Day: September 21, 2022

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Application In Synthesis of 31181-90-5.

Giraldi, Erica;Depallens, Adrien B.;Ortiz, Daniel;Fadaei-Tirani, Farzaneh;Scopelliti, Rosario;Severin, Kay research published 《 Boronate Ester-Capped Helicates》, the research content is summarized as follows. Triple-stranded helicates were obtained by metal-templated multicomponent reactions of bispyridyloxime ligands with arylboronic acids. The helicates feature two hexacoordinated M^II ions (M = Fe, Zn, or Mn), which are embedded in a macrobicyclic ligand framework, and two arylboronate ester capping groups. The latter can be used to introduce functional groups such as pyridines, aldehydes, nitriles, and carboxylic acids in apical position. The functionalized helicates have the potential to be used as nanoscale building blocks for more complex assemblies, as evidenced by the synthesis of a 3. nm-sized trianglimine.

Application In Synthesis of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Computed Properties of 5315-25-3.

Giordano, Marco;Volpi, Giorgio;Bonomo, Matteo;Mariani, Paolo;Garino, Claudio;Viscardi, Guido research published 《 Methoxy-substituted copper complexes as possible redox mediators in dye-sensitized solar cells》, the research content is summarized as follows. Three aromatic diimine ligands and the corresponding homoleptic copper(I) and copper(II) complexes have been synthesized and characterized. The copper(II) derivatives are stabilized by an ancillary chlorido ligand. The nature of the chelating ligand seriously impacts the photophys. and electrochem. properties of the complexes. The substitution of the pendant Me groups with methoxy influences the coordination geometry of the complexes, resulting in an intramol. dynamic equilibrium between different coordination modes (i.e. nitrogen and oxygen binding), proved by variable-temperature ¹H-NMR measurements. As a proof of concept, the most promising complexes were employed as redox mediators in semi-transparent dye-sensitized solar cells. Once implemented in devices, the nature of the ligand plays a crucial role: the methoxy-substituted derivatives appear upon severe ligand exchange with tert-butylpyridine, resulting in an unexpectedly high open circuit voltage.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Computed Properties of 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Category: pyridine-derivatives.

Giddens, Anna C.;Gamage, Swarna A.;Kendall, Jackie D.;Lee, Woo-Jeong;Baguley, Bruce C.;Buchanan, Christina M.;Jamieson, Stephen M. F.;Dickson, James M. J.;Shepherd, Peter R.;Denny, William A.;Rewcastle, Gordon W. research published 《 Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474》, the research content is summarized as follows. Replacing one of the morpholine groups of the phosphatidylinositol 3-kinase (PI3K) inhibitor ZSTK474 with a variety of sulfonamide-linked solubilizing substituents produced a new class of active and potent PI3Kα inhibitors, with several derivatives demonstrating high PI3Kα enzyme potency and good cellular potency in two human derived cell lines. The overall results suggest a preference for linear and somewhat flexible solubilizing functions. From this series, compound 16, also known as SN32976, was selected for advanced preclin. evaluation.

Category: pyridine-derivatives, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Related Products of 16133-25-8.

Ghosh, Animesh;Tan, Nigel C. S.;Shi, Raymond R. S.;Webster, Richard D.;Steele, Terry W. J. research published 《 Optimizing the Reduction Potential of Sulfonamides on Polyamidoamine Dendrimers》, the research content is summarized as follows. p-Toluenesulfonamide serves as an important functional group to protect alkyl amines. However, the electrochem. deprotection of sulfonamides requires relatively high reduction potentials (-2.4 V vs SCE) that would interfere with other functional groups. Previous investigations suggest that methods are available to decrease the reduction potential, but no systematic investigation has been conducted that evaluates the reduction potential as a function of aryl-substitution, mediator, or multi-arm grafting. Cyclic voltammetric studies of a library of bis-sulfonamides bearing different aryl substituents in DMF reveals that p-NO2 substituted bis-sulfonamide has the lowest reduction potential. Further investigations aimed at lowering the cathodic potential with polycyclic aromatic hydrocarbon mediators display negligible or no impact. This optimized condition was successfully applied to fully p-nitrobenzenesulfonyl protected generation-zero and generation-one polyamidoamine dendrimers (G0.0-PAMAM-Ns and G1.0-PAMAM-Ns, resp.), demonstrating successful amine protection and deprotection on dendrimers for the first time.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Related Products of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Computed Properties of 766-11-0.

Gazzard, Lewis;Williams, Karen;Chen, Huifen;Axford, Lorraine;Blackwood, Elizabeth;Burton, Brenda;Chapman, Kerry;Crackett, Peter;Drobnick, Joy;Ellwood, Charles;Epler, Jennifer;Flagella, Michael;Gancia, Emanuela;Gill, Matthew;Goodacre, Simon;Halladay, Jason;Hewitt, Joanne;Hunt, Hazel;Kintz, Samuel;Lyssikatos, Joseph;Macleod, Calum;Major, Sarah;Medard, Guillaume;Narukulla, Raman;Ramiscal, Judi;Schmidt, Stephen;Seward, Eileen;Wiesmann, Christian;Wu, Ping;Yee, Sharon;Yen, Ivana;Malek, Shiva research published 《 Mitigation of Acetylcholine Esterase Activity in the 1,7-Diazacarbazole Series of Inhibitors of Checkpoint Kinase 1》, the research content is summarized as follows. Checkpoint kinase 1 (ChK1) plays a key role in the DNA damage response, facilitating cell-cycle arrest to provide sufficient time for lesion repair. This leads to the hypothesis that inhibition of ChK1 might enhance the effectiveness of DNA-damaging therapies in the treatment of cancer. Lead compound 1 (GNE-783), the prototype of the 1,7-diazacarbazole class of ChK1 inhibitors, was found to be a highly potent inhibitor of acetylcholine esterase (AChE) and unsuitable for development. A campaign of analog synthesis established SAR delineating ChK1 and AChE activities and allowing identification of new leads with improved profiles. In silico docking using a model of AChE permitted rationalization of the observed SAR. Compounds 19 (GNE-900) and 30 (GNE-145) were identified as selective, orally bioavailable ChK1 inhibitors offering excellent in vitro potency with significantly reduced AChE activity. In combination with gemcitabine, these compounds demonstrate an in vivo pharmacodynamic effect and are efficacious in a mouse p53 mutant xenograft model.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Computed Properties of 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. SDS of cas: 766-11-0.

Gardinier, Kevin M.;Gernert, Douglas L.;Porter, Warren J.;Reel, Jon K.;Ornstein, Paul L.;Spinazze, Patrick;Stevens, F. Craig;Hahn, Patric;Hollinshead, Sean P.;Mayhugh, Daniel;Schkeryantz, Jeff;Khilevich, Albert;De Frutos, Oscar;Gleason, Scott D.;Kato, Akihiko S.;Luffer-Atlas, Debra;Desai, Prashant V.;Swanson, Steven;Burris, Kevin D.;Ding, Chunjin;Heinz, Beverly A.;Need, Anne B.;Barth, Vanessa N.;Stephenson, Gregory A.;Diseroad, Benjamin A.;Woods, Tim A.;Yu, Hong;Bredt, David;Witkin, Jeffrey M. research published 《 Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8》, the research content is summarized as follows. Transmembrane AMPA receptor regulatory proteins (TARPs) are a family of scaffolding proteins that regulate AMPA receptor trafficking and function. TARP γ-8 is one member of this family and is highly expressed within the hippocampus relative to the cerebellum. A selective TARP γ-8-dependent AMPA receptor antagonist (TDAA) is an innovative approach to modulate AMPA receptors in specific brain regions to potentially increase the therapeutic index relative to known non-TARP-dependent AMPA antagonists. We describe here, for the first time, the discovery of a noncompetitive AMPA receptor antagonist that is dependent on the presence of TARP γ-8. Three major iteration cycles were employed to improve upon potency, CYP1A2-dependent challenges, and in vivo clearance. An optimized mol., compound (-)-25 (LY3130481), was fully protective against pentylenetetrazole-induced convulsions in rats without the motor impairment associated with non-TARP-dependent AMPA receptor antagonists. Compound (-)-25 could be utilized to provide proof of concept for antiepileptic efficacy with reduced motor side effects in patients.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , SDS of cas: 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Formula: C5H4ClNO2S.

Gao, Yuting;Sun, Yang;Fang, Xianfu;Zhao, Guixian;Li, Xufeng;Zhang, Gong;Li, Yangfeng;Li, Yizhou research published 《 Development of on-DNA vinyl sulfone synthesis for DNA-encoded chemical libraries》, the research content is summarized as follows. The DNA-encoded chem. library (DEL) technol. is a novel drug discovery tool, benefiting from its large number of compound collections with chem. space coverage. Vinyl sulfone is a privileged functional group, eliciting diverse pharmacol. activities as the covalent warhead. In this report, we incorporated vinyl sulfone into the DEL chem. field by developing a mild and efficient DNA-compatible method starting from simple sodium sulfinates and DNA-conjugated alkenes, affording a broad substrate scope with moderate-to-excellent conversions. Further chem. transformations including the thiol-Michael addition reaction, together with enzymic ligation, were also successfully implemented to demonstrate the feasibility of this DNA-compatible synthesis in DEL construction.

Formula: C5H4ClNO2S, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Related Products of 766-11-0.

Gao, Tai-Heng;Ying Xiong;Guo, Pengfeng;Liu, Feng-Shou;Zhao, Limin research published 《 Rigid α-diimine palladium complexes as direct C-H arylation precatalysts for thiophenes and heteroaryl bromides》, the research content is summarized as follows. The direct C-H heteroarylation of thiophenes, promoted by rigid α-diimine palladium complexes is described. This approach exhibits broad substrate scopes with functional group tolerant, and proceeds with the formation of regioselective products.

Related Products of 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. HPLC of Formula: 1603-41-4.

Gaikwad, Sanjay Subhas;Thorat, Nitin Madhu;Patil, Limbraj Rajaram research published 《 Sonication Assisted One-Pot Synthesis of Substituted Imidazopyridine from Styrene in Water》, the research content is summarized as follows. The present protocol was a simple and eco-friendly approach for the one-pot procedure for the synthesis of substituted imidazopyridines I [R = H, t-Bu. F, etc.; R¹ = H, Me, Br; R² = H, Me] ranging from important feedstock’s like styrene promoted by NBS. Through sonicator and microwave com. available styrene with NBS in water followed by reaction with 2-aminopyridines afforded important heterocyclic scaffolds in an one-pot procedure.

HPLC of Formula: 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Electric Literature of 5315-25-3.

Fujiwara, Yusuke;Takayama, Tomoaki;Nakazawa, Jun;Okamura, Masaya;Hikichi, Shiro research published 《 Development of a novel scorpionate ligand with 6-methylpyridine and comparison of the structural and electronic properties of nickel(II) complexes with related tris(azolyl)borates》, the research content is summarized as follows. A novel anionic tridentate borate ligand with a 6-methylpyridyl donor, Tpy^Me, has been synthesized. Comparison of the mol. structures and reactivities of nickel(II)-bromido complexes with tris(azolyl)borate ligands composed of pyridyl, pyrazolyl, or oxazolinyl donors indicates the characteristic sterically demanding nature and strong electron donating ability of Tpy^Me.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Electric Literature of 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem