimethyl sulfoxide, there is obtained 14 g. of the title product as a viscous orange glass. Thin layer chromatographic analysis of this material shows essentially one spot.

The chemical industry reduces the impact on the environment during synthesis 58602-02-1, I believe this compound will play a more active role in future production and life.

Reference:
Patent; American Home Products Corporation; US4138564; (1979); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 116855-08-4, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 116855-08-4 as follows.

Step 5: lH-Pyrazolor3,4blpyridine-3-carboxylic Acid Methyl Ester The mixture of solids from the preceding step 4 (95 g) was suspended in methanol (500 mL) and sulfuric acid (5 mL) was added carefully. The reaction mixture was then heated to reflux for 6-8 h, and the reaction was monitored using TLC. After completion of the reaction, inorganic solids were filtered off from the reaction mixture and the solid cake was washed with hot methanol. The main filtrate and the washings were combined, then methanol was distilled off under reduced pressure on the rotary evaporator. The resulting solids were suspended in 5% sodium bicarbonate solution (300 mL) and stirred for 5 min. at room temperature. The white solids were filtered off and dried in an oven at 90-95 0C to constant weight (8.07 g, 42% based on 3-methyl-lH-pyrazolo[3,4b]pyridine), mp 201-203 0C. 1H NMR: (CDCl3) 14.4 (brs, 1 H), 8.74 (dd, J = 4.6 and 1.5 Hz, 1 H), 8.64 (dd, J = 8.1 and 1.5 Hz, 1 H), 7.39 (dd J = 8.1 and 4.6 Hz, 1 H), 4.10 (s, 3 H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,116855-08-4, its application will become more common.

Reference:
Patent; UNIVERSITY OF KANSAS; GEORGE, Ingrid, Gunda; TASH, Joseph, S.; CHAKRSALI, Ramappa; JAKKARAJ, Sudhakar, R.; CALVET, James, P.; WO2011/5759; (2011); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 667932-24-3, Adding some certain compound to certain chemical reactions, such as: 667932-24-3, name is 2-Ethynylpyridin-4-amine,molecular formula is C7H6N2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 667932-24-3.

Step E Compound 240 (513 mg) was dissolved in dry dichloromethane (50 mL) and Et3N (0. 786ml, 1.3equiv.) was added under nitrogen. The mixture was cooled in an ice bath and a solution of dichloroacetyl chloride (0.483 mL, [L.] [LEQUIV.)] in dry dichloromethane (5 mL) was added dropwise. The reaction was allowed to warm to room temperature over 6 hours and then diluted with EtOAc, washed with a saturated solution of sodium bicarbonate, dried, filtered and concentrated in vacuo. The crude material was passed through a plug of silica gel, eluted with 1: 1 hexanes/EtOAc. The fractions were concentrated to produce a purple oil that solidified under high vacuum to yield compound 255 (658mg).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 667932-24-3, 2-Ethynylpyridin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; RIGEL PHARMACEUTICALS, INC.; WO2004/18463; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 183208-34-6, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridin-2-one, the common compound, a new synthetic route is introduced below. name: 5-Bromo-1H-pyrrolo[2,3-b]pyridin-2-one

Step 3: 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrrolo[2,3-b]pyridin-2(3H)-one To a solution of 5-bromo-lH-pyrrolo[2,3-b]pyridin-2(3H)-one (3 g, 14.08 mmol) in 1,4-dioxane (60 mL) were added 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(l,3,2-dioxaborolane) (4.29 g, 16.9 mmol), potassium acetate (2.07 g, 21.12 mmol) and l,l’-bis(diphenylphosphino)ferrocene- palladium(II)dichloride (1.02 g, 1.41 mmol). The reaction mixture was purged with nitrogen for 2 min and heated to 110 C for 1 h. After cooling down the mixture was filtered and the solid was washed with ethyl acetate. The mother liquid was diluted with methanol and the precipitate was filtered and dried in vacuo to afford 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-lH-pyrrolo[2,3- b]pyridin-2(3H)-one (1.1 g, 30%): lU NMR (400 MHz, DMSO-d6) delta 11.14 (s, 1H), 8.29 (s, 1H), 7.68 (s, 1H), 3.54 (s, 2H), 1.29 (s, 12H).

The synthetic route of 183208-34-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; ESTRADA, Anthony; HUESTIS, Malcolm; KELLAR, Terry; PATEL, Snahel; SHORE, Daniel; SIU, Michael; (260 pag.)WO2016/142310; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 116785-23-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 116785-23-0, name is 4,6-Dimethylnicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.

4,6-Dimethyl-3-pyridinecarbaldehyde1 (2.52g) and methyl D-alloisoleucinatehydrochloride (3.4g) were dissolved in 2,2,2-trifluoroethanol (50ml). To this wasadded triethylamine (2.61ml) and the reaction mixture was left to stand for 18 hours.

According to the analysis of related databases, 116785-23-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/399; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 1206775-52-1, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1206775-52-1, name is 5-Bromo-6-methoxypicolinaldehyde, molecular formula is C7H6BrNO2, molecular weight is 216.032, as common compound, the synthetic route is as follows.

5-Bromo-6-methoxypyridine-2-carboxaldehyde (15 g, 69.3 mmol, 1 eq.) Was dissolved in 300 ml of dichloromethane, and the temperature was lowered to -78 C. Under nitrogen protection, diethylaminosulfur trifluoride (44.7 g, 277.2 mmol, 4 eq.) Was added dropwise. After completion of the dropwise addition, the reaction was carried out at 18 C for 18 hours.After the reaction was completed, the reaction solution was dropped into ice water and made alkaline with a saturated sodium bicarbonate solution. Extraction with dichloromethane, concentration of the organic phase and column chromatography gave 15 g of 3-bromo-6- (difluoromethyl) -2-methoxypyridine as a white solid with a yield of 91%.

Statistics shows that 1206775-52-1 is playing an increasingly important role. we look forward to future research findings about 5-Bromo-6-methoxypicolinaldehyde.

Reference:
Patent; Ali Biological New Materials (Changzhou) Co., Ltd.; Shi Jianyun; Xu Yibo; Dai Hongsheng; Xu Xiangcheng; Liu Chao; (10 pag.)CN110724091; (2020); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 887115-56-2, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 887115-56-2 as follows.

A mixture of 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (3.04 g, 14.0 mmol), bis(pinacolato)diboron (4.37 g, 17.0 mmol), PdCl2(dppf) (0.992 g, 1 mmol), and potassium acetate (3.52 g, 36 mmol) in dioxane was heated at 100 C. for 1 hour. Reaction mixture was portioned between ethyl acetate and saturated sodium bicarbonate solution, organic layer dried (MgSO4), filtered, concentrated and purified by CombiFlash (ethyl acetate/hexanes) to give desired product. LCMS-ESI+: calc’d for C13H19BN3O2: 260.2 (M+H)+; found: 260.2 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,887115-56-2, its application will become more common.

Reference:
Patent; Gilead Sciences, Inc.; Cai, Zhenhong R.; Guo, Hongyan; Ji, Mingzhe; Jin, Haolun; Lee, Amy; McFadden, Ryan; Mitchell, Michael L.; Munoz, Manuel; Pyun, Hyung-Jung; Xu, Lianhong; Yang, Hong; (272 pag.)US2018/118734; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 13296-04-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 13296-04-3 as follows.

EXAMPLE 11 N-[4-(4-Pyridinyl)phenyl]butanamide–To a mixture containing 19.6 g. of n-butanoic acid anhydride in 150 ml. of chloroform was added with stirring 6.81 g. of 4-(4-pyridinyl)benzeneamine and the resulting mixture was stirred at room temperature for 17 hours and then refluxed with stirring for 90 minutes. The reaction mixture while warm was filtered through diatomaceous earth and the filtrate was concentrated on a steam bath to remove the solvent. The residue was diluted with water, the aqueous mixture made alkaline with ammonium hydroxide and the resulting mixture was stirred, concentrated further to remove small amount of remaining chloroform and the resulting solid was collected. The solid was recrystallized from 150 ml. of ethanol plus water and dried in vacuo at 90 C. for 20 hours to yield 8.2 g. of N-[4-(4-pyridinyl)phenyl]butanamide, m.p. 174-175 C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,13296-04-3, its application will become more common.

Reference:
Patent; Sterling Drug Inc.; US4317827; (1982); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 23056-47-5, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 23056-47-5, name is 2-Bromo-4-methyl-5-nitropyridine. This compound has unique chemical properties. The synthetic route is as follows.

A suspension of 2-bromo-4-methyl-5-nitropyridine (XIV) (200 g, 921 mmol, 1.00 eq) and NH4C1 (240 g, 4.49 mol, 4.87 eq) in EtOH (3.50 L) and water (150 mL) was heated with stirring to 50C. To this mixture was added Fe (120 g, 2.15 mol, 2.33 eq) and HC1 (10.2 g, 279 mmol, 0.30 eq). The suspension was then heated to 80C for another 3 h. The reaction was cooled to 25C and filtered through a plug of Celite. The filtrate was concentrated under reduced pressure to yield a residue that was taken up in EtOAc (1 Lx 3) and washed with brine. The organic layer was dried over sodium sulfate, filtered and concentrated under reduced pressure to give 6- bromo-4-methylpyridin-3-amine (XV) as brown solid (167.9 g, 898 mmol, 97.4% yield) which was used for the next step without any purification. ?H NMR (CDC13, 400 MHz) ppm 2.15 (s, 3H), 3.44 (br s, 2H), 7.14 (s, 1H), 7.78 (s, 1H); ESIMS found for C6H7BrN2 mlz 186.8 (M+H).

According to the analysis of related databases, 23056-47-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (240 pag.)WO2017/23975; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 57963-08-3, name is 5,6-Dimethylpyridin-2-amine. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C7H10N2

A pressure tube was charged with ethyl 4,6-dichloropyridazine-3-carboxylate (300 mg, 1.36 mmol), 5,6-dimethylpyridin-2-amine (249 mg, 2.04 mmol) in acetonitrile (8 mL) and the mixture was heated in an oil bath at 140 C. for 18 h. After cooling to room temperature, the mixture was concentrated in vacuo, adsorbed on silica gel and then purified by chromatography (silica, 50 mum, 80 g column from Analogix, 0% to 10% acetone in dichloromethane, 20 min) to afford ethyl 6-chloro-4-(5,6-dimethylpyridin-2-ylamino)pyridazine-3-carboxylate (150 mg, 36%) as a yellow solid. 1H NMR (400 MHz, DMSO-d6) delta ppm 10.20 (s, 1H) 8.86 (s, 1H) 7.57 (d, J=8.08 Hz, 1H) 6.97 (d, J=8.08 Hz, 1H) 4.40 (q, J=7.24 Hz, 2H) 2.42 (s, 3H) 2.23 (s, 3H) 1.35 (t, J=7.20 Hz, 3H); LCMS (EI/CI) m/z: 307 [M+H].

With the rapid development of chemical substances, we look forward to future research findings about 57963-08-3.

Reference:
Patent; Hoffman-La Roche Inc.; Hermann, Johannes Cornelius; Kennedy-Smith, Joshua; Lucas, Matthew C.; Padilla, Fernando; Soth, Michael; US2013/178478; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem