Day: September 16, 2022

Yu, Dan;He, Jiahong;Xie, Taiping;Xu, Qiang;Li, Guoqiang;Du, Ling;Huang, Junhao;Yang, Jun;Li, Wenpo;Wang, Jiankang published 《Peroxymonosulfate activation using a composite of copper and nickel oxide coated on SBA-15 for the removal of sulfonamide antibiotics》. The research results were published in《Environmental Research》 in 2022.Synthetic Route of C10H9ClN4O2S The article conveys some information:

The sluggish Ni(II)/Ni(III) redox cycle does not benefit perxymonosulfate (PMS) activation for recalcitrant pollutant degradation To solve this problem, a heterogeneous catalyst, Cu0.2Ni0.8O/SBA-15 (CNS), was constructed to activate PMS for decomposing two sulfonamide antibiotics, sulfachlorpyridazine (SACP) and sulfapyridine (SAP). SACP and SAP were completely degraded over Cu0.2Ni0.8O/SBA-15/PMS (CNSP) after 90 min. O.-2 was the dominant active species involved in the degradation of SACP and SAP. Structural anal. and elemental valence state observations indicated that Cu(I) provided electrons through Cu-O-Ni bonds to realize the charge compensation for Ni(III) in the CNSP system. Thus, the in situ Cu(I)/Cu(II) promoting the Ni(II)/Ni(III) cycle could accelerate the PMS activation. This work provides new insights into the electron transfer between transition metals and the charge compensation mechanism for PMS activation. The degradation mechanism was proposed based on the XPS results before and after the reaction, a radical quenching test, and an EPR test. Combined with the SACP and SAP degradation intermediates identified by LC-MS, we suggest that the choice of treatment process depends on the occurrence of a steric hindrance effect between the mol. structure of the degradation target and free radicals.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Synthetic Route of C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morgan, Angela L.;Torpy, Fraser R.;Irga, Peter J.;Fleck, Robert;Gill, Raissa L.;Pettit, Thomas published 《The botanical biofiltration of volatile organic compounds and particulate matter derived from cigarette smoke》. The research results were published in《Chemosphere》 in 2022.COA of Formula: C6H4N2 The article conveys some information:

Despite the growing use of control measures, environmental tobacco smoke (ETS) remains a significant pollutant source in indoor air in many areas of the world. Current control methods for reducing ETS exposure are inadequate to protect public health in environments where cigarettes are smoked. An alternative solution is botanical biofiltration which has previously been shown to lower concentrations of volatile organic compounds (VOCs) and particulate matter (PM) from a range of polluted air streams. This study is the first to assess the potential of a botanical biofilter with the species Spathiphyllum wallisii (Peace Lily) for the removal of cigarette-derived VOCs and all size fractions of PM. Single pass removal efficiencies of 43.26% for total VOCs and 34.37% for total suspended particles were achieved. The botanical biofilter reduced the concentrations of a range of harmful ETS chems. including nicotine, limonene, and toluene. Evaluation of the re-emission of ETS constituents filtered by the botanical biofilter revealed no particle resuspension or off gassing. The results demonstrate the potential of botanical biofilters to reduce public ETS exposure, although further research is needed to improve upon and ensure the efficiency of these systems for practical applications. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) also shows biological activity against autoimmune diseases, such as murine hepatitis, by inhibiting the proliferation of B cells and T cells.COA of Formula: C6H4N2 This drug is not effective against cancer cells because it does not inhibit DNA synthesis or protein synthesis.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wu, Huizhen;Zhou, Min;Xu, Jie;Wang, Jianmei;Tong, Jianying;Sun, Nabo;Qian, Mingrong published 《Determining a wide range of antibiotics and pesticides in poultry feathers using selective accelerated solvent extraction-liquid chromatography-mass spectrometry》. The research results were published in《Analytical Methods》 in 2022.Category: pyridine-derivatives The article conveys some information:

This study established a detection method based on accelerated solvent extraction-liquid chromatog.-mass spectrometry for determining residues of 3 chloramphenicols, 8 macrolides, 18 sulfonamides, 4 nitroimidazoles, 15 insecticides, and 22 fungicides in poultry feathers. The extraction solvent, methanol, was used for a static extraction time of 5 min, and repeated three times. Fifty milligrams of adsorbents C18/PSA (1 : 1, W/W) were added to the extraction cell to achieve simultaneous extraction and purification The extraction efficiency of three solvents, methanol, acetonitrile and Et acetate, was investigated. An orthogonal exptl. design was used to explore the optimal combination of extraction temperature, static extraction time, number of extraction cycles, and adsorbent ratio for accelerated solvent extraction After the optimal ratio was determined, the dosage of adsorbents was optimized. The extracted sample solution was concentrated by blowing nitrogen, redissolved, passed through a 0.22 μm PTFE membrane filter, then injected for instrumental anal. The validation results showed that the recovery of the proposed method was 60.4-107.6%, the limit of detection 0.2-3.0 μg kg^-1, and the limit of quantification 0.5-8.3 μg kg^-1. This quant. multi-residue detection method was able to determine the residues of 70 target compounds in poultry feathers.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C6H4N2In 2022, Hethcox, J. Caleb;Sifri, Renee J. published 《Air-Tolerant Nickel-Catalyzed Cyanation of (Hetero)aryl Halides Enabled by Polymethylhydrosiloxane, a Green Reductant》. 《Journal of Organic Chemistry》published the findings. The article contains the following contents:

An air-tolerant nickel-catalyzed cyanation of aryl bromides ArBr (Ar = 3,5-difluorophenyl, 2-naphthyl, pyridin-3-yl, etc.) is reported. The reaction uses a NiCl₂/Xantphos catalyst in combination with substoichiometric quantities of zinc cyanide and polymethylhydrosiloxane. This silane is a green, homogeneous alternative to the traditional, insoluble solid reductant zinc and renders the reaction tolerant to air. The reaction can be performed under an air atm., obviating the need for degassing, a glovebox, or Schlenk techniques. The reaction scope is broad, proceeding in good yields with a variety of (hetero)arenes. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.COA of Formula: C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nishida, Yoshihide;Sato, Katsutoshi;Chaudhari, Chandan;Yamada, Hiroshi;Toriyama, Takaaki;Yamamoto, Tomokazu;Matsumura, Syo;Aspera, Susan Menez;Nakanishi, Hiroshi;Haneda, Masaaki;Nagaoka, Katsutoshi published 《Nitrile hydrogenation to secondary amines under ambient conditions over palladium-platinum random alloy nanoparticles》 in 2022. The article was appeared in 《Catalysis Science & Technology》. They have made some progress in their research.Safety of 3-Cyanopyridine The article mentions the following:

Bimetalization between palladium (Pd) and platinum (Pt) nanoparticles, which resulted in a catalyst that showed high yield of secondary amines. Although Pd and Pt were thermodynamically immiscible, successfully alloyed the two metals by means of rapid chem. reduction assisted by microwave heating. X-ray absorption spectroscopy suggested the formation of heteroat. Pd^δ+Pt^δ- sites via charge transfer between neighboring Pd and Pt atoms in the alloy structure. Moreover, Fourier transform IR spectroscopy and scanning transmission electron microscopy-energy-dispersive X-ray spectroscopy indicated that decreasing the size of the PdPt (50 : 50) nanoparticles improved the degree of alloying and facilitated the formation of electron-enriched Pt^δ- species. On the basis of kinetics studies and d. functional theory calculations, that cyano group activation, which was the rate-determining step over monometallic Pd and Pt catalysts, was accelerated over the heteroat. Pd^δ+Pt^δ- sites because of strong back-donation from electron-enriched Pt^δ- species to the carbon atom of the cyano groups. The PdPt random alloy nanoparticles catalyzed the reactions of various aromatic and heterocyclic nitriles, and the corresponding secondary amines were selectively obtained in just a few hours. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Safety of 3-Cyanopyridine It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pokrant, Ekaterina;Trincado, Lina;Yevenes, Karina;Terraza, Gigliola;Maddaleno, Aldo;Martin, Betty San;Zavala, Sebastian;Hidalgo, Hector;Lapierre, Lisette;Cornejo, Javiera published 《Determination of five antimicrobial families in droppings of therapeutically treated broiler chicken by high-performance liquid chromatography-tandem mass spectrometry》. The research results were published in《Poultry Science》 in 2021.Name: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide The article conveys some information:

Antimicrobials are currently used in poultry for disease treatment. However, their excretion in bird feces may contaminate the environment. Considering this, the objective of this work was to quantify antimicrobials residues concentrations in therapeutically treated broiler chicken droppings throughout the post-treatment period. For this aim a multiresidue method using high-performance liquid chromatog.-tandem mass spectrometry (HPLC-MS/MS) was validated. Forty-eight male broiler chickens were distributed and treated with com. formulations of 5 different antimicrobials. Anal. showed that oxytetracycline and 4-epi-oxytetracycline, presented the highest concentrations during all sampling period, detecting concentrations of 1471.41μg kg-1 at the last sampling point (day 22 post-treatment). Florfenicol, tylosin, enrofloxacin, and ciprofloxacin were eliminated and detected in treated chicken droppings until d 18 post-treatment. Sulfachloropyridazine decrease gradually during post-treatment period until day 30. Anal. demonstrate that studied antimicrobials in treated chicken droppings were eliminated for prolonged periods, therefore becoming a significant route of residues dissemination into the environment. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Name: 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Yu;Cheng, Dengmiao;Xie, Jun;Zhang, Yuting;Wan, Yu;Zhang, Yueqiang;Shi, Xiaojun published 《Impacts of farmland application of antibiotic-contaminated manures on the occurrence of antibiotic residues and antibiotic resistance genes in soil: A meta-analysis study》 in 2022. The article was appeared in 《Chemosphere》. They have made some progress in their research.Formula: C10H9ClN4O2S The article mentions the following:

Meta-anal. of 94 published studies was conducted to explore the impacts of farmland application of antibiotic-contaminated manures on antibiotic concentrations and ARG abundances in manure-amended soil. Forty-nine antibiotics were reported, in which chlortetracycline, oxytetracycline, doxycycline, tetracycline, enrofloxacin, ciprofloxacin and norfloxacin were the most prevalent and had relatively high concentrations The responses of ARG and mobile genetic element (MGE) abundances to farmland application of antibiotic-contaminated manures varied considerably under different management strategies and environmental settings. On average, compared to unamended treatments, farmland application of antibiotic-contaminated manures significantly increased the total ARG and MGE abundances by 591% and 351%, resp. (P < 0.05). Of all the included ARG classes, the largest increase was found for sulfonamide resistance genes (1121%), followed by aminoglycoside (852%) and tetracycline (763%) resistance genes. Correlation anal. suggested that soil organic carbon (SOC) was significantly neg. correlated with antibiotic concentrations in manured soil (P < 0.05) due to the formation of covalent bonds and nonextractable residues. Soil silt content was significantly pos. correlated with antibiotic concentration (P < 0.05), which was attributed to greater sorption capacities. The ARG abundances were significantly pos. correlated with soil silt content, antibiotic concentrations, mean annual temperature, SOC, MGEs and soil pH (P < 0.05), suggesting that changes in these factors may shape the ARG profiles. Collectively, these findings advanced our understanding of the occurrence of antibiotics and ARGs in manure-amended soil and potential factors affecting them and will contribute to better management of these contaminants in future agricultural production To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Formula: C10H9ClN4O2S Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jian, Ningge;Dai, Yuanyuan;Liu, Li-e;Wu, Di;Qi, Feifei;Wu, Yongjun published 《Simultaneous extraction of multi-antibiotic residues in environmental water by DTPA-modified polyaniline nanofibers membrane》 in 2022. The article was appeared in 《Separation and Purification Technology》. They have made some progress in their research.Product Details of 80-32-0 The article mentions the following:

In this study, novel diethylenetriaminepentaacetic acid modified polyaniline nanofibers membrane (DTPA-PANI NFsM) was designed and fabricated. By the synergistic effect of PANI and DTPA, the DTPA-PANI NFsM demonstrated superior sorption performance towards three classes of antibiotics with very different properties: phenicols, tetracyclines and sulfonamides. The mass transfer efficiency of DTPA-PANI NFsM was particularly high. From the isotherm and thermodn. studies, favorable and spontaneous adsorption processes were confirmed. The potential adsorption mechanisms were investigated by FT-IR anal. Under the optimized conditions, an efficient, fast, sensitive and economical method for the high-throughput detection of antibiotic residues in environmental water was developed. Low detection limits (1.6-28.6 ng/L for phenicols, 10-34.3 ng/L for tetracyclines, 0.46-15 ng/L for sulfonamides), broad linear range (1.5 ng/L-5 μg/L) as well as satisfactory recoveries and precisions were obtained. In addition, DTPA-PANI NFsM exhibited excellent regeneration and reusability properties, which could be reused for at least 12 times. Also, the practical application feasibility of the method was confirmed by the test of actual samples.4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) were involved in the experimental procedure.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Product Details of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wang, Fan;Chen, Yangwu;Wang, Lin;Meng, Dan;Zhu, Rongxia;Li, Yong;Tan, Zhouliang;Deng, Qinwen published 《Fates of antibiotic resistance genes during upgrading process of a municipal wastewater treatment plant in southwest China》 in 2022. The article was appeared in 《Chemical Engineering Journal (Amsterdam, Netherlands)》. They have made some progress in their research.Category: pyridine-derivatives The article mentions the following:

This study comprehensively analyzed the fates of antibiotics, antibiotic resistance genes (ARGs) and microbial community during upgrading process of municipal wastewater treatment plant (MWTP) of Anaerobic/Anoxic/Oxic-membrane bioreactor (A2/O-MBR) from regulation to stable operation phase. The factors most affecting ARGs profile were investigated, and the potential hosts for ARGs were further determined Results showed that the removal rate of total antibiotics and the reduction of ARGs increased by 10.49% and 1.37 logs in A2/O-MBR during upgrading process, resp. The most prevalent ARG was sul1 in both water and sludge phase. Mobile genetic elements (MGEs) and microbial community were the most significant factors affecting ARGs distribution in water phase and sludge, resp. Notably, the abundance of potential antibiotic resistance bacteria (ARB) was significantly decreased during upgrading process. Therefore, sul1and intI1 proliferation as well as microbial community succession should be emphasized in ARGs pollution management and control. This study expected to provide a theor. basis for the application of MBR process to remove antibiotics and ARGs in upgrading of MWTPs. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lei Lu, Tan;Shahriman, Mohamad Shariff;Sambasevam, Kavirajaa Pandian;Mohamad Zain, Nur Nadhirah;Yahaya, Noorfatimah;Lim, Vuanghao;Raoov, Muggundha published 《In-tip solid-phase microextraction: a method for determination of sulphonamide residues in environmental water samples》 in . The article was appeared in 《International Journal of Environmental Analytical Chemistry》. They have made some progress in their research.Category: pyridine-derivatives The article mentions the following:

This study involved the development of an in-pipet tip solid-phase microextraction (SPME) method using activated charcoal as an adsorbent. Simultaneous determination of three sulfonamide antibiotic residues in environmental water was performed using this method, coupled with high-performance liquid chromatog.-photodiode array (HPLC-PDA) detection. Seven extraction parameters were optimized by one-variable-at-a-time (OVAT) and response surface (RSM) methods. Optimum extraction efficiency was achieved when 10 mL of sample solution at a natural pH (pH 5-6) was loaded through a 1 mL pipet tip packed with 10 mg of adsorbent, washed with 1 mL of hexane and eluted with 500 μL of 1% ammonium in methanol solution Under the optimized exptl. condition, this method manifested good linearity (5-500 μg L^-1) at the coefficient of determination, R2 of 0.9992 to 0.9993, high sensitivity (limit of detection, LOD: 0.38-1.14 μg L^-1; limit of quantification, LOQ: 1.14-3.35 μg L^-1), and satisfactory recoveries (82.8-108.7%) with acceptable reproducibility (RSD < 4.6%). Real sample anal. of five environmental water samples sourced from Universiti Malaya, Kuala Lumpur and Malacca showed that the samples contained either none or traces of the target sulfonamides (SAs) with their concentration lower than the LOQs. In contrast to other methods, the comparison outcomes depicted that this in-tip SPME method was beneficial in terms of its simple, reusable, cost-saving setup together with a significant reduction in chem. consumption. The experimental procedure involved many compounds, such as 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Category: pyridine-derivativesDue to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem