Day: September 21, 2022

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Related Products of 16133-25-8.

Heightman, Tom D.;Callahan, James F.;Chiarparin, Elisabetta;Coyle, Joseph E.;Griffiths-Jones, Charlotte;Lakdawala, Ami S.;McMenamin, Rachel;Mortenson, Paul N.;Norton, David;Peakman, Torren M.;Rich, Sharna J.;Richardson, Caroline;Rumsey, William L.;Sanchez, Yolanda;Saxty, Gordon;Willems, Henriette M. G.;Wolfe, Lawrence;Woolford, Alison J.-A.;Wu, Zining;Yan, Hongxing;Kerns, Jeffrey K.;Davies, Thomas G. research published 《 Structure-Activity and Structure-Conformation Relationships of Aryl Propionic Acid Inhibitors of the Kelch-like ECH-Associated Protein 1/Nuclear Factor Erythroid 2-Related Factor 2 (KEAP1/NRF2) Protein-Protein Interaction》, the research content is summarized as follows. The KEAP1-NRF2-mediated cytoprotective response plays a key role in cellular homoeostasis. Insufficient NRF2 signaling during chronic oxidative stress may be associated with the pathophysiol. of several diseases with an inflammatory component, and pathway activation through direct modulation of the KEAP1-NRF2 protein-protein interaction is being increasingly explored as a potential therapeutic strategy. Nevertheless, the physicochem. nature of the KEAP1-NRF2 interface suggests that achieving high affinity for a cell-penetrant druglike inhibitor might be challenging. We recently reported the discovery of a highly potent tool compound which was used to probe the biol. associated with directly disrupting the interaction of NRF2 with the KEAP1 Kelch domain. We now present a detailed account of the medicinal chem. campaign leading to this mol., which included exploration and optimization of protein-ligand interactions in three energetic “hot spots” identified by fragment screening. In particular, we also discuss how consideration of ligand conformational stabilization was important to its development and present evidence for preorganization of the lead compound which may contribute to its high affinity and cellular activity.

Related Products of 16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Synthetic Route of 31181-90-5.

He, Zhang-Xu;Huo, Jin-Ling;Gong, Yun-Peng;An, Qi;Zhang, Xin;Qiao, Hui;Yang, Fei-Fei;Zhang, Xin-Hui;Jiao, Le-Min;Liu, Hong-Min;Ma, Li-Ying;Zhao, Wen research published 《 Design, synthesis and biological evaluation of novel thiosemicarbazone-indole derivatives targeting prostate cancer cells》, the research content is summarized as follows. To discover novel anticancer agents with potent and low toxicity, a range of new thiosemicarbazone-indole analogs I [R = H, Me, Cl, OMe; R¹ = H, Me, R² = H, Me, OH, etc.; R³ = H, Me; X = N, C] based on lead compound II were designed and synthesized previously. Most compounds displayed moderate to high anticancer activities against five tested tumor cells (PC3, EC109, DU-145, MGC803, MCF-7). Specifically, the represented compound I [R = H, R¹ = Me; R² = Me, R³ = H] (III) possessed strong antiproliferative potency and high selectivity toward PC3 cells with the IC₅₀ value of 0.054μM, compared with normal WPMY-1 cells with the IC₅₀ value of 19.470μM. Preliminary mechanism research indicated that compound (III) could significantly suppress prostate cancer cells (PC3, DU-145) growth and colony formation in a dose-dependent manner. Besides, derivative (III) induced G1/S cycle arrest and apoptosis, which may be related to ROS accumulation due to the activation of MAPK signaling pathway. Furthermore, mol. (III) could effectively inhibit tumor growth through a xenograft model bearing PC3 cells and had no evident toxicity in vivo. Overall, based on the biol. activity evaluation, analog (III) can be viewed as a potential lead compound for further development of novel anti-prostate cancer drug.

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., Synthetic Route of 31181-90-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application of C6H4BrNO.

He, Zhangxu;Qiao, Hui;Yang, Feifei;Zhou, Wenjuan;Gong, Yunpeng;Zhang, Xinhui;Wang, Haojie;Zhao, Bing;Ma, Liying;Liu, Hong-min;Zhao, Wen research published 《 Novel thiosemicarbazone derivatives containing indole fragment as potent and selective anticancer agent》, the research content is summarized as follows. A series of novel thiosemicarbazone derivatives I [R¹ = Ph, benzyl, phenylethyl,etc.; R² = 2-pyridyl, 3-methyl-2-pyridyl, 4-methyl-2-pyridyl,etc.; R³ = H, Me] containing indole fragment were designed and synthesized. Most compounds exhibited excellent antiproliferative activity against PC3, MGC803 and EC109 cell lines with low micromolar IC₅₀ (0.14-12μM). Especially, compound I [R¹ = 2-(5-chloro-1H-indol-3-yl)ethyl; R² = 5-methyl-2-pyridyl; R³ = H] can selectively inhibit PC3 cells in three tested tumor cells with IC₅₀ value of 0.14 μM, which was attributed to a synergistic effect after introducing indole fragment into the TSC structure. Meanwhile, compound I [R¹ = 2-(5-chloro-1H-indol-3-yl)ethyl; R² = 5-methyl-2-pyridyl; R³ = H] displayed more selectivity in PC3 cells toward two normal WPMY-1 and GES-1 cell lines, compared to those of 3-AP and DPC. It was also found that I [R¹ = 2-(5-chloro-1H-indol-3-yl)ethyl; R² = 5-methyl-2-pyridyl; R³ = H] can effectively inhibit PC3 cell proliferation, colonization and induce apoptosis. Compound I [R¹ = 2-(5-chloro-1H-indol-3-yl)ethyl; R² = 5-methyl-2-pyridyl; R³ = H] may significantly suppress migration and invasion by blocking the EMT process but had no effect on cell cycle. Collectively, this findings indicated that I [R¹ = 2-(5-chloro-1H-indol-3-yl)ethyl; R² = 5-methyl-2-pyridyl; R³ = H] with structure of thiosemicarbazone containing indole may serve as a useful anticancer lead for further optimization and development.

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., Application of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Safety of 2-Amino-5-methylpyridine.

He, Jian;Zhao, Huining;Hu, Xinru;Fang, Zhiyong;Wang, Jilin;Zhang, Rui;Zheng, Guoyuan;Zhou, Bing;Long, Fei research published 《 Synthesis, Structure, and Photoelectric Properties of a Novel 0-Dimensional Organic-Inorganic Hybrid Perovskite (2-5-py)₂MnBr₄》, the research content is summarized as follows. In this study, a new type of 0-dimensional organic-inorganic hybrid perovskite single crystal (2-5-py)₂MnBr₄ was synthesized using 2-amino-5-methylpyridine (2-5-py) as the organic ligand. The crystal is a center-sym. P-1 space group with a grain size of 20 mm, which belongs to the triclinic crystal system. It has a strong absorption of violet and blue light as well as excellent thermal stability. Its optical band gap is 2.38 eV, which is in good agreement with the theor. band gap (2.39 eV) calculated by d. functional theory. Under the excitation of a suitable light source, it can emit 526 nm pure bright green lights, which are confirmed by the main peaks to be almost in the green range with a full width at half maximum of 45 nm. As a result, the quantum efficiency and fluorescence lifetime reached a high level of 44.2% and 117 μs, resp. Based on the good fluorescence performance of the crystal, a white LED with a color rendering index of 97 was finally successfully fabricated, realizing the leap from basic materials to optoelectronic devices.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Safety of 2-Amino-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Recommanded Product: 5-Bromopicolinaldehyde.

Hauke, Tobias J.;Hoefner, Georg;Wanner, Klaus T. research published 《 Generation and screening of pseudostatic hydrazone libraries derived from 5-substituted nipecotic acid derivatives at the GABA transporter mGAT4》, the research content is summarized as follows. The γ-aminobutyric acid (GABA) transporter mGAT4 represents a promising drug target for the treatment of epilepsy and other neurol. disorders; however, the lack of highly potent and selective inhibitors for mGAT4 still retards its pharmacol. elucidation. Herein, the generation and screening of pseudostatic combinatorial hydrazone libraries at the murine GABA transporter mGAT4 for the search of novel GABA uptake inhibitors is described. The hydrazone libraries contained more than 1100 compounds derived from nipecotic acid derivatives substituted at the 5-position instead, as common, at the 1-position of the core structure. Two hits were found and evaluated, which display potencies in the lower micromolar range at mGAT4 and its human equivalent hGAT3. These compounds possess a lipophilic moiety derived from a biphenyl residue attached to the 5-position of the hydrophilic nipecotic acid moiety via a three-atom spacer. Thus, the novel structures with potencies close to that of the bench mark mGAT4 inhibitor (S)-SNAP-5114 add new insights into the structure-activity relationship of mGAT4 inhibitors and could provide a promising starting point for the development of new mGAT4 inhibitors with even higher potencies.

Recommanded Product: 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Recommanded Product: 5-Bromopicolinaldehyde.

Hardy, Matthias;Struch, Niklas;Topic, Filip;Schnakenburg, Gregor;Rissanen, Kari;Luetzen, Arne research published 《 Stepwise Construction of Heterobimetallic Cages by an Extended Molecular Library Approach》, the research content is summarized as follows. Two novel heterobimetallic complexes, a trigonal-bipyramidal and a cubic one, have been synthesized and characterized using the same C₃-sym. metalloligand, prepared by a simple subcomponent self-assembly strategy. Adopting the mol. library approach, we chose a mononuclear, preorganized iron(II) complex as the metalloligand capable of self-assembly into a trigonal-bipyramidal or a cubic aggregate upon coordination to cis-protected C₂-sym. palladium(II) or unprotected tetravalent palladium(II) ions, resp. The trigonal-bipyramidal complex was characterized by NMR and UV-vis spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and single-crystal X-ray diffraction. The cubic structure was characterized by NMR and UV-vis spectroscopy and ESI-MS.

Recommanded Product: 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application In Synthesis of 1603-41-4.

Hao, Wei;Li, Kailu;Ye, Chenyang;Yu, Wenquan;Chang, Junbiao research published 《 Iodine-Mediated C=C Double Bond Cleavage toward Pyrido[2,1-b]quinazolinones》, the research content is summarized as follows. A transition-metal-free C=C double bond cleavage reaction employing mol. iodine is described. In the presence of K₂CO₃ as the base, I₂-mediated C = C bond cleavage followed by intramol. annulation of N-(2-vinylaryl)pyridin-2-amine substrates, e.g., N-(2-vinylnaphthalen-1-yl)pyridin-2-amine produces pyrido[2,1-b]quinazolinones, e.g., 7H-benzo[h]pyrido[2,1-b] quinazolin-7-one and related heterocyclic compounds This reaction can be completed on a gram scale and has been successfully applied to the synthesis of compounds with important biol. properties such as 11H-pyrido[2,1-b]quinazolin-11-one and 2-methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, including efflux pump inhibitory and antiallergic activities.

Application In Synthesis of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Computed Properties of 766-11-0.

Hansen, Eric C.;Li, Changfeng;Yang, Sihang;Pedro, Dylan;Weix, Daniel J. research published 《 Coupling of Challenging Heteroaryl Halides with Alkyl Halides via Nickel-Catalyzed Cross-Electrophile Coupling》, the research content is summarized as follows. Despite their importance, the synthesis of alkylated heterocycles from the cross-coupling of Lewis basic nitrogen heteroaryl halides with alkyl halides remains a challenge. We report here a general solution to this challenge enabled by a new collection of ligands based around 2-pyridyl-N-cyanocarboxamidine and 2-pyridylcarboxamidine cores. Both primary and secondary alkyl halides can be coupled with 2-, 3-, and 4-pyridyl halides as well as other more complex heterocycles in generally good yields (41 examples, 69% ave yield).

Computed Properties of 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reference of 1603-41-4.

Hansa, Raj KC.;Khan, M. M. K.;Frangie, M. M.;Gilmore, D. F.;Shelton, R. S.;Savenka, A. V.;Basnakian, A. G.;Shuttleworth, S. L.;Smeltzer, M. S.;Alam, M. A. research published 《 4-4-(Anilinomethyl)-3-[4-(trifluoromethyl)phenyl]-1H-pyrazol-1-ylbenzoic acid derivatives as potent anti-gram-positive bacterial agents》, the research content is summarized as follows. A collection of potent antimicrobials consisting of novel 1,3-bis-benzoic acid and trifluoromethyl Ph derived pyrazoles I [R = HO(O)C, F₃C; R¹ = Ph, 3-bromophenyl, 5-iodopyridin-2-yl, etc.] was synthesized and tested for antibacterial activity. The majority of trifluoromethyl Ph derivatives are highly potent growth inhibitors of Gram-pos. bacteria and showed low toxicity to human cultured cells. In particular, two compounds I [R = F₃C; R¹ = 3-fluoro-5-(trifluoromethyl)phenyl, 3,5-dichloro-4-fluorophenyl] were selected for addnl. studies. These compounds were highly effective against Staphylococcus aureus as shown by a low min. inhibitory concentration (MIC), a bactericidal effect in time-kill assays, moderate inhibition of biofilm formation as well as biofilm destruction and a bactericidal effect against stationary phase cells representing non-growing persister cells. Multistep resistance assays showed a very low tendency for S. aureus and Enterococcus faecalis to develop resistance through mutation. Addnl., in vivo mouse model studies showed no harmful effects at doses up to 50 mg/kg using 14 blood plasma organ toxicity markers or TUNEL assay in liver and kidney. Investigations into the mode of action by performing macromol. synthesis inhibition studies showed a broad range of inhibitory effects, suggesting targets that have a global effect on bacterial cell function.

Reference of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. COA of Formula: C6H6BrN.

Handa, Sachin;Jin, Bo;Bora, Pranjal P.;Wang, Ye;Zhang, Xiaohua;Gallou, Fabrice;Reilly, John;Lipshutz, Bruce H. research published 《 Sonogashira Couplings Catalyzed by Fe Nanoparticles Containing ppm Levels of Reusable Pd, under Mild Aqueous Micellar Conditions》, the research content is summarized as follows. Nanoparticles derived from FeCl₃ containing the ligand XPhos and only 500 ppm Pd effect Sonogashira couplings in water between rt and 45°. The entire aqueous reaction medium can be easily recycled using an “in-flask” extraction Several tandem processes in one pot are illustrated, including a sequence involving five steps (10 reactions) in good overall yield.

COA of Formula: C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem