Day: April 12, 2022

Related Products of 1111637-94-5, Adding some certain compound to certain chemical reactions, such as: 1111637-94-5, name is 5-Bromo-3-methyl-1H-pyrrolo[2,3-b]pyridine,molecular formula is C8H7BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1111637-94-5.

NaH (60 in oil, 284 mg, 7.11 mmol) is added to an ice-cooled sol. of 5-bromo-3-methyl-7-azaindole (1.0 g, 4.74 mmol) in THF (12 mL). The mixture is stirred at rt for 15 min, then cooled again to 0 C. Mel (1.19 mL, 19 mmol) is added, and the resulting mixture is stirred at 0 C for 10 min, then at rt overnight. Water is slowly added, followed by MgSC^. The mixture is filtered, and the solvents are removed under reduced pressure. Purification of the residue by automated FC (Combiflash, column 40 g, flow 40 mL/min, EtOAc / heptane 0: 100?20:80) yields the title product. LC-MS: tR = 0.87 min, MH+ = 226.94 (conditions 3).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 1111637-94-5, 5-Bromo-3-methyl-1H-pyrrolo[2,3-b]pyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; SIEGRIST, Romain; HEIDMANN, Bibia; STAMM, Simon; GATFIELD, John; BEZENCON, Olivier; WO2015/186056; (2015); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 896722-51-3 ,Some common heterocyclic compound, 896722-51-3, molecular formula is C14H12N2O2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

To a solution of 14b (4.50 mmol, 1.22 g) in 30 mL ethanol wasadded 4N NaOH solutions (10 mL). The resulting mixture washeated to reflux for 10 h, cooled down to room temperature andconcentrated under reduced vacuum. Water (30 mL) was added tothe reaction, and the mixturewas extracted with EtOAc (15mL 3).The combined organic phase was dried over anhydride sodiumsulfate and concentrated under reduced vacuum. The residue wasfurther purified by column chromatography on silica gel using PE/EA as eluent to afford product 7o, yield: 70%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,896722-51-3, its application will become more common.

Reference:
Article; Liu, Bin; Yuan, Xia; Xu, Bo; Zhang, Han; Li, Ridong; Wang, Xin; Ge, Zemei; Li, Runtao; European Journal of Medicinal Chemistry; vol. 170; (2019); p. 1 – 15;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 896139-85-8, Adding some certain compound to certain chemical reactions, such as: 896139-85-8, name is Imidazo[1,2-a]pyridin-7-ol,molecular formula is C7H6N2O, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 896139-85-8.

A solution of imidazo [1,2-a] pyridine-7-ol (218 mg, 1.63 mmol)N-Boc-4-hydroxypiperidine (654 mg, 3.25 mmol) and Ph3P (1.71 g, 6.52 mmol) were dissolved in THF (30 mL)Then DBAD (748 mg, 3.25 mmol) dissolved in THF (10 mL) was added dropwise to the reaction solution at 0 C,After the room temperature reaction is complete,The product was quenched by the addition of water to give the product 7 (250 mg, 48%) by vacuum spin column chromatography.

According to the analysis of related databases, 896139-85-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; East China Normal University; Hu Wenhao; Xi Jianbei; Lei Ruirui; Zhu Mengli; Ma Mingliang; Xiao Guolan; Zhang Xiongwen; Fang Yanfen; Li Hongyu; (28 pag.)CN106496222; (2017); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 130473-26-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 130473-26-6 as follows.

C174 (500 mg, 3.42 mmol) is dissolved in 1.5 mL formic acid. The solution is cooled to in an ice bath, 30% aqueous hydrogen peroxide (722 RL, 6.8 mmol) is added drop-wise, and the reaction is stirred 1 h in an ice bath, and allowed to stand overnight at 5C. The mixture is diluted with water, the solid is collected, washed with water and is dried to give 522 mg of an off-white solid. The formate salt is added to 7 mL water, 3 mL 2N NAOH is added, and the pH is adjusted to 3 with 5% aqueous HC1. The precipitate is collected and is dried to afford 1H-pyrrolo [2,3-c] pyridine-5- carboxylic acid (C176 (67% yield). HRMS (FAB) calculated for CGH6N202+H : 163.0508, found 163.0507 (M+H) +.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,130473-26-6, its application will become more common.

Reference:
Patent; PHARMACIA & UPJOHN COMPANY; WO2004/39815; (2004); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 120739-77-7, N-((6-Chloropyridin-3-yl)methyl)ethanamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 120739-77-7, blongs to pyridine-derivatives compound. category: pyridine-derivatives

1, In the 5000L stainless steel reactor,put disodium hydrogenphosphate 284kg, sodium dihydrogen phosphate, 67.9kg,720kg of tap water was added. Stirred solution becomes clear. At 25 deg.C, then 1500kg of methylene chloride was added, as well as N- (6-chloro – 3-pyridylmethyl) -N- ethylamine 341kg. Cooled 0 deg. C;2, was added dropwise 325 kg of 1,1-dichloro-2-nitroethylene, about 2 ~ 3h, temperature 5 ~ 10 deg.C;3, addition was complete at 5 ~ 10 deg.C. Maintain temperature for 2h; 4, then dropping 40% monomethylamine 390kg,about 2 ~ 3h, and maintain temperature for 2h at 5 ~ 10 deg.C ;5, then heated to 30 deg.C and hold temperature 1h; 6, still 30min, separated and the aqueous layer was further 500kg, extracted once with methylene chloride; 7, the combined organic phases, first at atmospheric pressure and then vacuum recovery methylene chloride, ethyl acetate500kg;8, 0 ~ 5 deg.C cooling crystallization 2h, centrifugal drying drying material, was 494.1kg, HPLC?99.5%,external standard content ?98%, a yield of 0.92.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,120739-77-7, its application will become more common.

Reference:
Patent; Shanghai Jinjing Chemical Co., Ltd.; Long, Congwei; Ma, Jun; Zhou, Xianpei; Tang, Songqing; Lv, Yejun; (9 pag.)CN105330593; (2016); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1196152-34-7, name is 2-Bromo-6-methoxypyridin-4-amine. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 1196152-34-7

[00177] A solution of 1-methylpiperidine-4-carboxylic acid (1 eq, 0.49 mmol) in thionyl chloride (2 ml_) was stirred under nitrogen atmosphere at RT for 1 h. The reaction was concentrated in vacuo under nitrogen to give a pale yellow solid which was dissolved in DCM (1.5 ml_) and cooled to 0 C. Then pyridine (2.5 eq, 0.1 ml_) and 2-bromo-6-methoxy-pyridin-4- amine (0.8 eq, 0.39 mmol) were added. The mixture was stirred at 0C for 5 mins then a RT for 1 h. The compound was extracted with dichloromethane, washed with water, brine, dried over magnesium sulphate, filtered and concentrated in vacuo. The compound was then purified by reverse phase preparative HPLC-MS to afford A/-(2-bromo-6-methoxy-4-pyridyl)-1- methyl-piperidine-4-carboxamide (90 mg, 56%) as a white solid.

With the rapid development of chemical substances, we look forward to future research findings about 1196152-34-7.

Reference:
Patent; OXFORD UNIVERSITY INNOVATION LIMITED; RABBITTS, Terrence; QUEVEDO, Camilo; CRUZ, Abimael; PHILIPS, Simon; FALLON, Philip Spencer; DUNN, Jonathan Neil; FREEM, Joshua Robert; LEE, Lydia Yuen-Wah; TRAORE, Tenin; WILLIAMS, Sophie Caroline; (219 pag.)WO2019/145718; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 1256561-65-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1256561-65-5, name is 3-(Bromomethyl)-5-fluoropyridine hydrobromide. A new synthetic method of this compound is introduced below.

A mixture of 3-(bromomethyl)-5-fluoropyridine hydrobromide (3.4 mmol), 6-methyl- 2-sulfanylpyrimidin-4-ol (370 mg, 2.6 mmol), and triethylamine (1.7 mL, 12.0 mmol) in absolute ethanol (40 mL) was stirred at room temperature overnight. The solid material was removed by filtration. The filtrate was recovered, evaporated, co- evaporated with EtOAc (20 mL), and then dried in vacuo. The solid residue was treated with water (100 mL). The solid product was recovered by filtration, washed with water (1 x 20 mL) and diethyl ether (2 x 20 mL), and then dried in vacuo, affording the 2-{[(5-fluoropyridin-3-yl)methyl]sulfanyl}-6-methylpyrimidin-4-ol (200 mg, 23% yield); 1H NMR (400 MHz, OMS0-d6): delta 2.21 (s, 3H), 4.41 (s, 2H), 6.02 (s (br), IH), 7. 80 (m, IH), 8.05 (dd, IH, / = 2.0 Hz, 7.6 Hz), 8.46 (d, IH, J = 2.7 Hz), 8.54 (t, IH, J = 1.6 Hz); M+ 252. The product was used without further purification.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1256561-65-5, its application will become more common.

Reference:
Patent; CHLORION PHARMA, INC.; UNIVERSITE LAVAL; ATTARDO, Giorgio; TRIPATHY, Sasmita; WO2010/132999; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.98273-79-1, name is Methyl 3-chloroisonicotinate, molecular formula is C7H6ClNO2, molecular weight is 171.58, as common compound, the synthetic route is as follows.Quality Control of Methyl 3-chloroisonicotinate

A solution of 1-(bromomethyl)-4-(methylsulfanyl)benzene (prepared according to D. D. M. Wayner, D. R. Arnold, Can J. Chem., 1984, 62, 1164) (2.54 g, 11.7 mmol) in THF (10 mL) was added dropwise to a slurry of Riecke Zinc in THF (22.8 mL of a commercial suspension [5g Zn/100 mL], 17.5 mmol) under nitrogen. During this time the temperature rose steadily to 35C. After allowing the black slurry to cool to room temperature over 30 min bis(triphenylphosphine)nickel (II) chloride (762 mg, 1.17 mmol) was added followed by a solution of methyl 3-chloroisonicotinate (prepared according to J. Epsztajn, M. W. Plotka, A. Grabowska, Synth. Commun., 1997, 27, 1075) (1.0 g, 5.83 mmol) in THF (10 mL), dropwise, taking care to keep the temperature below 30C. After the addition was complete the reaction was allowed to cool to room temperature over 1 h before being quenched by the addition of sat. NH4Cl (aq) (20 mL) while cooling with an ice bath. The mixture was filtered through Celite ), washing well with EtOAc (3 x 20 mL), the organic layer was separated, dried (MgS04) and evaporated to give a brown oil. The residue was purified by column chromatography [SiO2; EtOAc:pentane, 1:3 increasing polarity to EtOAc:pentane, 1:1 and then to (EtOAc:MeOH:NH40H, 95:5:0.5):pentane, 1:1] to give the title compound as an orange oil; & delta H (CDCl3, 400 MHz) 2.43 (3H, s), 3.82 (3H, s), 4.30 (2H, s), 7.05 (2H, d), 7.18 (2H, d), 7.67 (1H, br), 8.59 (2H, br); MS m/z (TS+) 274 (MH+)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,98273-79-1, Methyl 3-chloroisonicotinate, and friends who are interested can also refer to it.

Reference:
Patent; Pfizer Limited; Pfizer Inc.; WO2004/16593; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 67058-77-9, Adding some certain compound to certain chemical reactions, such as: 67058-77-9, name is 3-Nitro-1H-pyrrolo[2,3-c]pyridine,molecular formula is C7H5N3O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 67058-77-9.

To a solution of 3-nitro-1H-pyrrolo[2,3-c]pyridine (200 mg, 1.23 mmol) in MeOH (20 mL) was added 10% Pd/C (130 mg, 0.12 mmol). After stirred at balloon hydrogen atmosphere for 2 hrs, the mixture was filtered. The filtrate was evaporated in vacuum to give 1H- pyrrolo[2,3-c]pyridin-3-amineas a crude product which was used for next step without further purification.

According to the analysis of related databases, 67058-77-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE; GARDELL, Stephen; PINKERTON, Anthony B.; SERGIENKO, Eduard; SESSIONS, Hampton; (428 pag.)WO2018/132372; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 184368-74-9, name is 1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate. This compound has unique chemical properties. The synthetic route is as follows. Computed Properties of C12H19NO4

To a solution of 1-tert-butyl 4-methyl 3,6-dihydro-2H-pyridine-l,4-dicarboxylate (500 mg, 2.07 mmol) in toluene (2.5 mL) was added tetrabutylammoniumbromide (33 mg, 0.10 mmol) under N2, then [bromo(difluoro)methyl]-trimethyl-silane (842 mg, 4.14 mmol) was added drop-wise under N2. The reaction mixture was heated at 110 C and stirred for 16 h in a sealed tube. The residue was filtered and concentrated under reduced pressure to provide the title compound (700 mg) as a brown oil, which was used in the next step without further purification. LC-MS: m/z = 192.1 [M+H]+.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 184368-74-9, 1-tert-Butyl 4-methyl 5,6-dihydropyridine-1,4(2H)-dicarboxylate.

Reference:
Patent; DENALI THERAPEUTICS INC.; DE VICENTE FIDALGO, Javier; ESTRADA, Anthony A.; FENG, Jianwen A.; FOX, Brian; FRANCINI, Cinzia Maria; HALE, Christopher R.H.; HU, Cheng; LESLIE, Colin Philip; OSIPOV, Maksim; SERRA, Elena; SWEENEY, Zachary K.; THOTTUMKARA, Arun; (226 pag.)WO2018/213632; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem