Day: April 2, 2022

Adding a certain compound to certain chemical reactions, such as: 76102-92-6, 2-Amino-N-(pyridin-3-yl)benzamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C12H11N3O, blongs to pyridine-derivatives compound. Computed Properties of C12H11N3O

Example 30 To a solution of 180 mg of 2-[methyl(tetrahydro-2H-pyran-4-ylmethyl)amino]-1,3-thiazole-4-carboxylic acid in 1.2 ml of DMF were added 117 mg of 2-amino-N-pyridin-3-yl benzamide, 110 mg of WSC-HCl, and 100 mg of HOBt, followed by stirring at 60C for 3 days. To the reaction liquid was added an aqueous sodium hydrogen carbonate solution, and the resulting insoluble materials were collected by filtration. This was washed with acetonitrile to prepare 195 mg of 2-[methyl(tetrahydro-2H-pyran-4-ylmethyl)amino]-N-[2-(pyridin-3-ylcarbamoyl)phenyl]-1,3-thiazole-4-carboxamide.

The synthetic route of 76102-92-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP2206707; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1124-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1124-29-4, name is 5-Acetylpyridin-2(1H)-one, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.

[0561] To a solution of III-3 (1 eq.) in DCM (0.1 mmol/mL) was added boronic acid III-4 (2 eq.), Cu(OAc)2 (1 eq), Pyridine (10 eq.) and Pyridine-N-Oxide (2 eq.), followed by addition of 4 molecular sieve (quantity approx. equal to III-3). The reaction mixture was stirred at rt under oxygen atmosphere overnight. After completion of the reaction indicated by TLC, the resulting mixture was filtered and washed with, the filtrate was washed with brine, dried over Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel to give III-5 [0572] Compound 20 was prepared following the general procedure, except the solvent was changed to acetonitrile (10% yield). 1H NMR (CDCl3, 400 MHz) delta 8.06 (d, J=2.4 Hz, 1H), 7.97 (dd, J=10, 2.4 Hz, 1H), 7.53-7.45 (m, 1H), 7.43-7.36 (m, 1H), 7.34-7.25 (m, 2H), 6.67 (d, J=10 Hz, 1H), 2.45 (s, 3H). MS (ESI) m/z (M+H)+ 232.0.

The chemical industry reduces the impact on the environment during synthesis 1124-29-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/94456; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 946002-90-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 946002-90-0, name is (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol. A new synthetic method of this compound is introduced below.

(S)-5-Bromo-2-(3-tert-butyl-dimethyl-silanyloxy)-pyrrolidin-l-yl)pyridine (G2). To a sol. of compound Gl (20.9 g, 85.8 mmol) in DMF (350 mL) at 0 0C were added imidazole (14.6 g, 215 mmol) and TBDMS-Cl (19.4 g, 129 mmol). This mixture was stirred at rt for 1.5 h, and aq. 10% K2CO3 (150 mL) was added. The mixture was extracted with heptane (2x). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane/EtOAc 5 : 1 ? 4: 1 ? 3 : 1 ? 1 : 1) yielded the title compound (30.5 g, 99%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,946002-90-0, its application will become more common.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2007/88514; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 85686-48-2, name is 6-(2,4-Dichlorophenoxy)pyridin-3-amine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

EXAMPLE 15 N-[6-(2,4-Dichlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide Following the procedure of Example 1, using 2,3,4,5-tetrahydro-1H-benzazepine and 6-(2,4-dichlorophenoxy)pyridin-3-amine as the starting materials, the title compound was prepared as a colorless solid (88%): mp 154-155 C.; IR (KBr) 3377, 3070, 3024, 3000, 2943, 2928, 2899, 1642, 1604, 1593, 1530, 1485, 1467, 1276, 1263, 1232, 1215, 863, 844, 819, 750, 734 cm-1; 1H NMR (400 MHz, CDCl3) delta7.98 (dd, J=8.8, 2.7 Hz, 1H), 7.93 (d, J=2.7 Hz, 1H), 7.45 (d, J=2.4 Hz, 1H), 7.26-7.23 (m, 1H), 7.18-7.12 (m, 4H), 7.10 (d, J=8.6 Hz, 1H), 6.95 (d, J=8.8 Hz, 1H), 6.50 (s, 1H), 3.68-3.66 (m, 4H), 3.02-3.00 (m, 4H); 13C NMR (100 MHz, CDCl3) delta158.8, 154.9, 149.0, 140.1, 139.0, 133.7, 131.9, 130.5, 130.3, 130.0, 128.0, 126.8, 124.3, 111.1, 47.1, 37.5; MS (EI) m/z 428 (M+-H), 426 (M+-H); HRMS (FAB) calcd. for C22H19Cl2N3O2+H: 428.0932, found: 428.0916; Anal. Calcd. for C22H19Cl2N3O2: C, 61.69; H, 4.47; N, 9.81. Found: C, 61.73; H, 4.54; N, 9.75.

The synthetic route of 85686-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fu, Jian-Min; US2003/149024; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73177-35-2, 2-Methyl-1H-pyrrolo[3,2-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Methyl-1H-pyrrolo[3,2-b]pyridine, blongs to pyridine-derivatives compound. Quality Control of 2-Methyl-1H-pyrrolo[3,2-b]pyridine

In the same manner as in Preparation Example 16-2, the objective compound (1.23 g) was obtained as a colorless solid from 2-methylpyrrolo[3,2-b]pyridine (500 mg). 1H-NMR(DMSO-d6): 2.75(3H, s), 7.07(1H, dd, J=8, 5 Hz), 7.38(1H, d, J=8 Hz), 7.48(1H, d, J=8 Hz), 7.65(1H, s), 7.74(1H, d, J=8 Hz), 8.14(1H, d, J=5 Hz). MASS(ESI): m/z 303(M-1)

The synthetic route of 73177-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6348474; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Cytotoxic activity of new cerium (III) complexes of bis-coumarins. Author is Kostova, Irena; Manolov, Ilia; Momekov, Georgi; Tzanova, Tzvetomira; Konstantinov, Spiro; Karaivanova, Margarita.

Complexes of Ce (III) with bis-coumarins, 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) and bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-(1H-pyrazol-3-yl)methane, were synthesized by reaction of Ce(III) salt and the ligands, in amounts equal to metal/ligand molar ratio of 1:2. The complexes were prepared by adding an aqueous solution of Ce (III) salt to an aqueous solution of the ligand subsequently raising the pH of the mixture gradually to ∼5.0 by adding dilute solution of NaOH. The Ce (III) complexes with bis-coumarins were characterized by different physicochem. methods-elemental anal., IR-, 1H- and 13C-NMR-spectroscopies and mass-spectral data. The spectral data of Ce (III) complexes were interpreted from comparison with the spectra of the free ligands. This anal. showed that in the Ce (III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. From the ν(C=O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. The authors performed comparative evaluation of the cytotoxic effects of the two newly synthesized Ce complexes against the acute myeloid leukemia derived HL-60 and the chronic myeloid leukemia (CML)-derived BV-173. The cytotoxic effects of Ce (III) complex with 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) were evaluated on the CML-derived K-562 and LAMA-84 cells, characterized by relative low responsiveness to chemotherapy. The DNA isolated from the cytosolic fraction of BV-173 cells after 24 h treatment with the same complex (at 100 and 200 μM) demonstrated a laddering phenomenon that is indicative for apoptotic cell death.

This compound(1H-Pyrazole-5-carbaldehyde)Product Details of 948552-36-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Synthesis of pyrrolo[1,2-c]imidazol-5-one, pyrrolo[1,2-a]imidazol-5-one, and pyrrolo[1,2-b]pyrazol-6-one (three isomeric azapyrrolizinones) by pyrolysis of Meldrum’s acid derivatives. Author is McNab, Hamish.

Reaction of Meldrum’s acid with 4- or 2-imidazolecarboxaldehyde or 3-pyrazolecarboxaldehyde gave condensation products, which were pyrolyzed in the gas phase to give the title aza analogs I-III, resp., of 3-pyrrolizinone, as air-sensitive yellow solids.

This compound(1H-Pyrazole-5-carbaldehyde)Product Details of 948552-36-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 625-82-1, is researched, SMILESS is CC1=CNC(C)=C1, Molecular C6H9NJournal, Article, Research Support, Non-U.S. Gov’t, Angewandte Chemie, International Edition called An Ethacrynic Acid-Brominated BODIPY Photosensitizer (EA-BPS) Construct Enhances the Lethality of Reactive Oxygen Species in Hypoxic Tumor-Targeted Photodynamic Therapy, Author is Won, Miae; Koo, Seyoung; Li, Hao; Sessler, Jonathan L.; Lee, Jin Yong; Sharma, Amit; Kim, Jong Seung, the main research direction is ethacrynic acid brominated BODIPY preparation photosensitizer PDT hypoxic cancer; BODIPY; Hypoxia; ethacrynic acid; glutathione S-transferase-pi; photodynamic therapy.Application of 625-82-1.

Despite being a clin. approved intervention for cancer, photodynamic therapy (PDT) still suffers from limitations. Prime among these is a therapeutic response that is mostly oxygen dependent. This limits the utility of PDT in treating hypoxic tumors since lower levels of cytotoxic reactive oxygen species (ROS) are generated in regions of low oxygen tension. Glutathione-pi (GST-pi) is a key enzyme that militates against ROS-mediated apoptosis. We report herein a new construct, EA-BPS, that contains both a brominated BODIPY photosensitizer (BPS) and an ethacrynic acid (EA) GST-pi inhibitor. Photoirradiation of EA-BPS induces a synergistic antitumor effect that results from the combination of ROS production and GST-pi inhibition. Relative to BPS alone, an enhanced cell-killing effect is seen under hypoxic conditions both in vitro and in vivo. We conclude that by making better use of the available oxygen in tumor environments, improved therapeutic PDT outcomes should be achievable even under hypoxic conditions.

This compound(2,4-Dimethyl-1H-pyrrole)Application of 625-82-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pfeifer, David; Russegger, Andreas; Klimant, Ingo; Borisov, Sergey M. published the article 《Green to red emitting BODIPY dyes for fluorescent sensing and imaging of carbon dioxide》. Keywords: dipyrrometheneboron difluoride preparation fluorescent imaging emitting carbon dioxide sensor.They researched the compound: 2,4-Dimethyl-1H-pyrrole( cas:625-82-1 ).COA of Formula: C6H9N. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:625-82-1) here.

Several new BODIPY pH indicators are prepared and tested as transducers in polymer-based optical carbon dioxide sensors. Apart from classical BODIPY chromophore absorbing at around 505 nm, π-extended analogs showing absorption maxima at around 635 and 665 nm are prepared All the dyes possess excellent brightness due to combination of high molar absorption coefficients and fluorescence quantum yields. Addnl., the π-extended BODIPYs show unmatched photostability whereas the classical 1,3,5,7-tetramethyl-8-aryl-4,4-difluoroboradiazaindacene is found to be photolabile. The phenol receptors render BODIPY dyes pH sensitive inducing fluorescence quenching in the phenolate form. Carbon dioxide sensors are prepared via immobilization of the dyes into Et cellulose along with tetraoctylammonium hydrogencarbonate. The sensitivity of these sensors is mainly guided by the nature of the receptor and to a smaller extent by the nature of the chromophore, and can be tuned over a very wide range covering all important applications. Introduction of the receptor bearing carboxylic group in the o-position towards OH group of the receptor enables highly sensitive sensors resolving ambient CO2 levels (LOD 0.009 hPa). Sensors based on other indicators show optimal response from 0.2 to 60 hPa and from 20 to 400 hPa, making them attractive for medical and food packaging applications, resp. Materials for referenced sensing with phase fluorometry and ratiometric imaging with RGB cameras have also been prepared

This compound(2,4-Dimethyl-1H-pyrrole)COA of Formula: C6H9N was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Dalton Transactions called Energetic C-trinitromethyl-substituted pyrazoles: synthesis and characterization, Author is Zhang, Yiying; Li, Yanan; Hu, Jianjian; Ge, Zhongxue; Sun, Chenghui; Pang, Siping, which mentions a compound: 948552-36-1, SMILESS is O=CC1=CC=NN1, Molecular C4H4N2O, Quality Control of 1H-Pyrazole-5-carbaldehyde.

A new family of C-trinitromethyl-substituted pyrazoles was designed and obtained in good yields by the reaction of N2O4 with the pyrazolecarbaldehyde oxime followed by further N-nitration and C-nitration. All of the new compounds were fully characterized by IR and NMR spectroscopy, elemental anal. and differential scanning calorimetry (DSC). Compounds 2 and 3 were further confirmed by X-ray crystallog. These pyrazole derivatives have good densities, pos. enthalpies of formation and acceptable sensitivity values. Theor. calculations carried out using Gaussian 03 and EXPLO5 program demonstrate good to excellent detonation velocities and pressures in the range of ADN and HMX. Compound 3 exhibiting a pos. oxygen balance, high specific impulse and moderate thermal stability is a promising high energy d. oxidizer.

This compound(1H-Pyrazole-5-carbaldehyde)Quality Control of 1H-Pyrazole-5-carbaldehyde was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem