Day: March 22, 2022

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 851607-27-7, name is 5-Bromo-4-chloro-2-methoxypyridine, the common compound, a new synthetic route is introduced below. Product Details of 851607-27-7

A mixture of 5-bromo-4-chloro-2-methoxypyridine (416 mg),ethyl (6-(piperidin-4-ylmethoxy)-3,4-dihydro-2H-pyrano[2,3-c]pyridin-4-yl)acetate (938 mg), potassium carbonate (775 mg)and DMSO (10 mL) was stirred at 100C for 40 hr. The reactionmixture was added to water, and the mixture was extracted with ethyl acetate. The organic layer was separated, washedsuccessively with water and saturated brine, dried overanhydrous magnesium sulfate and concentrated under reducedpressure. The residue was purified by silica gel columnchromatography (ethyl acetate/hexane) to give the title35 compound ( 396.0 mg) . MS: [M+H] + 520. 1.

The synthetic route of 851607-27-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; SCOHIA PHARMA, INC.; MIWATASHI, Seiji; MIYAMOTO, Yasufumi; WATANABE, Koji; YOSHITOMI, Yayoi; HITOMI, Yuko; AIDA, Jumpei; TAKAKURA, Nobuyuki; FURUKAWA, Hideki; NOGUCHI, Naoyoshi; HIRATA, Yasuhiro; KASAI, Shizuo; KOBAYASHI, Toshitake; MAEKAWA, Tsuyoshi; SASAKI, Satoshi; MATSUMOTO, Shigemitsu; (190 pag.)WO2018/182050; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 942189-65-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 942189-65-3, name is 2-(6-Bromopyridin-3-yl)pyrimidine, molecular formula is C9H6BrN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 2-(6-Bromo-pyridin-3-yl)-pyrimidine 76 (100mg, 0.425mmol), potassium carbonate (100mg,0.724mmol), and piperazine (100mg,1.16mmol) in DMF’ (5ml), were stirred at 1000C for 1 hour. The reaction was cooled, solvent evaporated^/ – under reduced pressure, and the residue dissolved in MeCI2 (150ml), washed with H2O (50ml),dried over MgSO4,filtered and evaporated solvent yielding title product 77 as a white solid (100mg,98%). ESMS (MH, 242).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 942189-65-3, 2-(6-Bromopyridin-3-yl)pyrimidine.

Reference:
Patent; SCHERING CORPORATION; WO2008/156739; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 1137-67-3, 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, blongs to pyridine-derivatives compound. Recommanded Product: 2-(Pyridin-3-yl)-1H-benzo[d]imidazole

A solution of CoCl2¢6H2O (0.25 g, 1.05 mmol), 3-PBIM(0.2 g, 1.03 mmol), 1,3-H2BDC (0.2 g, 1.2 mmol), and H2O(15 mL) was stirred under ambient condition. The mixturewas then sealed in a Teflon-lined steel vessel and heated at170C for three days. After slow cooling to room temperature, the resulting product was obtained (yield: 55%). Anal.Calcd. for C64H56Co2N12O14: C, 57.58; N, 12.59; H, 4.23%.Found: C, 58.13; N, 12.87; H, 4.54%. IR (KBr pellet, cm1):3450 s, 3050 s, 1870 m, 1615 s, 1565 w, 1535 m, 1500 m, 1478m, 1448 m, 1371 m, 1270 s, 1145 m, 1130 m, 1060 s, 1018 s,970 s, 880 m, 840 s, 770 m, 745 s, 705 m, 695 m, 593 m, 565 m.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1137-67-3, 2-(Pyridin-3-yl)-1H-benzo[d]imidazole, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Quanzheng; Xia, Changkun; Lu, Hongdian; Jiang, Rui; Zhang, Xueke; Wang, Xinghan; He, Longzhong; Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry; vol. 46; 4; (2016); p. 543 – 547;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53554-20-4, name is 6-Amino-2-chloronicotinonitrile, molecular formula is C6H4ClN3, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. name: 6-Amino-2-chloronicotinonitrile

[00227j Step 1: 6-Amino-2-chloronicotinonitrile (0.100 g, 0.65 1 mmol) was taken in a sealed tube and dissolved in dioxane (3 mL) and NMP (0.2 mL). To that was added (R)pyrrolidin-3-ol (0.05 7 g, 0.651 mmol) and NMP (0.2 mL) and the set up was heated at 150 C for 18 h. The solvents were evaporated from the reaction mixture and the crudewas dissolved in water and made basic by adding NaHCO3 and was extracted with DCM(3 x 15 mL). The combined organic layer were dried and evaporated to get the product(80 mg, 42% yield) which was directly in the next reaction. LCMS 205.2 (M+H).

With the rapid development of chemical substances, we look forward to future research findings about 53554-20-4.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; DUNCIA, John V.; HYNES, John; NAIR, Satheesh K.; PITTS, William J.; KUMAR, Sreekantha R.; GARDNER, Daniel S.; MURUGESAN, Natesan; PAIDI, Venkatram Reddy; SANTELLA, Joseph B.; SISTLA, Ramesh; WU, Hong; WO2014/74675; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 886371-28-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.886371-28-4, name is 3-Bromo-6-chloroimidazo[1,2-a]pyridine, molecular formula is C7H4BrClN2, molecular weight is 231.48, as common compound, the synthetic route is as follows.

General procedure: To an oven dried 5 mL microwave vessel was addedPd(dppf)Cl2·CH2Cl2 (4 mol%), halide/pseudohalide (1 equiv),boron coupling partner (1 equiv), and Cs2CO3 (3 equiv). Thevessel was then capped and purged with N2 before addition ofCyrene (1 mL, 0.25 M) and H2O (1.8 mL). The reaction mixturewas heated to 50 C and maintained at this temperature withstirring for 5 h before the vessel was vented and decapped. Thesolution was then diluted with Et2O (10 mL) and washed withwater (2 × 20 mL) and brine (2 × 20 mL). The organics were thenpassed through a hydrophobic frit and concentrated underreduced pressure to give a residue, which was purified by flashchromatography (silica gel) to afford the title compound.

The chemical industry reduces the impact on the environment during synthesis 886371-28-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Wilson, Kirsty L.; Murray, Jane; Jamieson, Craig; Watson, Allan J. B.; Synlett; vol. 29; 5; (2018); p. 650 – 654;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 77199-09-8 , The common heterocyclic compound, 77199-09-8, name is Ethyl 5-bromopicolinate, molecular formula is C8H8BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: A mixture 2a or 2b (1 g, 1 equiv.), anappropriate pinacol boronate ester (1.2 equiv.), [1,10-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complex withdichloromethane (10 mol %), cesium carbonate (2.0 equiv.), 1,4-dioxane (8 ml) and water (4 ml) was sealed in a 20 ml microwavereaction vial (Biotage). The vial was irradiated in a microwaveapparatus at 110 C, normal absorption for 30-90 min. The reactionmixture was cooled to room temperature and work up was performedas described in method 1 to obtain the esters 4b-i.

The synthetic route of 77199-09-8 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tung, Truong Thanh; Jakobsen, Tim Holm; Dao, Trong Tuan; Fuglsang, Anja Thoe; Givskov, Michael; Christensen, S°ren Br°gger; Nielsen, John; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 1011 – 1020;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 107867-51-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.107867-51-6, name is 5-(Trifluoromethyl)pyridine-2,3-diamine, molecular formula is C6H6F3N3, molecular weight is 177.1272, as common compound, the synthetic route is as follows.

Step C: 2-(chloromethyl)-6-(trifluoromethyl)-3H-imidazo[4,5-]pyridine To a DCM 2mL suspension of 5~(trifluoromethyl)rhoyridine-2,3 -diamine (454mg, 2.56mmol) was added 2~Chloro-l,l ,l-triethoxy-ethane (504mg, 2.56mmol). The mixture was heated to 1000C for 20 mill using a microwave reactor and resulting solid was suspended in 1 :1 DCM:hexanes (5mL) and gently sonicated. The precipitate was collected by suction filtration to give the title compound (324mg). LC/MS: m/z 236(M+H). 1H-NMR (500MHz, d6-DMSO): delta 4.98 (s, 2H), 8.42(d, 1H), 8.72 (d, 1H).

The chemical industry reduces the impact on the environment during synthesis 107867-51-6, I believe this compound will play a more active role in future production and life.

Reference:
Patent; MERCK & CO., INC.; WO2009/152072; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 127446-34-8, N-(6-Chloro-3-formylpyridin-2-yl)pivalamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 127446-34-8, blongs to pyridine-derivatives compound. Formula: C11H13ClN2O2

An oven-dried flask was charged with THF (80 mL) anddiisopropylamine (8.2 mL, 58.4 mmol). The solution was cooled to -78C then n-butyllithium (2.5 M solution in hexane, 23.3 mL, 58.3 mmol)was added. The mixture was stirred for 15 mm then a solution of tertbutyl acetate (7.8 mL, 58.3 mmol) in THF (2 mL) was added. Afterstirring at -78C for 20 mm a solution of N-(6-chloro-3-formylpyridin-2-yl)-2,2-dimethylpropanamide (6.7 g, 27.8 mmol) in THF (5 mL) was added. The mixture was allowed to warm to room temperature then was poured into sat. NH4CI. The resulting mixture was extracted with ethyl acetate and the organic phase was dried and evaporated in vacuo toobtain the title compound (9.4 g, 26.4 mmol, 95% yield). LC-MS (M-H) = 357.3

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,127446-34-8, its application will become more common.

Reference:
Patent; AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A.; OMBRATO, Rosella; MAGARO’, Gabriele; GAROFALO, Barbara; FURLOTTI, Guido; MANGANO, Giorgina; CAPEZZONE DE JOANNON, Alessandra; (182 pag.)WO2017/211759; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 49669-13-8, Adding some certain compound to certain chemical reactions, such as: 49669-13-8, name is 2-Acetyl-6-bromopyridine,molecular formula is C7H6BrNO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 49669-13-8.

1) Production of 1-(6-bromopyridin-2-yl)ethanolWith cooling with ice, 426 mg of sodium borohydride was added to ethanol (50 mL) solution of 4.50 g of 2-acetyl-6-bromopyridine. After stirred for 1 hour, aqueous saturated ammonium chloride solution was added to the reaction liquid, extracted with ethyl acetate, washed with saturated saline water, and dried with anhydrous magnesium sulfate. After concentrated under reduced pressure, 4.58 g of the entitled compound was obtained as a colorless oily substance.1H-NMR (400 MHz, CDCl3) ?: 7.56 (1H, t, J=7.8 Hz), 7.39 (1H, d, J=7.8 Hz), 7.29 (1H, d, J=7.8 Hz), 4.88 (1H, q, J=6.7 Hz), 1.51 (3H, d, J=6.3 Hz).ESI-MS Found: m/z[M+H]+ 202, 204.

According to the analysis of related databases, 49669-13-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sagara, Takeshi; Otsuki, Sachie; Sunami, Satoshi; Sakamoto, Toshihiro; Niiyama, Kenji; Yamamoto, Fuyuki; Yoshizumi, Takashi; Furuyama, Hidetomo; Goto, Yasuhiro; Bamba, Makoto; Takahashi, Keiji; Hirai, Hiroshi; Nishibata, Toshihide; US2007/254892; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 59146-67-7, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 59146-67-7, name is 5,6-Dimethylpicolinonitrile. This compound has unique chemical properties. The synthetic route is as follows.

5,6-Dimethyl-2-pyridinecarbonitrile 1 -oxide; To a solution of 5,6-dimethyl-2-pyridinecarbonitrile (3.68 g, Ref: Guay et al., Bioorg. Med. Chem. Letters, 8 (5), 453. (1998)) in chloroform (25 ml) was added dropwise a solution of m-chloroperbenzoic acid (7.35 g) in chloroform (75 ml) and the solution stirred at ambient temperature for 40 hours. Sodium sulphite (2.4 g) was added and the mixture stirred for 1 hour, filtered and the solid washed with dichloromethane. The filtrate was washed with saturated sodium bicarbonate (50 ml) and water (50 ml), dried (MgSO4) and concentrated in vacuo. The residue was recrystallised from ether to afford the title compound (3.44 g, 83%) as a white solid. LC/MS [MH+] = 149, RT = 1.30 min.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 59146-67-7, 5,6-Dimethylpicolinonitrile.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/66968; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem