Day: April 20, 2022

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 886365-46-4, name is 5-Chloro-3-methylpyridine-2-carboxylic acid, the common compound, a new synthetic route is introduced below. Quality Control of 5-Chloro-3-methylpyridine-2-carboxylic acid

Acid-16: 5-Chloro-4,6-dideutero-3-trideuteromethyl-pyridine-2-carboxylic acid; A suspension of 500 mg (2.91 mmol) 5-chloro-3-methyl-pyridine-2-carboxylic acid (CAS Nr.: 886365-46-4) in 9 ml of D20 (99,96% D) was treated with 1 ml of a 40% solution of NaOD in D20. The homogeneous solution was heated in a 100 ml Teflon vessel with a Synthos 3000 Microwave apparatus. The mixture was heated at 160 C for 5 h and cooled down. 1 H-NMR and MS analyses of the product showed that deuteration had progressed to a high degree. Only minor amounts of tetradeutero derivatives were present. The reaction mixture was acidified to pH3 with 2N HCI and extracted with EtOAc. The org. phase was dried with MgS04.H20 and evaporated to give the title compound as a white solid, pure enough for further transformations.HPLC: Rtm= 2.820 min; ESIMS [M+H]+ = 177 (5D);1H-NMR (360 MHz, D20): delta non deuterated impurities.

The synthetic route of 886365-46-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; NOVARTIS AG; HURTH, Konstanze; LUEOEND, Rainer Martin; MACHAUER, Rainer; NEUMANN, Ulf; RUEEGER, Heinrich; SCHAEFER, Michael; TINTELNOT-BLOMLEY, Marina; VEENSTRA, Siem Jacob; VOEGTLE, Markus; WO2012/95463; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 79055-63-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.79055-63-3, name is 2-Chloro-6-methylpyridin-4-amine, molecular formula is C6H7ClN2, molecular weight is 142.5862, as common compound, the synthetic route is as follows.

2-chloro-6-methylpyridin-4-amine (36 g, 0.25 mol) and sodium hydroxide (24 g, 1 mol) were dissolved in 1-butanol (400 mL). The solution was heated at reflux for 1O h, and then cooled to rt. The reaction mixture was diluted with water (300 mL) and then extracted with ethyl acetate (3 x 500 mL). The combined organic layers were washed with brine (500 mL), dried over sodium sulfate, and concentrated to afford 2-butoxy-6-methylpyridin-4-amine. 1H NMR (400 MHz, CDC13) delta 6.05 (d, J=0.6 Hz, IH), 5.75 (d, J=0.6 Hz, IH), 4.18 (t, J=6.4 Hz, IH), 2.30 (s, 3H), 1.71 (m, 2H), 1.48 (m, 2H), 0.98 (t, J=7.6 Hz, 3H). LRMS calc’d for (Ci0Hi6N2O) [M+H]+, 181; found 181.

Statistics shows that 79055-63-3 is playing an increasingly important role. we look forward to future research findings about 2-Chloro-6-methylpyridin-4-amine.

Reference:
Patent; MERCK & CO., INC.; WO2008/112217; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 393-55-5, Adding some certain compound to certain chemical reactions, such as: 393-55-5, name is 2-Fluoronicotinic acid,molecular formula is C6H4FNO2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 393-55-5.

Thionyl chloride (0.43 mL, 5.87 mmol) was added to a slurry of 2-fluoronicotinic acid (9, 0.69 g, 4.89 mmol) and N,N-dimethylformamide (0.1 mL, catalytic amount) in benzene (60 mL) at room temperature under nitrogen, after which the mixture was heated at reflux for 3 h. The solvent was removed under reduced pressure to provide an amber oil that was dissolved in 1,4-dioxane (40 mL) under nitrogen. The solution was treated with sodium borohydride (0.38 g, 10.0 mmol) and the mixture was stirred at room temperature for 24 h. The suspension was diluted with saturated NaHCO3 solution (200 mL) and extracted with diethyl ether (3×200 mL). The combined organic extracts were dried over Na2SO4, filtered and the solvents were removed under reduced pressure to provide the title compound: 1H NMR (300 MHz) 8.13 (d, J=3.7 Hz, 1H), 7.93-7.88 (m, 1H), 7.24-7.19 (m, 1H), 4.78 (s, 2H), 2.14 (bs, 1H) ppm.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 393-55-5, 2-Fluoronicotinic acid, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Coleman, Darrell Stephen; Jagdmann, Gunnar Erik; Johnson, Kirk Willis; Johnson, Michael Parvin; Large, Thomas Hallett; Monn, James Allen; Schoepp, Darryle Darwin; Barda, David Anthony; Britton, Thomas Charles; Dressman, Bruce Anthony; Henry, Steven Scott; Hornback, William Joseph; Tizzano, Joseph Patrick; Fichtner, Michael William; US2004/6114; (2004); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33252-28-7, name is 6-Chloronicotinonitrile, the common compound, a new synthetic route is introduced below. name: 6-Chloronicotinonitrile

To a mixture of 6-chloropyridine-3-carbonitrile (10 g, 0.06 mol) and (2R)-2-methylpiperazine(6.35 g, 0.06 mol) in acetonitrile (80 mL), K2C03 (12.0 g, 0.09 mol) was added at RT. Theresulting mixture was stirred at 60C for 2 h (TLC indicated complete consumption ofstarting material). The reaction was brought toRT, quenched with water (150 mL) andextracted with EtOAc (3 x 80 mL). The combined organic extracts were dried over anhydrousNa2S04 and concentrated under reduced pressure. The residue was purified by columnchromatography (100-200 silica gel, 5% MeOH-DCM) to afford 6-[(3R)-3-methylpiperazine-1-yl]-pyridine-3-carbonitrile (10.0 g, 69% yield).

The synthetic route of 33252-28-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MITOBRIDGE, INC.; TAKAHASHI, Taisuke; KLUGE, Arthur; LAGU, Bharat; JI, Nan; (162 pag.)WO2018/125961; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 623585-74-0 ,Some common heterocyclic compound, 623585-74-0, molecular formula is C7H5Cl2NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A 3N methylmagnesium bromide solution in ether (5.6 ml) was added dropwise to a mixture of methyl 2,5- dichloroisonicotinate (2.90 g) , iron (III) acetylacetonate (0.25 g) , THF (85 ml) and N-methylpyrrolidone (8.5 ml) under ice-cooling, and this was stirred at the same temperature for 1 hour. After an aqueous saturated sodium chloride solution (100 ml) was added to the reaction mixture, this was extracted with ethyl acetate, and the ethyl acetate layer was washed with an aqueous saturated sodium chloride solution, dried over magnesium sulfate, and concentrated. The residue was purified by silica gel column chromatography (ethyl acetate-hexane) to obtain the desired product (1.82 g) as an oil.1H-NMR (CDCl3) delta 2.52 (3H, s) , 3.99 (3H, s), 7.74 (IH, s) ,8.34 (IH, s) .

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,623585-74-0, its application will become more common.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2006/64944; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 85148-95-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 85148-95-4, name is 6-Formylpicolinonitrile, molecular formula is C7H4N2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(1) 2,6-Dimethyl-4-(6-cyano-2-pyridyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-chloroethyl ester 5-methyl ester 6-Cyano-2-pyridine aldehyde (1.613 g, 12.2 mmol), chloroethyl acetoacetate (2.009 g, 12.2 mmol) and methyl 3-aminocrotonate (1.364 g, 12.2 mmol) were dissolved in 16 ml of isopropanol, and the solution was stirred at 35° to 40° C. under a nitrogen gas stream for 14 hours. The reaction solvent was distilled off under reduced pressure, and the residue was purified by column chromatography [silica gel; ethyl acetate-n-hexane (5:6)]. The crude product thus obtained was recrystallized from isopropyl ether-methanol to obtain 1.546 g (34percent yield) of the above-captioned compound. IR numaxKBr cm-1: 2225(CN), 1695(C=O); 1680(C=O) STR7

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 85148-95-4, 6-Formylpicolinonitrile.

Reference:
Patent; The Green Cross Corporation; US4849429; (1989); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic Route of 851386-40-8, Adding some certain compound to certain chemical reactions, such as: 851386-40-8, name is 4-Chloro-2,5-difluoropyridine,molecular formula is C5H2ClF2N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 851386-40-8.

[(00592] Step 1 : Preparation of (4-chloro-2,5-difluoropyridin-3-yl)(5-cyclopropylisoxazol-3-yl)methanone . A cold (-78 C) solution of 4-chloro-2,5-difluoropyridine (246 mg, 1.65 mmol) in THF (15.0 mL) was treated with 2.5 M n-BuLi in hexanes (718 pL, 1.79 mmol). After stirring for 2 h at -78 C, the reaction mixture was treated with a solution of methyl 5- cyclopropylisoxazole-3-carboxylate (250 mg, 1.50 mmol) in THF (2 mL). The resulting mixture was stirred overnight at ambient temperature before quenching with saturated NH4Q(aq). Subsequently, the mixture was diluted with water, and extracted with EtOAc. The organic extracts were washed with brine, dried over anhydrous Na2S04(S>, filtered, and concentrated in vacuo. The crude residue was purified by silica chromatography (10-90% EtOAc in hexanes) to afford the title compound (201 mg, 47%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 851386-40-8, 4-Chloro-2,5-difluoropyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ARRAY BIOPHARMA INC.; WALLS, Shane M.; REN, Li; RAMANN, Ginelle A.; MORENO, David A.; METCALF, Andrew T.; MCFADDIN, Elizabeth A.; KOLAKOWSKI, Gabrielle R.; BLAKE, James F.; DAI, Donghua; HAAS, Julia; JIANG, Yutong; KAHN, Dean; (368 pag.)WO2019/143994; (2019); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 847729-27-5 ,Some common heterocyclic compound, 847729-27-5, molecular formula is C7H5ClFNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

STEP 2. Methyl 5-fluoro-2-methvlnicotinate; A mixture of methyl 2-chloro-5-fluoronicotinate (step 1, 1.5 g, 7.91 mmol), tetrakis (triphenylphoshine)palladium (914 mg, 0.79 mmol), methyboronic acid (521 mg, 8.70 mmol) and potassium carbonate (3.28 g, 23.7 mmol) in 1,4-dioxane (20 ml) was heated at 110 C for 20 h under nitrogen atmosphere. The reaction mixture was filtered through a pad of celite (Celite(trademark) (diatomaceous earth) ) and the filtrate was concentrated. The residue was purified by flush column chromatography on silica gel eluting with hexane/ethyl acetate (20/1 to 4/1) to afford 936 mg (64%) of the title compound: ¹H-NMR (CDCl3) No. 8.49 (1 H, d, J = 3.0 Hz), 7.93 (1 H, dd, J = 3.0, 8.7 Hz), 3.94 (3H, s), 2.81 (3H, s).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,847729-27-5, its application will become more common.

Reference:
Patent; PFIZER JAPAN INC.; PFIZER INC.; WO2005/105732; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of 1151989-04-6 ,Some common heterocyclic compound, 1151989-04-6, molecular formula is C19H14N2O5S2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Synthesis of Compound 11:Aleclon hemifumarate (121 mg, 0.22 mmol, 1 eq) at room temperature in the darkDissolved in dry dimethylformamide (4 mL),Triethylamine (34 mg, 46 muL, 0.33 mmol, 1.5 eq) was added slowlyStir for half an hour,Compound 8 (95 mg, 0.23 mmol, 1.05 eq) and then slowly addedTrace of 4-dimethylaminopyridine in dimethylformamide(2mL) solution,The mixture was stirred at room temperature under an argon atmosphere overnight. The solvent is removed under reduced pressure and subjected to rapid preparative column chromatography.One-step purification (methanol: methylene chloride, 1/50 to 1/10 v/v) afforded white solid (yield: 67 mg, 37%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1151989-04-6, its application will become more common.

Reference:
Patent; Fudan University; Sun Tao; Jiang Chen; (22 pag.)CN109846824; (2019); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 914358-72-8, Adding some certain compound to certain chemical reactions, such as: 914358-72-8, name is 5-Bromo-3-chloro-2-methylpyridine,molecular formula is C6H5BrClN, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 914358-72-8.

A suspension of 4,4,4?,4?,5,5,5?,5?-octamethyl-2,2?-bi( 1,3,2-dioxaborolane) (0.836 g, 3.29 mmol), 5-bromo-3-chloro-2-methylpyridine (0.34 g, 1.65 mmol), potassium acetate (0.485 g, 4.94 mmol) in dioxane (5 mL) was degassed with a stream of argon for a couple of minutes. 1,1?-bis(diphenylphosphino)ferrocene-palladium(II)dichloride dichloromethane complex (0.067 g, 0.08 mmol) was added and the mixture was heated at reflux under N2 for 1.5 h. The mixture was allowed to cool and filtered. The filter cake was washed with EtOAc. The filtrate was concentrated in vacuo and column chromatography using EtOAc 0% to 80% in heptane gave 442 mg (100%) of the title compound. 1H NMR (500 MHz, CDC13) delta ppm1.35 (s, 12 H), 2.65 (s, 3 H), 7.95 -8.03 (m, 1 H), 8.69 (d, 1 H); MS (ES+) mlz: 172 [M+C6H9]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 914358-72-8, 5-Bromo-3-chloro-2-methylpyridine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; MINIDIS, Anna; RAHM, Fredrik; VIKLUND, Jenny; WO2013/54108; (2013); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem