Reference of 76006-11-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.76006-11-6, name is 7-Chloro-1H-pyrazolo[3,4-c]pyridine, molecular formula is C6H4ClN3, molecular weight is 153.57, as common compound, the synthetic route is as follows.
Pyrazolopyridine 6 (0.44 g, 2.9 mmol) was dissolvedin dry methanol (50 mL) and N-iodosuccinimide (1.0 g,4.4 mmol) was added in portions. The mixture was stirred atroom temperature for 2h. Then, the solvent was removedunder reduced pressure and the residue was extracted withethyl acetate. The combined organic extracts were washedwith aqueous sodium thiosulfate (10% w/v) solution, thendried over sodium sulfate, filtered and concentrated. Thecrude product was purified by column chromatography (silicagel) using a mixture of cyclohexane/ethyl acetate (6/4,v/v) as the eluent to provide pure 7 as a yellow solid, in 99% yield. mp 252-3 C (EtOAc). 1H NMR (600 MHz, DMSO-d6) 7.50 (d, 1H, H-4, J = 5.5Hz), 8.08 (d, 1H, H-5, J =5.5Hz). HR-MS (ESI) m/z: calcd for C6H4ClIN3, [M1+H]+ =279.9133, found 279.9128. Anal. Calcd for C6H3ClIN3: C,25.79; H, 1.08; N, 15.04. Found: C, 25.91; H, 1.13; N, 14.88.
Statistics shows that 76006-11-6 is playing an increasingly important role. we look forward to future research findings about 7-Chloro-1H-pyrazolo[3,4-c]pyridine.
Reference:
Article; Gavriil, Efthymios-Spyridon; Lougiakis, Nikolaos; Pouli, Nicole; Marakos, Panagiotis; Skaltsounis, Alexios-Leandros; Nam, Sangkil; Jove, Richard; Horne, David; Gioti, Katerina; Pratsinis, Harris; Kletsas, Dimitris; Tenta, Roxane; Medicinal Chemistry; vol. 13; 4; (2017); p. 365 – 374;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem