Month: April 2022

Application of 131747-41-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 131747-41-6 as follows.

To a mixture of 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline (1.0 equiv.) and 3-(trifluoromethyl)benzoic acid (1.1 equiv.) in DMF (0.27 M) was added HOAt (1.3 equiv.) and EDC (1.3 equiv.) After 3 h the reaction mixture was diluted with water and then extracted with EtOAc. The organic phase was washed sequentially with 1 M aqueous sodium hydroxide and brine and was then dried over sodium sulfate. The solution was concentrated and dried under vacuo to give N-(4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-(trifluoromethyl)pisonicotinamide in 91% yield. LCMS (m/z) (M+H)=407.1, Rt=1.13 min.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,131747-41-6, its application will become more common.

Reference:
Patent; NOVARTIS AG; Barsanti, Paul A.; Burger, Matthew; Lou, Yan; Nishiguchi, Gisele; Polyakov, Valery; Ramurthy, Savithri; Rico, Alice; Setti, Lina; Smith, Aaron; Taft, Benjamin; Tanner, Huw; DiPesa, Alan; Yusuff, Naeem; US2014/275003; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 108118-69-0, name is 2,6-Difluoropyridin-3-amine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

To a stirred solution of 1-(4-methoxy-benzyl)-1H-pyrrolo[2,3-6]pyridine-5-carboxylic acid (47 mg, 0.17 mmol) in CH2C12 (2 mL) was added l-chloro-N,N-2-trimethylpropenylamine (45 muL, 0.34 mmol). Following formation of the resulting acid chloride, the reaction mixture was concentrated affording a residue that was dissolved in pyridine (2 mL) before 2,6-difiuoro- pyridin-3-ylamine (20 mg, 0.15 mmol) was added in one portion. After an additional 30 minutes the reaction mixture was concentrated to dryness affording a residue, to which was added DMF (2 mL) and K2CO3 (64 mg, 0.46 mmol). The resulting mixture was heated by microwave to 150 ºC for 10 min, after which the resulting mixture was filtered and concentrated, affording 5- fluoro-2-[ 1 -(4-methoxy-benzyl)-1H-pyrroIo[2,3-b]rhoyridin-5-yl]-oxazolo[5,4-^]pyridine as a crude residue which was subsequently used without further purification. ES MS (M+H+) = 375.

The synthetic route of 108118-69-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK & CO., INC.; WO2009/155017; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 627501-18-2, 5-Chloro-6-hydroxynicotinaldehyde, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde, blongs to pyridine-derivatives compound. Application In Synthesis of 5-Chloro-6-hydroxynicotinaldehyde

General procedure: Unless otherwise stated, the procedure was as follows. To a 1-dram (4 mL) vial equipped with a magnetic stir bar were added Pd(OAc)2 (4.4 mg, 0.02 mmol), alkene (0.2 mmol), acetic acid (6.0 mg, 0.1 mmol), nucleophile (0.3 mmol), and MeCN (0.1 mL). The vial was sealed with an unpunctured TFE septum-covered screw cap, and placed in a heating block that was pre-heated to 120 C. After the designated reaction time, the dark black reaction was purified either by flash column chromatography only or by flash column chromatography followed by an aqueous workup to produce the desired product.

The synthetic route of 627501-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gurak, John A.; Tran, Van T.; Sroda, Miranda M.; Engle, Keary M.; Tetrahedron; vol. 73; 26; (2017); p. 3636 – 3642;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Electric Literature of 52538-09-7 , The common heterocyclic compound, 52538-09-7, name is 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine, molecular formula is C8H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

PREPARATION K 3-Methyl-3H-imidazo[4,5-c]pyridine-2-carboxaldehyde Employing the procedure of Example 10B and starting with 774 mg of 2,3-dimethyl-3H-imidazo[4,5-c]pyridine (Preparation J2) and 584 mg of selenium dioxide in 30 ml of dioxane, there was obtained 442 mg of the desired product.

The synthetic route of 52538-09-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pfizer Inc.; US4782050; (1988); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 76102-92-6, 2-Amino-N-(pyridin-3-yl)benzamide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C12H11N3O, blongs to pyridine-derivatives compound. Computed Properties of C12H11N3O

Example 30 To a solution of 180 mg of 2-[methyl(tetrahydro-2H-pyran-4-ylmethyl)amino]-1,3-thiazole-4-carboxylic acid in 1.2 ml of DMF were added 117 mg of 2-amino-N-pyridin-3-yl benzamide, 110 mg of WSC-HCl, and 100 mg of HOBt, followed by stirring at 60C for 3 days. To the reaction liquid was added an aqueous sodium hydrogen carbonate solution, and the resulting insoluble materials were collected by filtration. This was washed with acetonitrile to prepare 195 mg of 2-[methyl(tetrahydro-2H-pyran-4-ylmethyl)amino]-N-[2-(pyridin-3-ylcarbamoyl)phenyl]-1,3-thiazole-4-carboxamide.

The synthetic route of 76102-92-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP2206707; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 1124-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1124-29-4, name is 5-Acetylpyridin-2(1H)-one, molecular formula is C7H7NO2, molecular weight is 137.14, as common compound, the synthetic route is as follows.

[0561] To a solution of III-3 (1 eq.) in DCM (0.1 mmol/mL) was added boronic acid III-4 (2 eq.), Cu(OAc)2 (1 eq), Pyridine (10 eq.) and Pyridine-N-Oxide (2 eq.), followed by addition of 4 molecular sieve (quantity approx. equal to III-3). The reaction mixture was stirred at rt under oxygen atmosphere overnight. After completion of the reaction indicated by TLC, the resulting mixture was filtered and washed with, the filtrate was washed with brine, dried over Na2SO4 and concentrated. The residue was purified by column chromatography on silica gel to give III-5 [0572] Compound 20 was prepared following the general procedure, except the solvent was changed to acetonitrile (10% yield). 1H NMR (CDCl3, 400 MHz) delta 8.06 (d, J=2.4 Hz, 1H), 7.97 (dd, J=10, 2.4 Hz, 1H), 7.53-7.45 (m, 1H), 7.43-7.36 (m, 1H), 7.34-7.25 (m, 2H), 6.67 (d, J=10 Hz, 1H), 2.45 (s, 3H). MS (ESI) m/z (M+H)+ 232.0.

The chemical industry reduces the impact on the environment during synthesis 1124-29-4, I believe this compound will play a more active role in future production and life.

Reference:
Patent; Buckman, Brad Owen; Nicholas, John Beamond; Ramphal, Johnnie Y.; Emayan, Kumaraswamy; Seiwert, Scott D.; US2014/94456; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 946002-90-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 946002-90-0, name is (S)-1-(5-Bromopyridin-2-yl)pyrrolidin-3-ol. A new synthetic method of this compound is introduced below.

(S)-5-Bromo-2-(3-tert-butyl-dimethyl-silanyloxy)-pyrrolidin-l-yl)pyridine (G2). To a sol. of compound Gl (20.9 g, 85.8 mmol) in DMF (350 mL) at 0 0C were added imidazole (14.6 g, 215 mmol) and TBDMS-Cl (19.4 g, 129 mmol). This mixture was stirred at rt for 1.5 h, and aq. 10% K2CO3 (150 mL) was added. The mixture was extracted with heptane (2x). The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Purification of the residue by FC (heptane/EtOAc 5 : 1 ? 4: 1 ? 3 : 1 ? 1 : 1) yielded the title compound (30.5 g, 99%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,946002-90-0, its application will become more common.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; WO2007/88514; (2007); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 85686-48-2, name is 6-(2,4-Dichlorophenoxy)pyridin-3-amine, the common compound, a new synthetic route is introduced below. category: pyridine-derivatives

EXAMPLE 15 N-[6-(2,4-Dichlorophenoxy)pyridin-3-yl]-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxamide Following the procedure of Example 1, using 2,3,4,5-tetrahydro-1H-benzazepine and 6-(2,4-dichlorophenoxy)pyridin-3-amine as the starting materials, the title compound was prepared as a colorless solid (88%): mp 154-155 C.; IR (KBr) 3377, 3070, 3024, 3000, 2943, 2928, 2899, 1642, 1604, 1593, 1530, 1485, 1467, 1276, 1263, 1232, 1215, 863, 844, 819, 750, 734 cm-1; 1H NMR (400 MHz, CDCl3) delta7.98 (dd, J=8.8, 2.7 Hz, 1H), 7.93 (d, J=2.7 Hz, 1H), 7.45 (d, J=2.4 Hz, 1H), 7.26-7.23 (m, 1H), 7.18-7.12 (m, 4H), 7.10 (d, J=8.6 Hz, 1H), 6.95 (d, J=8.8 Hz, 1H), 6.50 (s, 1H), 3.68-3.66 (m, 4H), 3.02-3.00 (m, 4H); 13C NMR (100 MHz, CDCl3) delta158.8, 154.9, 149.0, 140.1, 139.0, 133.7, 131.9, 130.5, 130.3, 130.0, 128.0, 126.8, 124.3, 111.1, 47.1, 37.5; MS (EI) m/z 428 (M+-H), 426 (M+-H); HRMS (FAB) calcd. for C22H19Cl2N3O2+H: 428.0932, found: 428.0916; Anal. Calcd. for C22H19Cl2N3O2: C, 61.69; H, 4.47; N, 9.81. Found: C, 61.73; H, 4.54; N, 9.75.

The synthetic route of 85686-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fu, Jian-Min; US2003/149024; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Adding a certain compound to certain chemical reactions, such as: 73177-35-2, 2-Methyl-1H-pyrrolo[3,2-b]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-Methyl-1H-pyrrolo[3,2-b]pyridine, blongs to pyridine-derivatives compound. Quality Control of 2-Methyl-1H-pyrrolo[3,2-b]pyridine

In the same manner as in Preparation Example 16-2, the objective compound (1.23 g) was obtained as a colorless solid from 2-methylpyrrolo[3,2-b]pyridine (500 mg). 1H-NMR(DMSO-d6): 2.75(3H, s), 7.07(1H, dd, J=8, 5 Hz), 7.38(1H, d, J=8 Hz), 7.48(1H, d, J=8 Hz), 7.65(1H, s), 7.74(1H, d, J=8 Hz), 8.14(1H, d, J=5 Hz). MASS(ESI): m/z 303(M-1)

The synthetic route of 73177-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US6348474; (2002); B1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Product Details of 948552-36-1. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 1H-Pyrazole-5-carbaldehyde, is researched, Molecular C4H4N2O, CAS is 948552-36-1, about Cytotoxic activity of new cerium (III) complexes of bis-coumarins. Author is Kostova, Irena; Manolov, Ilia; Momekov, Georgi; Tzanova, Tzvetomira; Konstantinov, Spiro; Karaivanova, Margarita.

Complexes of Ce (III) with bis-coumarins, 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) and bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-(1H-pyrazol-3-yl)methane, were synthesized by reaction of Ce(III) salt and the ligands, in amounts equal to metal/ligand molar ratio of 1:2. The complexes were prepared by adding an aqueous solution of Ce (III) salt to an aqueous solution of the ligand subsequently raising the pH of the mixture gradually to ∼5.0 by adding dilute solution of NaOH. The Ce (III) complexes with bis-coumarins were characterized by different physicochem. methods-elemental anal., IR-, 1H- and 13C-NMR-spectroscopies and mass-spectral data. The spectral data of Ce (III) complexes were interpreted from comparison with the spectra of the free ligands. This anal. showed that in the Ce (III) complexes the ligands coordinated to the metal ion through both deprotonated hydroxyl groups. From the ν(C=O) red shift observed, participation of the carbonyl groups in the coordination to the metal ion was also suggested. Cytotoxic screening by MTT assay was carried out. The authors performed comparative evaluation of the cytotoxic effects of the two newly synthesized Ce complexes against the acute myeloid leukemia derived HL-60 and the chronic myeloid leukemia (CML)-derived BV-173. The cytotoxic effects of Ce (III) complex with 3,3′-benzylidene-bis(4-hydroxy-2H-1-benzopyran-2-one) were evaluated on the CML-derived K-562 and LAMA-84 cells, characterized by relative low responsiveness to chemotherapy. The DNA isolated from the cytosolic fraction of BV-173 cells after 24 h treatment with the same complex (at 100 and 200 μM) demonstrated a laddering phenomenon that is indicative for apoptotic cell death.

This compound(1H-Pyrazole-5-carbaldehyde)Product Details of 948552-36-1 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem